{"id":"https://openalex.org/W4212972154","doi":"https://doi.org/10.2217/fvl-2021-0259","title":"Novel Chimeric Vectors Harboring Hepatitis B Viral Promoter and Reporter Gene Demonstrated Liver-Specific Significance","display_name":"Novel Chimeric Vectors Harboring Hepatitis B Viral Promoter and Reporter Gene Demonstrated Liver-Specific Significance","publication_year":2022,"publication_date":"2022-02-21","ids":{"openalex":"https://openalex.org/W4212972154","doi":"https://doi.org/10.2217/fvl-2021-0259"},"language":"en","primary_location":{"id":"doi:10.2217/fvl-2021-0259","doi":"https://doi.org/10.2217/fvl-2021-0259","is_oa":true,"landing_page_url":"https://doi.org/10.2217/fvl-2021-0259","pdf_url":null,"source":{"id":"https://openalex.org/S204562989","display_name":"Future Virology","issn_l":"1746-0794","issn":["1746-0794","1746-0808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2217/fvl-2021-0259","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067380119","display_name":"Ayesha Anwer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ayesha Anwer","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101860908","display_name":"Saniya Khan","orcid":"https://orcid.org/0000-0003-0201-3780","observed_orcids":["https://orcid.org/0000-0003-0201-3780"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saniya Khan","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023470355","display_name":"Fatima Amir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Fatima Amir","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101554477","display_name":"Sajad Ahmad Bhat","orcid":"https://orcid.org/0000-0002-6782-5459","observed_orcids":["https://orcid.org/0000-0002-6782-5459"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sajad Ahmad Bhat","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112039530","display_name":"Syed Ali Azam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Syed Ali Azam","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111565934","display_name":"Syed Kazim Hasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Syed Kazim Hasan","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067469370","display_name":"Masarrat Afroz","orcid":"https://orcid.org/0000-0002-3172-017X","observed_orcids":["https://orcid.org/0000-0002-3172-017X"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Masarrat Afroz","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016665364","display_name":"Rashid Waseem","orcid":"https://orcid.org/0000-0003-2750-0366","observed_orcids":["https://orcid.org/0000-0003-2750-0366"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rashid Waseem","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066278286","display_name":"Asimul Islam","orcid":"https://orcid.org/0000-0001-9060-7970","observed_orcids":["https://orcid.org/0000-0001-9060-7970"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Asimul Islam","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034621169","display_name":"Shama Parveen","orcid":"https://orcid.org/0000-0002-6359-0760","observed_orcids":["https://orcid.org/0000-0002-6359-0760","https://orcid.org/0009-0000-3143-458X"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shama Parveen","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061056666","display_name":"Syed Naqui Kazim","orcid":"https://orcid.org/0000-0002-4248-0511","observed_orcids":["https://orcid.org/0000-0002-4248-0511"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Syed Naqui Kazim","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences\rJamia Millia Islamia\rNew Delhi\r110025\rIndia"],"raw_orcid":"https://orcid.org/0000-0002-4248-0511","affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences\rJamia Millia Islamia\rNew Delhi\r110025\rIndia","institution_ids":["https://openalex.org/I59475050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59475050"],"apc_list":null,"apc_paid":null,"fwci":0.0735,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.24238513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"5","first_page":"281","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-specific-expression","display_name":"liver-specific gene expression","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cmv-promoter","display_name":"CMV promoter","score":0.7250000238418579},{"id":"https://openalex.org/keywords/u6-promoter","display_name":"U6 promoter","score":0.9760000109672546},{"id":"https://openalex.org/keywords/egfp-reporter","display_name":"EGFP reporter","score":0.7440000176429749},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hepatocyte-transfection","display_name":"hepatocyte