{"id":"https://openalex.org/W4214548714","doi":"https://doi.org/10.1002/wnan.1786","title":"Enzyme\u2010mediated intratumoral self\u2010assembly of nanotheranostics for enhanced imaging and tumor therapy","display_name":"Enzyme\u2010mediated intratumoral self\u2010assembly of nanotheranostics for enhanced imaging and tumor therapy","publication_year":2022,"publication_date":"2022-02-28","ids":{"openalex":"https://openalex.org/W4214548714","doi":"https://doi.org/10.1002/wnan.1786","pmid":"https://pubmed.ncbi.nlm.nih.gov/35229485","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437863"},"language":"en","primary_location":{"id":"doi:10.1002/wnan.1786","doi":"https://doi.org/10.1002/wnan.1786","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wnan.1786","pdf_url":null,"source":{"id":"https://openalex.org/S132212666","display_name":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","issn_l":"1939-0041","issn":["1939-0041","1939-5116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Nanomedicine and Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437863","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054817301","display_name":"Yue Yuan","orcid":"https://orcid.org/0000-0002-2653-8963","observed_orcids":["https://orcid.org/0000-0002-2653-8963"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yue Yuan","raw_affiliation_strings":["Department of Chemistry University of Science and Technology of China Hefei Anhui China"],"raw_orcid":"https://orcid.org/0000-0002-2653-8963","affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Science and Technology of China Hefei Anhui China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028758394","display_name":"Jeff W. M. Bulte","orcid":"https://orcid.org/0000-0003-1202-1610","observed_orcids":["https://orcid.org/0000-0003-1202-1610"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeff W. M. Bulte","raw_affiliation_strings":["Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering The Johns Hopkins University School of Medicine Baltimore Maryland USA","The Russell H. Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine Baltimore Maryland USA"],"raw_orcid":"https://orcid.org/0000-0003-1202-1610","affiliations":[{"raw_affiliation_string":"Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering The Johns Hopkins University School of Medicine Baltimore Maryland USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine Baltimore Maryland USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028758394","https://openalex.org/A5054817301"],"corresponding_institution_ids":["https://openalex.org/I126520041","https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":0.2003,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.16750757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"14","issue":"4","first_page":"e1786","last_page":"e1786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanotheranostics","display_name":"nanotheranostics","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/in-situ-self-assembly","display_name":"in situ self-assembly","score":0.6539999842643738},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.5550000071525574},{"id":"https://openalex.org/keywords/organic-inorganic-hybrid-nanomaterials","display_name":"organic-inorganic hybrid nanomaterials","score":0.828000009059906},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.8560000061988831},{"id":"https://openalex.org/keywords/radionuclide-imaging","display_name":"scintigraphy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/photoacoustic-imaging","display_name":"photoacoustic imaging","score":0.9980000257492065},{"id":"https://openalex.org/keywords/raman-imaging","display_name":"Raman imaging","score":0.9990000128746033},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.902999997138977},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"bioluminescence