{"id":"https://openalex.org/W4214520145","doi":"https://doi.org/10.1007/s13311-022-01203-0","title":"Ceruletide and Alpha-1 Antitrypsin as a Novel Combination Therapy for Ischemic Stroke","display_name":"Ceruletide and Alpha-1 Antitrypsin as a Novel Combination Therapy for Ischemic Stroke","publication_year":2022,"publication_date":"2022-02-28","ids":{"openalex":"https://openalex.org/W4214520145","doi":"https://doi.org/10.1007/s13311-022-01203-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/35226340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9226209"},"language":"en","primary_location":{"id":"doi:10.1007/s13311-022-01203-0","doi":"https://doi.org/10.1007/s13311-022-01203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13311-022-01203-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13311-022-01203-0.pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s13311-022-01203-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055156298","display_name":"Alba Simats","orcid":"https://orcid.org/0000-0002-0415-1135","observed_orcids":["https://orcid.org/0000-0002-0415-1135"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alba Simats","raw_affiliation_strings":["Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210102407","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090102317","display_name":"Laura Ramiro","orcid":"https://orcid.org/0000-0002-4121-4609","observed_orcids":["https://orcid.org/0000-0002-4121-4609"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Ramiro","raw_affiliation_strings":["Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210102407","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045740427","display_name":"Raquel Valls","orcid":"https://orcid.org/0000-0002-9280-0819","observed_orcids":["https://orcid.org/0000-0002-9280-0819"]},"institutions":[{"id":"https://openalex.org/I4210164457","display_name":"Anaxomics (Spain)","ror":"https://ror.org/05jnac203","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210164457"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Valls","raw_affiliation_strings":["Anaxomics Biotech, S.L, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anaxomics Biotech, S.L, Barcelona, Spain","institution_ids":["https://openalex.org/I4210164457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006074216","display_name":"Helena de Ram\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Helena de Ram\u00f3n","raw_affiliation_strings":["Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210102407","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038065903","display_name":"Paula Garc\u00eda\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-6596-8002","observed_orcids":["https://orcid.org/0000-0001-6596-8002"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Garc\u00eda-Rodr\u00edguez","raw_affiliation_strings":["Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210102407","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021094952","display_name":"Cyrille Orset","orcid":"https://orcid.org/0000-0002-9139-3430","observed_orcids":["https://orcid.org/0000-0002-9139-3430"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387153933","display_name":"Physiopathologie et imagerie des troubles neurologiques","ror":"https://ror.org/00vsvph51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyrille Orset","raw_affiliation_strings":["Inserm UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Universit\u00e9 Caen-Normandie, GIP Cyceron, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Universit\u00e9 Caen-Normandie, GIP Cyceron, Caen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011590301","display_name":"Laura Artigas","orcid":"https://orcid.org/0000-0003-4253-6682","observed_orcids":["https://orcid.org/0000-0003-4253-6682"]},"institutions":[{"id":"https://openalex.org/I4210164457","display_name":"Anaxomics (Spain)","ror":"https://ror.org/05jnac203","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210164457"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Artigas","raw_affiliation_strings":["Anaxomics Biotech, S.L, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anaxomics Biotech, S.L, Barcelona, Spain","institution_ids":["https://openalex.org/I4210164457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037461322","display_name":"Teresa Sard\u00f3n","orcid":"https://orcid.org/0000-0002-5935-9312","observed_orcids":["https://orcid.org/0000-0002-5935-9312"]},"institutions":[{"id":"https://openalex.org/I4210164457","display_name":"Anaxomics (Spain)","ror":"https://ror.org/05jnac203","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210164457"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Sardon","raw_affiliation_strings":["Anaxomics Biotech, S.L, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anaxomics Biotech, S.L, Barcelona, Spain","institution_ids":["https://openalex.org/I4210164457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066493625","display_name":"Anna Rosell","orcid":"https://orcid.org/0000-0003-1082-3599","observed_orcids":["https://orcid.org/0000-0003-1082-3599"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anna Rosell","raw_affiliation_strings":["Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210102407","https://openalex.org/I4210127641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048009605","display_name":"Joan Montaner","orcid":"https://orcid.org/0000-0003-4845-2279","observed_orcids":["https://orcid.org/0000-0003-4845-2279","https://orcid.org/0000-0001-9796-2422"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210090436","display_name":"Hospital Universitario Virgen Macarena","ror":"https://ror.org/016p83279","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210090436"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Joan Montaner","raw_affiliation_strings":["Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain. joan.montaner@vhir.org","Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain. joan.montaner@vhir.org","Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Roc\u00edo/CSIC, University of Seville, Seville, Spain. joan.montaner@vhir.org","Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Roc\u00edo/CSIC, University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9796-2422","affiliations":[{"raw_affiliation_string":"Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain. joan.montaner@vhir.org","institution_ids":["https://openalex.org/I4210090436"]},{"raw_affiliation_string":"Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain. joan.montaner@vhir.org","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210102407","https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Roc\u00edo/CSIC, University of Seville, Seville, Spain. joan.montaner@vhir.org","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]},{"raw_affiliation_string":"Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Roc\u00edo/CSIC, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5048009605"],"corresponding_institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210090436","https://openalex.org/I4210102407","https://openalex.org/I4210127641","https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.2478,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.78054505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"19","issue":"2","first_page":"513","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.22360000014305115,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9900000095367432},{"id":"https://openalex.org/keywords/caerulein","display_name":"caerulein","score":0.9679999947547913},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7789999842643738},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9300000071525574},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.6359999775886536},{"id":"https://openalex.org/keywords/in-silico-drug-screening","display_name":"in