{"id":"https://openalex.org/W4213035641","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.423","title":"Optimization of serum miR-371a-3p for the detection of chemotherapy-na\u00efve minimal residual germ cell tumor.","display_name":"Optimization of serum miR-371a-3p for the detection of chemotherapy-na\u00efve minimal residual germ cell tumor.","publication_year":2022,"publication_date":"2022-02-16","ids":{"openalex":"https://openalex.org/W4213035641","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.423"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.6_suppl.423","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.423","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.6_suppl.423","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038130865","display_name":"John T. Lafin","orcid":"https://orcid.org/0000-0003-2335-8999","observed_orcids":["https://orcid.org/0000-0003-2335-8999"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Lafin","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051632149","display_name":"Armon Amini","orcid":"https://orcid.org/0000-0002-8991-3708","observed_orcids":["https://orcid.org/0000-0002-8991-3708"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armon Amini","raw_affiliation_strings":["University of Texas Southwestern Medical School, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical School, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022857840","display_name":"Bendu Konneh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bendu Konneh","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103024812","display_name":"Anna Savelyeva","orcid":"https://orcid.org/0000-0002-9572-8904","observed_orcids":["https://orcid.org/0000-0002-9572-8904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Savelyeva","raw_affiliation_strings":["5323 Harry Hines Blvd, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5323 Harry Hines Blvd, Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019581189","display_name":"Jin Piao","orcid":"https://orcid.org/0000-0003-0516-6280","observed_orcids":["https://orcid.org/0000-0003-0516-6280"]},"institutions":[{"id":"https://openalex.org/I4210134079","display_name":"Children's Oncology Group","ror":"https://ror.org/03yyg2352","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210134079"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Piao","raw_affiliation_strings":["Children's Oncology Group, Monrovia, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Oncology Group, Monrovia, CA;","institution_ids":["https://openalex.org/I4210134079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063133870","display_name":"Michelle M. Nu\u00f1o","orcid":"https://orcid.org/0000-0003-2031-929X","observed_orcids":["https://orcid.org/0000-0003-2031-929X"]},"institutions":[{"id":"https://openalex.org/I4210134079","display_name":"Children's Oncology Group","ror":"https://ror.org/03yyg2352","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210134079"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Nuno","raw_affiliation_strings":["Children's Oncology Group, Monrovia, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Oncology Group, Monrovia, CA;","institution_ids":["https://openalex.org/I4210134079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065916505","display_name":"Cinzia G. Scarpini","orcid":"https://orcid.org/0000-0003-4730-5197","observed_orcids":["https://orcid.org/0000-0003-4730-5197"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cinzia Scarpini","raw_affiliation_strings":["University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026208837","display_name":"Jeffrey M. Howard","orcid":"https://orcid.org/0000-0002-0196-3875","observed_orcids":["https://orcid.org/0000-0002-0196-3875"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Howard","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011903621","display_name":"Thomas Gerald","orcid":"https://orcid.org/0000-0002-8877-6799","observed_orcids":["https://orcid.org/0000-0002-8877-6799"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Gerald","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108050312","display_name":"Liwei Jia","orcid":"https://orcid.org/0000-0002-2118-6428","observed_orcids":["https://orcid.org/0000-0002-2118-6428"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liwei Jia","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051562152","display_name":"Nicholas Coleman","orcid":"https://orcid.org/0000-0002-5374-739X","observed_orcids":["https://orcid.org/0000-0002-5374-739X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Coleman","raw_affiliation_strings":["University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085468231","display_name":"Matthew Jonathan Murray","orcid":"https://orcid.org/0000-0002-4480-1147","observed_orcids":["https://orcid.org/0000-0002-4480-1147"]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew Murray","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078106172","display_name":"A. Lindsay Frazier","orcid":"https://orcid.org/0000-0003-4748-8552","observed_orcids":["https://orcid.org/0000-0003-4748-8552"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay Lindsay Frazier","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086083448","display_name":"James F. Amatruda","orcid":"https://orcid.org/0000-0002-9901-2137","observed_orcids":["https://orcid.org/0000-0002-9901-2137"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Amatruda","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067264659","display_name":"Aditya Bagrodia","orcid":"https://orcid.org/0000-0002-3358-1193","observed_orcids":["https://orcid.org/0000-0002-3358-1193","https://orcid.org/0000-0001-9220-0349"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Bagrodia","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"6_suppl","first_page":"423","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-371a-3p","display_name":"miR-371a-3p","score":0.9300000071525574},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.9300000071525574},{"id":"https://openalex.org/keywords/germ-cell-tumors","display_name":"germ cell tumors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chemotherapy-naive-patients","display_name":"chemotherapy-naive