{"id":"https://openalex.org/W4211097010","doi":"https://doi.org/10.26226/morressier.5731a408d462b8028d88c9fe","title":"Transdermal estrogen prevents cyclically-recurrent genital herpes","display_name":"Transdermal estrogen prevents cyclically-recurrent genital herpes","publication_year":2016,"publication_date":"2016-06-30","ids":{"openalex":"https://openalex.org/W4211097010","doi":"https://doi.org/10.26226/morressier.5731a408d462b8028d88c9fe"},"language":"en","primary_location":{"id":"doi:10.26226/morressier.5731a408d462b8028d88c9fe","doi":"https://doi.org/10.26226/morressier.5731a408d462b8028d88c9fe","is_oa":false,"landing_page_url":"https://doi.org/10.26226/morressier.5731a408d462b8028d88c9fe","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://openresearchlibrary.org/viewer/4a1a042c-781e-4ded-89b5-88ae9b8c3fe5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001753218","display_name":"Peter Greenhouse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter Greenhouse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001753218"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-estradiol","display_name":"transdermal estradiol","score":0.875},{"id":"https://openalex.org/keywords/genital-herpes","display_name":"genital herpes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/premenstrual-syndrome","display_name":"premenstrual syndrome","score":0.8460000157356262},{"id":"https://openalex.org/keywords/perimenopause","display_name":"perimenopause","score":0.8149999976158142},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.7160000205039978},{"id":"https://openalex.org/keywords/luteal-phase","display_name":"luteal phase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/levonorgestrel-releasing-intrauterine-system","display_name":"levonorgestrel-releasing intrauterine system","score":0.6700000166893005},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2778498788","wikidata":"https://www.wikidata.org/wiki/Q7476596","display_name":"Genital herpes","level":4,"score":0.8409996628761292},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.7237913012504578},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6803510189056396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4728448987007141},{"id":"https://openalex.org/C183021626","wikidata":"https://www.wikidata.org/wiki/Q4620674","display_name":"Sex organ","level":2,"score":0.4188236594200134},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.36224275827407837},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3124716281890869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2960556745529175},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23830431699752808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23662301898002625},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11306142807006836},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.08655217289924622},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06588667631149292}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26226/morressier.5731a408d462b8028d88c9fe","doi":"https://doi.org/10.26226/morressier.5731a408d462b8028d88c9fe","is_oa":false,"landing_page_url":"https://doi.org/10.26226/morressier.5731a408d462b8028d88c9fe","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:biblioboard.com:4a1a042c-781e-4ded-89b5-88ae9b8c3fe5","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/4a1a042c-781e-4ded-89b5-88ae9b8c3fe5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-759a0011d80:Morressier 2020-2021","raw_type":"OTHER_DOCUMENT"}],"best_oa_location":{"id":"pmh:oai:biblioboard.com:4a1a042c-781e-4ded-89b5-88ae9b8c3fe5","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/4a1a042c-781e-4ded-89b5-88ae9b8c3fe5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-759a0011d80:Morressier 2020-2021","raw_type":"OTHER_DOCUMENT"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2556687108","https://openalex.org/W2546841418","https://openalex.org/W4212891180","https://openalex.org/W2385398835","https://openalex.org/W7096494505","https://openalex.org/W2805000363","https://openalex.org/W2325599789","https://openalex.org/W2428502305","https://openalex.org/W7006304468","https://openalex.org/W2076264041"],"abstract_inverted_index":{"Transdermal":[0],"estrogen":[1],"prevents":[2],"cyclically-recurrent":[3,225],"genital":[4,11,226],"herpesBackground:Some":[5],"women":[6,37,60,68,165],"suffer":[7],"cyclical":[8],"recurrences":[9,58],"of":[10,56,96,171,223],"herpes":[12,57,227],"(CH)":[13],"immediately":[14],"prior":[15],"to":[16,33,108],"menstruation,":[17],"which":[18,47,145],"are":[19],"effectively":[20],"prevented":[21],"using":[22,126],"aciclovir":[23,147],"in":[24,35,59,86,118,159,173,187,195],"the":[25,54,80,119,231],"luteal":[26,120],"phase":[27,121],"only.":[28],"This":[29],"is":[30,40,48,216],"more":[31],"likely":[32],"occur":[34],"perimenopausal":[36,65,67],"whose":[38],"immunity":[39],"diminished":[41],"by":[42,239],"severe":[43],"premenstrual":[44],"syndrome":[45],"(sPMS),":[46],"treatable":[49],"with":[50,131],"transdermal":[51,109],"estradiol.Aim:To":[52],"observe":[53],"frequency":[55],"commencing":[61],"estradiol":[62,111,214],"treatment":[63,156,186,215],"for":[64,82,115,124],"sPMS.Methods:12":[66],"median":[69],"age":[70],"41":[71],"years":[72],"(range":[73],"36u201345)":[74],"presented":[75],"between":[76],"2005u201315,":[77],"each":[78],"meeting":[79],"criteria":[81],"sPMS":[83,172,191],"subsequently":[84],"defined":[85],"DSM-5.":[87],"Each":[88],"had":[89],"at":[90],"least":[91],"4":[92],"consecutive":[93],"monthly":[94],"episodes":[95,183,193,202],"CH":[97,182],"(culture-proven":[98],"HSV2)":[99],"before":[100],"some":[101],"took":[102],"luteal-phase":[103],"aciclovir,":[104],"then":[105],"all":[106,174],"switched":[107],"17-beta":[110],"gel":[112],"0.5mg":[113],"daily":[114,134],"14":[116],"days":[117],"or":[122,168],"continuously":[123],"those":[125],"Mirena.":[127],"Subjects":[128],"self-reported":[129],"mood":[130],"a":[132,217],"modified":[133],"symptom":[135],"chart":[136],"and":[137,161,219,234],"herpetic":[138],"symptoms":[139],"over":[140],"9":[141,196],"months":[142,197],"follow-up":[143],"during":[144],"no":[146],"was":[148,157],"taken":[149],"pre-emptively.Intention-to-treat":[150],"analysis":[151],"included":[152],"10":[153],"cycles":[154],"where":[155],"omitted":[158],"error":[160],"both":[162],"conditions":[163],"recurred.Results:All":[164],"experienced":[166],"substantial":[167],"complete":[169],"relief":[170],"but":[175],"three":[176],"treated":[177],"cycles.":[178],"Only":[179],"13":[180,199],"symptomatic":[181],"occurred":[184],"on":[185],"108":[188],"woman-monthsu2019":[189],"observation.":[190],"HerpesTotal":[192],"observed":[194],"(I.T.T.)":[198],"23":[200],"Mean":[201],"per":[203],"month":[204],"Observed/Expected":[205],"(1.0)":[206],"0.12":[207],"0.21":[208],"Probability":[209],"(Studentu2019s":[210],"t-Test)":[211],"<0.0001":[212],"<0.0001Conclusion:Transdermal":[213],"novel":[218],"biologically":[220],"plausible":[221],"method":[222],"preventing":[224],"as":[228],"it":[229],"stabilises":[230],"hormonal":[232],"milieu":[233],"diminishes":[235],"immune":[236],"suppression":[237],"caused":[238],"sPMS.":[240]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-02-13T00:00:00"}
