{"id":"https://openalex.org/W4211266956","doi":null,"title":"Photodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.","display_name":"Photodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4211266956","pmid":"https://pubmed.ncbi.nlm.nih.gov/35141014","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8822289"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8822289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8822289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8822289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026960371","display_name":"Prathyusha Konda","orcid":"https://orcid.org/0000-0002-6861-4442","observed_orcids":["https://orcid.org/0000-0002-6861-4442"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Prathyusha Konda","raw_affiliation_strings":["Department of Microbiology & Immunology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084003871","display_name":"John A. Roque","orcid":"https://orcid.org/0000-0002-1841-8435","observed_orcids":["https://orcid.org/0000-0002-1841-8435"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]},{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A Roque Iii","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA","Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro Greensboro, North Carolina 27402, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro Greensboro, North Carolina 27402, USA","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062053312","display_name":"Liubov M. Lifshits","orcid":"https://orcid.org/0000-0002-2696-6220","observed_orcids":["https://orcid.org/0000-0002-2696-6220"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liubov M Lifshits","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078781867","display_name":"Angelita Alcos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Angelita Alcos","raw_affiliation_strings":["Department of Pathology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042703357","display_name":"Eissa Azzam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eissa Azzam","raw_affiliation_strings":["Department of Microbiology & Immunology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ge Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ge Shi","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004642101","display_name":"Colin G. Cameron","orcid":"https://orcid.org/0000-0003-0978-0894","observed_orcids":["https://orcid.org/0000-0003-0978-0894"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin G Cameron","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069274982","display_name":"Sherri A. McFarland","orcid":"https://orcid.org/0000-0002-8028-5055","observed_orcids":["https://orcid.org/0000-0002-8028-5055"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherri A McFarland","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington, Texas 76019-0065, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004261817","display_name":"Shashi Ashok Gujar","orcid":"https://orcid.org/0000-0002-5427-0829","observed_orcids":["https://orcid.org/0000-0002-5427-0829"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I4210087543","display_name":"Beatrice Hunter Cancer Research Institute","ror":"https://ror.org/0052qq196","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210087543"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shashi Gujar","raw_affiliation_strings":["Department of Microbiology & Immunology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","Department of Pathology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","Department of Biology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","Beatrice Hunter Cancer Research Institute Halifax, Nova Scotia B3H 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Department of Pathology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Department of Biology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Beatrice Hunter Cancer Research Institute Halifax, Nova Scotia B3H 1X5, Canada","institution_ids":["https://openalex.org/I4210087543"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5177,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82194947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"210","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ruthenium-ii-complexes","display_name":"ruthenium(II) complexes","score":0.902999997138977},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.871999979019165},{"id":"https://openalex.org/keywords/near-infrared-light","display_name":"near-infrared light","score":0.8230000138282776},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/atp-release","display_name":"ATP release","score":0.722000002861023},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cancer-vaccination","display_name":"cancer vaccination","score":0.4860000014305115},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.968999981880188},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8199999928474426},{"id":"https://openalex.org/keywords/proinflammatory-response","display_name":"pro-inflammatory response","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.9374940991401672},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.6730172634124756},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6584408283233643},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.653120219707489},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6119263172149658},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5512304902076721},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5403763055801392},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.49092987179756165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44362160563468933},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.43208983540534973},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4184880256652832},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41552895307540894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31599318981170654},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3007417917251587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24537202715873718},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0641152560710907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06264030933380127},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:8822289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8822289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:35141014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35141014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8822289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8822289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8532525389","display_name":"Immunomodulating