{"id":"https://openalex.org/W4214848784","doi":"https://doi.org/10.17116/jnevro20221220125","title":"Immunological and clinical aspects of the long-term stages of youth schizophrenia","display_name":"Immunological and clinical aspects of the long-term stages of youth schizophrenia","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4214848784","doi":"https://doi.org/10.17116/jnevro20221220125","pmid":"https://pubmed.ncbi.nlm.nih.gov/35238505"},"language":"ru","primary_location":{"id":"doi:10.17116/jnevro20221220125","doi":"https://doi.org/10.17116/jnevro20221220125","is_oa":false,"landing_page_url":"https://doi.org/10.17116/jnevro20221220125","pdf_url":null,"source":{"id":"https://openalex.org/S949205458","display_name":"S S Korsakov Journal of Neurology and Psychiatry","issn_l":"1997-7298","issn":["1997-7298","2309-4729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322616688","host_organization_name":"Media Sphera Publishing Group","host_organization_lineage":["https://openalex.org/P4322616688"],"host_organization_lineage_names":["Media Sphera Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4214848784"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059577045","display_name":"Svetlana A. Zozulya","orcid":"https://orcid.org/0000-0001-5390-6007","observed_orcids":["https://orcid.org/0000-0001-5390-6007"]},"institutions":[{"id":"https://openalex.org/I4210153069","display_name":"Mental Health Research Center of Russian Academy of Medical Sciences","ror":"https://ror.org/055csed06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210153069"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S.A. Zozulya","raw_affiliation_strings":["Mental Health Research Center, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0001-5390-6007","affiliations":[{"raw_affiliation_string":"Mental Health Research Center, Moscow, Russia","institution_ids":["https://openalex.org/I4210153069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046429930","display_name":"Sergey A. Golubev","orcid":"https://orcid.org/0000-0002-0021-4936","observed_orcids":["https://orcid.org/0000-0002-0021-4936"]},"institutions":[{"id":"https://openalex.org/I4210153069","display_name":"Mental Health Research Center of Russian Academy of Medical Sciences","ror":"https://ror.org/055csed06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210153069"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S.A. Golubev","raw_affiliation_strings":["Mental Health Research Center, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0021-4936","affiliations":[{"raw_affiliation_string":"Mental Health Research Center, Moscow, Russia","institution_ids":["https://openalex.org/I4210153069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045259770","display_name":"D. V. Tikhonov","orcid":"https://orcid.org/0000-0003-3001-7842","observed_orcids":["https://orcid.org/0000-0003-3001-7842"]},"institutions":[{"id":"https://openalex.org/I4210153069","display_name":"Mental Health Research Center of Russian Academy of Medical Sciences","ror":"https://ror.org/055csed06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210153069"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.V. Tikhonov","raw_affiliation_strings":["Mental Health Research Center, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-3001-7842","affiliations":[{"raw_affiliation_string":"Mental Health Research Center, Moscow, Russia","institution_ids":["https://openalex.org/I4210153069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067380961","display_name":"\u0412. \u0413. \u041a\u0430\u043b\u0435\u0434\u0430","orcid":"https://orcid.org/0000-0002-1209-1443","observed_orcids":["https://orcid.org/0000-0002-1209-1443"]},"institutions":[{"id":"https://openalex.org/I4210153069","display_name":"Mental Health Research Center of Russian Academy of Medical Sciences","ror":"https://ror.org/055csed06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210153069"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.G. Kaleda","raw_affiliation_strings":["Mental Health Research Center, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1209-1443","affiliations":[{"raw_affiliation_string":"Mental Health Research Center, Moscow, Russia","institution_ids":["https://openalex.org/I4210153069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051450530","display_name":"Tatiana P. Klyushnik","orcid":"https://orcid.org/0000-0001-5148-3864","observed_orcids":["https://orcid.org/0000-0001-5148-3864"]},"institutions":[{"id":"https://openalex.org/I4210153069","display_name":"Mental Health Research Center of Russian Academy of Medical Sciences","ror":"https://ror.org/055csed06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210153069"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T.P. Klyushnik","raw_affiliation_strings":["Mental Health Research Center, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0001-5148-3864","affiliations":[{"raw_affiliation_string":"Mental Health Research Center, Moscow, Russia","institution_ids":["https://openalex.org/I4210153069"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210153069"],"apc_list":null,"apc_paid":null,"fwci":0.5389,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59196476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"122","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.3337000012397766,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7990000247955322},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.8809999823570251},{"id":"https://openalex.org/keywords/leukocyte-elastase","display_name":"leukocyte