{"id":"https://openalex.org/W4213049271","doi":"https://doi.org/10.3389/fncel.2022.838548","title":"Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Family: Novel Prognostic Biomarkers and Tumor Microenvironment Regulators for Lower-Grade Glioma","display_name":"Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Family: Novel Prognostic Biomarkers and Tumor Microenvironment Regulators for Lower-Grade Glioma","publication_year":2022,"publication_date":"2022-02-18","ids":{"openalex":"https://openalex.org/W4213049271","doi":"https://doi.org/10.3389/fncel.2022.838548","pmid":"https://pubmed.ncbi.nlm.nih.gov/35250490","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8894330"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2022.838548","doi":"https://doi.org/10.3389/fncel.2022.838548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2022.838548","pdf_url":null,"source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fncel.2022.838548","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066548585","display_name":"Siming Gong","orcid":"https://orcid.org/0000-0002-0968-490X","observed_orcids":["https://orcid.org/0000-0002-0968-490X"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Siming Gong","raw_affiliation_strings":["Institute of Anatomy, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049243643","display_name":"Changwu Wu","orcid":"https://orcid.org/0000-0002-1986-5923","observed_orcids":["https://orcid.org/0000-0002-1986-5923","https://orcid.org/0009-0003-3562-7786"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Changwu Wu","raw_affiliation_strings":["Institute of Anatomy, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017147188","display_name":"Franziska K\u00f6hler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franziska K\u00f6hler","raw_affiliation_strings":["Institute of Anatomy, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113793382","display_name":"J\u00fcrgen Meixensberger","orcid":"https://orcid.org/0000-0002-1385-8255","observed_orcids":["https://orcid.org/0000-0002-1385-8255"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Meixensberger","raw_affiliation_strings":["Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006320004","display_name":"Nikolas Schopow","orcid":"https://orcid.org/0000-0002-6754-5692","observed_orcids":["https://orcid.org/0000-0002-6754-5692"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolas Schopow","raw_affiliation_strings":["Department of Orthopedics, Trauma and Plastic Surgery, Sarcoma Center, University Hospital Leipzig, Leipzig, Germany","Institute of Anatomy, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Trauma and Plastic Surgery, Sarcoma Center, University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]},{"raw_affiliation_string":"Institute of Anatomy, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087977424","display_name":"Sonja Kallendrusch","orcid":"https://orcid.org/0000-0003-2474-8307","observed_orcids":["https://orcid.org/0000-0003-2474-8307"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4392021211","display_name":"HMU Health and Medical University","ror":"https://ror.org/02xstm723","country_code":"DE","type":"education","lineage":["https://openalex.org/I4392021211"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sonja Kallendrusch","raw_affiliation_strings":["Department of Medicine, Health and Medical University Potsdam, Potsdam, Germany","Institute of Anatomy, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Health and Medical University Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I4392021211"]},{"raw_affiliation_string":"Institute of Anatomy, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049243643"],"corresponding_institution_ids":["https://openalex.org/I926574661"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2114,"currency":"EUR","value_usd":2279},"fwci":1.9178,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.8805491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"16","issue":null,"first_page":"838548","last_page":"838548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lower-grade-glioma","display_name":"lower-grade glioma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.949999988079071},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6019999980926514},{"id":"https://openalex.org/keywords/glioma-prognosis","display_name":"glioma prognosis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5879858732223511},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5501183867454529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5418099164962769},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5361303091049194},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.415410578250885},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41315433382987976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3152198791503906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31493279337882996},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30735456943511963},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.23801341652870178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14867186546325684}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fncel.2022.838548","doi":"https://doi.org/10.3389/fncel.2022.838548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2022.838548","pdf_url":null,"source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8894330","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8894330/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8894330/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmid:35250490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35250490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f1135ba052db4e97b7e959f668039179","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f1135ba052db4e97b7e959f668039179","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 