{"id":"https://openalex.org/W4220719458","doi":"https://doi.org/10.3389/fcell.2022.845457","title":"Troxerutin-Mediated Complement Pathway Inhibition is a Disease-Modifying Treatment for Inflammatory Arthritis","display_name":"Troxerutin-Mediated Complement Pathway Inhibition is a Disease-Modifying Treatment for Inflammatory Arthritis","publication_year":2022,"publication_date":"2022-03-31","ids":{"openalex":"https://openalex.org/W4220719458","doi":"https://doi.org/10.3389/fcell.2022.845457","pmid":"https://pubmed.ncbi.nlm.nih.gov/35433699","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9009527"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2022.845457","doi":"https://doi.org/10.3389/fcell.2022.845457","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.845457","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2022.845457","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101505483","display_name":"Debasis Sahu","orcid":"https://orcid.org/0000-0003-1720-2680","observed_orcids":["https://orcid.org/0000-0003-1720-2680"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["IN","US"],"is_corresponding":true,"raw_author_name":"Debasis Sahu","raw_affiliation_strings":["Department of Orthopedics Surgery, New York University School of Medicine, New York, NY, United States","Product Development Cell, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Surgery, New York University School of Medicine, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Product Development Cell, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048204282","display_name":"Subasa Chandra Bishwal","orcid":"https://orcid.org/0000-0002-3360-3022","observed_orcids":["https://orcid.org/0000-0002-3360-3022"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subasa Chandra Bishwal","raw_affiliation_strings":["Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078315190","display_name":"Md. Zubbair Malik","orcid":"https://orcid.org/0000-0001-6693-0401","observed_orcids":["https://orcid.org/0000-0001-6693-0401"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Md. Zubbair Malik","raw_affiliation_strings":["School of Computational & Integrative Sciences, Jawaharlal Nehru University, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computational & Integrative Sciences, Jawaharlal Nehru University, New Delhi, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020966444","display_name":"Sukanya Sahu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sukanya Sahu","raw_affiliation_strings":["Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071559772","display_name":"Sandeep Rai Kaushik","orcid":"https://orcid.org/0000-0002-3463-3522","observed_orcids":["https://orcid.org/0000-0002-3463-3522"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Rai Kaushik","raw_affiliation_strings":["Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021065960","display_name":"Shikha Sharma","orcid":"https://orcid.org/0000-0002-5879-0055","observed_orcids":["https://orcid.org/0000-0002-5879-0055"]},"institutions":[{"id":"https://openalex.org/I110360157","display_name":"Lovely Professional University","ror":"https://ror.org/00et6q107","country_code":"IN","type":"education","lineage":["https://openalex.org/I110360157"]},{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shikha Sharma","raw_affiliation_strings":["Amity Institute of Forensic Sciences, Amity University, Noida, India","Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity Institute of Forensic Sciences, Amity University, Noida, India","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, India","institution_ids":["https://openalex.org/I110360157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067252228","display_name":"Ekta Saini","orcid":"https://orcid.org/0000-0001-5701-6108","observed_orcids":["https://orcid.org/0000-0001-5701-6108"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Ekta Saini","raw_affiliation_strings":["Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016909200","display_name":"Rakesh Kumar Arya","orcid":"https://orcid.org/0000-0003-2089-0891","observed_orcids":["https://orcid.org/0000-0003-2089-0891"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rakesh Arya","raw_affiliation_strings":["Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053632477","display_name":"Archana Rastogi","orcid":"https://orcid.org/0000-0001-9669-3961","observed_orcids":["https://orcid.org/0000-0001-9669-3961"]},"institutions":[{"id":"https://openalex.org/I4210123001","display_name":"Institute of Liver and Biliary Sciences","ror":"https://ror.org/02v6vej93","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210123001"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Archana Rastogi","raw_affiliation_strings":["Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India","institution_ids":["https://openalex.org/I4210123001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024327747","display_name":"Sandeep Sharma","orcid":"https://orcid.org/0000-0001-9172-8512","observed_orcids":["https://orcid.org/0000-0001-9172-8512"]},"institutions":[{"id":"https://openalex.org/I110360157","display_name":"Lovely Professional