{"id":"https://openalex.org/W4213064502","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.455","title":"Long-term cost comparisons of radical cystectomy versus trimodal therapy for muscle-invasive bladder cancer.","display_name":"Long-term cost comparisons of radical cystectomy versus trimodal therapy for muscle-invasive bladder cancer.","publication_year":2022,"publication_date":"2022-02-16","ids":{"openalex":"https://openalex.org/W4213064502","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.455"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.6_suppl.455","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.455","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.6_suppl.455","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025808558","display_name":"Vishnukamal Golla","orcid":"https://orcid.org/0000-0003-4055-6305","observed_orcids":["https://orcid.org/0000-0003-4055-6305"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishnukamal Golla","raw_affiliation_strings":["Duke University, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, NC;","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109448065","display_name":"Yong Shan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Shan","raw_affiliation_strings":["Department of Surgery, Division of Urology, The University of Texas Medical Branch, Galveston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Urology, The University of Texas Medical Branch, Galveston, TX;","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022274226","display_name":"Elias J. Farran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Joseph Farran","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX;","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034539208","display_name":"Kevin Vu","orcid":"https://orcid.org/0000-0002-1288-147X","observed_orcids":["https://orcid.org/0000-0002-1288-147X"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Vu","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX;","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082672733","display_name":"Courtney A. Stewart","orcid":"https://orcid.org/0000-0002-1870-5805","observed_orcids":["https://orcid.org/0000-0002-1870-5805"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney A. Stewart","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX;","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011367118","display_name":"Ali Raza Khaki","orcid":"https://orcid.org/0000-0002-4655-4426","observed_orcids":["https://orcid.org/0000-0002-4655-4426"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Raza Khaki","raw_affiliation_strings":["University of Washington, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103400175","display_name":"Kirk A. Keegan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirk A. Keegan","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034005227","display_name":"Ashish M. Kamat","orcid":"https://orcid.org/0000-0003-3546-9928","observed_orcids":["https://orcid.org/0000-0003-3546-9928"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish M. Kamat","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015827608","display_name":"Douglas S. Tyler","orcid":"https://orcid.org/0000-0002-7434-846X","observed_orcids":["https://orcid.org/0000-0002-7434-846X"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas S. Tyler","raw_affiliation_strings":["Department of Surgery, The University of Texas Medical Branch, Galveston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Texas Medical Branch, Galveston, TX;","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036003731","display_name":"Stephen J. Freedland","orcid":"https://orcid.org/0000-0002-8104-6419","observed_orcids":["https://orcid.org/0000-0002-8104-6419"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Freedland","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA and Durham VA Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA and Durham VA Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210139568"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057298411","display_name":"Stephen Bentley Williams","orcid":"https://orcid.org/0000-0002-2683-2185","observed_orcids":["https://orcid.org/0000-0002-2683-2185"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Williams","raw_affiliation_strings":["Department of Surgery, Division of Urology, The University of Texas Medical Branch, Galveston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Urology, The University of Texas Medical Branch, Galveston, TX;","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"6_suppl","first_page":"455","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.4413999915122986,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-invasive-bladder-cancer","display_name":"muscle-invasive bladder cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radical-cystectomy","display_name":"radical cystectomy","score":0.949999988079071},{"id":"https://openalex.org/keywords/trimodality-therapy","display_name":"trimodality therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/medicare-spending","display_name":"Medicare spending","score":0.9120000004768372},{"id":"https://openalex.org/keywords/outpatient-costs","display_name":"outpatient costs","score":0.6510000228881836},{"id":"https://openalex.org/keywords/radiology-costs","display_name":"radiology costs","score":0.6639999747276306},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9486812353134155},{"id":"https://openalex.org/C2775910329","wikidata":"https://www.wikidata.org/wiki/Q245995","display_name":"Cystectomy","level":4,"score":0.7679003477096558},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7584779262542725},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5791909694671631},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5056278705596924},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4629536271095276},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.45997878909111023},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4183495044708252},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40987643599510193},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.389089435338974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36343902349472046}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.6_suppl.455","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.455","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.6_suppl.455","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2921544531","https://openalex.org/W4226315825","https://openalex.org/W2948590353","https://openalex.org/W4391303332","https://openalex.org/W3008487603","https://openalex.org/W2981737993","https://openalex.org/W4391302894","https://openalex.org/W2791358377","https://openalex.org/W4411540627","https://openalex.org/W2947567038"],"abstract_inverted_index":{"455":[0],"Background:":[1],"Earlier":[2],"studies":[3],"on":[4],"the":[5,25,54,242],"cost":[6],"of":[7,17,77,98,107,244],"muscle-invasive":[8,118,220],"bladder":[9,119,221],"cancer":[10,120,222],"treatments":[11,138],"are":[12],"limited":[13],"to":[14,23,79],"short-term":[15],"periods":[16],"cost.":[18],"Our":[19],"study":[20,52],"objective":[21],"is":[22],"compare":[24],"2-":[26],"and":[27,57,69,74,170,203,236],"5-year":[28],"costs":[29,41,82,85,131,156,182,196,216,230],"associated":[30,198,212,231],"with":[31,114,193,199,213,219,232],"trimodal":[32],"therapy":[33],"(TMT)":[34],"versus":[35,91],"radical":[36],"cystectomy":[37],"(RC)":[38],"benchmarked":[39],"against":[40],"for":[42,132,160],"patients":[43,109,133,218],"who":[44],"received":[45,135],"no":[46,136],"curative":[47],"treatment.":[48],"Methods:":[49],"This":[50],"cohort":[51],"used":[53],"Surveillance,":[55],"Epidemiology,":[56],"End":[58],"Results":[59],"(SEER)-Medicare":[60],"database.":[61],"Medicare":[62,84],"expenditures":[63],"were":[64,93,146,157],"summed":[65],"from":[66,121],"inpatient,":[67],"outpatient,":[68],"physician":[70],"services":[71,239],"within":[72],"2":[73],"5":[75],"years":[76,112],"diagnosis":[78],"determine":[80],"total":[81,106],"Total":[83,129,154],"at":[86,150,164],"2-and":[87,151],"5-years":[88,152,171],"following":[89],"TMT":[90,161,177,208],"RC":[92,163,184,210],"compared":[94],"using":[95],"inverse":[96],"probability":[97],"treatment-weighted":[99],"(IPTW)":[100],"propensity":[101],"score":[102],"models.":[103],"Results:":[104],"A":[105],"2,537":[108],"aged":[110],"66-85":[111],"diagnosed":[113],"clinical":[115],"stage":[116],"T2-4a":[117],"January":[122],"1,":[123],"2002":[124],"through":[125],"December":[126],"31,":[127],"2009.":[128],"median":[130,155,181],"that":[134],"definitive/systemic":[137],"(RC,":[139],"TMT,":[140],"radiotherapy":[141],"alone,":[142],"or":[143],"chemotherapy":[144],"alone)":[145],"$73,780":[147],"vs.":[148,167,173,187,191,209],"$88,275":[149],"respectively.":[153,176],"significantly":[158,194],"higher":[159,179,195,214],"than":[162,183],"2-years":[165],"($372,839":[166],"$191,363,":[168],"p<0.001)":[169],"($424,570":[172],"$253,651,":[174],"p<0.001),":[175],"had":[178],"outpatient":[180,226],"(2-yr:":[185],"$318,221":[186],"$100,900;":[188],"5-yr:":[189],"$367,092":[190],"$146,561)":[192],"largely":[197,223],"radiology,":[200,233],"medications,":[201,234],"pathology/laboratory,":[202,235],"other":[204,237],"professional":[205,238],"services.":[206],"Conclusions:":[207],"was":[211],"long-term":[215],"among":[217],"driven":[224],"by":[225],"expenditures.":[227],"Reduction":[228],"in":[229],"may":[240],"improve":[241],"value":[243],"TMT.[Table:":[245],"see":[246],"text]":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-02-24T00:00:00"}