{"id":"https://openalex.org/W4211237709","doi":"https://doi.org/10.3390/vaccines10020254","title":"Safety, Immunogenicity and Lot-to-Lot Consistency of Sabin-Strain Inactivated Poliovirus Vaccine in 2-Month-Old Infants: A Double-Blind, Randomized Phase III Trial","display_name":"Safety, Immunogenicity and Lot-to-Lot Consistency of Sabin-Strain Inactivated Poliovirus Vaccine in 2-Month-Old Infants: A Double-Blind, Randomized Phase III Trial","publication_year":2022,"publication_date":"2022-02-08","ids":{"openalex":"https://openalex.org/W4211237709","doi":"https://doi.org/10.3390/vaccines10020254","pmid":"https://pubmed.ncbi.nlm.nih.gov/35214712"},"language":"en","primary_location":{"id":"doi:10.3390/vaccines10020254","doi":"https://doi.org/10.3390/vaccines10020254","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines10020254","pdf_url":"https://www.mdpi.com/2076-393X/10/2/254/pdf?version=1644311825","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-393X/10/2/254/pdf?version=1644311825","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109988926","display_name":"Yan Ping Zheng","orcid":"https://orcid.org/0009-0000-8875-5974","observed_orcids":["https://orcid.org/0009-0000-8875-5974"]},"institutions":[{"id":"https://openalex.org/I4210123555","display_name":"Yunnan Center for Disease Control And Prevention","ror":"https://ror.org/02qdc7q41","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210123555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zheng","raw_affiliation_strings":["Vaccine Clinical Research Center, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Clinical Research Center, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650034, China","institution_ids":["https://openalex.org/I4210123555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100527949","display_name":"Zhifang Ying","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifang Ying","raw_affiliation_strings":["Respiratory Virus Vaccine Department, Biological Product Institute, National Institutes for Food and Drug Control, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Virus Vaccine Department, Biological Product Institute, National Institutes for Food and Drug Control, Beijing 100050, China","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069719070","display_name":"Yanxiang Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123555","display_name":"Yunnan Center for Disease Control And Prevention","ror":"https://ror.org/02qdc7q41","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210123555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanxiang Zou","raw_affiliation_strings":["Vaccine Clinical Research Center, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Clinical Research Center, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650034, China","institution_ids":["https://openalex.org/I4210123555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091654111","display_name":"Taotao Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802239252","display_name":"Sinovac Biotech","ror":"https://ror.org/057f25d66","country_code":"CN","type":"company","lineage":["https://openalex.org/I2802239252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Taotao Zhu","raw_affiliation_strings":["Clinical Research Department, Sinovac Biotech Co., Ltd., Beijing 100089, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Department, Sinovac Biotech Co., Ltd., Beijing 100089, China","institution_ids":["https://openalex.org/I2802239252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001130266","display_name":"Dinggu Qian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dinggu Qian","raw_affiliation_strings":["Vaccine Clinical Research Project Office, Qiubei County Center for Disease Control and Prevention, Wenshan Zhuang and Miao Autonomous Prefecture 663299, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Clinical Research Project Office, Qiubei County Center for Disease Control and Prevention, Wenshan Zhuang and Miao Autonomous Prefecture 663299, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018091807","display_name":"Weixiao Han","orcid":"https://orcid.org/0000-0002-7804-3786","observed_orcids":["https://orcid.org/0000-0002-7804-3786"]},"institutions":[{"id":"https://openalex.org/I2802239252","display_name":"Sinovac Biotech","ror":"https://ror.org/057f25d66","country_code":"CN","type":"company","lineage":["https://openalex.org/I2802239252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixiao Han","raw_affiliation_strings":["Clinical Research Department, Sinovac Biotech Co., Ltd., Beijing 100089, China"],"raw_orcid":"https://orcid.org/0000-0002-7804-3786","affiliations":[{"raw_affiliation_string":"Clinical