{"id":"https://openalex.org/W4213100738","doi":"https://doi.org/10.3390/ijms23042222","title":"Adipsin Serum Concentrations and Adipose Tissue Expression in People with Obesity and Type 2 Diabetes","display_name":"Adipsin Serum Concentrations and Adipose Tissue Expression in People with Obesity and Type 2 Diabetes","publication_year":2022,"publication_date":"2022-02-17","ids":{"openalex":"https://openalex.org/W4213100738","doi":"https://doi.org/10.3390/ijms23042222","pmid":"https://pubmed.ncbi.nlm.nih.gov/35216336","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8878597"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23042222","doi":"https://doi.org/10.3390/ijms23042222","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23042222","pdf_url":"https://www.mdpi.com/1422-0067/23/4/2222/pdf?version=1645096327","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/4/2222/pdf?version=1645096327","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072633974","display_name":"Margarete Milek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Margarete Milek","raw_affiliation_strings":["Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021700511","display_name":"Yusef Moulla","orcid":"https://orcid.org/0000-0002-5936-0217","observed_orcids":["https://orcid.org/0000-0002-5936-0217"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yusef Moulla","raw_affiliation_strings":["Clinic for Visceral, Transplantation and Thorax and Vascular Surgery, University Hospital Leipzig, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Visceral, Transplantation and Thorax and Vascular Surgery, University Hospital Leipzig, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043521676","display_name":"Matthias Kern","orcid":"https://orcid.org/0000-0002-0378-9698","observed_orcids":["https://orcid.org/0000-0002-0378-9698"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Kern","raw_affiliation_strings":["Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018542310","display_name":"Christine Stroh","orcid":"https://orcid.org/0000-0003-3308-2797","observed_orcids":["https://orcid.org/0000-0003-3308-2797","https://orcid.org/0000-0001-7064-3587"]},"institutions":[{"id":"https://openalex.org/I4210094380","display_name":"SRH Wald-Klinikum Gera","ror":"https://ror.org/00q236z92","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094380"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Stroh","raw_affiliation_strings":["Department of General, Abdominal and Pediatric Surgery, Municipal Hospital, 07548 Gera, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Abdominal and Pediatric Surgery, Municipal Hospital, 07548 Gera, Germany","institution_ids":["https://openalex.org/I4210094380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102853651","display_name":"Arne Dietrich","orcid":"https://orcid.org/0000-0002-8299-2386","observed_orcids":["https://orcid.org/0000-0002-8299-2386"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arne Dietrich","raw_affiliation_strings":["Clinic for Visceral, Transplantation and Thorax and Vascular Surgery, University Hospital Leipzig, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Visceral, Transplantation and Thorax and Vascular Surgery, University Hospital Leipzig, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael R Sch\u00f6n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090715","display_name":"St\u00e4dtisches Klinikum Karlsruhe","ror":"https://ror.org/00agtat91","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210090715"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael R Sch\u00f6n","raw_affiliation_strings":["St\u00e4dtisches Klinikum Karlsruhe, Clinic of Visceral Surgery, 76133 Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St\u00e4dtisches Klinikum Karlsruhe, Clinic of Visceral Surgery, 76133 Karlsruhe, Germany","institution_ids":["https://openalex.org/I4210090715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103213135","display_name":"Daniel G\u00e4rtner","orcid":"https://orcid.org/0000-0002-7086-2285","observed_orcids":["https://orcid.org/0000-0002-7086-2285"]},"institutions":[{"id":"https://openalex.org/I4210090715","display_name":"St\u00e4dtisches Klinikum Karlsruhe","ror":"https://ror.org/00agtat91","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210090715"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel G\u00e4rtner","raw_affiliation_strings":["St\u00e4dtisches Klinikum Karlsruhe, Clinic of Visceral Surgery, 76133 Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St\u00e4dtisches Klinikum Karlsruhe, Clinic of Visceral Surgery, 76133 Karlsruhe, Germany","institution_ids":["https://openalex.org/I4210090715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110551093","display_name":"Tobias Lohmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090100","display_name":"St\u00e4dtisches Klinikum Dresden","ror":"https://ror.org/007gt1a87","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210090100"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Lohmann","raw_affiliation_strings":["Municipal Clinic Dresden-Neustadt, 01129 Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Municipal Clinic Dresden-Neustadt, 01129 Dresden, Germany","institution_ids":["https://openalex.org/I4210090100"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027609828","display_name":"Miriam Dre\u00dfler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090100","display_name":"St\u00e4dtisches Klinikum Dresden","ror":"https://ror.org/007gt1a87","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210090100"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miriam Dressler","raw_affiliation_strings":["Municipal Clinic Dresden-Neustadt, 01129 Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Municipal Clinic Dresden-Neustadt, 01129 Dresden, Germany","institution_ids":["https://openalex.org/I4210090100"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102869604","display_name":"Peter Louis