patients","score":0.7129999995231628},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6779999732971191},{"id":"https://openalex.org/keywords/retroperitoneal-lymph-node-dissection","display_name":"retroperitoneal lymph node dissection","score":0.8650000095367432},{"id":"https://openalex.org/keywords/teratoma","display_name":"teratoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.821052074432373},{"id":"https://openalex.org/C94624232","wikidata":"https://www.wikidata.org/wiki/Q3150667","display_name":"Indeterminate","level":2,"score":0.6057029366493225},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5703532695770264},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5634300112724304},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.48670461773872375},{"id":"https://openalex.org/C2779511695","wikidata":"https://www.wikidata.org/wiki/Q7317049","display_name":"Retroperitoneal lymph node dissection","level":4,"score":0.43432891368865967},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.42686372995376587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41835343837738037},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4089552164077759},{"id":"https://openalex.org/C2776212926","wikidata":"https://www.wikidata.org/wiki/Q324464","display_name":"Testicular cancer","level":3,"score":0.277828574180603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08693167567253113},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.6_suppl.423","doi":"https://doi.org/10.1200/jco.2022.40.6_suppl.423","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.6_suppl.423","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4324136475","https://openalex.org/W4382631728","https://openalex.org/W4225258991","https://openalex.org/W3007714432","https://openalex.org/W4212831614","https://openalex.org/W4306685614","https://openalex.org/W4396778684","https://openalex.org/W7208747698","https://openalex.org/W2504019010","https://openalex.org/W3135468012"],"abstract_inverted_index":{"423":[0],"Background:":[1],"Currently":[2],"used":[3],"serum":[4,111,117],"tumor":[5],"markers":[6,59],"exhibit":[7],"middling":[8],"sensitivity":[9,310],"and":[10,74,119,156,159,175,185,215,307,313],"specificity":[11,302],"for":[12,331,339],"the":[13,30,34,61,77,80,178,236,260,332,337,351,367,370],"detection":[14],"of":[15,36,53,63,82,172,223,238,250,285,293,311,315,323,326,353,361,369],"germ":[16,357],"cell":[17,358],"tumors":[18],"(GCTs).":[19],"Circulating":[20],"miRNAs,":[21],"particularly":[22],"miR-371a-3p,":[23],"have":[24],"exhibited":[25],"strong":[26],"performance":[27,94,237,368],"characteristics":[28],"in":[29,49,60,247,259,343],"pre-orchiectomy":[31],"setting.":[32],"However,":[33],"ability":[35],"miR-371a-3p":[37,56,157,333,371],"to":[38,92,103,109,216,242,305,328],"detect":[39],"chemotherapy-na\u00efve":[40,64,354],"occult":[41,253],"disease":[42],"is":[43],"less":[44],"clear.":[45],"We":[46,87,113,199,233],"previously":[47],"reported":[48],"a":[50,201,211,243,248,281,294,309,340],"small":[51],"cohort":[52,249],"patients":[54,124,251,256],"that":[55,72,204],"outperforms":[57],"conventional":[58],"context":[62,352],"minimal":[65,355],"residual":[66,356],"disease.":[67,254],"Here,":[68],"we":[69],"expand":[70],"upon":[71],"experience":[73],"further":[75],"refine":[76],"assay,":[78],"including":[79],"recommendation":[81],"an":[83,220,362],"indeterminate":[84,221,228,269,279,363],"range.":[85],"Methods:":[86],"examined":[88],"over":[89],"250":[90],"assays":[91],"compare":[93],"between":[95],"classification":[96],"based":[97,138,191],"on":[98,139,192,270,280],"raw":[99],"Cq,":[100],"Cq":[101,224,324],"normalized":[102],"miR-30b-5p":[104,160],"(\u2206Cq),":[105],"or":[106,145,148,197,289],"relative":[107],"quantification":[108],"normal":[110,341],"(RQ).":[112],"prospectively":[114],"collected":[115],"pre-surgical":[116],"samples":[118,267],"clinical":[120],"information":[121],"from":[122,153,303],"GCT":[123],"undergoing":[125],"primary":[126],"retroperitoneal":[127],"lymph":[128],"node":[129],"dissection":[130],"(RPLND)":[131],"at":[132],"our":[133],"institution.":[134],"Patients":[135],"were":[136,163,257,268],"classified":[137],"histology":[140],"as":[141],"\u201cControl\u201d":[142],"(pure":[143],"teratoma":[144,288],"no":[146],"GCT)":[147],"\u201cGCT\u201d.":[149],"RNA":[150],"was":[151,168],"extracted":[152],"these":[154],"samples,":[155],"(target)":[158],"(reference":[161],"gene)":[162],"detected":[164],"by":[165,170],"qPCR.":[166],"Performance":[167],"assessed":[169],"calculation":[171],"sensitivity,":[173],"specificity,":[174,184],"area":[176],"under":[177],"ROC":[179],"curve":[180],"(AUC).":[181],"Results:":[182],"Sensitivity,":[183],"AUC":[186,314],"did":[187],"not":[188],"significantly":[189],"change":[190],"thresholding":[193],"metric":[194],"(Cq,":[195],"\u2206Cq,":[196],"RQ).":[198],"found":[200],"25%":[202],"chance":[203],"any":[205,227],"given":[206],"control":[207],"sample":[208,229,342],"would":[209,335],"return":[210],"false":[212,299],"positive":[213],"result,":[214],"combat":[217],"this,":[218],"estimated":[219],"range":[222,364],"28-35.":[225],"Repeating":[226],"once":[230],"improved":[231],"performance.":[232,349],"then":[234],"compared":[235],"this":[239],"updated":[240],"process":[241],"simple":[244],"binary":[245],"threshold":[246],"with":[252],"32":[255],"enrolled":[258],"study":[261],"(15":[262],"Control,":[263,274],"17":[264],"GCT).":[265,276],"12":[266],"first":[271],"run":[272,296,345],"(6":[273],"6":[275],"8":[277],"remained":[278],"second":[282,295],"run,":[283],"all":[284],"which":[286],"harbored":[287],"viable":[290],"GCT.":[291],"Inclusion":[292],"prevented":[297],"3":[298],"positives,":[300],"improving":[301],"86%":[304],"100%":[306],"yielding":[308],"92%":[312],"0.96":[316],"(95%":[317],"CI:":[318],"0.89-1).":[319],"Conclusions:":[320],"The":[321],"use":[322],"instead":[325],"RQ":[327],"classify":[329],"results":[330],"test":[334],"eliminate":[336],"need":[338],"each":[344],"without":[346],"injuring":[347],"assay":[348],"In":[350],"tumor,":[359],"consideration":[360],"may":[365],"improve":[366],"test.":[372]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-02-24T00:00:00"}