{"id":"https://openalex.org/W4213088488","doi":"https://doi.org/10.3389/fimmu.2022.830662","title":"B-Cell Homeostasis Is Maintained During Two Months of Head-Down Tilt Bed Rest With or Without Antioxidant Supplementation","display_name":"B-Cell Homeostasis Is Maintained During Two Months of Head-Down Tilt Bed Rest With or Without Antioxidant Supplementation","publication_year":2022,"publication_date":"2022-02-15","ids":{"openalex":"https://openalex.org/W4213088488","doi":"https://doi.org/10.3389/fimmu.2022.830662","pmid":"https://pubmed.ncbi.nlm.nih.gov/35251019","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8892569"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.830662","doi":"https://doi.org/10.3389/fimmu.2022.830662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.830662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.830662/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.830662/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006735315","display_name":"Julie Bonnefoy","orcid":"https://orcid.org/0000-0003-0495-6109","observed_orcids":["https://orcid.org/0000-0003-0495-6109"]},"institutions":[{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Bonnefoy","raw_affiliation_strings":["Stress Immunity Pathogens Laboratory, UR7300 SIMPA, Faculty of Medicine, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stress Immunity Pathogens Laboratory, UR7300 SIMPA, Faculty of Medicine, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048343346","display_name":"Bjorn Baselet","orcid":"https://orcid.org/0000-0001-9840-2822","observed_orcids":["https://orcid.org/0000-0001-9840-2822"]},"institutions":[{"id":"https://openalex.org/I4210114391","display_name":"Belgian Nuclear Research Centre","ror":"https://ror.org/020xs5r81","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114391"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bjorn Baselet","raw_affiliation_strings":["Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium","institution_ids":["https://openalex.org/I4210114391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020072409","display_name":"Dominique Moser","orcid":"https://orcid.org/0000-0002-3156-2976","observed_orcids":["https://orcid.org/0000-0002-3156-2976"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominique Moser","raw_affiliation_strings":["Laboratory of Translational Research Stress and Immunity, Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University (LUM), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Translational Research Stress and Immunity, Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University (LUM), Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034084280","display_name":"St\u00e9phanie Ghislin","orcid":"https://orcid.org/0000-0001-9456-6782","observed_orcids":["https://orcid.org/0000-0001-9456-6782"]},"institutions":[{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Ghislin","raw_affiliation_strings":["Stress Immunity Pathogens Laboratory, UR7300 SIMPA, Faculty of Medicine, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stress Immunity Pathogens Laboratory, UR7300 SIMPA, Faculty of Medicine, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039273421","display_name":"Silvana Miranda","orcid":"https://orcid.org/0000-0003-1365-1657","observed_orcids":["https://orcid.org/0000-0003-1365-1657"]},"institutions":[{"id":"https://openalex.org/I4210114391","display_name":"Belgian Nuclear Research Centre","ror":"https://ror.org/020xs5r81","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114391"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Silvana Miranda","raw_affiliation_strings":["Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium","institution_ids":["https://openalex.org/I4210114391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074147890","display_name":"\u00c9lodie Riant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405263539","display_name":"Genotoul coordination","ror":"https://ror.org/02f0kwz92","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210088668","https://openalex.org/I4405263539"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Riant","raw_affiliation_strings":["Cytometry Facility, I2MC, Universit\u00e9 de Toulouse, Inserm, Universit\u00e9 Toulouse III - Paul Sabatier (UPS), TRI Genotoul, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytometry Facility, I2MC, Universit\u00e9 de Toulouse, Inserm, Universit\u00e9 Toulouse III - Paul Sabatier (UPS), TRI Genotoul, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862","https://openalex.org/I4405263539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080373566","display_name":"Randy Vermeesen","orcid":"https://orcid.org/0000-0002-9850-8907","observed_orcids":["https://orcid.org/0000-0002-9850-8907"]},"institutions":[{"id":"https://openalex.org/I4210114391","display_name":"Belgian