{"id":"https://openalex.org/W4220800520","doi":"https://doi.org/10.1002/j.2040-4603.2022.tb00210.x","title":"Oxidative Stress and Redox Signaling in the Pathophysiology of Liver Diseases","display_name":"Oxidative Stress and Redox Signaling in the Pathophysiology of Liver Diseases","publication_year":2022,"publication_date":"2022-03-29","ids":{"openalex":"https://openalex.org/W4220800520","doi":"https://doi.org/10.1002/j.2040-4603.2022.tb00210.x","pmid":"https://pubmed.ncbi.nlm.nih.gov/35578969","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10074426"},"language":"en","primary_location":{"id":"doi:10.1002/j.2040-4603.2022.tb00210.x","doi":"https://doi.org/10.1002/j.2040-4603.2022.tb00210.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.2040-4603.2022.tb00210.x","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"journal-article"},"volume":{"id":"https://openalex.org/W2787983500","display_name":"Comprehensive Physiology"},"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10074426/pdf/nihms-1880813.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081665563","display_name":"Raja Gopal Reddy Mooli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raja Gopal Reddy Mooli","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065813965","display_name":"Dhanunjay Mukhi","orcid":"https://orcid.org/0000-0001-6179-5220","observed_orcids":["https://orcid.org/0000-0001-6179-5220"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhanunjay Mukhi","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016118917","display_name":"Sadeesh Kumar Ramakrishnan","orcid":"https://orcid.org/0000-0002-7255-2977","observed_orcids":["https://orcid.org/0000-0002-7255-2977"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sadeesh K. Ramakrishnan","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016118917"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":5.7291,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.97997693,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"2","first_page":"3167","last_page":"3192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.11559999734163284,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9599999785423279},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":1.0},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.8240000009536743},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.8799999952316284},{"id":"https://openalex.org/keywords/oxidative-stress-biomarkers","display_name":"oxidative stress biomarkers","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.9347773194313049},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.8055635094642639},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.6160492300987244},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.606197714805603},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5542075037956238},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.46349239349365234},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4374939799308777},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41899868845939636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41458797454833984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3971422016620636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3926292657852173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.342523455619812},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2445576786994934}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/j.2040-4603.2022.tb00210.x","doi":"https://doi.org/10.1002/j.2040-4603.2022.tb00210.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.2040-4603.2022.tb00210.x","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"journal-article"},{"id":"doi:10.1002/cphy.c200021","doi":"https://doi.org/10.1002/cphy.c200021","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cphy.c200021","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"other"},{"id":"pmid:35578969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35578969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10074426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10074426","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10074426/pdf/nihms-1880813.