16 (2022)","raw_type":"article"},{"id":"pmh:oai:qucosa:de:qucosa:84564","doi":null,"is_oa":true,"landing_page_url":"https://ul.qucosa.de/id/qucosa%3A84564","pdf_url":null,"source":{"id":"https://openalex.org/S4377196435","display_name":"Qucosa (Saxon State and University Library Dresden)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3132420320","host_organization_name":"SLUB Dresden","host_organization_lineage":["https://openalex.org/I3132420320"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.3389/fncel.2022.838548","doi":"https://doi.org/10.3389/fncel.2022.838548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2022.838548","pdf_url":null,"source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4213049271.pdf","grobid_xml":"https://content.openalex.org/works/W4213049271.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1992883702","https://openalex.org/W1999879982","https://openalex.org/W2033278321","https://openalex.org/W2034243687","https://openalex.org/W2034387476","https://openalex.org/W2048359260","https://openalex.org/W2063743512","https://openalex.org/W2085099489","https://openalex.org/W2116850676","https://openalex.org/W2124333358","https://openalex.org/W2130430382","https://openalex.org/W2160609428","https://openalex.org/W2160872052","https://openalex.org/W2160943536","https://openalex.org/W2165871546","https://openalex.org/W2220215167","https://openalex.org/W2345745180","https://openalex.org/W2366536035","https://openalex.org/W2386703324","https://openalex.org/W2397727875","https://openalex.org/W2498125942","https://openalex.org/W2544079919","https://openalex.org/W2573339072","https://openalex.org/W2595863515","https://openalex.org/W2603523955","https://openalex.org/W2619332462","https://openalex.org/W2623637971","https://openalex.org/W2685700956","https://openalex.org/W2738946651","https://openalex.org/W2760885207","https://openalex.org/W2778033786","https://openalex.org/W2785803176","https://openalex.org/W2787045728","https://openalex.org/W2800037441","https://openalex.org/W2808172467","https://openalex.org/W2808438085","https://openalex.org/W2889190248","https://openalex.org/W2891487738","https://openalex.org/W2899387167","https://openalex.org/W2899516298","https://openalex.org/W2901271466","https://openalex.org/W2920600229","https://openalex.org/W2945329147","https://openalex.org/W2949273159","https://openalex.org/W2951880440","https://openalex.org/W2974227664","https://openalex.org/W2991037706","https://openalex.org/W2991642816","https://openalex.org/W2993940039","https://openalex.org/W3003340961","https://openalex.org/W3006163888","https://openalex.org/W3034695976","https://openalex.org/W3041279264","https://openalex.org/W3083449539","https://openalex.org/W3092316673","https://openalex.org/W3094490779","https://openalex.org/W3112371012","https://openalex.org/W3117948387","https://openalex.org/W3130844090","https://openalex.org/W3135035839","https://openalex.org/W3162157235","https://openalex.org/W3194539461","https://openalex.org/W3200294745","https://openalex.org/W3203802230","https://openalex.org/W3215505254","https://openalex.org/W4286959915","https://openalex.org/W6756213379","https://openalex.org/W6802339454"],"related_works":["https://openalex.org/W3121740024","https://openalex.org/W3162157235","https://openalex.org/W7155492854","https://openalex.org/W4280636392","https://openalex.org/W2790240577","https://openalex.org/W4281627341","https://openalex.org/W3039387427","https://openalex.org/W4311961707","https://openalex.org/W3046069745","https://openalex.org/W4281617345"],"abstract_inverted_index":{"Lower-grade":[0],"glioma":[1],"(LGG)":[2],"is":[3,52,93,151],"a":[4,145,152],"group":[5],"of":[6,12,34,85,119,130,139],"tumors":[7],"arising":[8],"from":[9,65],"the":[10,13,23,32,66,83,90,110,120,134,140],"cells":[11,132],"central":[14],"nervous":[15],"system.":[16],"Although":[17],"various":[18],"therapy":[19],"interventions":[20],"are":[21,29],"used,":[22],"prognosis":[24,33,126,149],"remains":[25],"different.":[26],"Novel":[27],"biomarkers":[28],"needed":[30],"for":[31,148,155],"disease":[35],"and":[36,51,72,101,127,150],"novel":[37,146],"therapeutic":[38],"strategies":[39],"in":[40,62,87,95,114,159],"LGG.":[41,63,88,115,160],"The":[42,73,136],"procollagen-lysine,":[43],"2-oxoglutarate":[44],"5-dioxygenase":[45],"(PLOD)":[46],"family":[47,92,122,142],"contains":[48],"three":[49],"members":[50],"related":[53],"to":[54,81,109,124],"multiple":[55],"cancers,":[56],"yet":[57],"it":[58],"was":[59],"not":[60],"investigated":[61],"Data":[64],"Chinese":[67],"Glioma":[68],"Genome":[69,75],"Atlas":[70,76],"(CGGA)":[71],"Cancer":[74],"(TCGA)":[77],"cohorts":[78],"were":[79],"used":[80],"analyze":[82],"role":[84],"PLOD":[86,91,121,141],"As":[89],"involved":[94],"processes,":[96],"such":[97],"as":[98],"tumor":[99,111],"formation":[100],"cancer":[102],"metastasis,":[103],"we":[104],"focused":[105],"on":[106],"its":[107],"relationship":[108],"microenvironment":[112],"(TME)":[113],"A":[116],"high":[117,128],"expression":[118,137],"relates":[123],"poor":[125],"infiltration":[129],"immune":[131],"within":[133],"TME.":[135],"level":[138],"might":[143],"become":[144],"biomarker":[147],"potential":[153],"target":[154],"individual":[156],"treatment":[157],"decisions":[158]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-02-24T00:00:00"}