Nuclear Research Centre","ror":"https://ror.org/020xs5r81","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114391"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Randy Vermeesen","raw_affiliation_strings":["Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium","institution_ids":["https://openalex.org/I4210114391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038012554","display_name":"Annekathrin M. Keiler","orcid":"https://orcid.org/0000-0002-2157-4711","observed_orcids":["https://orcid.org/0000-0002-2157-4711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annekathrin M. Keiler","raw_affiliation_strings":["Institute of Doping Analysis and Sports Biochemistry Dresden, Kreischa, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Doping Analysis and Sports Biochemistry Dresden, Kreischa, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063366433","display_name":"Sarah Baatout","orcid":"https://orcid.org/0000-0001-8110-751X","observed_orcids":["https://orcid.org/0000-0001-8110-751X"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210114391","display_name":"Belgian Nuclear Research Centre","ror":"https://ror.org/020xs5r81","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114391"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sarah Baatout","raw_affiliation_strings":["Department of Molecular Biotechnology, Faculty of Biosciences Engineering, Ghent University, Ghent, Belgium","Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biotechnology, Faculty of Biosciences Engineering, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Center (SCK CEN), Mol, Belgium","institution_ids":["https://openalex.org/I4210114391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085612736","display_name":"Alexander Chouk\u00e8r","orcid":"https://orcid.org/0000-0002-0133-4104","observed_orcids":["https://orcid.org/0000-0002-0133-4104"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Chouk\u00e9r","raw_affiliation_strings":["Laboratory of Translational Research Stress and Immunity, Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University (LUM), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Translational Research Stress and Immunity, Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University (LUM), Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039276492","display_name":"Jean\u2010Pol Frippiat","orcid":"https://orcid.org/0000-0002-4027-6269","observed_orcids":["https://orcid.org/0000-0002-4027-6269"]},"institutions":[{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Pol Frippiat","raw_affiliation_strings":["Stress Immunity Pathogens Laboratory, UR7300 SIMPA, Faculty of Medicine, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stress Immunity Pathogens Laboratory, UR7300 SIMPA, Faculty of Medicine, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5039276492"],"corresponding_institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":3.1682,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.92690398,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"830662","last_page":"830662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-homeostasis","display_name":"B cell homeostasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/head-down-bed-rest","display_name":"head-down bed rest","score":0.9539999961853027},{"id":"https://openalex.org/keywords/spaceflight-analog","display_name":"spaceflight analog","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antibody-isotypes","display_name":"antibody isotypes","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7490000128746033},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.8889999985694885},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.996999979019165},{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":1.0}],"concepts":[{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.8886669874191284},{"id":"https://openalex.org/C2777854218","wikidata":"https://www.wikidata.org/wiki/Q850197","display_name":"Bed rest","level":2,"score":0.7478526830673218},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.639029324054718},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5701691508293152},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5551750063896179},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48578861355781555},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4597404897212982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4578832685947418},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4397452473640442},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.43892166018486023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4216034412384033},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41073620319366455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3442589044570923},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24276971817016602},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018475","descriptor_name":"Head-Down