{"id":"https://openalex.org/W4213031964","doi":"https://doi.org/10.3390/ijms23042196","title":"Discovery of Small Molecule Activators of Chemokine Receptor CXCR4 That Improve Diabetic Wound Healing","display_name":"Discovery of Small Molecule Activators of Chemokine Receptor CXCR4 That Improve Diabetic Wound Healing","publication_year":2022,"publication_date":"2022-02-16","ids":{"openalex":"https://openalex.org/W4213031964","doi":"https://doi.org/10.3390/ijms23042196","pmid":"https://pubmed.ncbi.nlm.nih.gov/35216311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8879702"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23042196","doi":"https://doi.org/10.3390/ijms23042196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23042196","pdf_url":"https://www.mdpi.com/1422-0067/23/4/2196/pdf?version=1645153355","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/4/2196/pdf?version=1645153355","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100737479","display_name":"Junwang Xu","orcid":"https://orcid.org/0000-0001-7905-8915","observed_orcids":["https://orcid.org/0000-0001-7905-8915"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junwang Xu","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA","Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101565933","display_name":"Junyi Hu","orcid":"https://orcid.org/0000-0003-4461-2482","observed_orcids":["https://orcid.org/0000-0003-4461-2482","https://orcid.org/0009-0006-5727-2674"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junyi Hu","raw_affiliation_strings":["Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041831745","display_name":"Shaquia Idlett-Ali","orcid":"https://orcid.org/0000-0003-4463-7065","observed_orcids":["https://orcid.org/0000-0003-4463-7065"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaquia Idlett-Ali","raw_affiliation_strings":["Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0003-4463-7065","affiliations":[{"raw_affiliation_string":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100426734","display_name":"Liping Zhang","orcid":"https://orcid.org/0000-0001-7716-0000","observed_orcids":["https://orcid.org/0000-0001-7716-0000"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liping Zhang","raw_affiliation_strings":["Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040762069","display_name":"Karly Caples","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karly Caples","raw_affiliation_strings":["Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020637694","display_name":"Satyamaheshwar Peddibhotla","orcid":"https://orcid.org/0000-0001-5381-0507","observed_orcids":["https://orcid.org/0000-0001-5381-0507"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satyamaheshwar Peddibhotla","raw_affiliation_strings":["Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":"https://orcid.org/0000-0001-5381-0507","affiliations":[{"raw_affiliation_string":"Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049339798","display_name":"Morgan E. Reeves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Reeves","raw_affiliation_strings":["Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021392303","display_name":"Carlos Zgheib","orcid":"https://orcid.org/0000-0001-9977-8055","observed_orcids":["https://orcid.org/0000-0001-9977-8055"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Zgheib","raw_affiliation_strings":["Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029970248","display_name":"Siobhan Malany","orcid":"https://orcid.org/0000-0003-0710-7460","observed_orcids":["https://orcid.org/0000-0003-0710-7460"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Siobhan Malany","raw_affiliation_strings":["Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":"https://orcid.org/0000-0003-0710-7460","affiliations":[{"raw_affiliation_string":"Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101442154","display_name":"Kenneth W. Liechty","orcid":"https://orcid.org/0000-0001-8084-5342","observed_orcids":["https://orcid.org/0000-0001-8084-5342"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth W. Liechty","raw_affiliation_strings":["Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, Anschutz Medical Campus, University of Colorado Denver Aurora, Denver, CO 80045, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029970248","https://openalex.org/A5101442154"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":3.5801,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.93800677,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"23","issue":"4","first_page":"2196","last_page":"2196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.9330000281333923},{"id":"https://openalex.org/keywords/diabetic-ulcers","display_name":"diabetic