silico drug screening","score":0.5379999876022339},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7160000205039978},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8593871593475342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8176881074905396},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6346741914749146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6205764412879944},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.6051069498062134},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5017156600952148},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4720134437084198},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45768964290618896},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4555235803127289},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.43657371401786804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25647374987602234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09011241793632507},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s13311-022-01203-0","doi":"https://doi.org/10.1007/s13311-022-01203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13311-022-01203-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13311-022-01203-0.pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},{"id":"pmid:35226340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35226340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9226209","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9226209/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/304074","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/304074","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"}],"best_oa_location":{"id":"doi:10.1007/s13311-022-01203-0","doi":"https://doi.org/10.1007/s13311-022-01203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13311-022-01203-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13311-022-01203-0.pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1716605215","display_name":null,"funder_award_id":"2017SGR 1427","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G1894287339","display_name":null,"funder_award_id":"RD 16/0019","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3779662906","display_name":null,"funder_award_id":"00012","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4012124032","display_name":"MULTI-BIO-TARGETS: una nueva estrategia para el manejo del ictus combinando biomarcadores pron\u00f3sticos y neuroprotectores","funder_award_id":"PI18/00804","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4145981930","display_name":null,"funder_award_id":"PI18/00804","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G4886284","display_name":null,"funder_award_id":"RD16/0019/0021","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5286674353","display_name":"Stroke Bio-Targets: Nuevas estrategias para descubrir biomarcadores de isquemia cerebral y su aplicaci\u00f3n como dianas terap\u00e9uticas en el ictus","funder_award_id":"PI15/00354","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5756568917","display_name":null,"funder_award_id":"PE-0527-2019","funder_id":"https://openalex.org/F4320326489","funder_display_name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G6367362008","display_name":null,"funder_award_id":"PE-0527-2019","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6770824917","display_name":null,"funder_award_id":"IFI17/00012","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320326489","display_name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","ror":null},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4214520145.pdf","grobid_xml":"https://content.openalex.org/works/W4214520145.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W139494526","https://openalex.org/W585874556","https://openalex.org/W1085107126","https://openalex.org/W1773516416","https://openalex.org/W1853721709","https://openalex.org/W1923983266","https://openalex.org/W1956974093","https://openalex.org/W1964691436","https://openalex.org/W1965002413","https://openalex.org/W1969730567","https://openalex.org/W1970127550","https://openalex.org/W1975572742","https://openalex.org/W1976239388","https://openalex.org/W1978053766","https://openalex.org/W1980465321","https://openalex.org/W1992939666","https://openalex.org/W1996698832","https://openalex.org/W1998734009","https://openalex.org/W2006824741","https://openalex.org/W2015615473","https://openalex.org/W2017053673","https://openalex.org/W2019871576","https://openalex.org/W2022376539","https://openalex.org/W2023720138","https://openalex.org/W2029527746","https://openalex.org/W2044025814","https://openalex.org/W2049069390","https://openalex.org/W2052834936","https://openalex.org/W2053442326","https://openalex.org/W2057099776","https://openalex.org/W2058035871","https://openalex.org/W2058134060","https://openalex.org/W2065548817","https://openalex.org/W2070050178","https://openalex.org/W2077449266","https://openalex.org/W2082586225","https://openalex.org/W2083632281","https://openalex.org/W2095634557","https://openalex.org/W2096644872","https://openalex.org/W2096940309","https://openalex.org/W2099198771","https://openalex.org/W2102447759","https://openalex.org/W2109792189","https://openalex.org/W2114044413","https://openalex.org/W2116455560","https://openalex.org/W2120850582","https://openalex.org/W2127366468","https://openalex.org/W2131037246","https://openalex.org/W2132440175","https://openalex.org/W2142267556","https://openalex.org/W2146512944","https://openalex.org/W2147318997","https://openalex.org/W2155845033","https://openalex.org/W2155885439","https://openalex.org/W2157368934","https://openalex.org/W2159233098","https://openalex.org/W2161844490","https://openalex.org/W2162405246","https://openalex.org/W2168576606","https://openalex.org/W2170125790","https://openalex.org/W2171402810","https://openalex.org/W2254528440","https://openalex.org/W2289844080","https://openalex.org/W2332737993","https://openalex.org/W2351673993","https://openalex.org/W2406739237","https://openalex.org/W2473514068","https://openalex.org/W2557154264","https://openalex.org/W2568954699","https://openalex.org/W2580792129","https://openalex.org/W2587953391","https://openalex.org/W2592205401","https://openalex.org/W2615601352","https://openalex.org/W2752379117","https://openalex.org/W2767891136","https://openalex.org/W2768287125","https://openalex.org/W2795508812","https://openalex.org/W2805994895","https://openalex.org/W2884891453","https://openalex.org/W2896234507","https://openalex.org/W2899973971","https://openalex.org/W2904020446","https://openalex.org/W2923363662","https://openalex.org/W2974087886","https://openalex.org/W2977503526","https://openalex.org/W2982075999","https://openalex.org/W3005708697","https://openalex.org/W3005782944","https://openalex.org/W3090567217","https://openalex.org/W3110787106","https://openalex.org/W3133688913","https://openalex.org/W3155179768","https://openalex.org/W3157113084","https://openalex.org/W4296816736"],"related_works":["https://openalex.org/W4410413037","https://openalex.org/W2360051764","https://openalex.org/W2085333523","https://openalex.org/W7111659002","https://openalex.org/W7139109031","https://openalex.org/W7208722704","https://openalex.org/W3166960529","https://openalex.org/W4392110241","https://openalex.org/W6926327240","https://openalex.org/W1982575195"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-03-02T00:00:00"}