Tilt","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3389/fimmu.2022.830662","doi":"https://doi.org/10.3389/fimmu.2022.830662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.830662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.830662/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:35251019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35251019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8892569","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8892569/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-03602755v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.univ-lorraine.fr/hal-03602755","pdf_url":"https://hal.univ-lorraine.fr/hal-03602755v1/file/fimmu-13-830662.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 2022, 13, pp.830662. &#x27E8;10.3389/fimmu.2022.830662&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:archive.ugent.be:8743020","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/8743020","pdf_url":"https://biblio.ugent.be/publication/8743020/file/8743021.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1664-3224","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/693871","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/693871","pdf_url":"https://lirias.kuleuven.be/retrieve/09b0cc09-4def-4aa2-92d4-ad0d1b14ebe3","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers In Immunology, vol. 13, Art.No. ARTN 830662","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7b5e58cd47a6479995705ecf6fc97af0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7b5e58cd47a6479995705ecf6fc97af0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.830662","doi":"https://doi.org/10.3389/fimmu.2022.830662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.830662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.830662/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1709849291","display_name":null,"funder_award_id":"DAR 4800000841","funder_id":"https://openalex.org/F4320321519","funder_display_name":"Centre National d\u2019Etudes Spatiales"},{"id":"https://openalex.org/G19867267","display_name":null,"funder_award_id":"50WB1931","funder_id":"https://openalex.org/F4320321469","funder_display_name":"Bundesministerium f\u00fcr Wirtschaft und Technologie"},{"id":"https://openalex.org/G6740152044","display_name":null,"funder_award_id":"50WB1622","funder_id":"https://openalex.org/F4320318240","funder_display_name":"European Space Agency"}],"funders":[{"id":"https://openalex.org/F4320310925","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97"},{"id":"https://openalex.org/F4320318240","display_name":"European Space Agency","ror":"https://ror.org/03wd9za21"},{"id":"https://openalex.org/F4320321454","display_name":"Belgian Federal Science Policy Office","ror":"https://ror.org/01fapfv42"},{"id":"https://openalex.org/F4320321469","display_name":"Bundesministerium f\u00fcr Wirtschaft und Technologie","ror":"https://ror.org/02vgg2808"},{"id":"https://openalex.org/F4320321519","display_name":"Centre National d\u2019Etudes Spatiales","ror":"https://ror.org/04h1h0y33"},{"id":"https://openalex.org/F4320321602","display_name":"Deutsches Zentrum f\u00fcr Luft- und Raumfahrt","ror":"https://ror.org/04bwf3e34"},{"id":"https://openalex.org/F4320322727","display_name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","ror":"https://ror.org/03sjk9a61"},{"id":"https://openalex.org/F4320322890","display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche","ror":"https://ror.org/03sjk9a61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4213088488.pdf","grobid_xml":"https://content.openalex.org/works/W4213088488.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W2732391","https://openalex.org/W1965840684","https://openalex.org/W1968191137","https://openalex.org/W1968561190","https://openalex.org/W1969082595","https://openalex.org/W1984444465","https://openalex.org/W1990891254","https://openalex.org/W1990947374","https://openalex.org/W1999056435","https://openalex.org/W2009690260","https://openalex.org/W2032781893","https://openalex.org/W2050986536","https://openalex.org/W2052143567","https://openalex.org/W2068849530","https://openalex.org/W2069833430","https://openalex.org/W2081889177","https://openalex.org/W2087217644","https://openalex.org/W2100564424","https://openalex.org/W2114682229","https://openalex.org/W2123322798","https://openalex.org/W2131643056","https://openalex.org/W2132661305","https://openalex.org/W2133148337","https://openalex.org/W2136746620","https://openalex.org/W2137042254","https://openalex.org/W2162406277","https://openalex.org/W2266281134","https://openalex.org/W2272797373","https://openalex.org/W2284759896","https://openalex.org/