{"id":"https://openalex.org/W4212763501","doi":"https://doi.org/10.3389/fonc.2022.811850","title":"Triptolide Shows High Sensitivity and Low Toxicity Against Acute Myeloid Leukemia Cell Lines Through Inhibiting WSTF-RNAPII Complex","display_name":"Triptolide Shows High Sensitivity and Low Toxicity Against Acute Myeloid Leukemia Cell Lines Through Inhibiting WSTF-RNAPII Complex","publication_year":2022,"publication_date":"2022-02-16","ids":{"openalex":"https://openalex.org/W4212763501","doi":"https://doi.org/10.3389/fonc.2022.811850","pmid":"https://pubmed.ncbi.nlm.nih.gov/35251980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8888427"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.811850","doi":"https://doi.org/10.3389/fonc.2022.811850","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.811850","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fonc.2022.811850","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109845060","display_name":"Di Kang","orcid":"https://orcid.org/0009-0006-5712-1518","observed_orcids":["https://orcid.org/0009-0006-5712-1518","https://orcid.org/0000-0002-1361-7953"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Di Kang","raw_affiliation_strings":["Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351002","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0001-7294-6661","observed_orcids":["https://orcid.org/0000-0001-7294-6661"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":["Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101441299","display_name":"Yi Song","orcid":"https://orcid.org/0000-0003-0125-6019","observed_orcids":["https://orcid.org/0000-0003-0125-6019"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Song","raw_affiliation_strings":["Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038093914","display_name":"Bingqian Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingqian Fang","raw_affiliation_strings":["Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100656070","display_name":"Qichun Zhang","orcid":"https://orcid.org/0000-0003-1854-8659","observed_orcids":["https://orcid.org/0000-0003-1854-8659"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qichun Zhang","raw_affiliation_strings":["Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001424435","display_name":"Lihong Hu","orcid":"https://orcid.org/0000-0003-3231-2829","observed_orcids":["https://orcid.org/0000-0003-3231-2829"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lihong Hu","raw_affiliation_strings":["Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001424435","https://openalex.org/A5109845060"],"corresponding_institution_ids":["https://openalex.org/I131434179"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.6782,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.87632444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"811850","last_page":"811850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triptolide","display_name":"triptolide","score":1.0},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wstf","display_name":"WSTF","score":0.8259999752044678},{"id":"https://openalex.org/keywords/rpb1","display_name":"RPB1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/dosing-regimen-optimization","display_name":"dosing regimen optimization","score":0.8539999723434448},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2781164371","wikidata":"https://www.wikidata.org/wiki/Q906351","display_name":"Triptolide","level":3,"score":0.9991855025291443},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6741673946380615},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5821890234947205},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5021483898162842},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48162955045700073},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.460322767496109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44998690485954285},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27640223503112793},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.18516144156455994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15910205245018005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13638558983802795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04560273885726929},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2022.811850","doi":"https://doi.org/10.3389/fonc.2022.811850","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.811850","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8888427","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8888427/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8888427/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:35251980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35251980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6330a9d40c08443c8d82c24425a9b204","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6330a9d40c08443c8d82c24425a9b204","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.811850","doi":"https://doi.org/10.3389/fonc.2022.811850","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.811850","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2123788604","display_name":null,"funder_award_id":"82104270","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3580253138","display_name":null,"funder_award_id":"81873027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4865799931","display_name":null,"funder_award_id":"82104270, 81873027, 81573635","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7189103250","display_name":null,"funder_award_id":"81573635","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324804","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19"},{"id":"https://openalex.org/F4320324852","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4212763501.pdf","grobid_xml":"https://content.openalex.org/works/W4212763501.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W26477306","https://openalex.org/W248383993","https://openalex.org/W1526377515","https://openalex.org/W1971949734","https://openalex.org/W1988524540","https://openalex.org/W2011162627","https://openalex.org/W2016408686","https://openalex.org/W2029056941","https://openalex.org/W2038294557","https://openalex.org/W2039484835","https://openalex.org/W2057636545","https://openalex.org/W2085760714","https://openalex.org/W2086933069","https://openalex.org/W2118774187","https://openalex.org/W2134358746","https://openalex.org/W2167355583","https://openalex.org/W2170659029","https://openalex.org/W2322725545","https://openalex.org/W2333643642","https://openalex.org/W2558945204","https://openalex.org/W2605479380","https://openalex.org/W2750399833","https://openalex.org/W2790965152","https://openalex.org/W2804063283","https://openalex.org/W2806507289","https://openalex.org/W2807088556","https://openalex.org/W2901422983","https://openalex.org/W2939361294","https://openalex.org/W2942587013","https://openalex.org/W2945326378","https://openalex.org/W2976933599","https://openalex.org/W2995587299","https://openalex.org/W3009266182","https://openalex.org/W3030184127","https://openalex.org/W3038021126","https://openalex.org/W3145256917","https://openalex.org/W3157513056","https://openalex.org/W4240432099"],"related_works":["https://openalex.org/W2583311389","https://openalex.org/W2946933439","https://openalex.org/W2499446124","https://openalex.org/W2010653836","https://openalex.org/W1986643690","https://openalex.org/W2039484835","https://openalex.org/W2979625770","https://openalex.org/W4245974243","https://openalex.org/W2570916501","https://openalex.org/W2054543570"],"abstract_inverted_index":{"Triptolide":[0],"exhibits":[1],"superior":[2],"and":[3,34,64,99,106,122],"broad-spectrum":[4],"antitumor":[5],"activity.":[6],"However,":[7],"the":[8,14,30,70,78,82,91,118,139,147],"narrow":[9],"safety":[10,148],"window":[11,149],"caused":[12],"by":[13,58],"toxicity":[15],"of":[16,85,150],"triptolide":[17,27,33,57,94],"limits":[18],"its":[19,35,154],"clinical":[20,155],"applications.":[21],"Although":[22],"several":[23],"characterized":[24],"targets":[25,36],"for":[26,132],"are":[28,54,87],"reported,":[29],"association":[31],"between":[32],"in":[37,61,65,95,103,143],"cancer":[38,97],"therapy":[39],"is":[40],"not":[41],"fully":[42],"understood.":[43],"Here,":[44],"we":[45,110],"show":[46,111],"that":[47,112],"acute":[48],"myeloid":[49],"leukemia":[50],"(AML)":[51],"cell":[52,63,134],"lines":[53,135],"sensitive":[55],"to":[56,93,130,145],"constructing":[59],"an":[60],"vitro":[62],"vivo":[66],"xenograft":[67,79],"models.":[68,80],"Meanwhile,":[69],"triptolide-induced":[71],"hepatotoxicity":[72],"increases":[73],"with":[74,90],"increasing":[75,153],"dosages":[76],"within":[77],"Additionally,":[81],"expression":[83],"levels":[84],"WSTF-RPB1":[86],"strongly":[88],"associated":[89],"sensitivity":[92],"hematological":[96],"cells":[98],"can":[100,116],"be":[101],"downregulated":[102],"a":[104],"dose":[105],"time-dependent":[107],"manner.":[108],"Finally,":[109],"optimizing":[113],"dosing":[114],"regimens":[115],"achieve":[117],"same":[119],"pharmaceutical":[120],"effect":[121],"reduce":[123],"toxicity.":[124],"In":[125],"summary,":[126],"this":[127],"study":[128],"aims":[129],"search":[131],"triptolide-sensitive":[133],"as":[136,138],"well":[137],"underlying":[140],"molecular":[141],"mechanisms":[142],"order":[144],"broaden":[146],"triptolide;":[151],"thus,":[152],"utility.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-02-24T00:00:00"}