transfection","score":0.5720000267028809},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7094506025314331},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.661470890045166},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.628665030002594},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.567851185798645},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5287615656852722},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5117390155792236},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5099519491195679},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.4888874590396881},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4688243567943573},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.457538366317749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44515568017959595},{"id":"https://openalex.org/C33161422","wikidata":"https://www.wikidata.org/wiki/Q5421712","display_name":"Expression vector","level":4,"score":0.43022871017456055},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4120885729789734},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3588191866874695},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.34070903062820435},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.19544050097465515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04755598306655884}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2217/fvl-2021-0259","doi":"https://doi.org/10.2217/fvl-2021-0259","is_oa":true,"landing_page_url":"https://doi.org/10.2217/fvl-2021-0259","pdf_url":null,"source":{"id":"https://openalex.org/S204562989","display_name":"Future Virology","issn_l":"1746-0794","issn":["1746-0794","1746-0808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Virology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2217/fvl-2021-0259","doi":"https://doi.org/10.2217/fvl-2021-0259","is_oa":true,"landing_page_url":"https://doi.org/10.2217/fvl-2021-0259","pdf_url":null,"source":{"id":"https://openalex.org/S204562989","display_name":"Future Virology","issn_l":"1746-0794","issn":["1746-0794","1746-0808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1490153393","https://openalex.org/W2063867717","https://openalex.org/W2080141551","https://openalex.org/W2120998010","https://openalex.org/W2123782548","https://openalex.org/W2401125218","https://openalex.org/W2413726467","https://openalex.org/W2589094119","https://openalex.org/W2801167100","https://openalex.org/W2804535713","https://openalex.org/W2955618621","https://openalex.org/W2960636016","https://openalex.org/W2972973101","https://openalex.org/W2990322947","https://openalex.org/W3094443688","https://openalex.org/W3121474544","https://openalex.org/W7100896295"],"related_works":["https://openalex.org/W2063867717","https://openalex.org/W2316383227","https://openalex.org/W2107748073","https://openalex.org/W2366764947","https://openalex.org/W758002136","https://openalex.org/W1480719064","https://openalex.org/W2431702822","https://openalex.org/W2374803340","https://openalex.org/W2014699519","https://openalex.org/W2526826101"],"abstract_inverted_index":{"Aim:":[0],"Expression":[1],"of":[2,12,42,52,58,81,112],"EGFP":[3],"was":[4,46,60,85],"investigated":[5],"to":[6,100],"ascertain":[7],"the":[8,79],"strength":[9],"and":[10,15,24,66],"specificity":[11],"CMV,":[13],"U6":[14,56],"hepatitis":[16],"B":[17],"virus":[18],"(HBV)":[19],"core":[20,64,83,96],"promoters":[21],"in":[22,87,103,109],"hepatic":[23,88],"non-hepatic":[25,91],"cells.":[26,93],"Materials":[27],"&":[28],"methods:":[29],"pSilencer-2.1":[30,59],"plasmid":[31],"vector":[32],"is":[33],"known":[34],"for":[35,118],"siRNA-based":[36,119],"inhibition.":[37],"To":[38],"achieve":[39],"target-specific":[40],"correction":[41],"disease-causing":[43],"genes,":[44,54],"pSilencer\u2013GFP":[45],"constructed.":[47],"For":[48],"liver":[49,113],"specific":[50,101],"expression":[51,77,102],"therapeutic":[53,120],"endogenous":[55],"promoter":[57,65,84,97],"replaced":[61],"with":[62],"HBV":[63,82,95],"ubiquitously":[67],"active":[68],"CMV":[69],"promoter.":[70],"Results:":[71],"Transfection":[72],"results":[73],"showed":[74],"that":[75],"GFP":[76],"under":[78],"control":[80],"higher":[86],"Hep3B":[89],"than":[90],"HEK293T":[92],"Conclusion:":[94],"could":[98],"lead":[99],"hepatocytes,":[104],"which":[105],"might":[106],"be":[107],"used":[108],"gene":[110],"therapy":[111],"diseases":[114],"as":[115,117],"well":[116],"strategies.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-02-24T00:00:00"}
