{"id":"https://openalex.org/W4212929528","doi":"https://doi.org/10.3389/fnins.2022.824888","title":"Microglia and Astrocyte Function and Communication: What Do We Know in Humans?","display_name":"Microglia and Astrocyte Function and Communication: What Do We Know in Humans?","publication_year":2022,"publication_date":"2022-02-16","ids":{"openalex":"https://openalex.org/W4212929528","doi":"https://doi.org/10.3389/fnins.2022.824888","pmid":"https://pubmed.ncbi.nlm.nih.gov/35250459","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8888691"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2022.824888","doi":"https://doi.org/10.3389/fnins.2022.824888","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.824888","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.824888/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.824888/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014446210","display_name":"Emma F Garland","orcid":"https://orcid.org/0000-0002-8501-4326","observed_orcids":["https://orcid.org/0000-0002-8501-4326"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma F. Garland","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065529137","display_name":"Iain James Hartnell","orcid":"https://orcid.org/0000-0002-4929-2302","observed_orcids":["https://orcid.org/0000-0002-4929-2302"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iain J. Hartnell","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008325892","display_name":"Delphine Boche","orcid":"https://orcid.org/0000-0002-5884-130X","observed_orcids":["https://orcid.org/0000-0002-5884-130X"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Delphine Boche","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008325892"],"corresponding_institution_ids":["https://openalex.org/I43439940"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":3.1563,"has_fulltext":true,"cited_by_count":168,"citation_normalized_percentile":{"value":0.94256491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"16","issue":null,"first_page":"824888","last_page":"824888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":1.0},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.6449999809265137},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.6850000023841858},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.675000011920929},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/cell-culture-model","display_name":"cell culture model","score":0.7590000033378601},{"id":"https://openalex.org/keywords/fluid-biomarkers","display_name":"fluid biomarkers","score":0.8289999961853027},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.6959999799728394},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.921400785446167},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8471142649650574},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8210040330886841},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.6632615923881531},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5855427980422974},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5594270825386047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46535947918891907},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.45910903811454773},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.44515499472618103},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4210493564605713},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33513322472572327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33098119497299194},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27662280201911926},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1400143802165985},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1364140510559082},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fnins.2022.824888","doi":"https://doi.org/10.3389/fnins.2022.824888","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.824888","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.824888/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8888691","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8888691","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:35250459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35250459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:215305","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/215305/1/Microglia%20and%20Astrocyte%20Function%20and%20Communication%20What%20Do%20We%20Know%20in%20Humans.pdf","pdf_url":"https://eprints.whiterose.ac.uk/215305/1/Microglia%20and%20Astrocyte%20Function%20and%20Communication%20What%20Do%20We%20Know%20in%20Humans.