{"id":"https://openalex.org/W4213291663","doi":"https://doi.org/10.1080/17425255.2022.2043849","title":"Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects","display_name":"Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects","publication_year":2022,"publication_date":"2022-01-02","ids":{"openalex":"https://openalex.org/W4213291663","doi":"https://doi.org/10.1080/17425255.2022.2043849","pmid":"https://pubmed.ncbi.nlm.nih.gov/35176217"},"language":"en","primary_location":{"id":"doi:10.1080/17425255.2022.2043849","doi":"https://doi.org/10.1080/17425255.2022.2043849","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425255.2022.2043849","pdf_url":null,"source":{"id":"https://openalex.org/S102336391","display_name":"Expert Opinion on Drug Metabolism & Toxicology","issn_l":"1742-5255","issn":["1742-5255","1744-7607"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Metabolism & Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045868347","display_name":"Sarah\u2010Jane Leigh","orcid":"https://orcid.org/0000-0002-6776-6487","observed_orcids":["https://orcid.org/0000-0002-6776-6487"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sarah-Jane Leigh","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Cork, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-6776-6487","affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021127165","display_name":"Caoimhe M. K. Lynch","orcid":"https://orcid.org/0000-0002-6974-6770","observed_orcids":["https://orcid.org/0000-0002-6974-6770"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Caoimhe M.K. Lynch","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Cork, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-6974-6770","affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050921686","display_name":"Brian Bird","orcid":"https://orcid.org/0000-0001-8562-0564","observed_orcids":["https://orcid.org/0000-0001-8562-0564"]},"institutions":[{"id":"https://openalex.org/I2800693937","display_name":"Bon Secours Hospital Cork","ror":"https://ror.org/0197t7j38","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I160713005","https://openalex.org/I2800693937"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Brian R. Healey Bird","raw_affiliation_strings":["Bon Secours Cork Cancer Centre, Cork, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-8562-0564","affiliations":[{"raw_affiliation_string":"Bon Secours Cork Cancer Centre, Cork, Ireland","institution_ids":["https://openalex.org/I2800693937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000845292","display_name":"Brendan T. Griffin","orcid":"https://orcid.org/0000-0001-5433-8398","observed_orcids":["https://orcid.org/0000-0001-5433-8398"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Brendan T. Griffin","raw_affiliation_strings":["School of Pharmacy, University College Cork, Cork, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-5433-8398","affiliations":[{"raw_affiliation_string":"School of Pharmacy, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084928512","display_name":"John F. Cryan","orcid":"https://orcid.org/0000-0001-5887-2723","observed_orcids":["https://orcid.org/0000-0001-5887-2723"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John F. Cryan","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Cork, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-5887-2723","affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003021083","display_name":"Gerard A. Clarke","orcid":"https://orcid.org/0000-0001-9771-3979","observed_orcids":["https://orcid.org/0000-0001-9771-3979"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Gerard Clarke","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Cork, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-9771-3979","affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003021083"],"corresponding_institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"],"apc_list":null,"apc_paid":null,"fwci":0.3781,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.34831774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"5","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-pharmacotherapy","display_name":"cancer pharmacotherapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antibiotics","display_name":"antibiotics","score":0.652999997138977},{"id":"https://openalex.org/keywords/interpatient-variability","display_name":"interpatient variability","score":0.6669999957084656},{"id":"https://openalex.org/keywords/microbial-metabolism","display_name":"microbial