Research Department, Sinovac Biotech Co., Ltd., Beijing 100089, China","institution_ids":["https://openalex.org/I2802239252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102940463","display_name":"Ya Jiang","orcid":"https://orcid.org/0000-0002-2837-0236","observed_orcids":["https://orcid.org/0000-0002-2837-0236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya Jiang","raw_affiliation_strings":["Vaccine Clinical Research Project Office, Mile County Center for Disease Control and Prevention, Honghe Hani and Yi Autonomous Prefecture 652399, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Clinical Research Project Office, Mile County Center for Disease Control and Prevention, Honghe Hani and Yi Autonomous Prefecture 652399, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110157918","display_name":"Zhiwei Jiang","orcid":"https://orcid.org/0000-0002-7646-8238","observed_orcids":["https://orcid.org/0000-0002-7646-8238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiwei Jiang","raw_affiliation_strings":["Statistics Department, Beijing Key Tech Statistical Consulting Co., Ltd., Beijing 100025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics Department, Beijing Key Tech Statistical Consulting Co., Ltd., Beijing 100025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103124681","display_name":"Xingyan Li","orcid":"https://orcid.org/0000-0002-7831-7169","observed_orcids":["https://orcid.org/0000-0002-7831-7169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingyan Li","raw_affiliation_strings":["Division of Acute Infectious Disease Control and Prevention, Yanshan County Center for Disease Control and Prevention, Wenshan Zhuang and Miao Autonomous Prefecture 663299, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Acute Infectious Disease Control and Prevention, Yanshan County Center for Disease Control and Prevention, Wenshan Zhuang and Miao Autonomous Prefecture 663299, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115694733","display_name":"Jianfeng Wang","orcid":"https://orcid.org/0009-0004-4376-7786","observed_orcids":["https://orcid.org/0009-0004-4376-7786","https://orcid.org/0000-0002-4407-4891"]},"institutions":[{"id":"https://openalex.org/I2802239252","display_name":"Sinovac Biotech","ror":"https://ror.org/057f25d66","country_code":"CN","type":"company","lineage":["https://openalex.org/I2802239252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng Wang","raw_affiliation_strings":["Clinical Research Department, Sinovac Biotech Co., Ltd., Beijing 100089, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Department, Sinovac Biotech Co., Ltd., Beijing 100089, China","institution_ids":["https://openalex.org/I2802239252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100867107","display_name":"Lei Jin","orcid":"https://orcid.org/0009-0007-2075-8723","observed_orcids":["https://orcid.org/0009-0007-2075-8723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Lei","raw_affiliation_strings":["Immunization Program Division, Gejiu County Center for Disease Control and Prevention, Honghe Hani and Yi Autonomous Prefecture 661099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunization Program Division, Gejiu County Center for Disease Control and Prevention, Honghe Hani and Yi Autonomous Prefecture 661099, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802239252","display_name":"Sinovac Biotech","ror":"https://ror.org/057f25d66","country_code":"CN","type":"company","lineage":["https://openalex.org/I2802239252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Xu","raw_affiliation_strings":["Quality Assurance Department, Sinovac Biotech Co., Ltd., Beijing 100089, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quality Assurance Department, Sinovac Biotech Co., Ltd., Beijing 100089, China","institution_ids":["https://openalex.org/I2802239252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102952645","display_name":"Deyu Jiang","orcid":"https://orcid.org/0009-0003-4796-881X","observed_orcids":["https://orcid.org/0009-0003-4796-881X"]},"institutions":[{"id":"https://openalex.org/I2802239252","display_name":"Sinovac Biotech","ror":"https://ror.org/057f25d66","country_code":"CN","type":"company","lineage":["https://openalex.org/I2802239252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deyu Jiang","raw_affiliation_strings":["R&D Department, Sinovac Life Sciences Co., Ltd., Beijing 102629, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Department, Sinovac Life Sciences Co., Ltd., Beijing 102629, China","institution_ids":["https://openalex.org/I2802239252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043859457","display_name":"Changgui