imaging","score":0.9240000247955322},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.6008143424987793},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.558725118637085},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5524894595146179},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5197136402130127},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5101611614227295},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.4790850281715393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47824373841285706},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45439082384109497},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.38102298974990845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28834888339042664},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2878892421722412},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2811804413795471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1795961856842041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1585659682750702},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/wnan.1786","doi":"https://doi.org/10.1002/wnan.1786","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wnan.1786","pdf_url":null,"source":{"id":"https://openalex.org/S132212666","display_name":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","issn_l":"1939-0041","issn":["1939-0041","1939-5116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Nanomedicine and Nanobiotechnology","raw_type":"journal-article"},{"id":"pmid:35229485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35229485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9437863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wiley Interdiscip Rev Nanomed Nanobiotechnol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9437863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wiley Interdiscip Rev Nanomed Nanobiotechnol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2997365208","display_name":"Intracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor Therapy","funder_award_id":"R01EB030376","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G853334774","display_name":null,"funder_award_id":"WK2060000020","funder_id":"https://openalex.org/F4320329878","funder_display_name":"Central University Basic Research Fund of China"},{"id":"https://openalex.org/G9000897719","display_name":"Resource for Molecular Imaging Agents in Precision Medicine","funder_award_id":"P41EB024495","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320329878","display_name":"Central University Basic Research Fund of China","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W68291119","https://openalex.org/W94842645","https://openalex.org/W187972430","https://openalex.org/W1048568792","https://openalex.org/W1576210721","https://openalex.org/W1749453950","https://openalex.org/W1788864363","https://openalex.org/W1834558494","https://openalex.org/W1917794559","https://openalex.org/W1937753295","https://openalex.org/W1968029051","https://openalex.org/W1974043792","https://openalex.org/W1974222323","https://openalex.org/W1976062460","https://openalex.org/W1980029809","https://openalex.org/W1982823397","https://openalex.org/W1984990803","https://openalex.org/W1991945497","https://openalex.org/W1992406775","https://openalex.org/W1994724903","https://openalex.org/W1995205742","https://openalex.org/W1996459206","https://openalex.org/W2010002143","https://openalex.org/W2017015661","https://openalex.org/W2019436999","https://openalex.org/W2025996614","https://openalex.org/W2032185182","https://openalex.org/W2033439612","https://openalex.org/W2049716172","https://openalex.org/W2053861477","https://openalex.org/W2066052326","https://openalex.org/W2067502344","https://openalex.org/W2076263734","https://openalex.org/W2082259697","https://openalex.org/W2086705938","https://openalex.org/W2089260591","https://openalex.org/W2093633290","https://openalex.org/W2094005944","https://openalex.org/W2108747405","https://openalex.org/W2111190523","https://openalex.org/W2113939544","https://openalex.org/W2126036312","https://openalex.org/W2126346850","https://openalex.org/W2130127152","https://openalex.org/W2132257110","https://openalex.org/W2143010345","https://openalex.org/W2151457506","https://openalex.org/W2157828615","https://openalex.org/W2159182565","https://openalex.org/W2177603935","https://openalex.org/W2218497166","https://openalex.org/W2288952466","https://openalex.org/W2294780803","https://openalex.org/W2313142763","https://openalex.org/W2318590484","https://openalex.org/W2322972210","https://openalex.org/W2328547225","https://openalex.org/W2334512228","https://openalex.org/W2335036158","https://openalex.org/W2343828707","https://openalex.org/W2344644350","https://openalex.org/W2411562804","https://openalex.org/W2413359062","https://openalex.org/W2511364181","https://openalex.org/W2516305941","https://openalex.org/W2517268210","https://openalex.org/W2549641338","https://openalex.org/W2559787613","https://openalex.org/W2605054024","https://openalex.org/W2608501084","https://openalex.org/W2616129231","https