{"id":"https://openalex.org/W4212949593","doi":"https://doi.org/10.1093/hmg/ddac045","title":"Genetic risk factors and COVID-19 severity in Brazil: results from BRACOVID study","display_name":"Genetic risk factors and COVID-19 severity in Brazil: results from BRACOVID study","publication_year":2022,"publication_date":"2022-02-14","ids":{"openalex":"https://openalex.org/W4212949593","doi":"https://doi.org/10.1093/hmg/ddac045","pmid":"https://pubmed.ncbi.nlm.nih.gov/35368071"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddac045","doi":"https://doi.org/10.1093/hmg/ddac045","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddac045","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2021/10/07/2021.10.06.21264631.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032544285","display_name":"Alexandre C. Pereira","orcid":"https://orcid.org/0000-0002-7782-5540","observed_orcids":["https://orcid.org/0000-0002-7782-5540"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Alexandre C Pereira","raw_affiliation_strings":["Genetics Department, Harvard Medical School , Boston, 02115 , USA","Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department, Harvard Medical School , Boston, 02115 , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068162334","display_name":"Taniela Marli Bes","orcid":"https://orcid.org/0000-0002-9094-1319","observed_orcids":["https://orcid.org/0000-0002-9094-1319"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Taniela M Bes","raw_affiliation_strings":["Divisao de Doen\u00e7as Infecciosas, Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","Genetics Department, Harvard Medical School , Boston, 02115 , USA"],"raw_orcid":"https://orcid.org/0000-0002-9094-1319","affiliations":[{"raw_affiliation_string":"Divisao de Doen\u00e7as Infecciosas, Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]},{"raw_affiliation_string":"Genetics Department, Harvard Medical School , Boston, 02115 , USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017875755","display_name":"Mariliza Velho Rodrigues","orcid":"https://orcid.org/0000-0002-6475-9556","observed_orcids":["https://orcid.org/0000-0002-6475-9556"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariliza Velho","raw_affiliation_strings":["Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6475-9556","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045553870","display_name":"Emanuelle Ferreira Marques","orcid":"https://orcid.org/0009-0002-5146-9645","observed_orcids":["https://orcid.org/0009-0002-5146-9645"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Emanuelle Marques","raw_affiliation_strings":["Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090813932","display_name":"Cintia E Jannes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cintia E Jannes","raw_affiliation_strings":["Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072485948","display_name":"Karina Ramos Valino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karina R Valino","raw_affiliation_strings":["Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033668012","display_name":"Carla Luana Dinardo","orcid":"https://orcid.org/0000-0002-0453-7863","observed_orcids":["https://orcid.org/0000-0002-0453-7863","https://orcid.org/0000-0002-6460-4546"]},"institutions":[{"id":"https://openalex.org/I4210157969","display_name":"Funda\u00e7\u00e3o Pr\u00f3-Sangue Hemocentro de S\u00e3o Paulo","ror":"https://ror.org/05cjk9k86","country_code":"BR","type":"government","lineage":["https://openalex.org/I4210157969"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carla L Dinardo","raw_affiliation_strings":["Funda\u00e7\u00e3o Pr\u00f3Sangue Hemocentro de S\u00e3o Paulo, Divis\u00e3o de Imunohematologia , S\u00e3o Paulo, 05403-000 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o Pr\u00f3Sangue Hemocentro de S\u00e3o Paulo, Divis\u00e3o de Imunohematologia , S\u00e3o Paulo, 05403-000 , Brazil","institution_ids":["https://openalex.org/I4210157969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003824515","display_name":"S\u00edlvia Figueiredo Costa","orcid":"https://orcid.org/0000-0003-1087-752X","observed_orcids":["https://orcid.org/0000-0003-1087-752X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvia F Costa","raw_affiliation_strings":["Divisao de Doen\u00e7as Infecciosas, Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisao de Doen\u00e7as Infecciosas, Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107842955","display_name":"Alberto J.S. Duarte","orcid":"https://orcid.org/0000-0002-8707-4904","observed_orcids":["https://orcid.org/0000-0002-8707-4904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto J S Duarte","raw_affiliation_strings":["Departamento de Dermatologia, Laborat\u00f3rio de Dermatologia e Imunodefici\u00eancias, Faculdade de Medicina e Instituto de Medicina