ulcers","score":0.8700000047683716},{"id":"https://openalex.org/keywords/sdf-1alpha","display_name":"SDF-1\u03b1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.6959999799728394},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8069999814033508},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.7896678447723389},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7664302587509155},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7150949239730835},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.5519959330558777},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5371570587158203},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5123311281204224},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5066331028938293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4803972542285919},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4777071475982666},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4682527482509613},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.4101316034793854},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36826616525650024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3268192708492279}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms23042196","doi":"https://doi.org/10.3390/ijms23042196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23042196","pdf_url":"https://www.mdpi.com/1422-0067/23/4/2196/pdf?version=1645153355","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:35216311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35216311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8879702","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8879702/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ecc6b77166684251ba448debc4c933b9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ecc6b77166684251ba448debc4c933b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 2196, p 2196 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms23042196","doi":"https://doi.org/10.3390/ijms23042196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23042196","pdf_url":"https://www.mdpi.com/1422-0067/23/4/2196/pdf?version=1645153355","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3641565321","display_name":"The role of long non-coding RNA GAS5 in diabetic wounds","funder_award_id":"R01GM128660","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4881902463","display_name":"Advancing small molecule CXCR4 agonists for diabetic wound healing","funder_award_id":"R01DK126371","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000048721","display_name":null,"funder_award_id":"DK105010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4213031964.pdf","grobid_xml":"https://content.openalex.org/works/W4213031964.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1555423999","https://openalex.org/W1877433127","https://openalex.org/W1967162280","https://openalex.org/W1969592520","https://openalex.org/W1973473416","https://openalex.org/W1982861439","https://openalex.org/W2019507287","https://openalex.org/W2025130596","https://openalex.org/W2049051295","https://openalex.org/W2059444094","https://openalex.org/W2069759108","https://openalex.org/W2087079752","https://openalex.org/W2093274127","https://openalex.org/W2101004085","https://openalex.org/W2105325479","https://openalex.org/W2120923136","https://openalex.org/W2133496200","https://openalex.org/W2134161094","https://openalex.org/W2305067011","https://openalex.org/W2947570218","https://openalex.org/W3024684617"],"related_works":["https://openalex.org/W4386171519","https://openalex.org/W4404928016","https://openalex.org/W2743615855","https://openalex.org/W2901025332","https://openalex.org/W1997751192","https://openalex.org/W4291415238","https://openalex.org/W4409517157","https://openalex.org/W2049051295","https://openalex.org/W1987863814","https://openalex.org/W2048983858"],"abstract_inverted_index":{"Diabetes":[0],"produces":[1],"a":[2,42,81,94,101],"chronic":[3],"inflammatory":[4],"state":[5],"that":[6,45],"contributes":[7],"to":[8,58,62,84,112],"the":[9,19,50,90,162,170,181],"development":[10],"of":[11,25,49,64,73,141,147,172,184],"vascular":[12],"disease":[13],"and":[14,22,67,88,106,128,143,149,168],"impaired":[15],"wound":[16,85,163,194],"healing.":[17,35],"Despite":[18],"known":[20],"individual":[21],"societal":[23],"impacts":[24],"diabetic":[26,78,136,156,175],"ulcers,":[27],"there":[28],"are":[29],"limited":[30],"therapies":[31,191],"effective":[32],"at":[33],"improving":[34],"Stromal":[36],"cell-derived":[37],"factor":[38],"1\u03b1":[39],"(SDF-1\u03b1)":[40],"is":[41,75],"CXC":[43,51],"chemokine":[44,52],"functions":[46],"via":[47],"activation":[48],"receptor":[53,57,92],"type":[54,150],"4":[55],"(CXCR4)":[56],"recruit":[59],"hematopoietic":[60],"cells":[61],"locations":[63],"tissue":[65,69],"injury":[66],"promote":[68],"repair.":[70],"The":[71],"expression":[72],"SDF-1\u03b1":[74],"reduced":[76,139,161],"in":[77,133,135,155,174,196],"wounds,":[79],"suggesting":[80],"potential":[82,183],"contribution":[83],"healing":[86,195],"impairment":[87],"presenting":[89],"CXCR4":[91,118,122,187],"as":[93,117,189],"target":[95],"for":[96,115,192],"therapeutic":[97],"investigations.":[98],"We":[99,120],"developed":[100],"high-throughput":[102],"\u03b2-arrestin":[103],"recruitment":[104],"assay":[105],"conducted":[107],"structure-activity":[108],"relationship":[109],"(SAR)":[110],"studies":[111,127],"screen":[113],"compounds":[114],"utility":[116],"agonists.":[119],"identified":[121],"agonist":[123],"UCUF-728":[124,138,160],"from":[125],"our":[126],"further":[129],"validated":[130],"its":[131],"activity":[132],"vitro":[134],"fibroblasts.":[137,157],"overexpression":[140],"miRNA-15b":[142],"miRNA-29a,":[144],"negative":[145],"regulators":[146],"angiogenesis":[148,173],"I":[151],"collagen":[152],"production,":[153],"respectively,":[154],"In":[158],"vivo,":[159],"closure":[164],"time":[165],"by":[166],"36%":[167],"increased":[169],"evidence":[171],"mice.":[176],"Together,":[177],"this":[178],"work":[179],"demonstrates":[180],"clinical":[182],"small":[185],"molecule":[186],"agonists":[188],"novel":[190],"pathologic":[193],"diabetes.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-02-24T00:00:00"}
