{"id":"https://openalex.org/W4213020123","doi":"https://doi.org/10.1021/acs.jafc.1c06399","title":"Identification of Gossypol Acetate as an Autophagy Modulator with Potent Anti-tumor Effect against Cancer Cells","display_name":"Identification of Gossypol Acetate as an Autophagy Modulator with Potent Anti-tumor Effect against Cancer Cells","publication_year":2022,"publication_date":"2022-02-18","ids":{"openalex":"https://openalex.org/W4213020123","doi":"https://doi.org/10.1021/acs.jafc.1c06399","pmid":"https://pubmed.ncbi.nlm.nih.gov/35180345"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.1c06399","doi":"https://doi.org/10.1021/acs.jafc.1c06399","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.1c06399","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082836669","display_name":"Bicheng Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]},{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bicheng Cai","raw_affiliation_strings":["Institute of Shenzhen Respiratory Diseases, Shenzhen People\u2019s Hospital (The First Affiliated Hospital of Southern University of Science and Technology), 518020 Shenzhen, China","Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, 650091 Yunnan, China","State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Shenzhen Respiratory Diseases, Shenzhen People\u2019s Hospital (The First Affiliated Hospital of Southern University of Science and Technology), 518020 Shenzhen, China","institution_ids":["https://openalex.org/I3045169105","https://openalex.org/I4210105608"]},{"raw_affiliation_string":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, 650091 Yunnan, China","institution_ids":["https://openalex.org/I189210763"]},{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liang Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Gong","raw_affiliation_strings":["State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101970470","display_name":"Yiying Zhu","orcid":"https://orcid.org/0000-0002-5237-3525","observed_orcids":["https://orcid.org/0000-0002-5237-3525"]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiying Zhu","raw_affiliation_strings":["State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076058278","display_name":"Lingmei Kong","orcid":"https://orcid.org/0000-0003-0442-0726","observed_orcids":["https://orcid.org/0000-0003-0442-0726"]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingmei Kong","raw_affiliation_strings":["State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000742894","display_name":"Xiaoman Ju","orcid":"https://orcid.org/0000-0001-8399-516X","observed_orcids":["https://orcid.org/0000-0001-8399-516X"]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoman Ju","raw_affiliation_strings":["State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372225","display_name":"Xue Li","orcid":"https://orcid.org/0000-0002-6969-0674","observed_orcids":["https://orcid.org/0000-0002-6969-0674"]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Li","raw_affiliation_strings":["State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091419022","display_name":"Xiaodong Yang","orcid":"https://orcid.org/0000-0002-8466-5418","observed_orcids":["https://orcid.org/0000-0002-8466-5418"]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Yang","raw_affiliation_strings":["Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, 650091 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, 650091 Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023834243","display_name":"Hongyu Zhou","orcid":"https://orcid.org/0000-0001-5852-3953","observed_orcids":["https://orcid.org/0000-0001-5852-3953"]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongyu Zhou","raw_affiliation_strings":["School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500 Yunnan, China","State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":"https://orcid.org/0000-0001-5852-3953","affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500 Yunnan, China","institution_ids":["https://openalex.org/I26080491"]},{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100342549","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-4942-8863","observed_orcids":["https://orcid.org/0000-0002-4942-8863"]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Li","raw_affiliation_strings":["Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, 650091 Yunnan, China","State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, 650091 Yunnan, China","institution_ids":["https://openalex.org/I189210763"]},{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023834243","https://openalex.org/A5100342549"],"corresponding_institution_ids":["https://openalex.org/I13850615","https://openalex.org/I189210763","https://openalex.org/I19820366","https://openalex.org/I26080491"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0666,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.69510135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"8","first_page":"2589","last_page":"2599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gossypol-acetate","display_name":"gossypol acetate","score":1.0},{"id":"https://openalex.org/keywords/autophagy-modulation","display_name":"autophagy modulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/caspase-independent-cell-death","display_name":"caspase-independent cell death","score":0.9729999899864197},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.7509999871253967},{"id":"https://openalex.org/keywords/lc3-conversion","display_name":"LC3 conversion","score":0.7070000171661377},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lysosomal-activity","display_name":"lysosomal activity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/intracellular-atp-depletion","display_name":"intracellular ATP