Tropical de S\u00e3o Paulo , Sao Paulo, 05403-900 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Dermatologia, Laborat\u00f3rio de Dermatologia e Imunodefici\u00eancias, Faculdade de Medicina e Instituto de Medicina Tropical de S\u00e3o Paulo , Sao Paulo, 05403-900 , Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032091278","display_name":"Alexandre Rosa dos Santos","orcid":"https://orcid.org/0000-0003-2617-9451","observed_orcids":["https://orcid.org/0000-0003-2617-9451"]},"institutions":[{"id":"https://openalex.org/I4210148096","display_name":"Fleury S.A. (Brazil)","ror":"https://ror.org/04q9me654","country_code":"BR","type":"company","lineage":["https://openalex.org/I4210148096"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alexandre R Santos","raw_affiliation_strings":["Departamento de Genomica , Grupo Fleury, Sao Paulo, 04344-070 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Genomica , Grupo Fleury, Sao Paulo, 04344-070 , Brazil","institution_ids":["https://openalex.org/I4210148096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060917167","display_name":"Miguel Mitne\u2010Neto","orcid":"https://orcid.org/0000-0001-8252-3531","observed_orcids":["https://orcid.org/0000-0001-8252-3531"]},"institutions":[{"id":"https://openalex.org/I4210148096","display_name":"Fleury S.A. (Brazil)","ror":"https://ror.org/04q9me654","country_code":"BR","type":"company","lineage":["https://openalex.org/I4210148096"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Miguel Mitne-Neto","raw_affiliation_strings":["Departamento de Genomica , Grupo Fleury, Sao Paulo, 04344-070 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Genomica , Grupo Fleury, Sao Paulo, 04344-070 , Brazil","institution_ids":["https://openalex.org/I4210148096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062622682","display_name":"Jose Osmar Medina-Pestana","orcid":"https://orcid.org/0000-0002-0750-7360","observed_orcids":["https://orcid.org/0000-0002-0750-7360"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose Medina-Pestana","raw_affiliation_strings":["Departamento de Nefrologia , Hospital do Rim. Universidade Federal de S\u00e3o Paulo, Sao Paulo, 04038-002 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Nefrologia , Hospital do Rim. Universidade Federal de S\u00e3o Paulo, Sao Paulo, 04038-002 , Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088604083","display_name":"Jos\u00e9 Eduardo Krieger","orcid":"https://orcid.org/0000-0001-5464-1792","observed_orcids":["https://orcid.org/0000-0001-5464-1792"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose E Krieger","raw_affiliation_strings":["Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4181,"currency":"USD","value_usd":4181},"apc_paid":null,"fwci":4.0062,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.95537151,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"31","issue":"18","first_page":"3021","last_page":"3031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.875},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7689999938011169},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.7179999947547913},{"id":"https://openalex.org/keywords/ifnar2","display_name":"IFNAR2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rbbp5","display_name":"RBBP5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.7049999833106995},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7509999871253967},{"id":"https://openalex.org/keywords/brazilian-population","display_name":"Brazilian population","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7508877515792847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.733330249786377},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.7278743982315063},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5735753178596497},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.543369710445404},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5147652626037598},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4894801378250122},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4292908310890198},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.42171043157577515},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.41324660181999207},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.357586145401001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3441198468208313},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3409813642501831},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.26454442739486694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15866205096244812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15790140628814697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1449066400527954},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13003847002983093},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/hmg/ddac045","doi":"https://doi.org/10.1093/hmg/ddac045","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddac045","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/2021.10.06.21264631","doi":"https://doi.org/10.1101/2021.10.06.21264631","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.06.21264631","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/10/07/2021.10.06.21264631.