{"id":"https://openalex.org/W4211266951","doi":null,"title":"Modulation of BRCA1 mediated DNA damage repair by deregulated ER-\u03b1 signaling in breast cancers.","display_name":"Modulation of BRCA1 mediated DNA damage repair by deregulated ER-\u03b1 signaling in breast cancers.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4211266951","pmid":"https://pubmed.ncbi.nlm.nih.gov/35141003","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8822286"},"language":"en","primary_location":{"id":"pmid:35141003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35141003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8822286/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Arathi Rajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158338959","display_name":"University of Kerala","ror":"https://ror.org/05tqa9940","country_code":"IN","type":"education","lineage":["https://openalex.org/I158338959"]},{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arathi Rajan","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","Department of Biotechnology, University of Kerala Thiruvananthapuram 695011, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]},{"raw_affiliation_string":"Department of Biotechnology, University of Kerala Thiruvananthapuram 695011, Kerala, India","institution_ids":["https://openalex.org/I158338959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078481979","display_name":"Geetu Rose Varghese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Geetu R Varghese","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091766689","display_name":"Induprabha Yadev","orcid":"https://orcid.org/0000-0002-5086-6246","observed_orcids":["https://orcid.org/0000-0002-5086-6246"]},"institutions":[{"id":"https://openalex.org/I129862065","display_name":"Government Medical College","ror":"https://ror.org/007fenw03","country_code":"IN","type":"education","lineage":["https://openalex.org/I129862065"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Induprabha Yadev","raw_affiliation_strings":["Goverment Medical College Thiruvananthapuram 695011, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goverment Medical College Thiruvananthapuram 695011, Kerala, India","institution_ids":["https://openalex.org/I129862065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065660842","display_name":"Jaimie Anandan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129862065","display_name":"Government Medical College","ror":"https://ror.org/007fenw03","country_code":"IN","type":"education","lineage":["https://openalex.org/I129862065"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jaimie Anandan","raw_affiliation_strings":["Goverment Medical College Thiruvananthapuram 695011, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goverment Medical College Thiruvananthapuram 695011, Kerala, India","institution_ids":["https://openalex.org/I129862065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077876526","display_name":"Neetha Rajan Latha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neetha R Latha","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050631378","display_name":"Dipyaman Patra","orcid":"https://orcid.org/0000-0002-6324-7284","observed_orcids":["https://orcid.org/0000-0002-6324-7284"]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dipyaman Patra","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015395396","display_name":"Neethu Krishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neethu Krishnan","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076769153","display_name":"Krithiga Kuppusamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Krithiga Kuppusamy","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083279125","display_name":"Arathy V. Warrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arathy V Warrier","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030026212","display_name":"Satej Bhushan","orcid":"https://orcid.org/0000-0003-0790-5673","observed_orcids":["https://orcid.org/0000-0003-0790-5673"]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Satej Bhushan","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016574023","display_name":"Revathy Nadhan","orcid":"https://orcid.org/0000-0002-9492-3863","observed_orcids":["https://orcid.org/0000-0002-9492-3863"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Revathy Nadhan","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","OU Health Stephenson Cancer Centre Oklahoma, United State"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]},{"raw_affiliation_string":"OU Health Stephenson Cancer Centre Oklahoma, United State","institution_ids":["https://openalex.org/I4390039380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010921655","display_name":"Ram Mohan Ram Kumar","orcid":"https://orcid.org/0000-0002-0689-2957","observed_orcids":["https://orcid.org/0000-0002-0689-2957"]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ram Mohan Ram Kumar","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031951805","display_name":"Priya Srinivas","orcid":"https://orcid.org/0000-0003-3872-7128","observed_orcids":["https://orcid.org/0000-0003-3872-7128"]},"institutions":[{"id":"https://openalex.org/I89324447","display_name":"Rajiv Gandhi Centre for Biotechnology","ror":"https://ror.org/05sdqd547","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I89324447"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priya Srinivas","raw_affiliation_strings":["Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014, Kerala, India","institution_ids":["https://openalex.org/I89324447"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4412,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.48202255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"17","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.23070000112056732,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9319999814033508},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8149999976158142},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.8679999709129333},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9700000286102295},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9929999709129333},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8550000190734863},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8610000014305115},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.8980000019073486},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.7670000195503235},{"id":"https://openalex.org/keywords/brca1-mutation-carriers","display_name":"BRCA1 