{"id":"https://openalex.org/W4211260065","doi":"https://doi.org/10.1007/978-3-662-06119-0_4","title":"Blood-Surface Interactions During Cardiopulmonary Bypass","display_name":"Blood-Surface Interactions During Cardiopulmonary Bypass","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W4211260065","doi":"https://doi.org/10.1007/978-3-662-06119-0_4"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-662-06119-0_4","doi":"https://doi.org/10.1007/978-3-662-06119-0_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-662-06119-0_4","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Use in Cardiac Surgery","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W625377196","display_name":"Blood Use in Cardiac Surgery"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112177995","display_name":"L. Henry Edmunds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Henry Edmunds","raw_affiliation_strings":["W. M. Measey Professor, Chief,\n        Cardiothoracic Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA","W. M. Measey Professor, Chief,\n        Division of Cardiothoracic Surgery, Harrison Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA","W. M. Measey Professor, Chief,\n        Thrombosis Research Center and the Hematology-Oncology Sections and Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. M. Measey Professor, Chief,\n        Cardiothoracic Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"W. M. Measey Professor, Chief,\n        Division of Cardiothoracic Surgery, Harrison Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"W. M. Measey Professor, Chief,\n        Thrombosis Research Center and the Hematology-Oncology Sections and Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. W. Colman","raw_affiliation_strings":["W. M. Measey Professor, Chief,\n        Division of Cardiothoracic Surgery, Harrison Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA","W. M. Measey Professor, Chief,\n        Thrombosis Research Center and the Hematology-Oncology Sections and Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. M. Measey Professor, Chief,\n        Division of Cardiothoracic Surgery, Harrison Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"W. M. Measey Professor, Chief,\n        Thrombosis Research Center and the Hematology-Oncology Sections and Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023230653","display_name":"Stefan Niewiarowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Niewiarowski","raw_affiliation_strings":["W. M. Measey Professor, Chief,\n        Division of Cardiothoracic Surgery, Harrison Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA","W. M. Measey Professor, Chief,\n        Thrombosis Research Center and the Hematology-Oncology Sections and Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. M. Measey Professor, Chief,\n        Division of Cardiothoracic Surgery, Harrison Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"W. M. Measey Professor, Chief,\n        Thrombosis Research Center and the Hematology-Oncology Sections and Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61809045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"27","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.08540000021457672,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9660000205039978},{"id":"https://openalex.org/keywords/extracorporeal-circulation","display_name":"extracorporeal circulation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/nonthrombogenic-surfaces","display_name":"nonthrombogenic surfaces","score":0.8730000257492065},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/blood-activation","display_name":"blood activation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.8683712482452393},{"id":"https://openalex.org/C2994232697","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal circulation","level":2,"score":0.6612310409545898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5048542618751526},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40864866971969604},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35903310775756836},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.28349190950393677}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-662-06119-0_4","doi":"https://doi.org/10.1007/978-3-662-06119-0_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-662-06119-0_4","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Use in Cardiac