://openalex.org/W2619181032","https://openalex.org/W2655395436","https://openalex.org/W2725237902","https://openalex.org/W2737283086","https://openalex.org/W2760971081","https://openalex.org/W2768880040","https://openalex.org/W2782688529","https://openalex.org/W2783496111","https://openalex.org/W2795980237","https://openalex.org/W2808997364","https://openalex.org/W2884304605","https://openalex.org/W2887779633","https://openalex.org/W2891986888","https://openalex.org/W2896852102","https://openalex.org/W2901725625","https://openalex.org/W2911030372","https://openalex.org/W2911185848","https://openalex.org/W2917169363","https://openalex.org/W2922029620","https://openalex.org/W2941037131","https://openalex.org/W2966647731","https://openalex.org/W2970636828","https://openalex.org/W2980903185","https://openalex.org/W2990722305","https://openalex.org/W2996133723","https://openalex.org/W2996652484","https://openalex.org/W3003317145","https://openalex.org/W3009853035","https://openalex.org/W3036469782","https://openalex.org/W3083698728","https://openalex.org/W3086939546","https://openalex.org/W3093738570","https://openalex.org/W3103979403","https://openalex.org/W3107538180","https://openalex.org/W3111292427","https://openalex.org/W3122113160","https://openalex.org/W3127225837","https://openalex.org/W3128962903","https://openalex.org/W3161014063","https://openalex.org/W3162713906","https://openalex.org/W4211199440","https://openalex.org/W4237906573"],"related_works":["https://openalex.org/W3003317145","https://openalex.org/W4400307935","https://openalex.org/W4414476522","https://openalex.org/W2757942160","https://openalex.org/W7214994232","https://openalex.org/W2113339066","https://openalex.org/W4386255368","https://openalex.org/W3112834410","https://openalex.org/W2901725625","https://openalex.org/W2288952466"],"abstract_inverted_index":{"Enzyme-mediated":[0],"intratumoral":[1],"self-assembled":[2],"(EMISA)":[3],"nanotheranostics":[4,77,98,152],"represent":[5],"a":[6],"new":[7],"class":[8],"of":[9,17,57,68,82,96,102,123],"smart":[10],"agents":[11],"for":[12,27,144,164],"combined":[13],"imaging":[14,129],"and":[15,32,35,105,117,131,178,193],"therapy":[16],"cancer.":[18],"Cancer":[19],"cells":[20,61],"overexpress":[21],"various":[22],"enzymes":[23],"that":[24,41,73,86,140],"are":[25,87,162],"essential":[26],"high":[28],"metabolism,":[29],"fast":[30],"proliferation,":[31],"tissue":[33],"invasion":[34],"metastasis.":[36],"By":[37],"conjugating":[38],"small":[39,70],"molecules":[40,72],"contain":[42],"an":[43,127],"enzyme-specific":[44],"cleavage":[45],"site":[46],"to":[47,54,126],"appropriate":[48],"chemical":[49],"linkers,":[50],"it":[51],"is":[52,184],"possible":[53],"induce":[55],"self-assembly":[56],"nanostructures":[58],"in":[59,78],"tumor":[60],"having":[62],"the":[63,83,100,137],"target":[64],"enzyme.":[65],"This":[66,182],"approach":[67],"injecting":[69,90],"theranostic":[71],"eventually":[74],"become":[75],"larger":[76],"situ":[79],"avoids":[80],"some":[81],"major":[84],"limitations":[85],"encountered":[88],"when":[89],"larger,":[91],"pre-assembled":[92],"nanotheranostics.":[93],"The":[94],"advantage":[95],"EMISA":[97],"include":[99],"avoidance":[101],"nonspecific":[103],"uptake":[104],"rapid":[106],"clearance":[107],"by":[108],"phagocytic":[109],"cells,":[110],"increased":[111],"cellular":[112,119],"accumulation,":[113],"reduced":[114],"drug":[115],"efflux":[116],"prolonged":[118],"exposure":[120],"time,":[121],"all":[122],"which":[124],"lead":[125],"amplified":[128],"signal":[130],"therapeutic":[132],"efficacy.":[133],"We":[134],"review":[135],"here":[136],"different":[138],"approaches":[139],"can":[141],"be":[142],"used":[143],"preparing":[145],"EMISA-based":[146],"organic,":[147],"inorganic,":[148],"or":[149],"organic/inorganic":[150],"hybrid":[151],"based":[153],"on":[154],"noncovalent":[155],"interactions":[156],"and/or":[157],"covalent":[158],"bonding.":[159],"Imaging":[160,194],"examples":[161],"shown":[163],"fluorescence":[165],"imaging,":[166,168,170,172,175,177],"nuclear":[167],"photoacoustic":[169],"Raman":[171],"computed":[173],"tomography":[174],"bioluminescent":[176],"magnetic":[179],"resonance":[180],"imaging.":[181],"article":[183],"categorized":[185],"under:":[186],"Diagnostic":[187],"Tools":[188],">":[189,197],"In":[190],"Vivo":[191],"Nanodiagnostics":[192],"Biology-Inspired":[195],"Nanomaterials":[196],"Peptide-Based":[198],"Structures.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-03-02T00:00:00"}