depletion","score":0.9340000152587891},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.6169999837875366},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9641477465629578},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.637546181678772},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6290298700332642},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.5699746608734131},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.5351539254188538},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.5344511866569519},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5327556133270264},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5131819844245911},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4963122010231018},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4805322289466858},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4542527496814728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41032010316848755},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3531675934791565},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3426183760166168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33919718861579895},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2401942014694214},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21123290061950684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17656701803207397},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06040334701538086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006072","descriptor_name":"Gossypol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jafc.1c06399","doi":"https://doi.org/10.1021/acs.jafc.1c06399","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.1c06399","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:35180345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35180345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G267783578","display_name":null,"funder_award_id":"82160697","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3225853046","display_name":null,"funder_award_id":"202101AY070001-001","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G6985750226","display_name":null,"funder_award_id":"81773783","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G833392188","display_name":null,"funder_award_id":"202101AY070001-001","funder_id":"https://openalex.org/F4320325440","funder_display_name":"Yunnan Provincial Science and Technology Department"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322268","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259"},{"id":"https://openalex.org/F4320325440","display_name":"Yunnan Provincial Science and Technology Department","ror":"https://ror.org/03whqdf70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1528462551","https://openalex.org/W1918384196","https://openalex.org/W1970637701","https://openalex.org/W1976108799","https://openalex.org/W1977109589","https://openalex.org/W1983706975","https://openalex.org/W1989051519","https://openalex.org/W1998319919","https://openalex.org/W2016677282","https://openalex.org/W2017098230","https://openalex.org/W2017593971","https://openalex.org/W2023445018","https://openalex.org/W2034603262","https://openalex.org/W2038592957","https://openalex.org/W2076295899","https://openalex.org/W2076570319","https://openalex.org/W2088063295","https://openalex.org/W2101166671","https://openalex.org/W2117874431","https://openalex.org/W2128681673","https://openalex.org/W2155808288","https://openalex.org/W2325949190","https://openalex.org/W2568995659","https://openalex.org/W2766375841","https://openalex.org/W2803156686","https://openalex.org/W3049262677","https://openalex.org/W3180658823","https://openalex.org/W4229885669","https://openalex.org/W4293712893"],"related_works":["https://openalex.org/W2625764591","https://openalex.org/W2073164616","https://openalex.org/W2017218400","https://openalex.org/W2952978525","https://openalex.org/W2322339550","https://openalex.org/W2034321020","https://openalex.org/W2355908034","https://openalex.org/W2805653013","https://openalex.org/W2108884880","https://openalex.org/W2036822760"],"abstract_inverted_index":{"Autophagy,":[0],"an":[1],"evolutionarily":[2],"conserved":[3],"process,":[4],"is":[5,224],"intricately":[6],"involved":[7,196,226],"in":[8,56,83,92,197,227],"many":[9],"aspects":[10],"of":[11,17,23,33,44,71,80,124,145,182,200],"human":[12,18],"health":[13],"and":[14,87,118,152,171,191,217],"a":[15,39],"variety":[16],"diseases,":[19],"including":[20],"cancer.":[21],"Discovery":[22],"small-molecule":[24],"autophagy":[25,51,137,201,216,220],"modulators":[26,52],"with":[27,53],"potent":[28,54],"anticancer":[29],"effect":[30,181],"would":[31],"be":[32,195],"great":[34],"significance.":[35],"To":[36],"this":[37],"end,":[38],"natural":[40,46],"product":[41],"library":[42],"consisting":[43],"170":[45],"compounds":[47],"were":[48],"screened":[49],"as":[50,112],"cytotoxicity":[55],"our":[57,206],"present":[58,207],"study.":[59],"Among":[60],"these":[61],"compounds,":[62],"gossypol":[63],"acetate":[64],"(GAA),":[65],"the":[66,78,179,198,210],"mostly":[67],"used":[68],"medicinal":[69],"form":[70],"gossypol,":[72],"was":[73],"identified.":[74],"GAA":[75,99,132,146,158,166,183,214,223],"effectively":[76],"increased":[77],"number":[79],"autophagic":[81,163],"puncta":[82],"GFP-LC3B-labeled":[84],"293T":[85],"cells":[86],"significantly":[88,126],"decreased":[89,119,167,188],"cell":[90,107,129,230],"viability":[91],"different":[93],"cancer":[94,229],"cells.":[95],"In":[96],"A549":[97],"cells,":[98],"at":[100,133,159],"concentrations":[101,135,144,161],"below":[102],"10":[103],"\u03bcM":[104],"triggered":[105],"caspase-independent":[106],"death":[108],"via":[109],"targeting":[110,139],"autophagy,":[111,185],"evidenced":[113],"by":[114,203,212,222],"elevated":[115],"LC3":[116,125,148],"conversion":[117],"p62/SQSTM1":[120],"levels.":[121],"Knocking":[122],"down":[123],"attenuated":[127],"GAA-induced":[128,228],"death.":[130,231],"Mechanistically,":[131,165],"low":[134],"induced":[136,147],"through":[138],"AMPK-mTORC1-ULK1":[140],"signaling.":[141],"Interestingly,":[142],"high":[143,160],"conversion,":[149],"p62":[150],"accumulation,":[151],"yellow":[153],"autophagosome":[154],"formation,":[155],"indicating":[156],"that":[157,187],"blocked":[162],"flux.":[164],"intracellular":[168],"ATP":[169,176,189],"level":[170,190],"suppressed":[172],"lysosome":[173,192],"activity.":[174],"Exogenous":[175],"partially":[177],"reversed":[178],"inhibitory":[180],"on":[184],"suggesting":[186],"activity":[193],"might":[194],"blocking":[199],"flux":[202],"GAA.":[204],"Collectively,":[205],"study":[208],"reveals":[209],"mechanisms":[211],"which":[213],"modulates":[215],"illustrates":[218],"whether":[219],"regulation":[221],"functionally":[225]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-02-24T00:00:00"}