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Compr Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10074426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10074426","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10074426/pdf/nihms-1880813.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Compr Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3135956428","display_name":"The Role of Intestinal Hypoxia Signaling in Glucose Homeostasis","funder_award_id":"K99DK110537","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3932160339","display_name":null,"funder_award_id":"DK110537","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6387831398","display_name":"The Role of Intestinal Hypoxia Signaling in Glucose Homeostasis","funder_award_id":"R00DK110537","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000856395","display_name":"Pittsburgh Liver Research Center","funder_award_id":"P30DK120531","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220800520.pdf","grobid_xml":"https://content.openalex.org/works/W4220800520.grobid-xml"},"referenced_works_count":478,"referenced_works":["https://openalex.org/W28771307","https://openalex.org/W985842495","https://openalex.org/W1165140024","https://openalex.org/W1211413901","https://openalex.org/W1483567609","https://openalex.org/W1485237380","https://openalex.org/W1488079166","https://openalex.org/W1490817952","https://openalex.org/W1524495238","https://openalex.org/W1531285870","https://openalex.org/W1533418331","https://openalex.org/W1564324814","https://openalex.org/W1568529372","https://openalex.org/W1585390661","https://openalex.org/W1598978469","https://openalex.org/W1599970242","https://openalex.org/W1618134065","https://openalex.org/W1813230101","https://openalex.org/W1820314031","https://openalex.org/W1830033513","https://openalex.org/W1882356554","https://openalex.org/W1894585747","https://openalex.org/W1910361842","https://openalex.org/W1911608194","https://openalex.org/W1914169609","https://openalex.org/W1915485606","https://openalex.org/W1958979802","https://openalex.org/W1963890445","https://openalex.org/W1964995369","https://openalex.org/W1965114923","https://openalex.org/W1966831322","https://openalex.org/W1967096183","https://openalex.org/W1967236260","https://openalex.org/W1967291007","https://openalex.org/W1967396537","https://openalex.org/W1967727543","https://openalex.org/W1970165515","https://openalex.org/W1970935798","https://openalex.org/W1971890183","https://openalex.org/W1972662172","https://openalex.org/W1974961331","https://openalex.org/W1975184180","https://openalex.org/W1975745651","https://openalex.org/W1976599392","https://openalex.org/W1976777085","https://openalex.org/W1976887467","https://openalex.org/W1979705609","https://openalex.org/W1981057948","https://openalex.org/W1981932198","https://openalex.org/W1982573446","https://openalex.org/W1983419107","https://openalex.org/W1983937216","https://openalex.org/W1984205437","https://openalex.org/W1984400347","https://openalex.org/W1989020470","https://openalex.org/W1989957948","https://openalex.org/W1990098732","https://openalex.org/W1991372889","https://openalex.org/W1992454850","https://openalex.org/W1992999472","https://openalex.org/W1993137461","https://openalex.org/W1993742623","https://openalex.org/W1993839684","https://openalex.org/W1994465213","https://openalex.org/W1994473516","https://openalex.org/W1995486154","https://openalex.org/W1997023449","https://openalex.org/W1997757821","https://openalex.org/W1998762014","https://openalex.org/W1998926980","https://openalex.org/W1999178895","https://openalex.org/W1999773502","https://openalex.org/W1999956739","https://openalex.org/W2000791749","https://openalex.org/W2000819485","https://openalex.org/W2000863347","https://openalex.org/W2001422326","https://openalex.org/W2001830362","https://openalex.org/W2002426440","https://openalex.org/W2002467106","https://openalex.org/W2003034989","https://openalex.org/W2004572248","https://openalex.org/W2005573382","https://openalex.org/W2005709691","https://openalex.org/W2006221512","https://openalex.org/W2006566278","https://openalex.org/W2006626994","https://openalex.org/W2007636933","https://openalex.org/W2007733439","https://openalex.org/W2008141541","https://openalex.org/W2010135469","https://openalex.org/W2010958373","https://openalex.org/W2012154009","https://openalex.org/W2013049918","https://openalex.org/W2013092102","https://openalex.org/W2013281318","https://openalex.org/W2013322023","https://openalex.org/W2013593508","https://openalex.org/W2013907285","https://openalex.org/W2014717081","https://openalex.org/W2015577297","https://openalex.org/W2016085979","https://openalex.org/W2016468663","https://openalex.org/W2016934214","https://openalex.org/W2016947117","https://openalex.org/W2016985488","https://openalex.org/W2017168681","https://openalex.org/W2017275974","https://openalex.org/W2018076136","https://openalex.org/W2018214249","https://openalex.org/W2019694067","https://openalex.org/W2020430412","https://openalex.org/W2023140876","https://openalex.org/W2023237311","https://openalex.org/W2023503151","https://openalex.org/W2023975386","https://openalex.org/W2024597705","https://openalex.org/W2025639892","https://openalex.org/W2025650191","https://openalex.org/W2026525843","https://openalex.org/W2029342214","https://openalex.org/W2030085966","https://openalex.org/W2031889049","https://openalex.org/W2031934416","https://openalex.org/W2032611112","https://openalex.org/W2033878606","https://openalex.org/W2035245572","https://openalex.org/W2036891300","https://openalex.org/W2037855793","https://openalex.org/W2038366805","https://openalex.org/W2038424101","https://openalex.org/W2039854830","https://openalex.org/W2039855282","https://openalex.org/W2040624227","https://openalex.org/W2041392003","https://openalex.org/W2042083424","https://openalex.org/W2043046089","https://openalex.org/W2045631219","https://openalex.org/W2046658835","https://openalex.org/W2046935888","https://openalex.org/W2049714772","https://openalex.org/W2051690738","https://openalex.org/W2052719041","https://openalex.org/W2053542703","https://openalex.org/W2053779702","https://openalex.org/W2055081996","https://openalex.org/W2055528768","https://openalex.org/W2056564149","https://openalex.org/W2057310513","https://openalex.org/W2059389984","https://openalex.org/W2060125001","https://openalex.org/W2060157902","https://openalex.org/W2062807736","https://openalex.org/W2063182639","https://openalex.org/W2064182246","https://openalex.org/W2066383486","https://openalex.org/W2067449732","https://openalex.org/W2067593902","https://openalex.org/W2068435297","https://openalex.org/W2069349400","https://openalex.org/W2070141763","https://openalex.org/W2070188060","https://openalex.org/W2070549269","https://openalex.org/W2072721395","https://openalex.org/W2074503081","https://openalex.org/W2076014158","https://openalex.org/W2077248911","https://openalex.org/W2077264573","https://openalex.org/W2079132836","https://openalex.org/W2080325240","https://openalex.org/W2081803191","https://openalex.org/W2082185635","https://openalex.org/W2082245790","https://openalex.org/W2082548756","https://openalex.org/W2082561182","https://openalex.org/W2084455391","https://openalex.org/W2085067380","https://openalex.org/W2085396235","https://openalex.org/W2086341178","https://openalex.org/W2086667809","https://openalex.org/W2087432006","https://openalex.org/W2088971991","https://openalex.org/W2091375059","https://openalex.org/W2093091016","https://openalex.org/W2093222587","https://openalex.org/W2095073054","https://openalex.org/W2096031729","https://openalex.org/W2096348285","https://openalex.org/W2096627428","https://openalex.org/W2099026216","https://openalex.org/W2099425792","https://openalex.org/W2101982676","https://openalex.org/W2102101176","https://openalex.org/W2102354517","https://openalex.org/W2102508479","https://openalex.org/W2102572332","https://openalex.org/W2102619095","https://openalex.org/W2102831230","https://openalex.org/W2103284366","https://openalex.org/W2103644580","https://openalex.org/W2107683043","https://openalex.org/W2108086395","https://openalex.org/W2110118982","https://openalex.org/W2110995808","https://openalex.org/W2112990256","https://openalex.org/W2113610552","https://openalex.org/W2114111268","https://openalex.org/W2114728551","https://openalex.org/W2114787032","https://openalex.org/W2114797146","https://openalex.org/W2114806766","https://openalex.org/W2114809075","https://openalex.org/W2116951302","https://openalex.org/W2117339132","https://openalex.org/W2117497424","https://openalex.org/W2118852675","https://openalex.org/W2121699889","https://openalex.org/W2122341467","https://openalex.org/W2122386753","https://openalex.org/W2122481751","https://openalex.org/W2124105006","https://openalex.org/W2124515491","https://openalex.org/W2124898423","https://openalex.org/W2125793701","https://openalex.org/W2126503463","https://openalex.org/W2127011184","https://openalex.org/W2129363220","https://openalex.org/W2132344671","https://openalex.org/W2134523442","https://openalex.org/W2136956219","https://openalex.org/W2137652355","https://openalex.org/W2139131794","https://openalex.org/W2139328007","https://openalex.org/W2140126848","https://openalex.org/W2143267750","https://openalex.org/W2143693669","https://openalex.org/W2144275312","https://openalex.org/W2144821195","https://openalex.org/W2147849026","https://openalex.org/W2148300725","https://openalex.org/W2149168766","https://openalex.org/W2153509490","https://openalex.org/W2157638939","https://openalex.org/W2160523206","https://openalex.org/W2160832007","https://openalex.org/W2161854858","https://openalex.org/W2161877652","https://openalex.org/W2162051951","https://openalex.org/W2163275136","https://openalex.org/W2163387317","https://openalex.org/W2164828140","https://openalex.org/W2165089770","https://openalex.org/W2165201727","https://openalex.org/W2166284858","https://openalex.org/W2167878661","https://openalex.org/W2169129430","https://openalex.org/W2169229217","https://openalex.org/W2169291702","https://openalex.org/W2170236911","https://openalex.org/W2170562611","https://openalex.org/W2172115472","https://openalex.org/W2178044610","https://openalex.org/W2189102226","https://openalex.org/W2189205651","https://openalex.org/W2200184851","https://openalex.org/W2212632191","https://openalex.org/W2216289728","https://openalex.org/W2224956025","https://openalex.org/W2242359920","https://openalex.org/W2257297310","https://openalex.org/W2259709654","https://openalex.org/W2260903586","https://openalex.org/W2264072217","https://openalex.org/W2275001158","https://openalex.org/W2277468569","https://openalex.org/W2283843704","https://openalex.org/W2303275783","https://openalex.org/W2312476219","https://openalex.org/W2322155498","https://openalex.org/W2335972659","https://openalex.org/W2395880234","https://openalex.org/W2395943362","https://openalex.org/W2405977822","https://openalex.org/W2409227936","https://openalex.org/W2413496845","https://openalex.org/W2415203717","https://openalex.org/W2415854929","https://openalex.org/W2418260023","https://openalex.org/W2470906679","https://openalex.org/W2477382777","https://openalex.org/W2480062499","https://openalex.org/W2508296626","https://openalex.org/W2518640481","https://openalex.org/W2521050851","https://openalex.org/W2521662433","https://openalex.org/W2525933343","https://openalex.org/W2528512574","https://openalex.org/W2529646902","https://openalex.org/W2534403962","https://openalex.org/W2551474197","https://openalex.org/W2552043470","https://openalex.org/W2552317891","https://openalex.org/W2553876215","https://openalex.org/W2557372214","https://openalex.org/W2559792682","https://openalex.org/W2562949639","https://openalex.org/W2564221522","https://openalex.org/W2565367159","https://openalex.org/W2570675177","https://openalex.org/W2572229363","https://openalex.org/W2574409354","https://openalex.org/W2577851679","https://openalex.org/W2580291574","https://openalex.org/W2581492548","https://openalex.org/W2585046292","https://openalex.org/W2589913602","https://openalex.org/W2594430933","https://openalex.org/W2600348465","https://openalex.org/W2606492212","https://openalex.org