University","ror":"https://ror.org/00et6q107","country_code":"IN","type":"education","lineage":["https://openalex.org/I110360157"]},{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Sharma","raw_affiliation_strings":["Amity Institute of Forensic Sciences, Amity University, Noida, India","Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity Institute of Forensic Sciences, Amity University, Noida, India","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, India","institution_ids":["https://openalex.org/I110360157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112557431","display_name":"Shanta Sen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shanta Sen","raw_affiliation_strings":["Product Development Cell, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Product Development Cell, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065435920","display_name":"Reman Kumar Singh","orcid":"https://orcid.org/0000-0001-6160-4586","observed_orcids":["https://orcid.org/0000-0001-6160-4586"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. K. Brojen Singh","raw_affiliation_strings":["School of Computational & Integrative Sciences, Jawaharlal Nehru University, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computational & Integrative Sciences, Jawaharlal Nehru University, New Delhi, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039402267","display_name":"C.-J. Liu","orcid":"https://orcid.org/0000-0002-7181-8032","observed_orcids":["https://orcid.org/0000-0002-7181-8032"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuan-Ju Liu","raw_affiliation_strings":["Department of Orthopedics Surgery, New York University School of Medicine, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Surgery, New York University School of Medicine, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018656859","display_name":"Ranjan Kumar Nanda","orcid":"https://orcid.org/0000-0002-2163-4411","observed_orcids":["https://orcid.org/0000-0002-2163-4411"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ranjan Kumar Nanda","raw_affiliation_strings":["Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Health Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060003459","display_name":"Amulya Kumar Panda","orcid":"https://orcid.org/0000-0002-3648-1390","observed_orcids":["https://orcid.org/0000-0002-3648-1390"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Amulya Kumar Panda","raw_affiliation_strings":["Product Development Cell, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Product Development Cell, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5018656859","https://openalex.org/A5060003459","https://openalex.org/A5101505483"],"corresponding_institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I4210156726","https://openalex.org/I57206974"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0448,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72848409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":null,"first_page":"845457","last_page":"845457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/troxerutin","display_name":"troxerutin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adjuvant-induced-arthritis","display_name":"adjuvant-induced arthritis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/inflammatory-arthritis","display_name":"inflammatory arthritis","score":0.949999988079071},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.6060000061988831},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.8429999947547913},{"id":"https://openalex.org/keywords/anti-inflammatory-phytochemicals","display_name":"anti-inflammatory phytochemicals","score":0.6140000224113464},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6060000061988831},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5570055842399597},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5138871669769287},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4048766493797302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3664188086986542},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3414604663848877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3208366930484772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14157599210739136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2022.845457","doi":"https://doi.org/10.3389/fcell.2022.845457","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.845457","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9009527","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9009527","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:35433699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35433699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:049a1ce6644943798f359fdad5a16fbe","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/049a1ce6644943798f359fdad5a16fbe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2022.845457","doi":"https://doi.org/10.3389/fcell.2022.845457","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.845457","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7099999785423279,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320327259","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1256856040","https://