Li","orcid":"https://orcid.org/0000-0002-9660-0216","observed_orcids":["https://orcid.org/0000-0002-9660-0216","https://orcid.org/0000-0002-4622-3731"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changgui Li","raw_affiliation_strings":["Respiratory Virus Vaccine Department, Biological Product Institute, National Institutes for Food and Drug Control, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Virus Vaccine Department, Biological Product Institute, National Institutes for Food and Drug Control, Beijing 100050, China","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100334297","display_name":"Xiaoqiang Liu","orcid":"https://orcid.org/0000-0002-6150-2296","observed_orcids":["https://orcid.org/0000-0002-6150-2296"]},"institutions":[{"id":"https://openalex.org/I4210123555","display_name":"Yunnan Center for Disease Control And Prevention","ror":"https://ror.org/02qdc7q41","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210123555"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoqiang Liu","raw_affiliation_strings":["Vaccine Clinical Research Center, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Clinical Research Center, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650034, China","institution_ids":["https://openalex.org/I4210123555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100334297"],"corresponding_institution_ids":["https://openalex.org/I4210123555"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":0.6207,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67172571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"2","first_page":"254","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-polio-vaccine","display_name":"oral polio vaccine","score":0.7789999842643738},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.6370000243186951},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/lot-to-lot-consistency","display_name":"lot-to-lot consistency","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.7329999804496765},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8169999718666077},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.8080000281333923},{"id":"https://openalex.org/keywords/inactivated-poliovirus-vaccine","display_name":"inactivated poliovirus vaccine","score":0.7450000047683716},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8320000171661377},{"id":"https://openalex.org/keywords/polio-eradication","display_name":"polio eradication","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.8675205111503601},{"id":"https://openalex.org/C2779631682","wikidata":"https://www.wikidata.org/wiki/Q12438936","display_name":"Poliovirus","level":3,"score":0.7776827812194824},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7712928652763367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.764230489730835},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6038293838500977},{"id":"https://openalex.org/C4870876","wikidata":"https://www.wikidata.org/wiki/Q12195","display_name":"Poliomyelitis","level":2,"score":0.5443082451820374},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5127507448196411},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5028106570243835},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4865264296531677},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4289607107639313},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40773338079452515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3041187524795532},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2569073438644409},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22786006331443787},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1289440095424652},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10306549072265625}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/vaccines10020254","doi":"https://doi.org/10.3390/vaccines10020254","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines10020254","pdf_url":"https://www.mdpi.com/2076-393X/10/2/254/pdf?version=1644311825","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},{"id":"pmid:35214712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35214712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8879689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8879689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8f03e541be8c4179b419867d0315f6a2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f03e541be8c4179b419867d0315f6a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, Vol 10, Iss 2, p 254 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/vaccines10020254","doi":"https://doi.org/10.3390/vaccines10020254","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines10020254","pdf_url":"https://www.mdpi.com/2076-393X/10/2/254/pdf?version=1644311825","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.5699999928474426}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4211237709.pdf","grobid_xml":"https://content.openalex.org/works/W4211237709.