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:35368071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35368071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2021.10.06.21264631","doi":"https://doi.org/10.1101/2021.10.06.21264631","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.06.21264631","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/10/07/2021.10.06.21264631.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4212949593.pdf","grobid_xml":"https://content.openalex.org/works/W4212949593.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2073836327","https://openalex.org/W2162530578","https://openalex.org/W2171777347","https://openalex.org/W2264585211","https://openalex.org/W2805983714","https://openalex.org/W2885727518","https://openalex.org/W3001897055","https://openalex.org/W3015507975","https://openalex.org/W3028410545","https://openalex.org/W3032315650","https://openalex.org/W3036779511","https://openalex.org/W3041470702","https://openalex.org/W3044986275","https://openalex.org/W3048531412","https://openalex.org/W3090928025","https://openalex.org/W3094067238","https://openalex.org/W3112105690","https://openalex.org/W3138513807","https://openalex.org/W3151250046","https://openalex.org/W3177553934","https://openalex.org/W3188442326","https://openalex.org/W3196738455","https://openalex.org/W3202259720","https://openalex.org/W3208886282","https://openalex.org/W4210547052"],"related_works":["https://openalex.org/W7000685922","https://openalex.org/W3092328415","https://openalex.org/W4285386515","https://openalex.org/W3135574951","https://openalex.org/W7221753698","https://openalex.org/W3196738455","https://openalex.org/W4212998579","https://openalex.org/W7208700787","https://openalex.org/W4289637440","https://openalex.org/W4312213266"],"abstract_inverted_index":{"The":[0,198],"coronavirus":[1,40],"disease":[2,11,21],"2019":[3],"(COVID-19)":[4],"pandemic":[5,57],"has":[6,201],"changed":[7],"the":[8,51,56,59,64,68,73,76,80,85,115,130,145,158,164,193,221],"paradigms":[9],"for":[10,19,93,163],"surveillance":[12],"and":[13,24,102,114,173,196,214],"rapid":[14],"deployment":[15],"of":[16,50,55,63,75,84,209],"scientific-based":[17],"evidence":[18],"understanding":[20],"biology,":[22],"susceptibility":[23],"treatment.":[25],"We":[26,88],"have":[27,89],"organized":[28],"a":[29,91,183,207,217],"large-scale":[30],"genome-wide":[31,185],"association":[32],"study":[33],"(GWAS)":[34],"in":[35,45,58,67,79,144,219,224],"severe":[36],"acute":[37],"respiratory":[38],"syndrome":[39],"2":[41],"(SARS-CoV-2)":[42],"infected":[43],"individuals":[44],"Sao":[46],"Paulo,":[47],"Brazil,":[48],"one":[49,62],"most":[52,65,140,166],"affected":[53,66],"areas":[54],"country,":[60],"itself":[61],"world.":[69],"Here,":[70],"we":[71],"present":[72],"results":[74,138],"initial":[77],"analysis":[78],"first":[81,117],"5233":[82],"participants":[83],"BRACOVID":[86,126,137],"study.":[87],"conducted":[90,124],"GWAS":[92],"COVID-19":[94,100,106,168,225],"hospitalization":[95,127],"enrolling":[96],"3533":[97],"cases":[98],"(hospitalized":[99],"participants)":[101],"1700":[103],"controls":[104],"(non-hospitalized":[105],"participants).":[107],"Models":[108],"were":[109],"adjusted":[110],"by":[111,181],"age,":[112],"sex":[113],"4":[116],"principal":[118],"components.":[119],"A":[120],"meta-analysis":[121],"was":[122,161,188],"also":[123,202],"merging":[125],"data":[128,179],"with":[129,206],"Human":[131],"Genetic":[132],"Initiative":[133],"(HGI)":[134],"Consortia":[135],"results.":[136],"validated":[139],"loci":[141],"previously":[142,204],"identified":[143,189],"HGI":[146],"meta-analysis.":[147],"In":[148],"addition,":[149],"no":[150],"significant":[151,186],"heterogeneity":[152],"according":[153],"to":[154],"ancestral":[155],"group":[156],"within":[157],"Brazilian":[159],"population":[160],"observed":[162],"two":[165],"important":[167],"severity":[169],"associated":[170,199,205],"loci:":[171],"3p21.31":[172],"Chr21":[174],"near":[175,192],"IFNAR2.":[176],"Using":[177],"only":[178],"provided":[180],"BRACOVID,":[182],"new":[184],"locus":[187],"on":[190],"Chr1":[191],"genes":[194],"DSTYK":[195],"RBBP5.":[197],"haplotype":[200],"been":[203],"number":[208],"blood":[210],"cell":[211],"related":[212],"traits":[213],"might":[215],"play":[216],"role":[218],"modulating":[220],"immune":[222],"response":[223],"cases.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-02-24T00:00:00"}