mutation carriers","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7557582855224609},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6854298114776611},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6663210391998291},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.5478950142860413},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.5309120416641235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5131545662879944},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.43829256296157837},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.40932410955429077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34772205352783203},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.32262977957725525},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.17516395449638367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1747625172138214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13454031944274902}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:35141003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35141003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8822286","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8822286/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8822286","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8822286/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1529899924","https://openalex.org/W1529973934","https://openalex.org/W1873396772","https://openalex.org/W1963691994","https://openalex.org/W1964327569","https://openalex.org/W1970741995","https://openalex.org/W1971069767","https://openalex.org/W1976415291","https://openalex.org/W1977061516","https://openalex.org/W1983432011","https://openalex.org/W1986450641","https://openalex.org/W2001481467","https://openalex.org/W2024682444","https://openalex.org/W2033344337","https://openalex.org/W2039435798","https://openalex.org/W2050646440","https://openalex.org/W2051193631","https://openalex.org/W2059569390","https://openalex.org/W2066554319","https://openalex.org/W2067866652","https://openalex.org/W2070721957","https://openalex.org/W2076951953","https://openalex.org/W2089654173","https://openalex.org/W2099254999","https://openalex.org/W2103770333","https://openalex.org/W2107715574","https://openalex.org/W2108326951","https://openalex.org/W2119043093","https://openalex.org/W2121213878","https://openalex.org/W2130447102","https://openalex.org/W2140930673","https://openalex.org/W2141798197","https://openalex.org/W2146899967","https://openalex.org/W2155668399","https://openalex.org/W2165102663","https://openalex.org/W2166542841","https://openalex.org/W2237087006","https://openalex.org/W2301292218","https://openalex.org/W2333848321","https://openalex.org/W2409661687","https://openalex.org/W2804482488","https://openalex.org/W2804870483","https://openalex.org/W2889831190","https://openalex.org/W2913695705","https://openalex.org/W2975628629","https://openalex.org/W2981349374","https://openalex.org/W3013268433","https://openalex.org/W3098294146"],"related_works":["https://openalex.org/W3107697126","https://openalex.org/W2885039052","https://openalex.org/W1556138995","https://openalex.org/W4225287881","https://openalex.org/W1764653742","https://openalex.org/W1559170038","https://openalex.org/W2358710252","https://openalex.org/W1547728820","https://openalex.org/W4408488707","https://openalex.org/W4415522221"],"abstract_inverted_index":{"BRCA1":[0,22,31,68,110,136],"mutation":[1],"carriers":[2],"have":[3,52],"a":[4,53,102,156],"greater":[5],"risk":[6],"of":[7,21,29,39,56,89,97,104,119,158,179,183,220,226],"developing":[8],"cancers":[9,24,34],"in":[10,151,165,170,198,231],"hormone-responsive":[11],"tissues":[12],"like":[13,141,210],"breasts":[14],"and":[15,51,59,125,146,181,223],"ovaries.":[16],"However,":[17],"this":[18],"tissue-specific":[19],"incidence":[20],"related":[23],"remains":[25],"elusive.":[26],"The":[27,91],"majority":[28],"the":[30,85,109,196,203],"mutated":[32],"breast":[33,152],"exhibit":[35],"typical":[36],"histopathological":[37],"features":[38],"high-grade":[40],"tumors,":[41],"with":[42,69],"basal":[43],"epithelial":[44],"phenotype,":[45],"classified":[46],"as":[47,101],"triple-negative":[48],"molecular":[49],"subtype":[50],"higher":[54],"percentage":[55],"DNA":[57,86,172,185,221],"damage":[58,127,173],"chromosomal":[60],"abnormality.":[61],"Though":[62],"there":[63],"are":[64],"many":[65],"studies":[66],"relating":[67],"ER-\u03b1":[70,98,133,159,167,191,216],"(Estrogen":[71],"receptor-\u03b1),":[72],"it":[73],"has":[74],"not":[75,193],"been":[76],"reported":[77],"whether":[78,95],"E2":[79],"(Estrogen)":[80],"-ER-\u03b1":[81],"signaling":[82],"can":[83,134],"modulate":[84],"repair":[87,124,205],"activities":[88],"BRCA1.":[90],"present":[92],"study":[93],"analyzes":[94],"deregulation":[96],"signaling,":[99],"arising":[100],"result":[103],"E2/ER-\u03b1":[105],"deficiency,":[106],"could":[107],"impact":[108],"dependent":[111],"DDR":[112,227],"(DNA":[113],"Damage":[114],"Response)":[115],"pathways,":[116],"predominantly":[117],"those":[118],"DNA-DSB":[120],"(Double":[121],"Strand":[122],"break)":[123],"oxidative":[126],"response.":[128],"We":[129],"demonstrate":[130],"that":[131],"E2/E2-stimulated":[132],"augment":[135],"mediated":[137],"high":[138],"fidelity":[139],"repairs":[140],"HRR":[142,197],"(Homologous":[143],"Recombination":[144],"Repair)":[145,150],"BER":[147],"(Base":[148],"Excision":[149],"cancer":[153],"cells.":[154],"Conversely,":[155],"condition":[157],"deficiency":[160,192,217],"itself":[161],"or":[162],"any":[163],"interruption":[164],"ligand-dependent":[166],"transactivation":[168],"resulted":[169],"delayed":[171],"repair,":[174],"leading":[175],"to":[176],"persistent":[177],"activation":[178],"\u03b3H2AX":[180],"retention":[182],"unrepaired":[184],"lesions,":[186],"thereby":[187],"triggering":[188],"tumor":[189],"progression.":[190],"only":[194],"limited":[195],"cells":[199],"but":[200],"also":[201],"facilitated":[202],"DSB":[204],"through":[206],"error":[207],"prone":[208],"pathways":[209],"NHEJ":[211],"(Non":[212],"Homologous":[213],"End":[214],"Joining).":[215],"associated":[218],"persistence":[219],"lesions":[222],"reduced":[224],"expression":[225],"proteins":[228],"were":[229],"validated":[230],"human":[232],"mammary":[233],"tumors.":[234]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}