{"id":"https://openalex.org/W4213065447","doi":"https://doi.org/10.3390/cancers14040961","title":"DNA Methylation in Lung Cancer: Mechanisms and Associations with Histological Subtypes, Molecular Alterations, and Major Epidemiological Factors","display_name":"DNA Methylation in Lung Cancer: Mechanisms and Associations with Histological Subtypes, Molecular Alterations, and Major Epidemiological Factors","publication_year":2022,"publication_date":"2022-02-15","ids":{"openalex":"https://openalex.org/W4213065447","doi":"https://doi.org/10.3390/cancers14040961","pmid":"https://pubmed.ncbi.nlm.nih.gov/35205708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8870477"},"language":"en","primary_location":{"id":"doi:10.3390/cancers14040961","doi":"https://doi.org/10.3390/cancers14040961","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14040961","pdf_url":"https://www.mdpi.com/2072-6694/14/4/961/pdf?version=1645074404","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/14/4/961/pdf?version=1645074404","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080996157","display_name":"Phuc H. Hoang","orcid":"https://orcid.org/0000-0002-9265-8525","observed_orcids":["https://orcid.org/0000-0002-9265-8525"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Phuc H. Hoang","raw_affiliation_strings":["Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0000-0002-9265-8525","affiliations":[{"raw_affiliation_string":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110966805","display_name":"Maria Teresa Landi","orcid":"https://orcid.org/0000-0002-9727-7772","observed_orcids":["https://orcid.org/0000-0002-9727-7772","https://orcid.org/0000-0003-4507-329X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria Teresa Landi","raw_affiliation_strings":["Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080996157","https://openalex.org/A5110966805"],"corresponding_institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":2.1085,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.91017462,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"14","issue":"4","first_page":"961","last_page":"961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9120000004768372},{"id":"https://openalex.org/keywords/race-and-ethnicity","display_name":"race and ethnicity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cancer-risk-factors","display_name":"cancer risk factors","score":0.7950000166893005},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7763159275054932},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7284606695175171},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6034919023513794},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.48167359828948975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4666668772697449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45538923144340515},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4416424334049225},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4377167224884033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43690264225006104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36677664518356323},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34648430347442627},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28648847341537476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23570606112480164},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10095450282096863}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers14040961","doi":"https://doi.org/10.3390/cancers14040961","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14040961","pdf_url":"https://www.mdpi.com/2072-6694/14/4/961/pdf?version=1645074404","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8870477","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8870477","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:35205708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35205708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2a72bcf64c154563818d1265776c2a11","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2a72bcf64c154563818d1265776c2a11","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 14, Iss 961, p 961 