{"id":"https://openalex.org/W4214908765","doi":"https://doi.org/10.26420/austinjendocrinoldiabetes.2021.1090","title":"A Sodium-Glucose Cotransporter-2 Inhibitor Modulates the Skin Hydration State in Type 2 Diabetes Patients: ost-Hoc Analysis of a Prospective, Open-Label Pilot Study","display_name":"A Sodium-Glucose Cotransporter-2 Inhibitor Modulates the Skin Hydration State in Type 2 Diabetes Patients: ost-Hoc Analysis of a Prospective, Open-Label Pilot Study","publication_year":2021,"publication_date":"2021-11-09","ids":{"openalex":"https://openalex.org/W4214908765","doi":"https://doi.org/10.26420/austinjendocrinoldiabetes.2021.1090"},"language":"en","primary_location":{"id":"doi:10.26420/austinjendocrinoldiabetes.2021.1090","doi":"https://doi.org/10.26420/austinjendocrinoldiabetes.2021.1090","is_oa":false,"landing_page_url":"https://doi.org/10.26420/austinjendocrinoldiabetes.2021.1090","pdf_url":null,"source":{"id":"https://openalex.org/S4210238664","display_name":"Austin Journal of Endocrinology and Diabetes","issn_l":"2381-9200","issn":["2381-9200"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Austin Journal of Endocrinology and Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tezuka Y","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tezuka Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sekine O","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sekine O","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hirano A","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirano A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hanada Y","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanada Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Harada K","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harada K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109149902","display_name":"C Azuma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azuma C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101504211","display_name":"Yasuko Yamamoto","orcid":"https://orcid.org/0000-0003-2243-2800","observed_orcids":["https://orcid.org/0000-0003-2243-2800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yamamoto Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011883299","display_name":"Jun Ito\u2010Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ito-Kobayashi J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060304668","display_name":"Miki Washiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Washiyama M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111646629","display_name":"Masanori Iwanishi","orcid":"https://orcid.org/0000-0002-5390-1000","observed_orcids":["https://orcid.org/0000-0002-5390-1000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iwanishi M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kanamori M","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanamori M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049772836","display_name":"Akira Shimatsu","orcid":"https://orcid.org/0000-0002-9688-006X","observed_orcids":["https://orcid.org/0000-0002-9688-006X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shimatsu A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060593407","display_name":"Aki Kashiwagi","orcid":"https://orcid.org/0000-0002-2656-8142","observed_orcids":["https://orcid.org/0000-0002-2656-8142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kashiwagi A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30137052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.15299999713897705,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ipragliflozin","display_name":"ipragliflozin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/skin-hydration","display_name":"skin hydration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/transepidermal-water-loss","display_name":"transepidermal water loss","score":1.0},{"id":"https://openalex.org/keywords/sitagliptin","display_name":"sitagliptin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.8330304622650146},{"id":"https://openalex.org/C2779284873","wikidata":"https://www.wikidata.org/wiki/Q419832","display_name":"Sitagliptin","level":4,"score":0.7012819051742554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6282426118850708},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5954518914222717},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5134838223457336},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5134154558181763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4704180061817169},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.46017730236053467},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.443510502576828},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3676961064338684},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3238610625267029},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2581586241722107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26420/austinjendocrinoldiabetes.2021.1090","doi":"https://doi.org/10.26420/austinjendocrinoldiabetes.2021.1090","is_oa":false,"landing_page_url":"https://doi.org/10.26420/austinjendocrinoldiabetes.2021.1090","pdf_url":null,"source":{"id":"https://openalex.org/S4210238664","display_name":"Austin Journal of Endocrinology and Diabetes","issn_l":"2381-9200","issn":["2381-9200"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Austin Journal of Endocrinology and Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3097856868","https://openalex.org/W4280628682","https://openalex.org/W4405690495","https://openalex.org/W6962700580","https://openalex.org/W4293796591","https://openalex.org/W4412650151","https://openalex.org/W2077028076","https://openalex.org/W2807917318","https://openalex.org/W4413378844","https://openalex.org/W2520320802"],"abstract_inverted_index":{"We":[0,50],"conducted":[1],"a":[2,43,52],"prospective":[3],"open-label,":[4],"short-term,":[5],"and":[6,93],"double-arm":[7],"exploratory":[8],"study":[9],"to":[10,59],"investigate":[11],"changes":[12],"in":[13,18,98,109,124],"the":[14,70,89,94,100,104,110,116,125,132,141],"skin":[15,65,72,76,90,133,142],"hydration":[16,66,77,134,143],"state":[17,78,135,144],"Japanese":[19],"patients":[20,102],"with":[21,28,103,148],"type":[22],"2":[23],"diabetes":[24],"mellitus":[25],"(T2DM)":[26],"treated":[27],"either":[29],"50":[30],"mg":[31],"ipragliflozin":[32],"(a":[33],"sodium-glucose":[34],"cotransporter-2":[35],"inhibitor:":[36],"SGLT2i)":[37],"(n=8)":[38],"or":[39],"50mg":[40],"sitagliptin":[41],"(as":[42],"control)":[44],"(n=6)":[45],"1\u00d7/day":[46],"for":[47],"14":[48],"days.":[49],"performed":[51],"post-hoc":[53],"analysis":[54],"of":[55],"reported":[56],"clinical":[57],"data":[58],"determine":[60],"whether":[61],"ipragliflozin\u2019s":[62],"effects":[63],"on":[64,69,140],"were":[67],"dependent":[68],"baseline":[71,106,112],"water":[73,91,96],"content.":[74],"The":[75],"was":[79],"measured":[80],"by":[81,115],"three":[82],"standard":[83],"methods.":[84],"SGLT2i":[85],"significantly":[86],"reduced":[87],"both":[88],"content":[92],"transepidermal":[95],"loss":[97],"only":[99],"T2DM":[101],"higher":[105],"values":[107],"(not":[108],"lower":[111],"group":[113],"classified":[114],"respective":[117],"median":[118],"values).":[119],"No":[120],"such":[121],"relationship":[122],"occurred":[123],"sitagliptin-treated":[126],"patients.":[127],"These":[128],"results":[129],"indicate":[130],"that":[131],"is":[136],"well":[137],"controlled":[138],"depending":[139],"during":[145],"14-day":[146],"treatment":[147],"SGLT2i.":[149]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2022-03-05T00:00:00"}