Ruthenium Metal Complexes for Melanoma PhotodynamicTherapy","funder_award_id":"R01CA222227","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1489012416","https://openalex.org/W1537669571","https://openalex.org/W1942176190","https://openalex.org/W1966621240","https://openalex.org/W1968783338","https://openalex.org/W1977179270","https://openalex.org/W1982935652","https://openalex.org/W1991241456","https://openalex.org/W1991605763","https://openalex.org/W1992354862","https://openalex.org/W2004593104","https://openalex.org/W2005621531","https://openalex.org/W2008536525","https://openalex.org/W2016612145","https://openalex.org/W2034611515","https://openalex.org/W2049784279","https://openalex.org/W2050231527","https://openalex.org/W2061499228","https://openalex.org/W2075819066","https://openalex.org/W2081447458","https://openalex.org/W2086727915","https://openalex.org/W2089222447","https://openalex.org/W2091209638","https://openalex.org/W2093231404","https://openalex.org/W2102891867","https://openalex.org/W2106166393","https://openalex.org/W2123469465","https://openalex.org/W2131289426","https://openalex.org/W2151734986","https://openalex.org/W2159016483","https://openalex.org/W2163252162","https://openalex.org/W2168797718","https://openalex.org/W2310787752","https://openalex.org/W2324177572","https://openalex.org/W2340110554","https://openalex.org/W2462653987","https://openalex.org/W2536322725","https://openalex.org/W2590947287","https://openalex.org/W2595092778","https://openalex.org/W2768292680","https://openalex.org/W2884537568","https://openalex.org/W2887043640","https://openalex.org/W2889823397","https://openalex.org/W2890875511","https://openalex.org/W2894609651","https://openalex.org/W2895214712","https://openalex.org/W2902690248","https://openalex.org/W2910937665","https://openalex.org/W2921693673","https://openalex.org/W2930388365","https://openalex.org/W2964325900","https://openalex.org/W2966691356","https://openalex.org/W2969159587","https://openalex.org/W2970536272","https://openalex.org/W2971798665","https://openalex.org/W2982050952","https://openalex.org/W2990179403","https://openalex.org/W3000930612","https://openalex.org/W3004914115","https://openalex.org/W3008938139","https://openalex.org/W3009426500","https://openalex.org/W3011497962","https://openalex.org/W3011642937","https://openalex.org/W3015470279","https://openalex.org/W3016662185","https://openalex.org/W3020918038","https://openalex.org/W3021367077","https://openalex.org/W3028523516","https://openalex.org/W3038225380","https://openalex.org/W3039484069","https://openalex.org/W3047903576","https://openalex.org/W3081948925","https://openalex.org/W3084261920","https://openalex.org/W3089064012","https://openalex.org/W3108774824","https://openalex.org/W3112671848","https://openalex.org/W3113450031","https://openalex.org/W3124083956","https://openalex.org/W3134746059","https://openalex.org/W3151427897"],"related_works":["https://openalex.org/W3113450031","https://openalex.org/W4416446350","https://openalex.org/W4205913767","https://openalex.org/W3120787688","https://openalex.org/W3009774292","https://openalex.org/W4387788404","https://openalex.org/W2995890910","https://openalex.org/W3167339577","https://openalex.org/W2982050952","https://openalex.org/W3148336754"],"abstract_inverted_index":{"Cancer":[0],"therapies":[1,66],"that":[2,47,123,229],"generate":[3,29],"T":[4,24],"cell-based":[5],"anti-cancer":[6,31,91],"immune":[7,26,107],"responses":[8,27],"are":[9,15],"critical":[10],"for":[11,99],"clinical":[12],"success":[13],"and":[14,28,50,80,94,106,121,160,172,182,191,199],"favored":[16],"over":[17],"traditional":[18],"therapies.":[19],"One":[20],"way":[21],"to":[22,131,138],"elicit":[23,132],"cell":[25,38,45,141],"long-lasting":[30],"immunity":[32,228],"is":[33,85],"through":[34],"induction":[35],"of":[36,43,148,165,195,214],"immunogenic":[37],"death":[39,46],"(ICD),":[40],"a":[41,86],"form":[42],"regulated":[44],"promotes":[48],"antigenicity":[49],"adjuvanticity":[51],"within":[52],"dying":[53,223],"cells.":[54,207,237],"Therefore,":[55],"research":[56],"in":[57],"the":[58,146,211],"last":[59],"decade":[60],"has":[61,95],"focused":[62],"on":[63,151],"developing":[64],"cancer":[65,224],"which":[67],"stimulate":[68],"ICD.":[69],"Herein,":[70],"we":[71,113,144],"report":[72],"novel":[73],"photodynamic":[74],"therapy":[75],"(PDT)":[76],"compounds":[77],"with":[78,127,158,220,235],"immunomodulatory":[79],"ICD":[81,185,215],"inducing":[82,217],"properties.":[83,135],"PDT":[84,156],"clinically":[87],"approved,":[88],"minimally":[89],"invasive":[90],"treatment":[92,157],"option":[93],"been":[96],"extensively":[97],"investigated":[98,145],"its":[100,139],"tumor-destroying":[101],"properties,":[102],"lower":[103],"side":[104],"effects,":[105],"activation":[108,194],"capabilities.":[109],"In":[110,136],"this":[111],"study,":[112],"explore":[114],"two":[115],"structurally":[116],"related":[117],"ruthenium":[118],"compounds,":[119],"ML19B01":[120,159],"ML19B02,":[122],"can":[124],"be":[125],"activated":[126],"near":[128],"infrared":[129],"light":[130],"superior":[133],"cytotoxic":[134],"addition":[137],"direct":[140],"killing":[142],"abilities,":[143],"effect":[147],"our":[149],"PSs":[150],"immunological":[152],"pathways":[153],"upon":[154],"activation.":[155],"ML19B02":[161],"induced":[162,179],"differential":[163],"expression":[164],"reactive":[166],"oxygen":[167],"species,":[168],"proinflammatory":[169],"response-mediating":[170],"genes,":[171],"heat":[173],"shock":[174],"proteins.":[175],"Dying":[176],"melanoma":[177,236],"cells":[178,225],"by":[180,203],"ML19B01-PDT":[181],"ML19B02-PDT":[183],"contained":[184],"hallmarks":[186],"such":[187],"as":[188],"calreticulin,":[189],"ATP,":[190],"HMGB1,":[192],"initiated":[193],"antigen":[196],"presenting":[197],"cells,":[198],"were":[200],"efficiently":[201],"phagocytosed":[202],"bone":[204],"marrow-derived":[205],"dendritic":[206],"Most":[208],"importantly,":[209],"despite":[210],"distinct":[212],"profiles":[213],"hallmark":[216],"capacities,":[218],"vaccination":[219],"both":[221],"PDT-induced":[222],"established":[226],"anti-tumor":[227],"protected":[230],"mice":[231],"against":[232],"subsequent":[233],"challenge":[234]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-10-10T00:00:00"}