{"id":"https://openalex.org/W4220775637","doi":"https://doi.org/10.1021/acsami.2c00376","title":"Light-Activated Nanodevice for On-Demand Imaging of miRNA in Living Cells via Logic Assembly","display_name":"Light-Activated Nanodevice for On-Demand Imaging of miRNA in Living Cells via Logic Assembly","publication_year":2022,"publication_date":"2022-03-08","ids":{"openalex":"https://openalex.org/W4220775637","doi":"https://doi.org/10.1021/acsami.2c00376","pmid":"https://pubmed.ncbi.nlm.nih.gov/35258940"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.2c00376","doi":"https://doi.org/10.1021/acsami.2c00376","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.2c00376","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101866831","display_name":"Huimin Zhou","orcid":"https://orcid.org/0009-0006-3266-8779","observed_orcids":["https://orcid.org/0009-0006-3266-8779"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Zhou","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694001","display_name":"Yao Jiang","orcid":"https://orcid.org/0000-0002-7313-7820","observed_orcids":["https://orcid.org/0000-0002-7313-7820"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Jiang","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043396737","display_name":"Wenjing Zhao","orcid":"https://orcid.org/0000-0003-1706-6324","observed_orcids":["https://orcid.org/0000-0003-1706-6324"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing Zhao","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100610307","display_name":"Shusheng Zhang","orcid":"https://orcid.org/0000-0002-8416-8331","observed_orcids":["https://orcid.org/0000-0002-8416-8331"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shusheng Zhang","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-8416-8331","affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China","institution_ids":["https://openalex.org/I15823474"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100610307","https://openalex.org/A5101694001"],"corresponding_institution_ids":["https://openalex.org/I15823474"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.1012,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88738474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"14","issue":"11","first_page":"13070","last_page":"13078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-detection","display_name":"microRNA detection","score":0.7210000157356262},{"id":"https://openalex.org/keywords/dna-nanotechnology","display_name":"DNA nanotechnology","score":0.984000027179718},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hybridization-chain-reaction","display_name":"hybridization chain reaction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hairpin-probe","display_name":"hairpin probe","score":0.6299999952316284},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.5149999856948853},{"id":"https://openalex.org/keywords/living-cells","display_name":"living cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/signal-amplification","display_name":"signal amplification","score":0.6850000023841858},{"id":"https://openalex.org/keywords/biomarker-detection","display_name":"biomarker detection","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2909374376","wikidata":"https://www.wikidata.org/wiki/Q2726733","display_name":"Nanodevice","level":2,"score":0.9544612169265747},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5989024639129639},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5814304947853088},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5389329791069031},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4113796353340149},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1711784303188324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16854706406593323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08557412028312683}],"mesh":[{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.2c00376","doi":"https://doi.org/10.1021/acsami.2c00376","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.2c00376","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},{"id":"pmid:35258940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35258940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1595428144","display_name":null,"funder_award_id":"22076073","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5244340129","display_name":null,"funder_award_id":"21775063","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W230874093","https://openalex.org/W1923260397","https://openalex.org/W1971460830","https://openalex.org/W1975941916","https://openalex.org/W1977569722","https://openalex.org/W1982925953","https://openalex.org/W2052566608","https://openalex.org/W2084311353","https://openalex.org/W2090495333","https://openalex.org/W2105477643","https://openalex.org/W2105915844","https://openalex.org/W2151366879","https://openalex.org/W2318093937","https://openalex.org/W2346149445","https://openalex.org/W2594377120","https://openalex.org/W2611664377","https://openalex.org/W2614455607","https://openalex.org/W2620625960","https://openalex.org/W2737525513","https://openalex.org/W2766058117","https://openalex.org/W2780750565","https://openalex.org/W2907573789","https://openalex.org/W2910094473","https://openalex.org/W2914426922","https://openalex.org/W2988419181","https://openalex.org/W2997832253","https://openalex.org/W3005645631","https://openalex.org/W3024151971","https://openalex.org/W3088003301","https://openalex.org/W3098409386","https://openalex.org/W3105958766","https://openalex.org/W3108639696","https://openalex.org/W3121565015","https://openalex.org/W3138935712","https://openalex.org/W3184450733","https://openalex.org/W3197515796","https://openalex.org/W4243012356"],"related_works":["https://openalex.org/W2934692920","https://openalex.org/W3197515796","https://openalex.org/W4413290040","https://openalex.org/W3046086628","https://openalex.org/W4409362534","https://openalex.org/W4409089525","https://openalex.org/W4399765032","https://openalex.org/W2961433641","https://openalex.org/W4401358835","https://openalex.org/W2784367824"],"abstract_inverted_index":{"Low-abundance":[0],"biomarker":[1],"amplification":[2,119],"detection":[3,43],"systems":[4,15],"have":[5],"been":[6],"widely":[7],"used":[8],"to":[9,63,115],"detect":[10],"miRNAs;":[11],"however,":[12],"\"always":[13],"active\"":[14],"are":[16],"insufficient":[17],"for":[18,37],"high":[19,38],"spatial":[20,39,131],"and":[21,40,50,80,87,130],"temporal":[22,41,129],"control":[23],"of":[24,44,59,76,103],"miRNAs.":[25],"Here,":[26],"we":[27],"constructed":[28],"a":[29],"light-activated":[30,117],"nanodevice":[31],"(LAN)":[32],"based":[33],"on":[34,56],"DNA":[35,86],"nanotechnology":[36],"precision":[42],"low-abundance":[45,104],"miRNA.":[46],"Light-activated":[47],"hairpin":[48,85],"probes":[49],"triple-helix":[51,97],"molecular":[52,98],"switches":[53],"were":[54],"modified":[55],"the":[57,74,82,89,95],"surface":[58],"gold":[60],"nanoparticles":[61],"(AuNPs)":[62],"trigger":[64],"miRNA":[65],"on-demand":[66,126],"imaging":[67,102],"analysis":[68],"by":[69],"UV":[70,78],"light":[71,79],"activation.":[72],"In":[73],"presence":[75],"both":[77,128],"miRNA,":[81],"LAN":[83],"releases":[84],"completes":[88],"hybridization":[90],"chain":[91],"reaction":[92],"(HCR)":[93],"with":[94],"conformation-altered":[96],"switch,":[99],"enabling":[100],"fluorescence":[101],"miRNAs":[105,125],"in":[106,127],"living":[107],"cells.":[108],"The":[109],"current":[110],"work":[111],"provides":[112],"an":[113],"opportunity":[114],"develop":[116],"signal":[118],"sensors":[120],"that":[121],"can":[122],"accurately":[123],"image":[124],"dimensions.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-03T00:00:00"}