{"id":"https://openalex.org/W4214930516","doi":"https://doi.org/10.3389/fcell.2022.845048","title":"Targeting MALT1 Suppresses the Malignant Progression of Colorectal Cancer via miR-375/miR-365a-3p/NF-\u03baB Axis","display_name":"Targeting MALT1 Suppresses the Malignant Progression of Colorectal Cancer via miR-375/miR-365a-3p/NF-\u03baB Axis","publication_year":2022,"publication_date":"2022-03-02","ids":{"openalex":"https://openalex.org/W4214930516","doi":"https://doi.org/10.3389/fcell.2022.845048","pmid":"https://pubmed.ncbi.nlm.nih.gov/35309901","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8924071"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2022.845048","doi":"https://doi.org/10.3389/fcell.2022.845048","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.845048","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4214930516"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2022.845048","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038731378","display_name":"Rui Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Qian","raw_affiliation_strings":["Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xinli Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinli Niu","raw_affiliation_strings":["Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443398","display_name":"Yinghui Wang","orcid":"https://orcid.org/0000-0002-9241-394X","observed_orcids":["https://orcid.org/0000-0002-9241-394X"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146741","display_name":"Jiangmen Central Hospital","ror":"https://ror.org/04baw4297","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146741"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghui Wang","raw_affiliation_strings":["Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China","Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020629024","display_name":"Zhi Jian Guo","orcid":"https://orcid.org/0000-0001-5796-1185","observed_orcids":["https://orcid.org/0000-0001-5796-1185"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Guo","raw_affiliation_strings":["Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102496683","display_name":"Xuyi Deng","orcid":"https://orcid.org/0000-0002-4889-4790","observed_orcids":["https://orcid.org/0000-0002-4889-4790"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuyi Deng","raw_affiliation_strings":["Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091777106","display_name":"Zhenhua Ding","orcid":"https://orcid.org/0000-0002-7458-8009","observed_orcids":["https://orcid.org/0000-0002-7458-8009"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenhua Ding","raw_affiliation_strings":["Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056957943","display_name":"Meijuan Zhou","orcid":"https://orcid.org/0000-0003-4962-3164","observed_orcids":["https://orcid.org/0000-0003-4962-3164"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meijuan Zhou","raw_affiliation_strings":["Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102857528","display_name":"Haijun Deng","orcid":"https://orcid.org/0000-0003-4632-2702","observed_orcids":["https://orcid.org/0000-0003-4632-2702"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haijun Deng","raw_affiliation_strings":["Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056957943","https://openalex.org/A5091777106","https://openalex.org/A5102857528"],"corresponding_institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0374,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.71677247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"845048","last_page":"845048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.02630000002682209,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malt1","display_name":"MALT1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/mir-375","display_name":"miR-375","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mir-365a-3p","display_name":"miR-365a-3p","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9929999709129333},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.7620000243186951},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7683658599853516},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7496300935745239},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6785556077957153},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5685875415802002},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5358949899673462},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4637238681316376},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43281450867652893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4259999990463257},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4143572151660919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3894692063331604},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.379846453666687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1422269642353058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11971601843833923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2022