{"id":"https://openalex.org/W4211237402","doi":"https://doi.org/10.52711/0974-360x.2022.00038","title":"Formulation and Evaluation of Lamotrigine Loaded Nanosponges","display_name":"Formulation and Evaluation of Lamotrigine Loaded Nanosponges","publication_year":2022,"publication_date":"2022-01-25","ids":{"openalex":"https://openalex.org/W4211237402","doi":"https://doi.org/10.52711/0974-360x.2022.00038"},"language":"en","primary_location":{"id":"doi:10.52711/0974-360x.2022.00038","doi":"https://doi.org/10.52711/0974-360x.2022.00038","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2022.00038","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091588104","display_name":"Tarun Kumar Satpathy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tarun Kumar Satpathy","raw_affiliation_strings":["College of pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore MP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore MP, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091803160","display_name":"Neelesh Chaubey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neelesh Chaubey","raw_affiliation_strings":["College of pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore MP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore MP, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112297521","display_name":"Chandan Kumar Brahma","orcid":"https://orcid.org/0009-0007-3928-6287","observed_orcids":["https://orcid.org/0009-0007-3928-6287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chandan Kumar Brahma","raw_affiliation_strings":["Department of Pharmaceutical Technology, KJR College of Pharmacy, Rajahmundry, A.P., India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, KJR College of Pharmacy, Rajahmundry, A.P., India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042999070","display_name":"Mittal Maheshwari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mittal Maheshwari","raw_affiliation_strings":["A-One Pharmacy College, SNME Campus, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A-One Pharmacy College, SNME Campus, Ahmedabad, Gujarat, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6767,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.59164084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"229","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanosponges","display_name":"nanosponges","score":0.9810000061988831},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8289999961853027},{"id":"https://openalex.org/keywords/emulsion-solvent-diffusion","display_name":"emulsion solvent diffusion","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ethylcellulose","display_name":"ethyl cellulose","score":0.9190000295639038},{"id":"https://openalex.org/keywords/polyvinyl-alcohol","display_name":"polyvinyl alcohol","score":0.996999979019165},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9129999876022339},{"id":"https://openalex.org/keywords/drug-solubility-enhancement","display_name":"drug solubility enhancement","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.8080000281333923},{"id":"https://openalex.org/keywords/immediate-release-tablets","display_name":"immediate release tablets","score":0.890999972820282},{"id":"https://openalex.org/keywords/higuchi-kinetics","display_name":"Higuchi model","score":0.7239999771118164},{"id":"https://openalex.org/keywords/bcs-class-ii","display_name":"BCS class II","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.6810526251792908},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6595349311828613},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.6305860280990601},{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.6300378441810608},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.613526463508606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.542325496673584},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3891708254814148},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.38672569394111633},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3739436864852905},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35953059792518616},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2024427056312561},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.054069340229034424},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52711/0974-360x.2022.00038","doi":"https://doi.org/10.52711/0974-360x.2022.00038","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2022.00038","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W632623301","https://openalex.org/W1987634822","https://openalex.org/W2057782877","https://openalex.org/W2170973317","https://openalex.org/W2181708217","https://openalex.org/W2184701833","https://openalex.org/W2256975934","https://openalex.org/W2271962423","https://openalex.org/W2767225452","https://openalex.org/W2805393837","https://openalex.org/W2876413351","https://openalex.org/W2888601248","https://openalex.org/W2921529823","https://openalex.org/W2924776764","https://openalex.org/W2991745713","https://openalex.org/W3045880970","https://openalex.org/W3045926844","https://openalex.org/W3046033149","https://openalex.org/W3081056934","https://openalex.org/W3081431072","https://openalex.org/W4256696864"],"related_works":["https://openalex.org/W2413698536","https://openalex.org/W2205976252","https://openalex.org/W195571679","https://openalex.org/W1984774530","https://openalex.org/W2530563462","https://openalex.org/W4300293002","https://openalex.org/W2063960875","https://openalex.org/W2041089713","https://openalex.org/W2133269645","https://openalex.org/W2343833623"],"abstract_inverted_index":{"The":[0,75,95,125,140,184],"main":[1],"purpose":[2],"of":[3,17,26,32,55,81,93,98,129,156,169,193],"this":[4,208],"investigation":[5],"study":[6],"is":[7],"to":[8,19,36],"fabricate":[9],"nanosponges":[10,42,57,97],"with":[11,153,204],"good":[12],"entrapment":[13,89],"efficiency":[14,90],"and":[15,23,50,73,85,91,121,176,195,201,211],"percentage":[16,92],"yield":[18],"enhance":[20],"the":[21,51,170,191],"solubility":[22,210],"dissolution":[24,142,194,212],"rate":[25],"poorly":[27],"water":[28],"soluble":[29],"antiepileptic":[30],"molecules":[31],"Lamotrigine,":[33],"which":[34],"belongs":[35],"BCS":[37],"-":[38],"II":[39,150],"class.":[40],"Lamotrigine":[41],"were":[43,58,65,101,137,173],"prepared":[44,59],"using":[45,67],"emulsion":[46],"solvent":[47],"diffusion":[48],"technique":[49],"immediate":[52,132],"release":[53,133],"tablets":[54,134],"lamotrigine":[56,99,186],"by":[60,146],"direct":[61],"compression":[62,135],"method.":[63],"Nanosponges":[64],"formulated":[66],"different":[68],"polymers":[69],"ratio":[70,79],"like":[71],"EC":[72],"PVA.":[74],"optimized":[76,96,126],"batch":[77],"containing":[78],"2:1:2":[80],"drug,":[82],"ethyl":[83],"cellulose":[84],"PVA":[86],"shows":[87,188],"maximum":[88],"yield.":[94],"(F1)":[100,128],"subjected":[102],"for":[103,214],"Practical":[104],"yield,":[105],"drug":[106],"content,":[107],"Saturation":[108],"solubility,":[109],"zeta":[110],"potential,":[111],"Fourier":[112],"transform":[113],"Infrared":[114],"spectroscopy":[115],"(FTIR),":[116],"Differential":[117],"Scanning":[118,122],"Calorimetry":[119],"(DSC)":[120],"electron":[123],"microscopy(SEM).":[124],"formulations":[127],"nanosponge":[130,187,215],"based":[131],"parameters":[136],"also":[138],"studied.":[139],"In-vitro":[141],"was":[143],"carried":[144],"out":[145],"USP":[147],"apparatus":[148],"type":[149],"(Paddle":[151],"Method)":[152],"900":[154],"ml":[155,168],"0.1":[157],"N":[158],"HCl":[159],"at":[160,179,190],"50":[161],"rpm.":[162],"At":[163],"definite":[164],"time":[165],"intervals,":[166],"5":[167],"receptor":[171],"fluid":[172],"withdrawn,":[174],"filtered":[175],"analyzed":[177],"spectro-photometrically":[178],"wave":[180],"length":[181],"265":[182],"nm.":[183],"compressed":[185],"99.7%":[189],"end":[192],"it":[196],"follows":[197],"first":[198],"order":[199],"kinetics":[200],"best":[202],"fit":[203],"Higuchi\u2019s":[205],"model.":[206],"In":[207],"research":[209],"demonstrated":[213],"formulation.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}