metabolism","score":0.5929999947547913},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gastrointestinal-function","display_name":"gastrointestinal function","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cognition","display_name":"cognition","score":0.828000009059906},{"id":"https://openalex.org/keywords/pain-perception","display_name":"pain perception","score":0.9490000009536743},{"id":"https://openalex.org/keywords/microbiota-targeted-therapy","display_name":"microbiota-targeted therapy","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6541200876235962},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6500157117843628},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6220652461051941},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5071084499359131},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.46633124351501465},{"id":"https://openalex.org/C149172746","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Efficacy","level":3,"score":0.4645874798297882},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41788196563720703},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4152299761772156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3030656576156616},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14780643582344055}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/17425255.2022.2043849","doi":"https://doi.org/10.1080/17425255.2022.2043849","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425255.2022.2043849","pdf_url":null,"source":{"id":"https://openalex.org/S102336391","display_name":"Expert Opinion on Drug Metabolism & Toxicology","issn_l":"1742-5255","issn":["1742-5255","1744-7607"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Metabolism & Toxicology","raw_type":"journal-article"},{"id":"pmid:35176217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35176217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug metabolism & toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:cora.ucc.ie:10468/12602","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10468/12602","pdf_url":null,"source":{"id":"https://openalex.org/S4306401150","display_name":"Cork Open Research Archive (University College Cork, Ireland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210141138","host_organization_name":"APC Microbiome Institute","host_organization_lineage":["https://openalex.org/I4210141138"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1383882326","display_name":null,"funder_award_id":"SFI/12/RC/","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G448368138","display_name":null,"funder_award_id":"SFI/12/RC/ 2273_P2","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G5098725405","display_name":null,"funder_award_id":"12/RC/","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G5243686281","display_name":"APC_Phase 2","funder_award_id":"12/RC/2273_P2","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G7859376619","display_name":null,"funder_award_id":"848228","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G8890405749","display_name":null,"funder_award_id":"CTIC-2021-002","funder_id":"https://openalex.org/F4320312041","funder_display_name":"Health Research Board"}],"funders":[{"id":"https://openalex.org/F4320312041","display_name":"Health Research Board","ror":"https://ror.org/003hb2249"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":209,"referenced_works":["https://openalex.org/W3899478","https://openalex.org/W32471882","https://openalex.org/W140248828","https://openalex.org/W1865977567","https://openalex.org/W1895819679","https://openalex.org/W1948266836","https://openalex.org/W1972237932","https://openalex.org/W1975312567","https://openalex.org/W1977807397","https://openalex.org/W1981500982","https://openalex.org/W1987370132","https://openalex.org/W1988005402","https://openalex.org/W1999906527","https://openalex.org/W2001616480","https://openalex.org/W2003342633","https://openalex.org/W2012694594","https://openalex.org/W2049506766","https://openalex.org/W2057179832","https://openalex.org/W2059128083","https://openalex.org/W2071748263","https://openalex.org/W2093944201","https://openalex.org/W2098016933","https://openalex.org/W2110235509","https://openalex.org/W2116277782","https://openalex.org/W2118743528","https://openalex.org/W2124632458","https://openalex.org/W2125060052","https://openalex.org/W2134859881","https://openalex.org/W2140145798","https://openalex.org/W2145336165","https://openalex.org/W2146275270","https://