{"id":"https://openalex.org/W4220707331","doi":"https://doi.org/10.3892/ol.2022.13280","title":"GPAA1 promotes the proliferation, invasion and migration of hepatocellular carcinoma cells by binding to RNA\u2011binding protein SF3B4","display_name":"GPAA1 promotes the proliferation, invasion and migration of hepatocellular carcinoma cells by binding to RNA\u2011binding protein SF3B4","publication_year":2022,"publication_date":"2022-03-22","ids":{"openalex":"https://openalex.org/W4220707331","doi":"https://doi.org/10.3892/ol.2022.13280","pmid":"https://pubmed.ncbi.nlm.nih.gov/35399327","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8987926"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2022.13280","doi":"https://doi.org/10.3892/ol.2022.13280","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2022.13280","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2022.13280/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/ol.2022.13280/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100624774","display_name":"Ge Song","orcid":"https://orcid.org/0009-0000-4535-2112","observed_orcids":["https://orcid.org/0009-0000-4535-2112"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Ge","raw_affiliation_strings":["Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381897","display_name":"Qiang Zhang","orcid":"https://orcid.org/0000-0002-2029-1824","observed_orcids":["https://orcid.org/0000-0002-2029-1824"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Zhang","raw_affiliation_strings":["Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040079151","display_name":"Xiaoyong Yang","orcid":"https://orcid.org/0000-0001-7263-3913","observed_orcids":["https://orcid.org/0000-0001-7263-3913"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyong Yang","raw_affiliation_strings":["Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210106614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040079151"],"corresponding_institution_ids":["https://openalex.org/I4210106614"],"apc_list":null,"apc_paid":null,"fwci":0.5268,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51262343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"5","first_page":"160","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.3686999976634979,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.3686999976634979,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpaa1","display_name":"GPAA1","score":1.0},{"id":"https://openalex.org/keywords/sf3b4","display_name":"SF3B4","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9959999918937683},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7215759754180908},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6611849069595337},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6067984104156494},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5663492679595947},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.562237024307251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5217831134796143},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.51457279920578},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.485387921333313},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.46439629793167114},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.46050071716308594},{"id":"https://openalex.org/C2780699576","wikidata":"https://www.wikidata.org/wiki/Q15327913","display_name":"MMP2","level":4,"score":0.4601178467273712},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4224313497543335},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.39820554852485657},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36421293020248413},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.336387038230896},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30446988344192505},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.28676050901412964},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.26358163356781006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18789011240005493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05993831157684326}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/ol.2022.13280","doi":"https://doi.org/10.3892/ol.2022.13280","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2022.13280","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2022.13280/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8987926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8987926","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"},{"id":"pmid:35399327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35399327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ol.2022.13280","doi":"https://doi.org/10.3892/ol.2022.13280","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2022.13280","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2022.13280/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220707331.pdf","grobid_xml":"https://content.openalex.org/works/W4220707331.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964184380","https://openalex.org/W1964728393","https://openalex.org/W2009258895","https://openalex.org/W2011256013","https://openalex.org/W2020215421","https://openalex.org/W2024542913","https://openalex.org/W2028599385","https://openalex.org/W2098824600","https://openalex.org/W2101636442","https://openalex.org/W2106285087","https://openalex.org/W2106787323","https://openalex.org/W2107277218","https://openalex.org/W2133037959","https://openalex.org/W2147172608","https://openalex.org/W2162233686","https://openalex.org/W2410733405","https://openalex.org/W2601103612","https://openalex.org/W2612976808","https://openalex.org/W2767072492","https://openalex.org/W2788693573","https://openalex.org/W2947669544","https://openalex.org/W2963216117","https://openalex.org/W3021372105","https://openalex.org/W3021622833","https://openalex.org/W3028043523","https://openalex.org/W4206594385","https://openalex.org/W4312686677","https://openalex.org/W6714764506","https://openalex.org/W6778134956"],"related_works":["https://openalex.org/W2024542913","https://openalex.org/W1944579306","https://openalex.org/W2067110241","https://openalex.org/W2774680816","https://openalex.org/W2618879894","https://openalex.org/W2417765618","https://openalex.org/W2050074145","https://openalex.org/W3031929111","https://openalex.org/W3196035154","https://openalex.org/W4289523739"],"abstract_inverted_index":{"It":[0],"has":[1],"previously":[2],"been":[3],"reported":[4],"that":[5,128,163],"glycosylphosphatidylinositol":[6],"anchor":[7],"attachment":[8],"1":[9],"(GPAA1)":[10],"is":[11],"overexpressed":[12],"in":[13,20,39,132],"hepatocellular":[14],"carcinoma":[15],"(HCC);":[16],"however,":[17],"its":[18],"role":[19,36],"regulating":[21],"the":[22,34,44,55,80,124,140,194,200,213,232],"development":[23],"of":[24,37,49,76,87,123,145,154,191,196,205,218,234],"HCC":[25,40,133,146,179,206,219],"remains":[26],"unknown.":[27],"The":[28,47,74,104,121,225],"present":[29,125,226],"study":[30,126,227],"aimed":[31],"to":[32,42,167,170,175,177,223],"examine":[33],"potential":[35],"GPAA1":[38,50,77,111,129,137,176,182,197],"and":[41,63,71,85,100,110,116,135,143,156,186,203,216],"characterize":[43],"associated":[45],"mechanism.":[46],"expression":[48],"was":[51,64,112,130,149,161,183,188],"first":[52],"examined":[53],"using":[54,67,92,118],"Gene":[56],"Expression":[57],"Profiling":[58],"Interactive":[59],"Analysis":[60],"2":[61],"database,":[62],"then":[65],"determined":[66],"reverse":[68],"transcription-quantitative":[69],"PCR":[70],"western":[72],"blotting.":[73],"effects":[75,195],"silencing":[78,136],"on":[79,199],"proliferation,":[81,141,201,214],"colony":[82,96],"formation,":[83,97],"migration":[84,142,202,217],"invasion":[86,144,204,215],"HuH-7":[88],"cells":[89,220],"were":[90],"measured":[91],"Cell":[93],"Counting":[94],"Kit-8,":[95],"wound":[98],"healing":[99],"Transwell":[101],"assays,":[102],"respectively.":[103],"interaction":[105],"between":[106],"splicing":[107],"factor":[108],"(SF)3B4":[109],"predicted":[113],"by":[114,151,221],"starBase":[115],"confirmed":[117],"RNA":[119],"immunoprecipitation.":[120],"results":[122],"demonstrated":[127],"upregulated":[131],"cells,":[134,147],"markedly":[138],"inhibited":[139],"which":[148],"accompanied":[150],"reduced":[152],"levels":[153],"MMP2":[155],"MMP9.":[157],"In":[158,208],"addition,":[159],"it":[160],"observed":[162],"SF3B4":[164,173,187,192,210],"could":[165],"bind":[166],"GPAA1.":[168,224],"Furthermore,":[169],"confirm":[171],"whether":[172],"binds":[174],"modulate":[178],"cell":[180],"behavior,":[181],"knocked":[184],"down":[185],"overexpressed.":[189],"Overexpression":[190],"reversed":[193],"knockdown":[198],"cells.":[207],"conclusion,":[209],"may":[211],"promote":[212],"binding":[222],"provided":[228],"novel":[229],"insight":[230],"into":[231],"pathogenesis":[233],"HCC.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-04-03T00:00:00"}