Surgery","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W12076958","https://openalex.org/W29667720","https://openalex.org/W31130990","https://openalex.org/W81640836","https://openalex.org/W100957145","https://openalex.org/W106670602","https://openalex.org/W224814214","https://openalex.org/W245119220","https://openalex.org/W630894473","https://openalex.org/W1483858132","https://openalex.org/W1525916153","https://openalex.org/W1532942777","https://openalex.org/W1538887755","https://openalex.org/W1555943967","https://openalex.org/W1557125148","https://openalex.org/W1569353770","https://openalex.org/W1569569492","https://openalex.org/W1599472569","https://openalex.org/W1599568592","https://openalex.org/W1963680493","https://openalex.org/W1965887484","https://openalex.org/W1970913336","https://openalex.org/W1976257261","https://openalex.org/W1978240058","https://openalex.org/W1980577220","https://openalex.org/W1985334666","https://openalex.org/W1986577399","https://openalex.org/W1988706691","https://openalex.org/W1994610964","https://openalex.org/W2019554080","https://openalex.org/W2036688878","https://openalex.org/W2041118362","https://openalex.org/W2043032770","https://openalex.org/W2052506903","https://openalex.org/W2055474534","https://openalex.org/W2056103155","https://openalex.org/W2059659031","https://openalex.org/W2063567752","https://openalex.org/W2064100323","https://openalex.org/W2069507071","https://openalex.org/W2072523014","https://openalex.org/W2073693267","https://openalex.org/W2075296811","https://openalex.org/W2082724742","https://openalex.org/W2091813106","https://openalex.org/W2092079486","https://openalex.org/W2121820707","https://openalex.org/W2146800979","https://openalex.org/W2152670226","https://openalex.org/W2170684533","https://openalex.org/W2174934515","https://openalex.org/W2188674398","https://openalex.org/W2197890368","https://openalex.org/W2317906013","https://openalex.org/W2330568965","https://openalex.org/W2338341558","https://openalex.org/W2341630418","https://openalex.org/W2396020067","https://openalex.org/W2398177205","https://openalex.org/W2401219762","https://openalex.org/W2409351365","https://openalex.org/W2409923453","https://openalex.org/W2411298912","https://openalex.org/W2415472575","https://openalex.org/W2417412324","https://openalex.org/W2417677669","https://openalex.org/W2417693740","https://openalex.org/W2422261067","https://openalex.org/W2432443528","https://openalex.org/W2435303346","https://openalex.org/W2441626675","https://openalex.org/W2467467260","https://openalex.org/W4205689766","https://openalex.org/W4293504266","https://openalex.org/W4323874325"],"related_works":["https://openalex.org/W2124162052","https://openalex.org/W2113219259","https://openalex.org/W2002136487","https://openalex.org/W2419273333","https://openalex.org/W2569429977","https://openalex.org/W2062022782","https://openalex.org/W2132051224","https://openalex.org/W2006647527","https://openalex.org/W2150642144","https://openalex.org/W3021884254"],"abstract_inverted_index":{"Approximately":[0],"15":[1],"years":[2],"ago,":[3],"we":[4,88],"began":[5],"to":[6,10,20,73,154],"investigate":[7],"what":[8,163],"happens":[9],"blood":[11,47,102,117],"during":[12,119,166],"extracorporeal":[13],"circulation.":[14],"We":[15,59],"were":[16,172],"discouraged":[17],"by":[18,55,108,174,178],"attempts":[19],"develop":[21],"a":[22,40,65],"nonthrombogenic":[23,67],"synthetic":[24],"surface":[25,42,68,109],"and":[26,49,71,134,157,176,185],"observed":[27],"that":[28,61,94,104],"only":[29],"the":[30,51,76,80,84,98,126,131,135,151,179,186,192],"endothelial":[31],"cell":[32],"possesses":[33],"this":[34,155],"attribute":[35],"[50].":[36],"Endothelial":[37],"cells":[38],"have":[39],"vast":[41],"area":[43],"in":[44],"contact":[45,110],"with":[46,141],"[51]":[48],"achieve":[50],"property":[52],"of":[53,64,79,97,101,116,128,150,162],"nonthrombogenicity":[54],"active":[56],"metabolic":[57],"processes.":[58],"concluded":[60],"short-term":[62],"development":[63],"synthetic,":[66],"was":[69],"unlikely,":[70],"decided":[72],"look":[74],"at":[75],"other":[77],"side":[78],"blood-surface":[81],"relationship.":[82],"Over":[83],"next":[85],"10":[86],"years,":[87],"presented":[89],"evidence":[90],"supporting":[91],"our":[92,159],"hypothesis":[93,156],"complete":[95],"inhibition":[96],"initial":[99],"reactions":[100,115],"constituents":[103],"are":[105],"activated":[106],"directly":[107],"will":[111,147],"prevent":[112],"all":[113],"subsequent":[114],"elements":[118],"cardiopulmonary":[120,143,168],"bypass":[121],"[31].":[122],"This":[123,145,181],"strategy":[124],"offers":[125],"possibility":[127],"controlling":[129],"both":[130],"bleeding":[132],"problems":[133],"\u201cwhole":[136],"body":[137],"inflammatory":[138],"response\u201d":[139],"associated":[140],"clinical":[142,167],"bypass.":[144,169],"\u201coverview\u201d":[146],"summarize":[148],"some":[149],"data":[152],"relevant":[153],"present":[158],"current":[160],"concept":[161],"is":[164,183],"happening":[165],"These":[170],"keywords":[171,187],"added":[173],"machine":[175],"not":[177],"authors.":[180],"process":[182],"experimental":[184],"may":[188],"be":[189],"updated":[190],"as":[191],"learning":[193],"algorithm":[194],"improves.":[195]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-02-13T00:00:00"}