Kovacs","orcid":"https://orcid.org/0000-0002-0290-5423","observed_orcids":["https://orcid.org/0000-0002-0290-5423"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Kovacs","raw_affiliation_strings":["Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0290-5423","affiliations":[{"raw_affiliation_string":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053898553","display_name":"Michael St\u00fcmvoll","orcid":"https://orcid.org/0000-0001-6225-8240","observed_orcids":["https://orcid.org/0000-0001-6225-8240","https://orcid.org/0000-0003-3054-1994"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Stumvoll","raw_affiliation_strings":["Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany","Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125843","https://openalex.org/I926574661"]},{"raw_affiliation_string":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073471236","display_name":"Matthias Bl\u00fcher","orcid":"https://orcid.org/0000-0003-0208-2065","observed_orcids":["https://orcid.org/0000-0003-0208-2065"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Bl\u00fcher","raw_affiliation_strings":["Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany","Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0208-2065","affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125843","https://openalex.org/I926574661"]},{"raw_affiliation_string":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037304323","display_name":"Esther Guiu\u2010Jurado","orcid":"https://orcid.org/0000-0001-9204-5780","observed_orcids":["https://orcid.org/0000-0001-9204-5780"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I4210160326","display_name":"German Center for Diabetes Research","ror":"https://ror.org/04qq88z54","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210160326","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Esther Guiu-Jurado","raw_affiliation_strings":["Deutsches Zentrum f\u00fcr Diabetesforschung e.V., 85764 Oberschlei\u00dfheim, Germany","Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany","Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9204-5780","affiliations":[{"raw_affiliation_string":"Deutsches Zentrum f\u00fcr Diabetesforschung e.V., 85764 Oberschlei\u00dfheim, Germany","institution_ids":["https://openalex.org/I4210160326"]},{"raw_affiliation_string":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125843","https://openalex.org/I926574661"]},{"raw_affiliation_string":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5037304323","https://openalex.org/A5073471236"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125843","https://openalex.org/I4210160326","https://openalex.org/I926574661"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":7.3056,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.98240654,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"23","issue":"4","first_page":"2222","last_page":"2222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipsin","display_name":"adipsin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.796999990940094},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8500000238418579},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.8610000014305115},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":1.0},{"id":"https://openalex.org/keywords/adipose-tissue-gene-expression","display_name":"adipose tissue gene expression","score":0.7929999828338623},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.953000009059906},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8389999866485596},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8039406538009644},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.788083553314209},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7863045930862427},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.6313190460205078},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6311286091804504},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5553257465362549},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4827403426170349},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.47516414523124695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4722641706466675},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.41529524326324463}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011416","descriptor_name":"Complement Factor D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050152","descriptor_name":"Intra-Abdominal Fat","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055105","descriptor_name":"Waist Circumference","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.3390/ijms23042222","doi":"https://doi.org/10.3390/ijms23042222","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23042222","pdf_url":"https://www.mdpi.com/1422-0067/23/4/2222/pdf?version=1645096327","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8878597","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8878597","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:35216336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35216336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:qucosa:de:qucosa:89178","doi":null,"is_oa":true,"landing_page_url":"https://ul.qucosa.de/id/qucosa%3A89178","pdf_url":null,"source":{"id":"https://openalex.org/S4377196435","display_name":"Qucosa (Saxon State and University Library Dresden)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3132420320","host_organization_name":"SLUB Dresden","host_organization_lineage":["https://openalex.org/I3132420320"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:64340","doi":null,"is_oa":true,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=64340","pdf_url":"https://push-zb.helmholtz-munich.de/deliver.php?id=32971","source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int. J. Mol. Sci. 23:2222 (2022)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:018edcd6c7234575a2d790845a0f0a7f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/018edcd6c7234575a2d790845a0f0a7f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 2222, p 2222 (2022)","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:64340","doi":null,"is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64340","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int. J. Mol. Sci. 23:2222 (2022)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:qucosa:de:qucosa:90109","doi":null,"is_oa":true,"landing_page_url":"https://ul.qucosa.de/id/qucosa%3A90109","pdf_url":null,"source":{"id":"https://openalex.org/S4377196435","display_name":"Qucosa (Saxon State and University Library Dresden)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3132420320","host_organization_name":"SLUB Dresden","host_organization_lineage":["https://openalex.org/I3132420320"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences 23 (), S. -","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.3390/ijms23042222","doi":"https://doi.org/10.3390/ijms23042222","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23042222","pdf_url":"https://www.mdpi.com/1422-0067/23/4/2222/pdf?version=1645096327","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1455670351","display_name":null,"funder_award_id":"SFB 1052","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2333769982","display_name":null,"funder_award_id":"82DZD00601","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5345868840","display_name":null,"funder_award_id":"Project B1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4213100738.pdf","grobid_xml":"https://content.openalex.org/works/W4213100738.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1563977056","https://openalex.org/W1954270231","https://openalex.org/W1964607854","https://openalex.org/W1970117178","https://openalex.org/W1971226856","https://openalex.org/W2010886780","https://openalex.org/W2013710242","https://openalex.org/W2042303325","https://openalex.org/W2044722821","https://openalex.org/W2053633351","https://openalex.org/W2070610372","https://openalex.org/W2083006263","https://openalex.org/W2083949311","https://openalex.org/W2084802447","https://openalex.org/W2085796361","https://openalex.org/W2093712462","https://openalex.org/W2112121424","https://openalex.org/W2123597656","https://openalex.org/W2131525837","https://openalex.org/W2134070809","https://openalex.org/W2134113528","https://openalex.org/W2136648677","https://openalex.org/W2140886368","https://openalex.org/W2141566387","https://openalex.org/W2157180876","https://openalex.org/W2289584262","https://openalex.org/W2408412665","https://openalex.org/W2441568152","https://openalex.org/W2499238762","https://openalex.org/W2611534373","https://openalex.org/W2735376054","https://openalex.org/W2751861084","https://openalex.org/W2762689525","https://openalex.org/W2768120616","https://openalex.org/W2789834118","https://openalex.org/W2792304088","https://openalex.org/W2901458318","https://openalex.org/W2905537819","https://openalex.org/W2906391704","https://openalex.org/W2917520831","https://openalex.org/W2924488055","https://openalex.org/W2976871993","https://openalex.org/W2980173668","https://openalex.org/W2982105581","https://openalex.org/W2985194635","https://openalex.org/W2989981414","https://openalex.org/W3030585082","https://openalex.org/W3088561589","https://openalex.org/W3118623772","https://openalex.org/W3172379734","https://openalex.org/W3175765750","https://openalex.org/W4240986128"],"related_works":["https://openalex.org/W6991331017","https://openalex.org/W2980173668","https://openalex.org/W4361273495","https://openalex.org/W4402076799","https://openalex.org/W2010886780","https://openalex.org/W2021628230","https://openalex.org/W2351098730","https://openalex.org/W1973438927","https://openalex.org/W2367955684","https://openalex.org/W2960892884"],"abstract_inverted_index":{"(1)":[0],"Adipsin":[1,99],"is":[2],"an":[3],"adipokine":[4],"that":[5,197],"may":[6],"link":[7],"increased":[8],"fat":[9],"mass":[10],"and":[11,26,41,59,86,89,148,175,206],"adipose":[12,27],"tissue":[13,28],"dysfunction":[14],"to":[15,35,110,190,204],"obesity-related":[16],"cardiometabolic":[17],"diseases.":[18],"Here,":[19],"we":[20,181],"investigated":[21],"whether":[22],"adipsin":[23,30,82,92,120,162,167,185,198,211,213],"serum":[24,81,100,121,150,168,199],"concentrations":[25,83,101,122,151,169,200],"(AT)":[29],"mRNA":[31,93,163],"expression":[32,94,164,186,215],"are":[33,201],"related":[34,203],"parameters":[36,217],"of":[37,50,57,119,178,218],"AT":[38,214],"function,":[39],"obesity":[40,205,227],"type":[42],"2":[43],"diabetes":[44],"(T2D).":[45],"(2)":[46],"Methods:":[47],"A":[48],"cohort":[49],"637":[51],"individuals":[52],"with":[53,68,107,123,166,226,228],"a":[54],"wide":[55],"range":[56],"age":[58,124],"body":[60,131],"weight":[61,132],"(Age:":[62],"18\u201385":[63],"years;":[64],"BMI:":[65],"19\u201370":[66],"kg/m2)":[67],"(n":[69,74],"=":[70,75,126,134,143,146,153],"237)":[71],"or":[72,221,229],"without":[73,230],"400)":[76],"T2D":[77,108,179],"was":[78],"analyzed":[79],"for":[80,172],"by":[84,95],"ELISA":[85],"visceral":[87],"(VAT)":[88],"subcutaneous":[90],"(SAT)":[91],"RT-PCR.":[96],"(3)":[97],"Results:":[98],"were":[102],"significantly":[103,183],"higher":[104,184],"in":[105,187,224],"patients":[106,225],"compared":[109,189],"normoglycemic":[111],"individuals.":[112],"We":[113],"found":[114,182],"significant":[115],"positive":[116],"univariate":[117],"relationships":[118],"(r":[125,133,142,152],"0.282,":[127],"p":[128,136,145,155],"<":[129,137,156],"0.001),":[130,138],"0.264,":[135],"fasting":[139],"plasma":[140],"glucose":[141,220],"0.136,":[144],"0.006)":[147],"leptin":[149],"0.362,":[154],"0.001).":[157],"Neither":[158],"VAT":[159,191],"nor":[160,212],"SAT":[161,188],"correlated":[165],"after":[170],"adjusting":[171],"age,":[173],"sex":[174],"BMI.":[176],"Independent":[177],"status,":[180],"(4)":[192],"Conclusions:":[193],"Our":[194],"data":[195],"suggest":[196],"strongly":[202],"age.":[207],"However,":[208],"neither":[209],"circulating":[210],"reflects":[216],"impaired":[219],"lipid":[222],"metabolism":[223],"T2D.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-02-24T00:00:00"}