elastase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/immune-heterogeneity","display_name":"immune heterogeneity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/schizophrenia-subtypes","display_name":"schizophrenia subtypes","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8178099393844604},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.7114686965942383},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7106665372848511},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6293611526489258},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43797537684440613},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2975943684577942}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.17116/jnevro20221220125","doi":"https://doi.org/10.17116/jnevro20221220125","is_oa":false,"landing_page_url":"https://doi.org/10.17116/jnevro20221220125","pdf_url":null,"source":{"id":"https://openalex.org/S949205458","display_name":"S S Korsakov Journal of Neurology and Psychiatry","issn_l":"1997-7298","issn":["1997-7298","2309-4729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322616688","host_organization_name":"Media Sphera Publishing Group","host_organization_lineage":["https://openalex.org/P4322616688"],"host_organization_lineage_names":["Media Sphera Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova","raw_type":"journal-article"},{"id":"pmid:35238505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35238505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1600157212","https://openalex.org/W2005459453","https://openalex.org/W2080105564","https://openalex.org/W2093030455","https://openalex.org/W2140606211","https://openalex.org/W2510217264","https://openalex.org/W2519381186","https://openalex.org/W2566084081","https://openalex.org/W2579952913","https://openalex.org/W2888647009","https://openalex.org/W2937074474","https://openalex.org/W2955394743","https://openalex.org/W2978528574","https://openalex.org/W2987422348","https://openalex.org/W2989892565","https://openalex.org/W3003327736","https://openalex.org/W3017474163","https://openalex.org/W3081365535","https://openalex.org/W3164312156","https://openalex.org/W3180630067","https://openalex.org/W3186148706","https://openalex.org/W4306290733"],"related_works":["https://openalex.org/W6903490462","https://openalex.org/W4414181679","https://openalex.org/W3195072867","https://openalex.org/W3195309187","https://openalex.org/W4408187479","https://openalex.org/W2337510508","https://openalex.org/W2313338555","https://openalex.org/W4224723134","https://openalex.org/W4404210739","https://openalex.org/W2336550298"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,12,21,38,58,74,94,103,118,130,148,161,175,192,199,202,208,217,229,233,247,259,282],"spectrum":[4],"of":[5,40,55,60,76,83,102,106,120,150,174,191,204,216,232,243,249,251,262,281],"inflammatory":[6,283],"markers":[7],"and":[8,67,86,110,124,155,170,181,201,212,223,271],"their":[9],"association":[10],"with":[11,17,31,93,160,198,207,276],"psychopathological":[13,77,255],"symptoms":[14,256],"in":[15,20,129,136,147,168,172,187,189,210,214,246,258],"patients":[16,30,56,142,173,190,215,275],"youth":[18],"schizophrenia":[19,32,263],"long-term":[22],"follow-up":[23,61],"study.":[24],"MATERIAL":[25],"AND":[26],"METHODS:":[27],"Thirty-four":[28],"male":[29],"(ICD-10":[33],"F20)":[34],"first":[35,176],"manifested":[36],"at":[37,57],"age":[39,54,92],"16-25":[41],"years":[42,47],"were":[43,70,134,164],"followed-up":[44],"for":[45,91],"20-25":[46],"(mean":[48],"duration":[49],"22\u00b12.9":[50],"years).":[51],"The":[52,79,97],"mean":[53],"time":[59],"examination":[62],"was":[63],"46.7\u00b13.2":[64],"years.":[65],"PANSS":[66],"PSP":[68],"scales":[69],"used":[71],"to":[72,122,239],"quantify":[73],"severity":[75],"symptoms.":[78],"control":[80],"group":[81],"consisted":[82],"20":[84],"mentally":[85],"somatically":[87],"healthy":[88],"people":[89],"matched":[90],"patient":[95],"group.":[96],"immunological":[98,230,241],"parameters":[99],"(the":[100],"activity":[101,149],"neutrophil":[104],"protease":[105],"leukocyte":[107],"elastase":[108],"(LE)":[109],"its":[111],"endogenous":[112],"inhibitor":[113],"\u03b11-PI,":[114],"as":[115,117],"well":[116],"level":[119,248],"antibodies":[121],"S100B":[123],"basic":[125],"myelin":[126],"protein)":[127],"included":[128],"medical":[131],"technology":[132],"\u00abNeuroimmunotest\u00bb":[133],"determined":[135,266],"blood":[137],"plasma.":[138],"RESULTS:":[139],"=15).":[140],"All":[141],"showed":[143],"a":[144,165,184],"significant":[145,166,185,205],"increase":[146,167,186],"LE":[151,169,211],"(227.9":[152],"nmol/min":[153,179,221],"ml)":[154],"\u03b11-PI":[156,171,188,213],"(45.8":[157],"IU/ml)":[158],"compared":[159,197],"controls.":[162],"There":[163],"type":[177,194,219],"(245":[178],"ml":[180,222],"46.4":[182],"IU/ml),":[183],"second":[193],"(42.0":[195],"IE/ml)":[196],"controls":[200,209],"absence":[203],"differences":[206,227],"third":[218],"(226.8":[220],"49.6":[224],"IE/ml).":[225],"These":[226],"reveal":[228],"heterogeneity":[231],"types":[234],"that":[235],"makes":[236],"it":[237],"possible":[238],"identify":[240],"groups":[242],"patients,":[244],"differing":[245],"activation":[250],"inflammation.":[252],"CONCLUSION:":[253],"Residual":[254],"observed":[257],"late":[260],"stages":[261],"can":[264],"be":[265],"by":[267],"both":[268],"low/moderate":[269],"inflammation":[270,278],"genetic":[272],"mechanisms":[273],"(in":[274],"damped":[277],"or":[279],"depletion":[280],"potential).":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-03-05T00:00:00"}