{"id":"https://openalex.org/W4211237888","doi":"https://doi.org/10.1016/j.bpj.2021.11.249","title":"Structural insight of the proton-activated chloride (PAC) channel revealed by cryo-EM","display_name":"Structural insight of the proton-activated chloride (PAC) channel revealed by cryo-EM","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4211237888","doi":"https://doi.org/10.1016/j.bpj.2021.11.249"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2021.11.249","doi":"https://doi.org/10.1016/j.bpj.2021.11.249","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2021.11.249","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bpj.2021.11.249","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071263487","display_name":"Zheng Ruan","orcid":"https://orcid.org/0000-0002-4412-4916","observed_orcids":["https://orcid.org/0000-0002-4412-4916"]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Ruan","raw_affiliation_strings":["Van Andel Institute, Grand Rapids, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI, USA","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019984785","display_name":"James Osei\u2010Owusu","orcid":"https://orcid.org/0000-0002-8676-4444","observed_orcids":["https://orcid.org/0000-0002-8676-4444"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Osei-Owusu","raw_affiliation_strings":["School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009342054","display_name":"Juan Du","orcid":"https://orcid.org/0000-0003-1467-1203","observed_orcids":["https://orcid.org/0000-0003-1467-1203"]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Du","raw_affiliation_strings":["Van Andel Institute, Grand Rapids, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI, USA","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091463065","display_name":"Zhaozhu Qiu","orcid":"https://orcid.org/0000-0002-9122-6077","observed_orcids":["https://orcid.org/0000-0002-9122-6077"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaozhu Qiu","raw_affiliation_strings":["School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100673141","display_name":"Wei L\u00fc","orcid":"https://orcid.org/0000-0002-3009-1025","observed_orcids":["https://orcid.org/0000-0002-3009-1025"]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei L\u00fc","raw_affiliation_strings":["Van Andel Institute, Grand Rapids, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI, USA","institution_ids":["https://openalex.org/I1317189400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01395471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"121","issue":"3","first_page":"506a","last_page":"506a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-sensing","display_name":"pH sensing","score":0.8090000152587891},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.6660000085830688},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.7149999737739563},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.8920000195503235},{"id":"https://openalex.org/keywords/domain-swapping","display_name":"domain swapping","score":0.7070000171661377},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nanodiscs","display_name":"nanodiscs","score":0.6759999990463257},{"id":"https://openalex.org/keywords/channel-structure","display_name":"channel structure","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6997804045677185},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6596938371658325},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.550740659236908},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.5229081511497498},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5007627010345459},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.48409831523895264},{"id":"https://openalex.org/C20702342","wikidata":"https://www.wikidata.org/wiki/Q5190506","display_name":"Cryo-electron microscopy","level":2,"score":0.47900980710983276},{"id":"https://openalex.org/C2780880673","wikidata":"https://www.wikidata.org/wiki/Q6964029","display_name":"Nanodisc","level":4,"score":0.4557378888130188},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32833003997802734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2807573080062866},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.22502952814102173},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.22183647751808167},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10908147692680359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10766905546188354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06223568320274353},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2021.11.249","doi":"https://doi.org/10.1016/j.bpj.2021.11.249","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2021.11.249","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2021.11.249","doi":"https://doi.org/10.1016/j.bpj.2021.11.249","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2021.11.249","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2898415872","https://openalex.org/W2407998709","https://openalex.org/W4246977563","https://openalex.org/W2148583286","https://openalex.org/W2187298189","https://openalex.org/W161174416","https://openalex.org/W2064457055","https://openalex.org/W2911853332","https://openalex.org/W3124821739","https://openalex.org/W2585397352"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-16T18:09:00.828671","created_date":"2025-10-10T00:00:00"}