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers14040961","doi":"https://doi.org/10.3390/cancers14040961","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14040961","pdf_url":"https://www.mdpi.com/2072-6694/14/4/961/pdf?version=1645074404","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8799999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338333","display_name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","ror":"https://ror.org/00vkwep27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4213065447.pdf","grobid_xml":"https://content.openalex.org/works/W4213065447.grobid-xml"},"referenced_works_count":219,"referenced_works":["https://openalex.org/W2047947","https://openalex.org/W410727792","https://openalex.org/W1254044211","https://openalex.org/W1503277017","https://openalex.org/W1504303645","https://openalex.org/W1531766774","https://openalex.org/W1669168502","https://openalex.org/W1827639246","https://openalex.org/W1874454018","https://openalex.org/W1892327752","https://openalex.org/W1902346661","https://openalex.org/W1903281529","https://openalex.org/W1904349774","https://openalex.org/W1929295557","https://openalex.org/W1964232579","https://openalex.org/W1964638345","https://openalex.org/W1966485273","https://openalex.org/W1968328969","https://openalex.org/W1969090518","https://openalex.org/W1969643849","https://openalex.org/W1970145665","https://openalex.org/W1971563492","https://openalex.org/W1973414121","https://openalex.org/W1974352623","https://openalex.org/W1974943501","https://openalex.org/W1975003033","https://openalex.org/W1976713001","https://openalex.org/W1977706798","https://openalex.org/W1977794292","https://openalex.org/W1978284325","https://openalex.org/W1978620346","https://openalex.org/W1979109110","https://openalex.org/W1979362779","https://openalex.org/W1979818557","https://openalex.org/W1983501949","https://openalex.org/W1985575613","https://openalex.org/W1989578834","https://openalex.org/W1989847639","https://openalex.org/W1992409001","https://openalex.org/W1992862760","https://openalex.org/W1996628512","https://openalex.org/W1997434130","https://openalex.org/W1998516698","https://openalex.org/W2005589635","https://openalex.org/W2007283154","https://openalex.org/W2010568588","https://openalex.org/W2010619056","https://openalex.org/W2024561451","https://openalex.org/W2025004154","https://openalex.org/W2027324111","https://openalex.org/W2030110104","https://openalex.org/W2030947105","https://openalex.org/W2035480447","https://openalex.org/W2035736394","https://openalex.org/W2037010522","https://openalex.org/W2038181620","https://openalex.org/W2041263849","https://openalex.org/W2044138830","https://openalex.org/W2044702943","https://openalex.org/W2045225294","https://openalex.org/W2045608427","https://openalex.org/W2049413309","https://openalex.org/W2050619503","https://openalex.org/W2052305820","https://openalex.org/W2052624043","https://openalex.org/W2053421436","https://openalex.org/W2053468229","https://openalex.org/W2053708409","https://openalex.org/W2054742531","https://openalex.org/W2054801287","https://openalex.org/W2056750246","https://openalex.org/W2057929153","https://openalex.org/W2058597729","https://openalex.org/W2059579018","https://openalex.org/W2060234591","https://openalex.org/W2066772704","https://openalex.org/W2067708335","https://openalex.org/W2068207552","https://openalex.org/W2072039942","https://openalex.org/W2072202929","https://openalex.org/W2081548587","https://openalex.org/W2094815969","https://openalex.org/W2096008575","https://openalex.org/W2097596835","https://openalex.org/W2099755355","https://openalex.org/W2099758265","https://openalex.org/W2100128545","https://openalex.org/W2102232287","https://openalex.org/W2103067815","https://openalex.org/W2103177465","https://openalex.org/W2103890313","https://openalex.org/W2104300284","https://openalex.org/W2104760300","https://openalex.org/W2106057638","https://openalex.org/W2106658124","https://openalex.org/W2107865352","https://openalex.org/W2110511887","https://openalex.org/W2110797244","https://openalex.org/W2111599976","https://openalex.org/W2112236435","https://openalex.org/W2112337406","https://openalex.org/W2113524127","https://openalex.org/W2113841146","https://openalex.org/W2115486450","https://openalex.org/W2115719453","https://openalex.org/W2115802074","https://openalex.org/W2116445953","https://openalex.org/W2122333207","https://openalex.org/W2122953117","https://openalex.org/W2124434348","https://openalex.org/W2126368856","https://openalex.org/W2127443176","https://openalex.org/W2132028465","https://openalex.org/W2133700934","https://openalex.org/W2133810641","https://openalex.org/W2135569177","https://openalex.org/W2136207344","https://openalex.org/W2136367995","https://openalex.org/W2138045897","https://openalex.org/W2140099805","https://openalex.org/W2143706694","https://openalex.org/W2144424143","https://openalex.org/W2147224186","https://openalex.org/W2147560440","https://openalex.org/W2148749032","https://openalex.org/W2150480196","https://openalex.org/W2152716163","https://openalex.org/W2152896792","https://openalex.org/W2153354021","https://openalex.org/W2154891376","https://openalex.org/W2158356654","https://openalex.org/W2161005330","https://openalex.org/W2161191622","https://openalex.org/W2168129414","https://openalex.org/W2168349532","https://openalex.org/W2168