{"id":"https://openalex.org/W4211063728","doi":"https://doi.org/10.1038/nature09552","title":"Rethinking schizophrenia","display_name":"Rethinking schizophrenia","publication_year":2010,"publication_date":"2010-11-09","ids":{"openalex":"https://openalex.org/W4211063728","doi":"https://doi.org/10.1038/nature09552","pmid":"https://pubmed.ncbi.nlm.nih.gov/21068826"},"language":"en","primary_location":{"id":"doi:10.1038/nature09552","doi":"https://doi.org/10.1038/nature09552","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature09552","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106182451","display_name":"Thomas R. Insel","orcid":"https://orcid.org/0000-0001-5031-0160","observed_orcids":["https://orcid.org/0000-0001-5031-0160"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas R. Insel","raw_affiliation_strings":["National Institute of Mental Health, Bethesda, Maryland 20892, USA. tinsel@mail.nih.gov","National Institute of Mental Health, Bethesda, 20892, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health, Bethesda, Maryland 20892, USA. tinsel@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"National Institute of Mental Health, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5106182451"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":44.6262,"has_fulltext":true,"cited_by_count":1789,"citation_normalized_percentile":{"value":0.9996102,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"468","issue":"7321","first_page":"187","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":1.0},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.9679999947547913},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/schizophrenia-risk-factors","display_name":"schizophrenia risk factors","score":0.6129999756813049},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antipsychotic-treatment-outcomes","display_name":"antipsychotic treatment outcomes","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.8101006746292114},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.6266524791717529},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.5419022440910339},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.524860143661499},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.501746654510498},{"id":"https://openalex.org/C2776674806","wikidata":"https://www.wikidata.org/wiki/Q12135","display_name":"Mental illness","level":3,"score":0.47638195753097534},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.45320063829421997},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.4352061152458191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37998709082603455},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012565","descriptor_name":"Schizophrenic Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049672","descriptor_name":"History, 19th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049674","descriptor_name":"History, 21st Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nature09552","doi":"https://doi.org/10.1038/nature09552","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature09552","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:21068826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21068826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Historical Article"},{"id":"pmh:oai:RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09552","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature09552","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W21879210","https://openalex.org/W1485901143","https://openalex.org/W1493671385","https://openalex.org/W1579594476","https://openalex.org/W1599446986","https://openalex.org/W1603591159","https://openalex.org/W1791871313","https://openalex.org/W1967224402","https://openalex.org/W1967674108","https://openalex.org/W1971624220","https://openalex.org/W1972369039","https://openalex.org/W1977917668","https://openalex.org/W1981084319","https://openalex.org/W1983623341","https://openalex.org/W1985065973","https://openalex.org/W1986644233","https://openalex.org/W1988455141","https://openalex.org/W1992203578","https://openalex.org/W1992595542","https://openalex.org/W1995362640","https://openalex.org/W1998927142","https://openalex.org/W2000165331","https://openalex.org/W2005848760","https://openalex.org/W2006473457","https://openalex.org/W2007163693","https://openalex.org/W2007816528","https://openalex.org/W2008639041","https://openalex.org/W2010407531","https://openalex.org/W2022689127","https://openalex.org/W2024449796","https://openalex.org/W2025011978","https://openalex.org/W2029037348","https://openalex.org/W2035319691","https://openalex.org/W2039996899","https://openalex.org/W2040073285","https://openalex.org/W2040789766","https://openalex.org/W2042325100","https://openalex.org/W2049304609","https://openalex.org/W2053045480","https://openalex.org/W2057646365","https://openalex.org/W2062359581","https://openalex.org/W2063505213","https://openalex.org/W2071587797","https://openalex.org/W2071836905","https://openalex.org/W2075910859","https://openalex.org/W2080082125","https://openalex.org/W2080775072","https://openalex.org/W2084107770","https://openalex.org/W2084200464","https://openalex.org/W2085450161","https://openalex.org/W2095119525","https://openalex.org/W2097441708","https://openalex.org/W2098597355","https://openalex.org/W2099610622","https://openalex.org/W2099704493","https://openalex.org/W2103189755","https://openalex.org/W2105343086","https://openalex.org/W2105454368","https://openalex.org/W2106799594","https://openalex.org/W2106949460","https://openalex.org/W2107878018","https://openalex.org/W2110168541","https://openalex.org/W2112064724","https://openalex.org/W2112572641","https://openalex.org/W2112810336","https://openalex.org/W2115690603","https://openalex.org/W2118376438","https://openalex.org/W2121313171","https://openalex.org/W2125136030","https://openalex.org/W2125154843","https://openalex.org/W2127054925","https://openalex.org/W2127115776","https://openalex.org/W2127205775","https://openalex.org/W2127888526","https://openalex.org/W2130372506","https://openalex.org/W2134262474","https://openalex.org/W2136824831","https://openalex.org/W2140824803","https://openalex.org/W2140909692","https://openalex.org/W2141069481","https://openalex.org/W2145098771","https://openalex.org/W2145754751","https://openalex.org/W2145850516","https://openalex.org/W2146136354","https://openalex.org/W2152616688","https://openalex.org/W2153902830","https://openalex.org/W2154978471","https://openalex.org/W2159155203","https://openalex.org/W2161641617","https://openalex.org/W2164138343","https://openalex.org/W2166036051","https://openalex.org/W2167287693","https://openalex.org/W2196858897","https://openalex.org/W2419330808","https://openalex.org/W2976207952","https://openalex.org/W3020958355","https://openalex.org/W4242927736","https://openalex.org/W4252922684","https://openalex.org/W4295915696","https://openalex.org/W6828155702"],"related_works":["https://openalex.org/W2059655841","https://openalex.org/W2052963268","https://openalex.org/W4230913203","https://openalex.org/W2060892340","https://openalex.org/W2165705377","https://openalex.org/W7020996595","https://openalex.org/W7098778282","https://openalex.org/W2107032044","https://openalex.org/W2399220451","https://openalex.org/W2013494933"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":106},{"year":2025,"cited_by_count":95},{"year":2024,"cited_by_count":111},{"year":2023,"cited_by_count":105},{"year":2022,"cited_by_count":136},{"year":2021,"cited_by_count":162},{"year":2020,"cited_by_count":121},{"year":2019,"cited_by_count":121},{"year":2018,"cited_by_count":136},{"year":2017,"cited_by_count":99},{"year":2016,"cited_by_count":103},{"year":2015,"cited_by_count":152},{"year":2014,"cited_by_count":108},{"year":2013,"cited_by_count":103},{"year":2012,"cited_by_count":77}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-02-13T00:00:00"}