/W2607592153","https://openalex.org/W2613674801","https://openalex.org/W2614814625","https://openalex.org/W2620099834","https://openalex.org/W2622908974","https://openalex.org/W2727069564","https://openalex.org/W2730698450","https://openalex.org/W2736274438","https://openalex.org/W2737357581","https://openalex.org/W2741636306","https://openalex.org/W2750054522","https://openalex.org/W2751939039","https://openalex.org/W2754133853","https://openalex.org/W2754246291","https://openalex.org/W2754550313","https://openalex.org/W2755654621","https://openalex.org/W2756208820","https://openalex.org/W2762656910","https://openalex.org/W2765694808","https://openalex.org/W2767241904","https://openalex.org/W2770432229","https://openalex.org/W2772781313","https://openalex.org/W2772973693","https://openalex.org/W2777958821","https://openalex.org/W2778677617","https://openalex.org/W2781993335","https://openalex.org/W2783367126","https://openalex.org/W2787406891","https://openalex.org/W2787794728","https://openalex.org/W2787928707","https://openalex.org/W2789786642","https://openalex.org/W2791564057","https://openalex.org/W2791604032","https://openalex.org/W2792021782","https://openalex.org/W2794532094","https://openalex.org/W2795148210","https://openalex.org/W2795787434","https://openalex.org/W2799986334","https://openalex.org/W2800340823","https://openalex.org/W2800341633","https://openalex.org/W2801326259","https://openalex.org/W2801929531","https://openalex.org/W2802324910","https://openalex.org/W2804518718","https://openalex.org/W2804648738","https://openalex.org/W2805023946","https://openalex.org/W2806090135","https://openalex.org/W2806182604","https://openalex.org/W2807007486","https://openalex.org/W2807476445","https://openalex.org/W2810166530","https://openalex.org/W2811266668","https://openalex.org/W2811323404","https://openalex.org/W2883577714","https://openalex.org/W2883860912","https://openalex.org/W2884216184","https://openalex.org/W2884510934","https://openalex.org/W2884616464","https://openalex.org/W2884618123","https://openalex.org/W2884835000","https://openalex.org/W2884907724","https://openalex.org/W2887693335","https://openalex.org/W2889135927","https://openalex.org/W2890276290","https://openalex.org/W2890780033","https://openalex.org/W2891066881","https://openalex.org/W2892533751","https://openalex.org/W2894876208","https://openalex.org/W2896511404","https://openalex.org/W2897773126","https://openalex.org/W2898537477","https://openalex.org/W2899241243","https://openalex.org/W2899457119","https://openalex.org/W2900825986","https://openalex.org/W2901726960","https://openalex.org/W2906120852","https://openalex.org/W2906401896","https://openalex.org/W2909660922","https://openalex.org/W2910830636","https://openalex.org/W2912101187","https://openalex.org/W2912258761","https://openalex.org/W2914225706","https://openalex.org/W2914406945","https://openalex.org/W2915824722","https://openalex.org/W2916135400","https://openalex.org/W2916578758","https://openalex.org/W2917099874","https://openalex.org/W2919083089","https://openalex.org/W2920290417","https://openalex.org/W2920751040","https://openalex.org/W2921276153","https://openalex.org/W2932093126","https://openalex.org/W2935856990","https://openalex.org/W2941033601","https://openalex.org/W2944315478","https://openalex.org/W2945880281","https://openalex.org/W2946074587","https://openalex.org/W2947034940","https://openalex.org/W2947833689","https://openalex.org/W2951096648","https://openalex.org/W2954698110","https://openalex.org/W2964552675","https://openalex.org/W2965579434","https://openalex.org/W2966150378","https://openalex.org/W2966736413","https://openalex.org/W2967638167","https://openalex.org/W2970026022","https://openalex.org/W2971914964","https://openalex.org/W2977218957","https://openalex.org/W2978111012","https://openalex.org/W2978270346","https://openalex.org/W2979433614","https://openalex.org/W2980921743","https://openalex.org/W2981297924","https://openalex.org/W2981523234","https://openalex.org/W2983129301","https://openalex.org/W2986572941","https://openalex.org/W2988672227","https://openalex.org/W2