{"id":"https://openalex.org/W4214717769","doi":"https://doi.org/10.1016/j.neo.2022.100776","title":"Combining selinexor with alisertib to target the p53 pathway in neuroblastoma","display_name":"Combining selinexor with alisertib to target the p53 pathway in neuroblastoma","publication_year":2022,"publication_date":"2022-02-22","ids":{"openalex":"https://openalex.org/W4214717769","doi":"https://doi.org/10.1016/j.neo.2022.100776","pmid":"https://pubmed.ncbi.nlm.nih.gov/35217309","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8866064"},"language":"en","primary_location":{"id":"doi:10.1016/j.neo.2022.100776","doi":"https://doi.org/10.1016/j.neo.2022.100776","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2022.100776","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000057/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000057/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036154152","display_name":"Rosa Nguyen","orcid":"https://orcid.org/0000-0001-5143-2055","observed_orcids":["https://orcid.org/0000-0001-5143-2055"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rosa Nguyen","raw_affiliation_strings":["Pediatric Oncology Branch, NCI, Bethesda, MD, USA. Electronic address: hongharosa.nguyen@nih.gov","Pediatric Oncology Branch, NCI, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0001-5143-2055","affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, MD, USA. Electronic address: hongharosa.nguyen@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370939","display_name":"Hong Wang","orcid":"https://orcid.org/0000-0002-6192-3082","observed_orcids":["https://orcid.org/0000-0002-6192-3082"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016984296","display_name":"Ming Sun","orcid":"https://orcid.org/0000-0002-6313-4458","observed_orcids":["https://orcid.org/0000-0002-6313-4458"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Sun","raw_affiliation_strings":["Pediatric Oncology Branch, NCI, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011015630","display_name":"Dong Geun Lee","orcid":"https://orcid.org/0000-0003-3668-0485","observed_orcids":["https://orcid.org/0000-0003-3668-0485","https://orcid.org/0000-0001-5856-5352"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Geun Lee","raw_affiliation_strings":["Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA"],"raw_orcid":"https://orcid.org/0000-0003-3668-0485","affiliations":[{"raw_affiliation_string":"Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005061089","display_name":"Junmin Peng","orcid":"https://orcid.org/0000-0003-0472-7648","observed_orcids":["https://orcid.org/0000-0003-0472-7648","https://orcid.org/0000-0002-4043-8475"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junmin Peng","raw_affiliation_strings":["Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA","Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA","Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005300334","display_name":"Carol J. Thiele","orcid":"https://orcid.org/0000-0003-2869-7690","observed_orcids":["https://orcid.org/0000-0003-2869-7690"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carol J. Thiele","raw_affiliation_strings":["Pediatric Oncology Branch, NCI, Bethesda, MD, USA. Electronic address: thielec@nih.gov","Pediatric Oncology Branch, NCI, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, MD, USA. Electronic address: thielec@nih.gov","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005300334","https://openalex.org/A5036154152"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":1.7066,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.84836531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":null,"first_page":"100776","last_page":"100776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/selinexor","display_name":"selinexor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alisertib","display_name":"alisertib","score":0.9869999885559082},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8109999895095825},{"id":"https://openalex.org/keywords/xpo1-inhibition","display_name":"XPO1 inhibition","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.6589999794960022},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.9599999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.8450000286102295},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.7179999947547913},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.7451626062393188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6369339823722839},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5871556997299194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5351485013961792},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.45329779386520386},{"id":"https://openalex.org/C2779425043","wikidata":"https://www.wikidata.org/wiki/Q14905704","display_name":"Aurora A kinase","level":3,"score":0.4423673748970032},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.44222551584243774},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43028175830841064},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31180083751678467},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2635781168937683},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.14960789680480957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12753498554229736},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.10228335857391357}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neo.2022.100776","doi":"https://doi.org/10.1016/j.neo.2022.100776","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2022.100776","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000057/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8866064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8866064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"Text"},{"id":"pmid:35217309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35217309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f28c112ca9fd4ed981602df52c5319d8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f28c112ca9fd4ed981602df52c5319d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoplasia: An International Journal for Oncology Research, Vol 26, Iss , Pp 100776- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neo.2022.100776","doi":"https://doi.org/10.1016/j.neo.2022.100776","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2022.100776","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000057/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1104523684","display_name":null,"funder_award_id":"CA191207","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4751187072","display_name":"Redox imaging for breast cancer prognosis","funder_award_id":"R01CA191207","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7026298914","display_name":null,"funder_award_id":"CA191207","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4214717769.pdf","grobid_xml":"https://content.openalex.org/works/W4214717769.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W63968789","https://openalex.org/W105646620","https://openalex.org/W1969873361","https://openalex.org/W1974673125","https://openalex.org/W1974771871","https://openalex.org/W1990317973","https://openalex.org/W2037114174","https://openalex.org/W2040485556","https://openalex.org/W2041817118","https://openalex.org/W2047163519","https://openalex.org/W2059281165","https://openalex.org/W2072115683","https://openalex.org/W2103562758","https://openalex.org/W2108541596","https://openalex.org/W2114915170","https://openalex.org/W2124857275","https://openalex.org/W2136462971","https://openalex.org/W2138745251","https://openalex.org/W2140946298","https://openalex.org/W2154445418","https://openalex.org/W2156683768","https://openalex.org/W2171308378","https://openalex.org/W2274409794","https://openalex.org/W2290633618","https://openalex.org/W2309066327","https://openalex.org/W2403906864","https://openalex.org/W2505118977","https://openalex.org/W2519691041","https://openalex.org/W2520937393","https://openalex.org/W2571353014","https://openalex.org/W2587008851","https://openalex.org/W2618869560","https://openalex.org/W2680325098","https://openalex.org/W2732764398","https://openalex.org/W2767942628","https://openalex.org/W2785372400","https://openalex.org/W2886380696","https://openalex.org/W2888184319","https://openalex.org/W2915169245","https://openalex.org/W2946202802","https://openalex.org/W2967976704","https://openalex.org/W2969931905","https://openalex.org/W2998763810","https://openalex.org/W3018670999","https://openalex.org/W3020317539","https://openalex.org/W3037697670","https://openalex.org/W3044915966","https://openalex.org/W3098085375","https://openalex.org/W3117342617","https://openalex.org/W3122489173","https://openalex.org/W3123833440","https://openalex.org/W3160522210","https://openalex.org/W6683049884"],"related_works":["https://openalex.org/W4200595785","https://openalex.org/W3160522210","https://openalex.org/W2505118977","https://openalex.org/W3167815968","https://openalex.org/W2886612097","https://openalex.org/W3177816379","https://openalex.org/W2562571519","https://openalex.org/W2564306850","https://openalex.org/W2741284531","https://openalex.org/W2595395902"],"abstract_inverted_index":{"Neuroblastoma":[0],"accounts":[1],"for":[2,13,44,116],"15%":[3],"of":[4,22,40,55,78,95,100,169],"cancer-related":[5],"deaths":[6],"in":[7,60,63,88,147],"children,":[8],"highlighting":[9],"an":[10,67],"unmet":[11],"need":[12],"novel":[14],"therapies.":[15],"Selinexor":[16,103],"is":[17,112,123],"a":[18,29,156],"small":[19],"molecule":[20],"inhibitor":[21],"XPO1.":[23],"XPO1":[24],"shuffles":[25],"cargo":[26],"proteins":[27],"with":[28],"nuclear":[30,93],"export":[31],"sequence":[32],"from":[33],"the":[34,37,53,91,133],"nucleus":[35],"to":[36,74,164],"cytosol,":[38],"many":[39],"which":[41,111],"are":[42],"essential":[43],"cancer":[45],"growth":[46],"and":[47,62,65,70,97,139,162],"cell":[48],"maintenance.":[49],"We":[50,80],"systematically":[51],"tested":[52],"effect":[54],"selinexor":[56,83,161],"against":[57],"neuroblastoma":[58,89],"cells":[59],"vitro":[61],"vivo":[64],"used":[66,132],"advanced":[68],"proteomic":[69],"phosphoproteomic":[71],"screening":[72],"approach":[73],"interrogate":[75],"unknown":[76],"mechanisms":[77],"action.":[79],"found":[81,140],"that":[82],"induced":[84,105],"its":[85],"cytotoxic":[86],"effects":[87],"through":[90],"predominantly":[92],"accumulation":[94],"p53":[96,106,117],"global":[98],"activation":[99],"apoptosis":[101],"pathways.":[102],"also":[104],"phosphorylation":[107,121],"at":[108],"site":[109],"S315,":[110],"one":[113],"initiating":[114],"step":[115,122],"degradation.":[118],"Since":[119],"this":[120],"undertaken":[124],"mostly":[125],"by":[126],"aurora":[127],"kinase":[128],"A":[129],"(AURKA),":[130],"we":[131],"clinically":[134],"available":[135],"AURKA":[136],"inhibitor,":[137],"alisertib,":[138],"p53-mediated":[141,167],"lethality":[142],"could":[143],"be":[144],"further":[145],"augmented":[146],"three":[148],"orthotopic":[149],"xenograft":[150],"mouse":[151],"models.":[152],"These":[153],"findings":[154],"suggest":[155],"potential":[157],"therapeutic":[158],"benefit":[159],"using":[160],"alisertib":[163],"synergistically":[165],"increase":[166],"cytotoxicity":[168],"high-risk":[170],"neuroblastoma.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-03-02T00:00:00"}