{"id":"https://openalex.org/W4211255495","doi":"https://doi.org/10.1016/j.isci.2022.103772","title":"Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia","display_name":"Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia","publication_year":2022,"publication_date":"2022-01-15","ids":{"openalex":"https://openalex.org/W4211255495","doi":"https://doi.org/10.1016/j.isci.2022.103772","pmid":"https://pubmed.ncbi.nlm.nih.gov/35141508","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8814755"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2022.103772","doi":"https://doi.org/10.1016/j.isci.2022.103772","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.103772","pdf_url":"http://www.cell.com/article/S2589004222000426/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2589004222000426/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101800884","display_name":"Brian Li","orcid":"https://orcid.org/0000-0002-1970-0272","observed_orcids":["https://orcid.org/0000-0002-1970-0272"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Li","raw_affiliation_strings":["UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA"],"raw_orcid":"https://orcid.org/0000-0002-1970-0272","affiliations":[{"raw_affiliation_string":"UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005088750","display_name":"Annie Maslan","orcid":"https://orcid.org/0000-0002-0928-3399","observed_orcids":["https://orcid.org/0000-0002-0928-3399"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annie Maslan","raw_affiliation_strings":["UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013991863","display_name":"Sean E. Kitayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean E. Kitayama","raw_affiliation_strings":["UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051679816","display_name":"Corinne Pierce","orcid":"https://orcid.org/0000-0003-2035-7552","observed_orcids":["https://orcid.org/0000-0003-2035-7552"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinne Pierce","raw_affiliation_strings":["Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064329611","display_name":"Aaron Streets","orcid":"https://orcid.org/0000-0002-3909-8389","observed_orcids":["https://orcid.org/0000-0002-3909-8389"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron M. Streets","raw_affiliation_strings":["Center for Computational Biology, University of California, Berkeley, CA 94709, USA","Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA","UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology, University of California, Berkeley, CA 94709, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063994602","display_name":"Lydia Lee Sohn","orcid":"https://orcid.org/0000-0003-2195-2521","observed_orcids":["https://orcid.org/0000-0003-2195-2521"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lydia L. Sohn","raw_affiliation_strings":["Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA","UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA"],"raw_orcid":"https://orcid.org/0000-0003-2195-2521","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94709, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063994602"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.0664,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.69458853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"2","first_page":"103772","last_page":"103772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.13199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid-resistance","display_name":"all-trans retinoic acid resistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cell-mechanics","display_name":"cell mechanics","score":0.906000018119812},{"id":"https://openalex.org/keywords/nuclear-mechanics","display_name":"nuclear mechanics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/chromatin-decondensation","display_name":"chromatin decondensation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.9950000047683716},{"id":"https://openalex.org/keywords/transcriptomic-changes","display_name":"transcriptomic changes","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.7465595006942749},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7213858366012573},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5987058877944946},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.5401334762573242},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4607139527797699},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4572013318538666},{"id":"https://openalex.org/C111441629","wikidata":"https://www.wikidata.org/wiki/Q18030615","display_name":"Promyelocytic leukemia protein","level":5,"score":0.4553722143173218},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4324977993965149},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.41381531953811646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3968627452850342},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3678061366081238},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.36659640073776245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.359072208404541},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.24456575512886047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21943369507789612},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21064338088035583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20106303691864014},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.19591960310935974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18654021620750427}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.isci.2022.103772","doi":"https://doi.org/10.1016/j.isci.2022.103772","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.103772","pdf_url":"http://www.cell.com/article/S2589004222000426/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.1101/2021.04.25.441378","doi":"https://doi.org/10.1101/2021.04.25.441378","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.04.25.441378","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/29/2021.04.25.441378.