989982619","https://openalex.org/W2995835183","https://openalex.org/W2996280175","https://openalex.org/W2999462394","https://openalex.org/W3003356608","https://openalex.org/W3003361050","https://openalex.org/W3005689864","https://openalex.org/W3006488526","https://openalex.org/W3009220429","https://openalex.org/W3009846732","https://openalex.org/W3011349816","https://openalex.org/W3011537607","https://openalex.org/W3013352992","https://openalex.org/W3014339066","https://openalex.org/W3015915734","https://openalex.org/W3020747578","https://openalex.org/W3023051922","https://openalex.org/W3024383047","https://openalex.org/W3025080852","https://openalex.org/W3025364843","https://openalex.org/W3033352061","https://openalex.org/W3035348286","https://openalex.org/W3038091087","https://openalex.org/W3081164506","https://openalex.org/W3100852364","https://openalex.org/W4230119926","https://openalex.org/W4243729710","https://openalex.org/W4247878364","https://openalex.org/W4248078302","https://openalex.org/W4293653706","https://openalex.org/W4300169625","https://openalex.org/W6643378000","https://openalex.org/W6664775979","https://openalex.org/W6687241064","https://openalex.org/W6695838797","https://openalex.org/W6730021854","https://openalex.org/W6741559652","https://openalex.org/W6742735757","https://openalex.org/W6760068275","https://openalex.org/W6829544573","https://openalex.org/W7065307452"],"related_works":["https://openalex.org/W4386069873","https://openalex.org/W2496829931","https://openalex.org/W3009220429","https://openalex.org/W3210066086","https://openalex.org/W4205812061","https://openalex.org/W2592590866","https://openalex.org/W2278333176","https://openalex.org/W3141053323","https://openalex.org/W1976902613","https://openalex.org/W4411721944"],"abstract_inverted_index":{"The":[0],"increased":[1],"production":[2],"of":[3,5,13,55,71,86,93,105,114,151,157,170,190,196],"derivatives":[4],"molecular":[6,25],"oxygen":[7,15],"and":[8,18,43,57,74,76,103,117,161,174],"nitrogen":[9,20],"in":[10,40,48,89,100,135,154,178,193],"the":[11,34,49,52,69,83,94,101,111,145,149,155,183,188,194,197],"form":[12],"reactive":[14,19],"species":[16,21],"(ROS)":[17],"(RNS)":[22],"lead":[23],"to":[24,61,120],"damage":[26],"called":[27],"oxidative":[28,62,87,137,152,171,191],"stress.":[29,63],"Under":[30],"normal":[31],"physiological":[32],"conditions,":[33],"ROS":[35,56,72],"generation":[36,54],"is":[37,98],"tightly":[38],"regulated":[39],"different":[41],"cells":[42],"cellular":[44,53],"compartments.":[45],"Any":[46],"disturbance":[47],"balance":[50,59],"between":[51],"antioxidant":[58,77],"leads":[60],"In":[64],"this":[65],"article,":[66],"we":[67,165],"discuss":[68],"sources":[70],"(endogenous":[73],"exogenous)":[75],"mechanisms.":[78],"We":[79,109,143],"also":[80],"focus":[81],"on":[82,148,187],"pathophysiological":[84],"significance":[85,189],"stress":[88,97,138,153,172,192],"various":[90,106,179],"cell":[91],"types":[92],"liver.":[95,198],"Oxidative":[96],"implicated":[99],"development":[102],"progression":[104],"liver":[107,121,125,162],"diseases.":[108,122],"narrate":[110],"master":[112],"regulators":[113],"ROS-mediated":[115],"signaling":[116],"their":[118,175],"contribution":[119],"Nonalcoholic":[123],"fatty":[124],"diseases":[126],"(NAFLD)":[127],"are":[128],"influenced":[129],"by":[130],"a":[131,140,167],"\"multiple":[132],"parallel-hit":[133],"model\"":[134],"which":[136],"plays":[139],"central":[141],"role.":[142],"highlight":[144],"recent":[146],"findings":[147],"role":[150],"spectrum":[156],"NAFLD,":[158],"including":[159],"fibrosis":[160],"cancer.":[163],"Finally,":[164],"provide":[166],"brief":[168],"overview":[169],"biomarkers":[173],"therapeutic":[176],"applications":[177],"liver-related":[180],"disorders.":[181],"Overall,":[182],"article":[184],"sheds":[185],"light":[186],"pathophysiology":[195],"\u00a9":[199],"2022":[200],"American":[201],"Physiological":[202],"Society.":[203],"Compr":[204],"Physiol":[205],"12:3167-3192,":[206],"2022.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":55},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-04-03T00:00:00"}