{"id":"https://openalex.org/W4212980955","doi":"https://doi.org/10.1093/gerona/glab381","title":"Relationship Between 5 Epigenetic Clocks, Telomere Length, and Functional Capacity Assessed in Older Adults: Cross-Sectional and Longitudinal Analyses","display_name":"Relationship Between 5 Epigenetic Clocks, Telomere Length, and Functional Capacity Assessed in Older Adults: Cross-Sectional and Longitudinal Analyses","publication_year":2022,"publication_date":"2022-01-15","ids":{"openalex":"https://openalex.org/W4212980955","doi":"https://doi.org/10.1093/gerona/glab381","pmid":"https://pubmed.ncbi.nlm.nih.gov/35032170"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/glab381","doi":"https://doi.org/10.1093/gerona/glab381","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glab381","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/77/9/1724/45613940/glab381.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/biomedgerontology/article-pdf/77/9/1724/45613940/glab381.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059489224","display_name":"Valentin Max Vetter","orcid":"https://orcid.org/0000-0001-5003-7766","observed_orcids":["https://orcid.org/0000-0001-5003-7766"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valentin M Vetter","raw_affiliation_strings":["Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany","Department of Psychology, Humboldt University Berlin , Berlin , Germany"],"raw_orcid":"https://orcid.org/0000-0001-5003-7766","affiliations":[{"raw_affiliation_string":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Psychology, Humboldt University Berlin , Berlin , Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035314086","display_name":"Christian Humberto Kalies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian H Kalies","raw_affiliation_strings":["Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013834303","display_name":"Yasmine Sommerer","orcid":"https://orcid.org/0000-0003-2323-9340","observed_orcids":["https://orcid.org/0000-0003-2323-9340"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yasmine Sommerer","raw_affiliation_strings":["L\u00fcbeck Interdisciplinary Platform for Genome Analytics, University of L\u00fcbeck , L\u00fcbeck , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u00fcbeck Interdisciplinary Platform for Genome Analytics, University of L\u00fcbeck , L\u00fcbeck , Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031882479","display_name":"Dominik Spira","orcid":"https://orcid.org/0000-0001-8913-1645","observed_orcids":["https://orcid.org/0000-0001-8913-1645"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Spira","raw_affiliation_strings":["Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081189802","display_name":"Johanna Drewelies","orcid":"https://orcid.org/0000-0002-3774-2169","observed_orcids":["https://orcid.org/0000-0002-3774-2169"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johanna Drewelies","raw_affiliation_strings":["Department of Psychology, Humboldt University Berlin , Berlin , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Humboldt University Berlin , Berlin , Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057574658","display_name":"Vera Regitz\u2010Zagrosek","orcid":"https://orcid.org/0000-0002-3566-3467","observed_orcids":["https://orcid.org/0000-0002-3566-3467"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Vera Regitz-Zagrosek","raw_affiliation_strings":["Department of Cardiology, University Hospital Z\u00fcrich, University of Z\u00fcrich , Z\u00fcrich , Switzerland","Institute for Gender in Medicine, Center for Cardiovascular Research, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health , Berlin , Germany"],"raw_orcid":"https://orcid.org/0000-0002-3566-3467","affiliations":[{"raw_affiliation_string":"Department of Cardiology, University Hospital Z\u00fcrich, University of Z\u00fcrich , Z\u00fcrich , Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Institute for Gender in Medicine, Center for Cardiovascular Research, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health , Berlin , Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004136948","display_name":"Lars Bertram","orcid":"https://orcid.org/0000-0002-0108-124X","observed_orcids":["https://orcid.org/0000-0002-0108-124X"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE","NO"],"is_corresponding":false,"raw_author_name":"Lars Bertram","raw_affiliation_strings":["Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway","L\u00fcbeck Interdisciplinary Platform for Genome Analytics, University of L\u00fcbeck , L\u00fcbeck , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"L\u00fcbeck Interdisciplinary Platform for Genome Analytics, University of L\u00fcbeck , L\u00fcbeck , Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010264892","display_name":"Denis Gerstorf","orcid":"https://orcid.org/0000-0002-2133-9498","observed_orcids":["https://orcid.org/0000-0002-2133-9498"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denis Gerstorf","raw_affiliation_strings":["Department of Psychology, Humboldt University Berlin , Berlin , Germany"],"raw_orcid":"https://orcid.org/0000-0002-2133-9498","affiliations":[{"raw_affiliation_string":"Department of Psychology, Humboldt University Berlin , Berlin , Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074668286","display_name":"Ilja Demuth","orcid":"https://orcid.org/0000-0002-4340-2523","observed_orcids":["https://orcid.org/0000-0002-4340-2523"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ilja Demuth","raw_affiliation_strings":["Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies , Berlin , Germany","Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies , Berlin , Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center , Berlin , Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5074668286"],"corresponding_institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"],"apc_list":{"value":4076,"currency":"USD","value_usd":4076},"apc_paid":null,"fwci":3.9968,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.95952001,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"77","issue":"9","first_page":"1724","last_page":"1733"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.27639999985694885,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.07020000368356705,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-clocks","display_name":"epigenetic clocks","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dna-methylation-age-acceleration","display_name":"DNA methylation age acceleration","score":0.9649999737739563},{"id":"https://openalex.org/keywords/aging-biomarkers","display_name":"aging biomarkers","score":0.6970000267028809},{"id":"https://openalex.org/keywords/functional-capacity","display_name":"functional capacity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8899999856948853},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mobility-physical-function","display_name":"mobility (physical function)","score":0.7179999947547913},{"id":"https://openalex.org/keywords/falls","display_name":"falls","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7839999794960022},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7850000262260437},{"id":"https://openalex.org/keywords/activities-of-daily-living","display_name":"activities of daily living","score":0.9739999771118164},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.8149999976158142},{"id":"https://openalex.org/keywords/horvath-clock","display_name":"Horvath clock","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hannum-clock","display_name":"Hannum clock","score":0.9750000238418579},{"id":"https://openalex.org/keywords/phenoage","display_name":"PhenoAge","score":0.949999988079071},{"id":"https://openalex.org/keywords/grimage","display_name":"GrimAge","score":0.8640000224113464},{"id":"https://openalex.org/keywords/berlin-aging-study-ii","display_name":"Berlin Aging Study II","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2775921022","wikidata":"https://www.wikidata.org/wiki/Q25104749","display_name":"dNaM","level":5,"score":0.7318474054336548},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5580198168754578},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5465251803398132},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5136639475822449},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5110212564468384},{"id":"https://openalex.org/C203187845","wikidata":"https://www.wikidata.org/wiki/Q7808098","display_name":"Tinetti test","level":3,"score":0.48990172147750854},{"id":"https://openalex.org/C2776760841","wikidata":"https://www.wikidata.org/wiki/Q5550831","display_name":"Geriatric Depression Scale","level":4,"score":0.4621911644935608},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44585633277893066},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.42536020278930664},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4029238224029541},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.38446879386901855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3485528826713562},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.21238911151885986},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.21058061718940735},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.15999707579612732},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14551782608032227},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10740754008293152},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.0948629379272461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07335397601127625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gerona/glab381","doi":"https://doi.org/10.1093/gerona/glab381","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glab381","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/77/9/1724/45613940/glab381.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},{"id":"doi:10.1101/2021.10.05.21264547","doi":"https://doi.org/10.1101/2021.10.05.21264547","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.05.21264547","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/10/07/2021.10.05.21264547.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:35032170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35032170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/gerona/glab381","doi":"https://doi.org/10.1093/gerona/glab381","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glab381","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/77/9/1724/45613940/glab381.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G125589385","display_name":null,"funder_award_id":"842/7-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2938354105","display_name":"Verbundprojekt: Berliner Altersstudie II - BASE II - , Teilvorhaben: Projektkoordination, Datenbank und Psychologie","funder_award_id":"16SV5837","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G3091166198","display_name":"GendAge - Geschlechts-sensitive Vorbeugung kardiovaskul\u00e4rer und metabolischer Krankheiten bei \u00e4lteren Erwachsenen in Deutschland - Teilprojekt 2 (GendAge-HU)","funder_award_id":"01GL1716B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G3262059928","display_name":"Verbundprojekt: Berliner Altersstudie II - BASE II - , Teilvorhaben: Survey Methodik und Sozialwissenschaft","funder_award_id":"16SV5537","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4580474731","display_name":null,"funder_award_id":"DE 842/7-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4678035637","display_name":"Verbundprojekt: Berliner Altersstudie II - BASE II - , Teilvorhaben: Innere Medizin/Geriatrie","funder_award_id":"16SV5536K","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6596934128","display_name":"GendAge - Geschlechts-sensitive Vorbeugung kardiovaskul\u00e4rer und metabolischer Krankheiten bei \u00e4lteren Erwachsenen in Deutschland - Teilprojekt 1 und Verbundkoordination (GendAge-Charit\u00e9)","funder_award_id":"01GL1716A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7695795989","display_name":"Verbundprojekt: Berliner Altersstudie II - BASE II - , Teilvorhaben: Molekulargenetik","funder_award_id":"16SV5538","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8783701546","display_name":"Die Berliner Altersstudie (BASE): Fortf\u00fchrung und Erweiterung (BASE II)","funder_award_id":"01UW0808","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320309944","display_name":"Cure Alzheimer's Fund","ror":"https://ror.org/05ewr7t48"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4212980955.pdf","grobid_xml":"https://content.openalex.org/works/W4212980955.