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8814755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8814755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:35141508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35141508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2841ba555add4e0091d595e04d74d677","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2841ba555add4e0091d595e04d74d677","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 25, Iss 2, Pp 103772- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2022.103772","doi":"https://doi.org/10.1016/j.isci.2022.103772","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.103772","pdf_url":"http://www.cell.com/article/S2589004222000426/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7235929600","display_name":"Stem Cell Biological Engineering Training Program","funder_award_id":"T32GM098218","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8972933196","display_name":"A Label-Free, Point-of-Care Platform to Diagnose Acute Promyelocytic Leukemia","funder_award_id":"R01CA190843","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309411","display_name":"University of California Berkeley","ror":"https://ror.org/01an7q238"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4211255495.pdf","grobid_xml":"https://content.openalex.org/works/W4211255495.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W182996286","https://openalex.org/W1516721790","https://openalex.org/W1531899330","https://openalex.org/W1557102547","https://openalex.org/W1589900156","https://openalex.org/W1927734345","https://openalex.org/W1967555932","https://openalex.org/W1972554719","https://openalex.org/W1973094248","https://openalex.org/W1984887826","https://openalex.org/W1987176851","https://openalex.org/W1991811857","https://openalex.org/W1995369623","https://openalex.org/W1996523330","https://openalex.org/W2006073003","https://openalex.org/W2010457001","https://openalex.org/W2011233324","https://openalex.org/W2015383096","https://openalex.org/W2016983464","https://openalex.org/W2018366980","https://openalex.org/W2023422490","https://openalex.org/W2027085235","https://openalex.org/W2032853423","https://openalex.org/W2034660092","https://openalex.org/W2043226662","https://openalex.org/W2043947252","https://openalex.org/W2050895547","https://openalex.org/W2072548585","https://openalex.org/W2073441848","https://openalex.org/W2077872976","https://openalex.org/W2085083114","https://openalex.org/W2090588873","https://openalex.org/W2093481931","https://openalex.org/W2094153893","https://openalex.org/W2095192232","https://openalex.org/W2096069292","https://openalex.org/W2097948046","https://openalex.org/W2100250094","https://openalex.org/W2101234009","https://openalex.org/W2110344693","https://openalex.org/W2113811443","https://openalex.org/W2114104545","https://openalex.org/W2116269551","https://openalex.org/W2119733997","https://openalex.org/W2123106337","https://openalex.org/W2124633704","https://openalex.org/W2125848058","https://openalex.org/W2126398084","https://openalex.org/W2130116522","https://openalex.org/W2130410032","https://openalex.org/W2131554707","https://openalex.org/W2132917470","https://openalex.org/W2137526110","https://openalex.org/W2138402450","https://openalex.org/W2146512944","https://openalex.org/W2148454908","https://openalex.org/W2154465669","https://openalex.org/W2158333823","https://openalex.org/W2159675211","https://openalex.org/W2170755361","https://openalex.org/W2197124664","https://openalex.org/W2276640786","https://openalex.org/W2288929640","https://openalex.org/W2334200141","https://openalex.org/W2526835542","https://openalex.org/W2530955838","https://openalex.org/W2571383784","https://openalex.org/W2592811885","https://openalex.org/W2621098621","https://openalex.org/W2755023008","https://openalex.org/W2765387868","https://openalex.org/W2765510117","https://openalex.org/W2787698240","https://openalex.org/W2792087335","https://openalex.org/W2799917713","https://openalex.org/W2800947875","https://openalex.org/W2805207307","https://openalex.org/W2883214832","https://openalex.org/W2913011480","https://openalex.org/W2913938658","https://openalex.org/W2951871640","https://openalex.org/W2965924975","https://openalex.org/W2979672689","https://openalex.org/W2997591727","https://openalex.org/W3035560027","https://openalex.org/W3037065298","https://openalex.org/W3092523002","https://openalex.org/W3113128990","https://openalex.org/W4237403594","https://openalex.org/W4247425028"],"related_works":["https://openalex.org/W2074858197","https://openalex.org/W2997326723","https://openalex.org/W2093481931","https://openalex.org/W2398984789","https://openalex.org/W7099939753","https://openalex.org/W4366827712","https://openalex.org/W3029232340","https://openalex.org/W298378544","https://openalex.org/W2047868757","https://openalex.org/W2532037357"],"abstract_inverted_index":{"Abstract":[0],"While":[1],"all-trans":[2],"retinoic":[3],"acid":[4],"(ATRA)":[5],"is":[6,153],"an":[7,18,103],"essential":[8],"therapy":[9],"in":[10,112,116,156,195],"the":[11,117,166,190],"treatment":[12],"of":[13,21,27,88,192],"acute":[14,22],"promyelocytic":[15],"leukemia":[16],"(APL),":[17],"aggressive":[19],"subtype":[20],"myeloid":[23],"leukemia,":[24],"nearly":[25],"20%":[26],"APL":[28,64,76,89,104,110,159,173,197],"patients":[29],"are":[30,78],"resistant":[31],"to":[32,92,124,128,133,164],"ATRA.":[33],"As":[34],"no":[35],"biomarkers":[36,194],"for":[37],"ATRA":[38],"resistance":[39],"yet":[40],"exist,":[41],"we":[42,72,96,120,139,188],"investigated":[43],"whether":[44],"cell":[45,65,118,122,137],"mechanics":[46,100],"could":[47,181],"be":[48,125,182],"associated":[49,183],"with":[50,150,184],"this":[51],"pathological":[52],"phenotype.":[53],"Using":[54],"mechano-node-pore":[55],"sensing,":[56],"a":[57],"single-cell":[58],"mechanical":[59,94,106,185],"phenotyping":[60],"platform,":[61],"and":[62,69,171,175],"patient-derived":[63],"lines,":[66],"NB4":[67],"(ATRA-sensitive)":[68],"AP-1060":[70],"(ATRA-resistant),":[71],"discovered":[73],"that":[74,98,141,180],"ATRA-resistant":[75,158,170],"cells":[77,90,111,174],"less":[79],"mechanically":[80],"pliable.":[81],"By":[82,108],"investigating":[83],"how":[84],"different":[85],"subcellular":[86],"components":[87],"contribute":[91],"whole-cell":[93],"phenotype,":[95],"determined":[97],"nuclear":[99,146],"strongly":[101],"influence":[102],"cell\u2019s":[105],"response.":[107],"arresting":[109],"S-phase":[113],"or":[114],"M-phase":[115],"cycle,":[119],"found":[121],"pliability":[123],"inversely":[126],"related":[127],"DNA":[129,134],"content.":[130],"In":[131],"addition":[132],"content":[135],"affecting":[136],"pliability,":[138],"observed":[140],"chromatin":[142,149],"condensation":[143],"also":[144],"affects":[145],"mechanics:":[147],"decondensing":[148],"trichostatin":[151],"A":[152],"especially":[154],"effective":[155],"softening":[157],"cells.":[160],"RNA-Seq":[161],"allowed":[162],"us":[163],"compare":[165],"transcriptomic":[167],"differences":[168],"between":[169],"ATRA-responsive":[172],"highlighted":[176],"gene":[177],"expression":[178],"changes":[179],"changes.":[186],"Overall,":[187],"demonstrate":[189],"potential":[191],"\u201cphysical\u201d":[193],"identifying":[196],"resistance.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-02-13T00:00:00"}