889003","https://openalex.org/W2169385429","https://openalex.org/W2171551964","https://openalex.org/W2222531233","https://openalex.org/W2231664225","https://openalex.org/W2262247264","https://openalex.org/W2286667211","https://openalex.org/W2288265988","https://openalex.org/W2312230243","https://openalex.org/W2325267338","https://openalex.org/W2333516377","https://openalex.org/W2344250613","https://openalex.org/W2346113315","https://openalex.org/W2395068978","https://openalex.org/W2441131537","https://openalex.org/W2466033276","https://openalex.org/W2506281344","https://openalex.org/W2508096274","https://openalex.org/W2510474544","https://openalex.org/W2530508394","https://openalex.org/W2554984004","https://openalex.org/W2560367415","https://openalex.org/W2565903745","https://openalex.org/W2582356738","https://openalex.org/W2600710767","https://openalex.org/W2749717647","https://openalex.org/W2752625590","https://openalex.org/W2755640313","https://openalex.org/W2756647124","https://openalex.org/W2767148244","https://openalex.org/W2768965084","https://openalex.org/W2784371446","https://openalex.org/W2800247524","https://openalex.org/W2804859499","https://openalex.org/W2805807916","https://openalex.org/W2888193510","https://openalex.org/W2898030310","https://openalex.org/W2898125316","https://openalex.org/W2903005847","https://openalex.org/W2910863241","https://openalex.org/W2911771361","https://openalex.org/W2912640278","https://openalex.org/W2913794413","https://openalex.org/W2921771746","https://openalex.org/W2953282545","https://openalex.org/W2973754433","https://openalex.org/W2980407838","https://openalex.org/W2999995623","https://openalex.org/W3004715029","https://openalex.org/W3006496567","https://openalex.org/W3013087254","https://openalex.org/W3013377779","https://openalex.org/W3014914235","https://openalex.org/W3015258598","https://openalex.org/W3024000125","https://openalex.org/W3036861244","https://openalex.org/W3080563305","https://openalex.org/W3083730060","https://openalex.org/W3089390531","https://openalex.org/W3092457640","https://openalex.org/W3096542674","https://openalex.org/W3097895358","https://openalex.org/W3121328438","https://openalex.org/W3121334342","https://openalex.org/W3128646645","https://openalex.org/W3139222214","https://openalex.org/W3169655252","https://openalex.org/W3190009518","https://openalex.org/W3205933154","https://openalex.org/W4206841660","https://openalex.org/W4232037809","https://openalex.org/W4234563374","https://openalex.org/W4301159569","https://openalex.org/W6631800413","https://openalex.org/W6637126441","https://openalex.org/W6639680413","https://openalex.org/W6658206903","https://openalex.org/W6674579726","https://openalex.org/W6677282541","https://openalex.org/W6678675054","https://openalex.org/W6681649372","https://openalex.org/W6683142020","https://openalex.org/W6773532866","https://openalex.org/W7221143472"],"related_works":["https://openalex.org/W1976811466","https://openalex.org/W4390971511","https://openalex.org/W2366551678","https://openalex.org/W2056750246","https://openalex.org/W2975926257","https://openalex.org/W2064549473","https://openalex.org/W7099727895","https://openalex.org/W3086917908","https://openalex.org/W7151324613","https://openalex.org/W2513799480"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,50,110],"is":[2],"the":[3,20,30,70],"major":[4,60],"leading":[5],"cause":[6],"of":[7,22,72],"cancer-related":[8],"mortality":[9],"worldwide.":[10],"Multiple":[11],"epigenetic":[12],"factors\u2014in":[13],"particular,":[14],"DNA":[15,34,73,106],"methylation\u2014have":[16],"been":[17],"associated":[18],"with":[19,45,79],"development":[21],"lung":[23,38,109],"cancer.":[24],"In":[25,98],"this":[26],"review,":[27],"we":[28,100],"summarize":[29],"current":[31],"knowledge":[32],"on":[33],"methylation":[35,74,107],"alterations":[36],"in":[37,108,114],"tumorigenesis,":[39],"as":[40,42],"well":[41],"their":[43,77],"associations":[44,78],"different":[46],"histological":[47],"subtypes,":[48],"common":[49],"driver":[51],"gene":[52],"mutations":[53],"(e.g.,":[54,64],"KRAS,":[55],"EGFR,":[56],"and":[57,59,76,89,95],"TP53),":[58],"epidemiological":[61],"risk":[62,81],"factors":[63,82],"sex,":[65],"smoking":[66],"status,":[67],"race/ethnicity).":[68],"Understanding":[69],"mechanisms":[71],"regulation":[75],"various":[80],"can":[83],"provide":[84],"further":[85],"insights":[86],"into":[87],"carcinogenesis,":[88],"create":[90],"future":[91,115],"avenues":[92],"for":[93],"prevention":[94],"personalized":[96],"treatments.":[97],"addition,":[99],"also":[101],"highlight":[102],"outstanding":[103],"questions":[104],"regarding":[105],"to":[111],"be":[112],"elucidated":[113],"studies":[116]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-02-24T00:00:00"}