.845048","doi":"https://doi.org/10.3389/fcell.2022.845048","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.845048","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8924071","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8924071/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8924071/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:35309901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35309901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:872eb1b903f9486a9213059177571586","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/872eb1b903f9486a9213059177571586","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2022.845048","doi":"https://doi.org/10.3389/fcell.2022.845048","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.845048","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G251461440","display_name":null,"funder_award_id":"2021A1515010989","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G4324912234","display_name":null,"funder_award_id":"31971167","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6713884731","display_name":null,"funder_award_id":"81972631","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8694613561","display_name":null,"funder_award_id":"2021A1515011055","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4214930516.pdf","grobid_xml":"https://content.openalex.org/works/W4214930516.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W107513776","https://openalex.org/W1121169392","https://openalex.org/W1550041354","https://openalex.org/W1554981631","https://openalex.org/W1988924112","https://openalex.org/W1990045094","https://openalex.org/W2080986462","https://openalex.org/W2091747532","https://openalex.org/W2105549148","https://openalex.org/W2108235071","https://openalex.org/W2137202388","https://openalex.org/W2341243222","https://openalex.org/W2558790575","https://openalex.org/W2574819148","https://openalex.org/W2588025094","https://openalex.org/W2751143162","https://openalex.org/W2756268343","https://openalex.org/W2763943047","https://openalex.org/W2785091318","https://openalex.org/W2791685494","https://openalex.org/W2802393842","https://openalex.org/W2805190814","https://openalex.org/W2894134798","https://openalex.org/W2913174563","https://openalex.org/W2918104070","https://openalex.org/W2929632390","https://openalex.org/W2945519993","https://openalex.org/W2947026234","https://openalex.org/W2958740395","https://openalex.org/W2976380466","https://openalex.org/W2976614495","https://openalex.org/W2987634200","https://openalex.org/W2996960386","https://openalex.org/W3001024433","https://openalex.org/W3007771263","https://openalex.org/W3009963727","https://openalex.org/W3015521841","https://openalex.org/W3032724680","https://openalex.org/W3128646645","https://openalex.org/W3196562373","https://openalex.org/W4211168195","https://openalex.org/W6604303387"],"related_works":["https://openalex.org/W2021996780","https://openalex.org/W2783795123","https://openalex.org/W4387494996","https://openalex.org/W7155631835","https://openalex.org/W1759372832","https://openalex.org/W2999390793","https://openalex.org/W6926970575","https://openalex.org/W3126924923","https://openalex.org/W1017675820","https://openalex.org/W3025838185"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"(CRC)":[2],"is":[3],"a":[4,120,126],"malignant":[5],"tumor":[6,98],"with":[7],"the":[8,13,18,21,40,43,60,73,84,93,96,130],"second":[9],"highest":[10,15],"morbidity":[11],"and":[12,56,76,104,134,137],"third":[14],"mortality":[16],"in":[17,53,99,129],"world,":[19],"while":[20],"therapeutic":[22,139],"options":[23],"of":[24,42,62,66,78,95,132],"targeted":[25],"agents":[26],"remain":[27],"limited.":[28],"Here,":[29],"mucosa-associated":[30],"lymphoid":[31],"tissue":[32],"lymphoma":[33],"translocation":[34],"protein":[35],"1":[36],"(MALT1),":[37],"known":[38],"as":[39],"upstream":[41],"NF-\u03baB":[44,110],"signaling":[45],"pathway,":[46],"was":[47],"identified":[48,107],"to":[49,108],"be":[50],"highly":[51],"upregulated":[52],"CRC":[54,79,133],"tumors":[55],"cell":[57,74],"lines.":[58],"Furthermore,":[59],"downregulation":[61],"MALT1":[63,85],"or":[64,87],"inhibition":[65],"its":[67,88],"proteolytic":[68],"function":[69],"by":[70],"MI-2":[71],"suppressed":[72],"proliferation":[75],"migration":[77],"cells.":[80],"In":[81],"vivo,":[82],"suppressing":[83],"expression":[86],"proteasome":[89],"activity":[90],"effectively":[91],"reduced":[92],"size":[94],"subcutaneous":[97],"nude":[100],"mice.":[101],"Mechanistically,":[102],"miR-375":[103],"miR-365a-3p":[105],"were":[106],"inhibit":[109],"activation":[111],"via":[112],"targeting":[113],"MALT1.":[114],"Overall,":[115],"our":[116],"results":[117],"highlight":[118],"that":[119],"novel":[121,136],"regulatory":[122],"axis,":[123],"miRNA-MALT1-NF-\u03baB,":[124],"plays":[125],"vital":[127],"role":[128],"progression":[131],"provides":[135],"hopeful":[138],"targets":[140],"for":[141],"clinical":[142],"treatment.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-03-05T00:00:00"}