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W128097364","https://openalex.org/W1979435678","https://openalex.org/W1994026293","https://openalex.org/W2041666158","https://openalex.org/W2056791802","https://openalex.org/W2097965467","https://openalex.org/W2103683759","https://openalex.org/W2115083851","https://openalex.org/W2142317414","https://openalex.org/W2314346321","https://openalex.org/W2461316297","https://openalex.org/W2510158554","https://openalex.org/W2528420611","https://openalex.org/W2753706058","https://openalex.org/W2782457156","https://openalex.org/W2890655773","https://openalex.org/W2913388203","https://openalex.org/W2938007286","https://openalex.org/W3153133659","https://openalex.org/W4200279093","https://openalex.org/W4231936662","https://openalex.org/W4235592968","https://openalex.org/W6804897919"],"related_works":["https://openalex.org/W1647607420","https://openalex.org/W2413643813","https://openalex.org/W2052413804","https://openalex.org/W1964807141","https://openalex.org/W1969304824","https://openalex.org/W1988605508","https://openalex.org/W2356105321","https://openalex.org/W2110324600","https://openalex.org/W2371208792","https://openalex.org/W982014063"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,149,185,235,283],"Sabin-strain-based":[2],"inactivated":[3],"poliovirus":[4,190,219],"vaccine":[5],"(sIPV)":[6],"plays":[7],"an":[8],"important":[9],"role":[10],"in":[11,14,40,53,64,145,152,246,263],"poliomyelitis":[12],"eradication":[13],"developing":[15],"countries.":[16],"As":[17],"part":[18],"of":[19,37,71,75,88,105,156,187,196,199,218,237,257,276,287,296],"the":[20,31,38,72,76,79,95,102,109,133,140,146,153,157,209,215,225,232,247,252,288,297],"phase":[21,47],"III":[22],"clinical":[23],"development":[24],"program,":[25],"this":[26],"study":[27,141],"aimed":[28],"to":[29,61,68,107,231,261,294],"evaluate":[30],"safety,":[32],"immunogenicity":[33],"and":[34,85,98,113,121,142,162,170,176,179,194,205,223,239,251,255,280,285,292],"lot-to-lot":[35],"consistency":[36],"sIPV":[39,77,158,227,249,277,289],"2-month-old":[41],"infants.":[42],"METHOD:":[43],"We":[44],"conducted":[45],"a":[46,65],"III,":[48],"randomized,":[49],"double-blind,":[50],"positive-controlled":[51],"trial":[52],"which":[54],"1300":[55,134],"healthy":[56],"infants":[57,138],"were":[58,92,116,143,159,201,259,270],"randomly":[59],"assigned":[60],"four":[62],"groups":[63],"1:1:1:1":[66],"ratio":[67],"receive":[69],"one":[70],"three":[73,154],"lots":[74,155,200,250,275],"or":[78],"control":[80],"IPV":[81,233,253],"at":[82],"2,":[83],"3":[84,195],"4":[86],"months":[87],"age.":[89],"Serum":[90],"samples":[91],"collected":[93],"before":[94],"first":[96],"dose":[97,104],"30":[99,126],"days":[100,120,127],"after":[101,128],"third":[103],"vaccination":[106],"assess":[108],"immunogenicity.":[110,282],"Solicited":[111],"local":[112],"systemic":[114],"reactions":[115,242],"recorded":[117],"within":[118,125],"7":[119],"unsolicited":[122,240],"adverse":[123,241,267],"events":[124,268],"each":[129,197],"vaccination.":[130],"RESULTS:":[131],"Of":[132],"randomized":[135],"infants,":[136],"1190":[137],"completed":[139],"included":[144],"per-protocol":[147],"population.":[148],"seroconversion":[150,216],"rates":[151],"95.67%,":[160],"97.03%":[161],"95.59%,":[163],"respectively,":[164,172,181],"for":[165,173,182,189],"type":[166,174,183],"1;":[167],"94.33%,":[168],"93.73%":[169],"92.88%,":[171],"2;":[175],"98.67%,":[177],"99.67%":[178],"99.32%,":[180],"3.":[184],"ratios":[186],"GMTs":[188],"types":[191,220],"1,":[192,221],"2":[193,222],"pair":[198],"all":[202],"between":[203],"0.67":[204],"1.50,":[206],"therefore":[207],"meeting":[208],"predefined":[210],"immunological":[211],"equivalence":[212],"criteria.":[213],"For":[214],"rate":[217],"3,":[224],"pooled":[226,248],"group":[228],"was":[229,244,290],"non-inferior":[230],"group.":[234],"incidence":[236],"solicited":[238],"(ARs)":[243],"similar":[245,293],"group,":[254],"most":[256],"them":[258],"mild":[260],"moderate":[262],"severity.":[264],"Non-vaccine-related":[265],"serious":[266],"(SAEs)":[269],"reported.":[271],"CONCLUSIONS:":[272],"Three":[273],"consecutive":[274],"demonstrated":[278],"robust":[279],"consistent":[281],"safety":[284],"tolerability":[286],"acceptable":[291],"that":[295],"IPV.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}