openalex.org/W1907909084","https://openalex.org/W1963924977","https://openalex.org/W1978349280","https://openalex.org/W1981671382","https://openalex.org/W1985213868","https://openalex.org/W1987134040","https://openalex.org/W1991314121","https://openalex.org/W2002396510","https://openalex.org/W2004266769","https://openalex.org/W2018049970","https://openalex.org/W2022252206","https://openalex.org/W2027954338","https://openalex.org/W2034342292","https://openalex.org/W2045910665","https://openalex.org/W2047998870","https://openalex.org/W2053713727","https://openalex.org/W2056914772","https://openalex.org/W2056981921","https://openalex.org/W2064140868","https://openalex.org/W2065933951","https://openalex.org/W2069806438","https://openalex.org/W2076832110","https://openalex.org/W2089125183","https://openalex.org/W2095293504","https://openalex.org/W2098045561","https://openalex.org/W2109802259","https://openalex.org/W2111368337","https://openalex.org/W2131681506","https://openalex.org/W2144656637","https://openalex.org/W2149055390","https://openalex.org/W2154556565","https://openalex.org/W2159675211","https://openalex.org/W2171707538","https://openalex.org/W2177023445","https://openalex.org/W2248456426","https://openalex.org/W2284964827","https://openalex.org/W2370089881","https://openalex.org/W2496508689","https://openalex.org/W2519703809","https://openalex.org/W2523303572","https://openalex.org/W2563578300","https://openalex.org/W2586156612","https://openalex.org/W2624684659","https://openalex.org/W2737896120","https://openalex.org/W2761830953","https://openalex.org/W2797816243","https://openalex.org/W2799363386","https://openalex.org/W2803973097","https://openalex.org/W2808855157","https://openalex.org/W2809904006","https://openalex.org/W2905076420","https://openalex.org/W2924129057","https://openalex.org/W2952562421","https://openalex.org/W2954782052","https://openalex.org/W2968582041","https://openalex.org/W2984589365","https://openalex.org/W2987635587","https://openalex.org/W2991360675","https://openalex.org/W3012314530"],"related_works":["https://openalex.org/W3050553631","https://openalex.org/W3158266033","https://openalex.org/W2965429835","https://openalex.org/W2342750304","https://openalex.org/W2548022594","https://openalex.org/W2921167467","https://openalex.org/W1969727499","https://openalex.org/W3043851936","https://openalex.org/W2041834228","https://openalex.org/W2015166531"],"abstract_inverted_index":{"Troxerutin":[0],"(TXR)":[1],"is":[2,193],"a":[3,60,99,114,182],"phytochemical":[4],"reported":[5],"to":[6,17,56,75,86,195,200],"possess":[7],"anti-inflammatory":[8],"and":[9,42,50,67,83,123,221],"hepatoprotective":[10],"effects.":[11],"In":[12,146],"this":[13],"study,":[14],"we":[15],"aimed":[16],"exploit":[18],"the":[19,34,39,88,130,159,164,197,209,218],"antiarthritic":[20,215],"properties":[21,228],"of":[22,46,91,101,113,116,151,163,185,211],"TXR":[23,47,92,183,212],"using":[24,135],"an":[25,214],"adjuvant-induced":[26],"arthritic":[27,226],"(AIA)":[28],"rat":[29],"model.":[30],"AIA-induced":[31],"rats":[32,85],"showed":[33],"highest":[35],"arthritis":[36,198],"score":[37,199],"at":[38],"disease":[40],"onset":[41],"by":[43],"oral":[44],"administration":[45],"(50,":[48],"100,":[49],"200":[51,186],"mg/kg":[52,187],"body":[53,188],"weight),":[54],"reduced":[55],"basal":[57,201],"level":[58],"in":[59,81,94,110,175,203,217],"dose-dependent":[61],"manner.":[62],"Isobaric":[63],"tags":[64],"for":[65,170,190,232],"relative":[66],"absolute":[68],"quantitative":[69],"(iTRAQ)":[70],"proteomics":[71,144],"tool":[72],"were":[73,133],"employed":[74],"identify":[76],"deregulated":[77,106],"joint":[78],"homogenate":[79],"proteins":[80,103,107,118],"AIA":[82,128,204,219],"TXR-treated":[84],"decipher":[87],"probable":[89],"mechanism":[90],"action":[93],"arthritis.":[95],"iTRAQ":[96],"analysis":[97],"identified":[98],"set":[100,115],"434":[102],"with":[104],"65":[105],"(log2":[108],"case/control\u22651.5)":[109],"AIA.":[111,176],"Expressions":[112],"important":[117],"(AAT,":[119],"T-kininogen,":[120],"vimentin,":[121],"desmin,":[122],"nucleophosmin)":[124],"that":[125,154,181],"could":[126,229],"classify":[127],"from":[129],"healthy":[131],"ones":[132],"validated":[134],"Western":[136,140],"blot":[137,141],"analysis.":[138],"The":[139],"data":[142],"corroborated":[143],"findings.":[145],"silico":[147],"protein\u2013protein":[148],"interaction":[149],"study":[150,179],"tissue-proteome":[152],"revealed":[153],"complement":[155],"component":[156],"9":[157],"(C9),":[158],"major":[160],"building":[161],"blocks":[162],"membrane":[165],"attack":[166],"complex":[167],"(MAC)":[168],"responsible":[169],"sterile":[171],"inflammation,":[172],"get":[173],"perturbed":[174],"Our":[177],"dosimetry":[178],"suggests":[180],"dose":[184],"weight":[189],"15":[191],"days":[192],"sufficient":[194],"bring":[196],"levels":[202],"rats.":[205],"We":[206],"have":[207],"shown":[208],"importance":[210],"as":[213],"agent":[216],"model":[220],"after":[222],"additional":[223],"investigation,":[224],"its":[225],"ameliorating":[227],"be":[230],"exploited":[231],"clinical":[233],"usability.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-04-03T00:00:00"}