openalex.org/W2150853783","https://openalex.org/W2155877563","https://openalex.org/W2158360095","https://openalex.org/W2162078360","https://openalex.org/W2165456770","https://openalex.org/W2185075416","https://openalex.org/W2194591433","https://openalex.org/W2275606382","https://openalex.org/W2292048640","https://openalex.org/W2340304486","https://openalex.org/W2343811598","https://openalex.org/W2346302302","https://openalex.org/W2350929109","https://openalex.org/W2409102718","https://openalex.org/W2409656339","https://openalex.org/W2503826119","https://openalex.org/W2516371018","https://openalex.org/W2558041282","https://openalex.org/W2561926137","https://openalex.org/W2591596154","https://openalex.org/W2592084636","https://openalex.org/W2604323123","https://openalex.org/W2616825195","https://openalex.org/W2716699759","https://openalex.org/W2734713643","https://openalex.org/W2755951643","https://openalex.org/W2756403351","https://openalex.org/W2758183934","https://openalex.org/W2765314233","https://openalex.org/W2773427199","https://openalex.org/W2779119900","https://openalex.org/W2780443557","https://openalex.org/W2782333299","https://openalex.org/W2782631069","https://openalex.org/W2783688279","https://openalex.org/W2790625311","https://openalex.org/W2792021903","https://openalex.org/W2796390286","https://openalex.org/W2797068438","https://openalex.org/W2802651807","https://openalex.org/W2804326576","https://openalex.org/W2804917228","https://openalex.org/W2831826689","https://openalex.org/W2860517324","https://openalex.org/W2886401819","https://openalex.org/W2887509155","https://openalex.org/W2889548639","https://openalex.org/W2898631010","https://openalex.org/W2910392909","https://openalex.org/W2920009718","https://openalex.org/W2924644564","https://openalex.org/W2925298688","https://openalex.org/W2931392259","https://openalex.org/W2940334427","https://openalex.org/W2946180204","https://openalex.org/W2946372752","https://openalex.org/W2947189704","https://openalex.org/W2948160364","https://openalex.org/W2948345271","https://openalex.org/W2954998528","https://openalex.org/W2955245896","https://openalex.org/W2963974009","https://openalex.org/W2967450000","https://openalex.org/W2969372641","https://openalex.org/W2969463435","https://openalex.org/W2970743640","https://openalex.org/W2971593808","https://openalex.org/W2972720814","https://openalex.org/W2975057435","https://openalex.org/W2976007626","https://openalex.org/W2976621574","https://openalex.org/W2977230696","https://openalex.org/W2980487229","https://openalex.org/W2981186196","https://openalex.org/W2986456778","https://openalex.org/W2992485470","https://openalex.org/W2995076193","https://openalex.org/W2995906558","https://openalex.org/W2996234046","https://openalex.org/W2997760533","https://openalex.org/W3000106048","https://openalex.org/W3000696551","https://openalex.org/W3004530491","https://openalex.org/W3005566802","https://openalex.org/W3006203496","https://openalex.org/W3008213618","https://openalex.org/W3010639002","https://openalex.org/W3011129791","https://openalex.org/W3011301336","https://openalex.org/W3012254223","https://openalex.org/W3012989060","https://openalex.org/W3013306876","https://openalex.org/W3013588846","https://openalex.org/W3015408469","https://openalex.org/W3016607029","https://openalex.org/W3019023480","https://openalex.org/W3019368774","https://openalex.org/W3020104645","https://openalex.org/W3021579311","https://openalex.org/W3022450273","https://openalex.org/W3027381800","https://openalex.org/W3030200736","https://openalex.org/W3030942202","https://openalex.org/W3031126723","https://openalex.org/W3035408224","https://openalex.org/W3036799928","https://openalex.org/W3037536942","https://openalex.org/W3042553188","https://openalex.org/W3042973980","https://openalex.org/W3048903784","https://openalex.org/W3049052172","https://openalex.org/W3049228301","https://openalex.org/W3080689243","https://openalex.org/W3082942945","https://openalex.org/W3083215834","https://openalex.org/W3083220670","https://openalex.org/W3084184895","https://openalex.org/W3085123120","https://openalex.org/W3088203083","https://openalex.org/W3088710714","https://openalex.org/W3092361963","https://openalex.org/W3092441320","https://openalex.org/W3093243853","https://openalex.org/W3096544444","https://openalex.org/W3097338697","https://openalex.org/W3097624000","https://openalex.org/W3097890239","https://openalex.org/W3098540694","https://openalex.org/W3103046667","https://openalex