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.soton.ac.uk:454754","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.3389/fnins.2022.824888>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Review"},{"id":"pmh:oai:doaj.org/article:a859d7b59a094e1e8ad2bea3dc620afa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a859d7b59a094e1e8ad2bea3dc620afa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2022.824888","doi":"https://doi.org/10.3389/fnins.2022.824888","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.824888","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.824888/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321081","display_name":"Alzheimer\u2019s Research UK","ror":"https://ror.org/02ymzm013"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4212929528.pdf","grobid_xml":"https://content.openalex.org/works/W4212929528.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W605176161","https://openalex.org/W1503511302","https://openalex.org/W1585095351","https://openalex.org/W1651376769","https://openalex.org/W1667616536","https://openalex.org/W1819889766","https://openalex.org/W1958554455","https://openalex.org/W1971125401","https://openalex.org/W1973439716","https://openalex.org/W1976135940","https://openalex.org/W1976829076","https://openalex.org/W1979252213","https://openalex.org/W1980990150","https://openalex.org/W1982326108","https://openalex.org/W1985451517","https://openalex.org/W1990636293","https://openalex.org/W1990912256","https://openalex.org/W1993748281","https://openalex.org/W1995111570","https://openalex.org/W1995528771","https://openalex.org/W1996024251","https://openalex.org/W1998855584","https://openalex.org/W1999631936","https://openalex.org/W2001618696","https://openalex.org/W2001949804","https://openalex.org/W2002962618","https://openalex.org/W2006161539","https://openalex.org/W2009867508","https://openalex.org/W2013999013","https://openalex.org/W2015412022","https://openalex.org/W2029190354","https://openalex.org/W2031786917","https://openalex.org/W2033617297","https://openalex.org/W2034450620","https://openalex.org/W2035471044","https://openalex.org/W2037366132","https://openalex.org/W2038419555","https://openalex.org/W2038604581","https://openalex.org/W2041572758","https://openalex.org/W2045175180","https://openalex.org/W2054472394","https://openalex.org/W2055316677","https://openalex.org/W2064609814","https://openalex.org/W2068334145","https://openalex.org/W2070160283","https://openalex.org/W2072210142","https://openalex.org/W2073673434","https://openalex.org/W2074424606","https://openalex.org/W2074515925","https://openalex.org/W2074661552","https://openalex.org/W2075110274","https://openalex.org/W2079313884","https://openalex.org/W2084566588","https://openalex.org/W2085558085","https://openalex.org/W2088033971","https://openalex.org/W2090804892","https://openalex.org/W2093584619","https://openalex.org/W2094660330","https://openalex.org/W2107094473","https://openalex.org/W2108435419","https://openalex.org/W2113887671","https://openalex.org/W2115699016","https://openalex.org/W2115779804","https://openalex.org/W2119581346","https://openalex.org/W2124334590","https://openalex.org/W2124490243","https://openalex.org/W2125987139","https://openalex.org/W2128613449","https://openalex.org/W2128846883","https://openalex.org/W2135032335","https://openalex.org/W2138889905","https://openalex.org/W2139406641","https://openalex.org/W2141706699","https://openalex.org/W2145907885","https://openalex.org/W2148898943","https://openalex.org/W2149954869","https://openalex.org/W2150197150","https://openalex.org/W2152460583","https://openalex.org/W2154780300","https://openalex.org/W2155009321","https://openalex.org/W2157585985","https://openalex.org/W2159424525","https://openalex.org/W2165413779","https://openalex.org/W2168203604","https://openalex.org/W2169263040","https://openalex.org/W2170706621","https://openalex.org/W2191292005","https://openalex.org/W2276853091","https://openalex.org/W2280077905","https://openalex.org/W2280881439","https://openalex.org/W2298656843","https://openalex.org/W2317961881","https://openalex.org/W2323303817","https://openalex.org/W2325622993","https://openalex.org/W2404695164","https://openalex.org/W2414662940","https://openalex.org/W2439159283","https://openalex.org/W2471609794","https://openalex.org/W2497241389","https://openalex.org/W2498133937","https://openalex.org/W2519960188","https://openalex.org/W2525538087","https://openalex.org/W2531941507","https://openalex.org/W2554948325","https://openalex.org/W2572710398","https://openalex.org/W2588541474","https://openalex.org/W2594292536","https://openalex.org/W2601518322","https://openalex.org/W2604553302","https://openalex.org/W2605401453","https://openalex.org/W2607261398","https://openalex.org/W2611225933","https://openalex.org/W2614951468","https://openalex.org/W2615586845","https://openalex.org/W2617811369","https://openalex.org/W2622807556","https://openalex.org/W2623352127","https://openalex.org/W2624641603","https://openalex.org/W2753593979","https://openalex.org/W2753908609","https://