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1513618424","https://openalex.org/W1826310230","https://openalex.org/W1974047233","https://openalex.org/W1978914901","https://openalex.org/W2000445173","https://openalex.org/W2036384654","https://openalex.org/W2036395225","https://openalex.org/W2060754339","https://openalex.org/W2113649341","https://openalex.org/W2120961780","https://openalex.org/W2121091193","https://openalex.org/W2121863888","https://openalex.org/W2126525177","https://openalex.org/W2128529067","https://openalex.org/W2146794662","https://openalex.org/W2150751047","https://openalex.org/W2158554646","https://openalex.org/W2164059021","https://openalex.org/W2166004706","https://openalex.org/W2219226197","https://openalex.org/W2290343632","https://openalex.org/W2293729118","https://openalex.org/W2463513647","https://openalex.org/W2505539351","https://openalex.org/W2576174750","https://openalex.org/W2582743722","https://openalex.org/W2589088833","https://openalex.org/W2599190942","https://openalex.org/W2625192659","https://openalex.org/W2796559433","https://openalex.org/W2800587679","https://openalex.org/W2885176254","https://openalex.org/W2887321095","https://openalex.org/W2901442889","https://openalex.org/W2940776377","https://openalex.org/W2949100461","https://openalex.org/W2950601408","https://openalex.org/W2951286195","https://openalex.org/W2952615074","https://openalex.org/W2979522572","https://openalex.org/W2981273727","https://openalex.org/W2990428470","https://openalex.org/W3019129256","https://openalex.org/W3106296722","https://openalex.org/W3158806857","https://openalex.org/W3160827273","https://openalex.org/W3175465443","https://openalex.org/W3193863613","https://openalex.org/W4210640311","https://openalex.org/W4230096730","https://openalex.org/W4240374452"],"related_works":["https://openalex.org/W2887321095","https://openalex.org/W3019129256","https://openalex.org/W4280603821","https://openalex.org/W3200599649","https://openalex.org/W7204595373","https://openalex.org/W2950601408","https://openalex.org/W7214067996","https://openalex.org/W2290343632","https://openalex.org/W2795961830","https://openalex.org/W4321440558"],"abstract_inverted_index":{"DNA":[0],"methylation":[1],"age":[2,77],"acceleration":[3],"(DNAmAA,":[4],"derived":[5],"from":[6,228],"an":[7,153],"epigenetic":[8,230],"clock)":[9,47],"and":[10,42,48,66,143,163,167,199],"relative":[11],"leukocyte":[12],"telomere":[13],"length":[14],"(rLTL)":[15],"are":[16],"widely":[17],"accepted":[18],"biomarkers":[19,158],"of":[20,29,54,60,88,105,138,177,187,238],"aging.":[21,55],"Nevertheless,":[22],"it":[23],"is":[24],"still":[25],"unclear":[26],"which":[27],"aspects":[28],"aging":[30],"they":[31],"represent":[32],"best.":[33],"Here":[34],"we":[35,57,148],"evaluated":[36],"longitudinal":[37,80],"associations":[38,186],"between":[39,155],"baseline":[40,102],"rLTL":[41,207],"DNAmAA":[43,71,164,190,210,226],"(estimated":[44],"with":[45,70,113,201],"7-CpG":[46,209],"functional":[49,168,202],"assessments":[50,65,169,219],"covering":[51],"different":[52,75],"domains":[53],"Additionally,":[56],"made":[58],"use":[59],"cross-sectional":[61,175,236],"data":[62,81,179],"on":[63,97],"these":[64],"examined":[67],"their":[68],"association":[69,154],"estimated":[72,227],"by":[73],"5":[74,229],"DNAm":[76],"measures.":[78],"Two-wave":[79],"were":[82,95,111],"available":[83],"for":[84,133,152,185],"1":[85],"083":[86],"participants":[87],"the":[89,106,122,156,188,217],"Berlin":[90],"Aging":[91],"Study":[92],"II":[93],"who":[94],"reexamined":[96],"average":[98],"7.4":[99],"years":[100],"after":[101],"as":[103],"part":[104],"GendAge":[107],"study.":[108],"Functional":[109],"outcomes":[110],"assessed":[112,170],"Fried's":[114],"frailty":[115],"score,":[116],"Tinetti":[117],"mobility":[118],"test,":[119],"falls":[120],"in":[121,216],"past":[123],"12":[124],"months":[125],"(yes/no),":[126],"finger-floor":[127],"distance,":[128],"Mini-Mental":[129],"State":[130],"Examination,":[131],"Center":[132],"Epidemiologic":[134],"Studies-Depression":[135],"scale,":[136],"activities":[137],"daily":[139],"living,":[140],"instrumented":[141],"ADL,":[142],"mini":[144],"nutritional":[145],"assessment.":[146],"Overall,":[147],"found":[149],"no":[150],"evidence":[151,184],"molecular":[157],"measured":[159],"at":[160,171],"baseline,":[161],"rLTL,":[162],"(7-CpG":[165,192],"clock),":[166],"follow-up.":[172],"Similarly,":[173,225],"a":[174,221,234],"analysis":[176],"follow-up":[178],"did":[180],"also":[181],"not":[182,233],"show":[183],"various":[189],"measures":[191],"clock,":[193,195],"Horvath's":[194],"Hannum's":[196],"clock":[197],"PhenoAge,":[198],"GrimAge)":[200],"assessments.":[203],"In":[204],"conclusion,":[205],"neither":[206],"nor":[208],"was":[211,232],"able":[212],"to":[213],"predict":[214],"impairment":[215],"analyzed":[218],"over":[220],"~7-year":[222],"time":[223],"course.":[224],"clocks":[231],"good":[235],"marker":[237],"health":[239],"deterioration":[240],"either.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-02-24T00:00:00"}