W2336360042","https://openalex.org/W2462988603","https://openalex.org/W2521574223","https://openalex.org/W2548179736","https://openalex.org/W2560639677","https://openalex.org/W2594591188","https://openalex.org/W2596220060","https://openalex.org/W2598976658","https://openalex.org/W2746657538","https://openalex.org/W2753887226","https://openalex.org/W2780519796","https://openalex.org/W2794079760","https://openalex.org/W2802040687","https://openalex.org/W2808186163","https://openalex.org/W2895114763","https://openalex.org/W2902284322","https://openalex.org/W2903357802","https://openalex.org/W2911203605","https://openalex.org/W2916968581","https://openalex.org/W2917399591","https://openalex.org/W2923464495","https://openalex.org/W2924216098","https://openalex.org/W2951257832","https://openalex.org/W2955714090","https://openalex.org/W2991097048","https://openalex.org/W3006005115","https://openalex.org/W3030541694","https://openalex.org/W3037456528","https://openalex.org/W3080628909","https://openalex.org/W3091938656","https://openalex.org/W3092206077","https://openalex.org/W3113092717","https://openalex.org/W3133009961","https://openalex.org/W3140784839","https://openalex.org/W3154251641","https://openalex.org/W3195622846","https://openalex.org/W4253756243"],"related_works":["https://openalex.org/W2903357802","https://openalex.org/W2055903609","https://openalex.org/W848025324","https://openalex.org/W2156472843","https://openalex.org/W2114682229","https://openalex.org/W2009690260","https://openalex.org/W2032781893","https://openalex.org/W156465879","https://openalex.org/W2050648434","https://openalex.org/W4237758201"],"abstract_inverted_index":{"Alterations":[0],"of":[1,25,59,99,162,179,182,200,209,215,237,261],"the":[2,8,23,28,32,97,157,201,207,210,216,221,225,235],"immune":[3],"system":[4],"could":[5],"seriously":[6],"impair":[7],"ability":[9],"to":[10,35,52,224,245],"combat":[11],"infections":[12],"during":[13,151,253],"future":[14,254],"long-duration":[15,53],"space":[16],"missions.":[17],"However,":[18],"little":[19],"is":[20,250],"known":[21],"about":[22],"effects":[24],"spaceflight":[26],"on":[27,186],"B-cell":[29,71,128,175,187,248],"compartment.":[30],"Given":[31,234],"limited":[33,196],"access":[34],"astronaut":[36],"samples,":[37],"we":[38,95],"addressed":[39],"this":[40,238],"question":[41],"using":[42],"blood":[43,64,121],"samples":[44],"collected":[45],"from":[46],"20":[47],"healthy":[48],"male":[49],"volunteers":[50,229],"subjected":[51],"bed":[54,134,152,170,184],"rest,":[55],"an":[56,146,180],"Earth-based":[57],"analog":[58],"spaceflight.":[60],"Hematopoietic":[61],"progenitors,":[62,119],"white":[63,120],"cells,":[65,122],"total":[66,123],"lymphocytes":[67,124],"and":[68,81,111,125,127,167,227],"B-cells,":[69,126],"four":[70],"subsets,":[72],"immunoglobulin":[73],"isotypes,":[74],"six":[75],"cytokines":[76],"involved":[77],"in":[78,148,158,165],"inflammation,":[79],"cortisone":[80],"cortisol":[82],"were":[83,130,204],"quantified":[84],"at":[85,190],"five":[86],"time":[87],"points.":[88],"Tibia":[89],"microarchitecture":[90],"was":[91],"also":[92],"studied.":[93],"Moreover,":[94],"investigated":[96],"efficiency":[98],"antioxidant":[100,211],"supplementation":[101],"with":[102],"a":[103,139],"cocktail":[104],"including":[105],"polyphenols,":[106],"omega":[107],"3,":[108],"vitamin":[109],"E":[110],"selenium.":[112],"Our":[113],"results":[114],"show":[115,168],"that":[116,169,258],"circulating":[117],"hematopoietic":[118],"subsets":[129],"not":[131,173],"affected":[132,205],"by":[133,145,195,206],"rest.":[135,153],"Cytokine":[136],"quantification":[137],"suggested":[138],"lower":[140],"systemic":[141],"inflammatory":[142],"status,":[143],"supported":[144],"increase":[147],"serum":[149],"cortisone,":[150],"These":[154],"data":[155],"confirm":[156],"vivo":[159],"hormonal":[160],"dysregulation":[161],"immunity":[163],"observed":[164],"astronauts":[166],"rest":[171,185],"does":[172],"alter":[174],"homeostasis.":[176],"This":[177],"lack":[178],"impact":[181],"long-term":[183],"homeostasis":[188,249],"can,":[189],"least":[191],"partially,":[192],"be":[193,219,243,260],"explained":[194],"bone":[197],"remodeling.":[198],"None":[199],"evaluated":[202],"parameters":[203],"administration":[208],"supplement.":[212],"The":[213],"non-effectiveness":[214],"supplement":[217],"may":[218],"because":[220],"diet":[222],"provided":[223],"non-supplemented":[226],"supplemented":[228],"already":[230],"contained":[231],"sufficient":[232],"antioxidants.":[233],"limitations":[236],"model,":[239],"further":[240],"studies":[241],"will":[242,259],"required":[244],"determine":[246],"whether":[247],"affected,":[251],"especially":[252],"deep-space":[255],"exploration":[256],"missions":[257],"unprecedented":[262],"durations.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-02-24T00:00:00"}