openalex.org/W2754890392","https://openalex.org/W2760961084","https://openalex.org/W2765364382","https://openalex.org/W2767733203","https://openalex.org/W2768957663","https://openalex.org/W2769484728","https://openalex.org/W2771554318","https://openalex.org/W2776178399","https://openalex.org/W2782565874","https://openalex.org/W2792811901","https://openalex.org/W2794760100","https://openalex.org/W2801244110","https://openalex.org/W2802803124","https://openalex.org/W2804648837","https://openalex.org/W2805798400","https://openalex.org/W2809913775","https://openalex.org/W2889106553","https://openalex.org/W2889172944","https://openalex.org/W2890749116","https://openalex.org/W2892352881","https://openalex.org/W2893505137","https://openalex.org/W2897297276","https://openalex.org/W2902587162","https://openalex.org/W2905048871","https://openalex.org/W2905335418","https://openalex.org/W2911442314","https://openalex.org/W2922178832","https://openalex.org/W2930060644","https://openalex.org/W2947673562","https://openalex.org/W2955012294","https://openalex.org/W2955533479","https://openalex.org/W2956009998","https://openalex.org/W2963077106","https://openalex.org/W2969179597","https://openalex.org/W2970592309","https://openalex.org/W2972082263","https://openalex.org/W2987198483","https://openalex.org/W2987376294","https://openalex.org/W2991414673","https://openalex.org/W2994850755","https://openalex.org/W2995742220","https://openalex.org/W2996950260","https://openalex.org/W2998795963","https://openalex.org/W3004974610","https://openalex.org/W3007066794","https://openalex.org/W3015907136","https://openalex.org/W3025128382","https://openalex.org/W3030239116","https://openalex.org/W3042540255","https://openalex.org/W3047911986","https://openalex.org/W3087743103","https://openalex.org/W3091491962","https://openalex.org/W3097688868","https://openalex.org/W3108559529","https://openalex.org/W3109942090","https://openalex.org/W3110168392","https://openalex.org/W3110926542","https://openalex.org/W3112427779","https://openalex.org/W3116421092","https://openalex.org/W3129001969","https://openalex.org/W3130437983","https://openalex.org/W3132240972","https://openalex.org/W3139185228","https://openalex.org/W3164295522","https://openalex.org/W3180278111","https://openalex.org/W3186800044","https://openalex.org/W3187530179","https://openalex.org/W3190756206","https://openalex.org/W4281823709","https://openalex.org/W4283360267"],"related_works":["https://openalex.org/W7196964340","https://openalex.org/W2808916408","https://openalex.org/W3005292279","https://openalex.org/W3043016915","https://openalex.org/W7118302894","https://openalex.org/W7213307472","https://openalex.org/W3112409504","https://openalex.org/W7163711931","https://openalex.org/W3049318948","https://openalex.org/W4402003834"],"abstract_inverted_index":{"Microglia":[0],"and":[1,22,36,39,43,60,95,107,112,116,127,146],"astrocytes":[2,37],"play":[3],"essential":[4,64],"roles":[5],"in":[6,55,72,86,93],"the":[7,47,53,67,80,125,133,139,147],"central":[8],"nervous":[9],"system":[10],"contributing":[11],"to":[12,52,65,78],"many":[13],"functions":[14],"including":[15],"homeostasis,":[16],"immune":[17],"response,":[18],"blood\u2013brain":[19],"barrier":[20],"maintenance":[21],"synaptic":[23],"support.":[24],"Evidence":[25],"has":[26],"emerged":[27],"from":[28],"experimental":[29],"models":[30],"of":[31,69,129],"glial":[32,56],"communication":[33],"that":[34,150],"microglia":[35],"influence":[38],"coordinate":[40],"each":[41],"other":[42],"their":[44],"effects":[45],"on":[46,83,141],"brain":[48],"environment.":[49],"However,":[50],"due":[51],"difference":[54],"cells":[57,143],"between":[58],"humans":[59],"rodents,":[61],"it":[62],"is":[63],"confirm":[66],"relevance":[68],"these":[70,130,135,142],"findings":[71],"human":[73],"brains.":[74],"Here,":[75],"we":[76,122],"aim":[77],"review":[79],"current":[81],"knowledge":[82,148],"microglia-astrocyte":[84],"crosstalk":[85],"humans,":[87],"exploring":[88],"novel":[89],"methodological":[90],"techniques":[91],"used":[92],"health":[94],"disease":[96],"conditions.":[97],"This":[98],"will":[99,123],"include":[100],"an":[101],"in-depth":[102],"look":[103],"at":[104],"cell":[105],"culture":[106],"iPSCs,":[108],"post-mortem":[109],"studies,":[110],"imaging":[111],"fluid":[113],"biomarkers,":[114],"genetics":[115],"transcriptomic":[117],"data.":[118],"In":[119],"this":[120],"review,":[121],"discuss":[124],"advantages":[126],"limitations":[128],"methods,":[131],"highlighting":[132],"understanding":[134],"methods":[136],"have":[137],"brought":[138],"field":[140],"communicative":[144],"abilities,":[145],"gaps":[149],"remain.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":41},{"year":2025,"cited_by_count":42},{"year":2024,"cited_by_count":50},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-02-24T00:00:00"}