{"id":"https://openalex.org/W4213069758","doi":"https://doi.org/10.1016/j.bioorg.2022.105687","title":"Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors","display_name":"Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors","publication_year":2022,"publication_date":"2022-02-16","ids":{"openalex":"https://openalex.org/W4213069758","doi":"https://doi.org/10.1016/j.bioorg.2022.105687","pmid":"https://pubmed.ncbi.nlm.nih.gov/35196595"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2022.105687","doi":"https://doi.org/10.1016/j.bioorg.2022.105687","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2022.105687","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049917537","display_name":"Heba S. Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799409690","display_name":"Nahda University","ror":"https://ror.org/05s29c959","country_code":"EG","type":"education","lineage":["https://openalex.org/I2799409690"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Heba S. Mohamed","raw_affiliation_strings":["Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt. Electronic address: heba.ibrahim@nub.edu.eg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt. Electronic address: heba.ibrahim@nub.edu.eg","institution_ids":["https://openalex.org/I2799409690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101860148","display_name":"Noha H. Amin","orcid":"https://orcid.org/0000-0003-0799-7934","observed_orcids":["https://orcid.org/0000-0003-0799-7934"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Noha H. Amin","raw_affiliation_strings":["Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027193278","display_name":"Mohammed T. El\u2010Saadi","orcid":"https://orcid.org/0000-0003-1245-503X","observed_orcids":["https://orcid.org/0000-0003-1245-503X"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]},{"id":"https://openalex.org/I1355163","display_name":"Sinai University","ror":"https://ror.org/01dd13a92","country_code":"EG","type":"education","lineage":["https://openalex.org/I1355163"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohammed T. El-Saadi","raw_affiliation_strings":["Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Sinai University-Kantra Branch, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Sinai University-Kantra Branch, Egypt","institution_ids":["https://openalex.org/I113643904","https://openalex.org/I1355163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035669689","display_name":"Hamdy Mohamed Abdel-Rahman","orcid":"https://orcid.org/0000-0003-1355-8380","observed_orcids":["https://orcid.org/0000-0003-1355-8380"]},"institutions":[{"id":"https://openalex.org/I2799409690","display_name":"Nahda University","ror":"https://ror.org/05s29c959","country_code":"EG","type":"education","lineage":["https://openalex.org/I2799409690"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hamdy M. Abdel-Rahman","raw_affiliation_strings":["Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt","institution_ids":["https://openalex.org/I2799409690","https://openalex.org/I91041137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049917537"],"corresponding_institution_ids":["https://openalex.org/I2799409690"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.9997,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.9295177,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"121","issue":null,"first_page":"105687","last_page":"105687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tubulin-polymerization-inhibitors","display_name":"tubulin polymerization inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9430000185966492},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.996999979019165},{"id":"https://openalex.org/keywords/colchicine-binding-site","display_name":"colchicine binding site","score":0.9869999885559082},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8119999766349792},{"id":"https://openalex.org/keywords/anticancer-lead-compounds","display_name":"anticancer lead compounds","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.844876766204834},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.8392179608345032},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.7325623035430908},{"id":"https://openalex.org/C2778275628","wikidata":"https://www.wikidata.org/wiki/Q5150954","display_name":"Combretastatin","level":4,"score":0.6282703876495361},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5671894550323486},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5406664609909058},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5312283635139465},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5174927711486816},{"id":"https://openalex.org/C2909009945","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule polymerization","level":4,"score":0.5073813796043396},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.46146658062934875},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.4453153908252716},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43531161546707153},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.41811302304267883},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.41117021441459656},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31026238203048706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30751723051071167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09964734315872192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08542376756668091},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07526242733001709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050257","descriptor_name":"Tubulin Modulators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bioorg.2022.105687","doi":"https://doi.org/10.1016/j.bioorg.2022.105687","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2022.105687","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:35196595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35196595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1153335416","https://openalex.org/W1880069888","https://openalex.org/W1898039780","https://openalex.org/W1958811049","https://openalex.org/W1984406525","https://openalex.org/W1985085616","https://openalex.org/W2049775197","https://openalex.org/W2054652979","https://openalex.org/W2071544105","https://openalex.org/W2073807681","https://openalex.org/W2084209221","https://openalex.org/W2109341852","https://openalex.org/W2126661983","https://openalex.org/W2160365238","https://openalex.org/W2161085764","https://openalex.org/W2172081252","https://openalex.org/W2311252557","https://openalex.org/W2312969661","https://openalex.org/W2368021708","https://openalex.org/W2465273468","https://openalex.org/W2493116523","https://openalex.org/W2535430357","https://openalex.org/W2574791363","https://openalex.org/W2606329797","https://openalex.org/W2608977478","https://openalex.org/W2609452519","https://openalex.org/W2617067794","https://openalex.org/W2735697753","https://openalex.org/W2760376760","https://openalex.org/W2767223270","https://openalex.org/W2783091713","https://openalex.org/W2785609916","https://openalex.org/W2790148155","https://openalex.org/W2883386390","https://openalex.org/W2905383087","https://openalex.org/W2906091607","https://openalex.org/W2924327433","https://openalex.org/W2946780854","https://openalex.org/W2966046591","https://openalex.org/W2972541435","https://openalex.org/W2992745749","https://openalex.org/W2996972660","https://openalex.org/W2998269048","https://openalex.org/W3003266034","https://openalex.org/W3008437665","https://openalex.org/W3011614078","https://openalex.org/W3013872821","https://openalex.org/W3014843513","https://openalex.org/W3017237254","https://openalex.org/W3028009950","https://openalex.org/W3038125686","https://openalex.org/W3039854014","https://openalex.org/W3041488145","https://openalex.org/W3042589130","https://openalex.org/W3043699906","https://openalex.org/W3047001898","https://openalex.org/W3083362053","https://openalex.org/W3085227186","https://openalex.org/W3106732052","https://openalex.org/W3136999914","https://openalex.org/W3156472232","https://openalex.org/W3157176432","https://openalex.org/W3157791576","https://openalex.org/W3210924324","https://openalex.org/W4200037584","https://openalex.org/W4383677033"],"related_works":["https://openalex.org/W2972541435","https://openalex.org/W2059981607","https://openalex.org/W2966615992","https://openalex.org/W3005675216","https://openalex.org/W4283527334","https://openalex.org/W3043699906","https://openalex.org/W4308487895","https://openalex.org/W3156472232","https://openalex.org/W3146659456","https://openalex.org/W2760376760"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-02-24T00:00:00"}