.org/W3104428311","https://openalex.org/W3106609857","https://openalex.org/W3106917142","https://openalex.org/W3106990080","https://openalex.org/W3107603134","https://openalex.org/W3108146325","https://openalex.org/W3111507870","https://openalex.org/W3111836013","https://openalex.org/W3111883011","https://openalex.org/W3112475740","https://openalex.org/W3112934313","https://openalex.org/W3115119009","https://openalex.org/W3118724893","https://openalex.org/W3118956265","https://openalex.org/W3119409060","https://openalex.org/W3120907929","https://openalex.org/W3122363818","https://openalex.org/W3126208996","https://openalex.org/W3130633483","https://openalex.org/W3133043072","https://openalex.org/W3133213560","https://openalex.org/W3134029116","https://openalex.org/W3134516572","https://openalex.org/W3134681765","https://openalex.org/W3135687130","https://openalex.org/W3136545015","https://openalex.org/W3136918079","https://openalex.org/W3138552287","https://openalex.org/W3143467719","https://openalex.org/W3147883768","https://openalex.org/W3149545639","https://openalex.org/W3150498393","https://openalex.org/W3152320455","https://openalex.org/W3153394500","https://openalex.org/W3154612073","https://openalex.org/W3155781357","https://openalex.org/W3156437156","https://openalex.org/W3156576433","https://openalex.org/W3158069567","https://openalex.org/W3158071568","https://openalex.org/W3158890392","https://openalex.org/W3159878005","https://openalex.org/W3164126481","https://openalex.org/W3164299529","https://openalex.org/W3168352971","https://openalex.org/W3178609592","https://openalex.org/W3182981660","https://openalex.org/W4211145083","https://openalex.org/W4243714145"],"related_works":["https://openalex.org/W7165002752","https://openalex.org/W2963961838","https://openalex.org/W4220769578","https://openalex.org/W2940482331","https://openalex.org/W7105682792","https://openalex.org/W2592084636","https://openalex.org/W2595926651","https://openalex.org/W4388850169","https://openalex.org/W4297009086","https://openalex.org/W4389003343"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,61],"gut":[2,104],"microbiota":[3,48,67,80,82,96,157,167],"is":[4,196],"involved":[5],"in":[6,22,39,97,141,158,171],"host":[7],"physiology":[8],"and":[9,25,41,45,69,86,107,123,129,137,149],"health.":[10],"Reciprocal":[11],"microbiota-drug":[12],"interactions":[13,116,195],"are":[14,30,71,117],"increasingly":[15],"recognized":[16],"as":[17,51],"underlying":[18,113],"some":[19],"individual":[20],"differences":[21],"therapy":[23,88,160],"response":[24],"adverse":[26,100],"events.":[27],"Cancer":[28],"pharmacotherapies":[29],"characterized":[31],"by":[32],"a":[33,52,153,190],"high":[34],"degree":[35],"of":[36,63,75,126,186],"interpatient":[37],"variability":[38],"efficacy":[40],"side":[42,172],"effect":[43,173],"profile":[44],"recently,":[46],"the":[47,76,92,95,142,166,184],"has":[49],"emerged":[50],"factor":[53],"that":[54,165],"may":[55,169],"underlie":[56],"these":[57],"differences.":[58],"AREAS":[59],"COVERED:":[60],"effects":[62],"cancer":[64,87,98,159],"pharmacotherapy":[65],"on":[66,135,179,192],"composition":[68],"function":[70],"reviewed":[72],"with":[73,162],"consideration":[74],"relationship":[77],"between":[78],"baseline":[79,156],"composition,":[81],"modification,":[83],"antibiotics":[84],"exposure,":[85],"efficacy.":[89],"We":[90],"assess":[91],"evidence":[93,164],"implicating":[94],"therapy-related":[99],"events":[101],"including":[102,119],"impaired":[103],"function,":[105],"cognition,":[106],"pain":[108],"perception.":[109],"Finally,":[110,189],"potential":[111],"mechanisms":[112],"microbiota-cancer":[114],"drug":[115],"described,":[118],"direct":[120],"microbial":[121,124],"metabolism,":[122],"modulation":[125],"liver":[127],"metabolism":[128],"immune":[130],"function.":[131],"This":[132],"review":[133],"focused":[134],"preclinical":[136],"clinical":[138,150],"studies":[139],"conducted":[140],"last":[143],"5":[144],"years.":[145],"EXPERT":[146],"OPINION:":[147],"Preclinical":[148],"research":[151],"supports":[152],"role":[154],"for":[155],"efficacy,":[161],"emerging":[163],"modification":[168],"assist":[170],"management.":[174],"Future":[175],"efforts":[176],"should":[177],"focus":[178,191],"exploiting":[180],"this":[181],"knowledge":[182],"toward":[183],"development":[185],"microbiota-targeted":[187],"therapies.":[188],"specific":[193],"drug-microbiota-cancer":[194],"warranted.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-02-24T00:00:00"}