{"id":"https://openalex.org/W4211045864","doi":"https://doi.org/10.1002/ana.410380604","title":"Neural apoptosis","display_name":"Neural apoptosis","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W4211045864","doi":"https://doi.org/10.1002/ana.410380604","pmid":"https://pubmed.ncbi.nlm.nih.gov/8526456"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410380604","doi":"https://doi.org/10.1002/ana.410380604","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410380604","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4211045864"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110224478","display_name":"Dale E. Bredesen","orcid":"https://orcid.org/0009-0000-1984-5220","observed_orcids":["https://orcid.org/0009-0000-1984-5220","https://orcid.org/0000-0002-9395-8263"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dale E. Bredesen","raw_affiliation_strings":["Program on Aging, La Jolla Cancer Research Foundation, CA 92037, USA","Program on Aging, La Jolla Cancer Research Foundation, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program on Aging, La Jolla Cancer Research Foundation, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Program on Aging, La Jolla Cancer Research Foundation, La Jolla, CA","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110224478"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":3.9573,"has_fulltext":false,"cited_by_count":485,"citation_normalized_percentile":{"value":0.96444122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"38","issue":"6","first_page":"839","last_page":"851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9049999713897705},{"id":"https://openalex.org/keywords/apoptosis-related-genes","display_name":"apoptosis-related genes","score":0.5979999899864197},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/p35","display_name":"p35","score":0.828000009059906},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.8510000109672546},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/amyloid-beta-toxicity","display_name":"amyloid-beta toxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.800430417060852},{"id":"https://openalex.org/C2992459734","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neural cell","level":3,"score":0.793086051940918},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7217334508895874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5719496607780457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5564010143280029},{"id":"https://openalex.org/C2777720223","wikidata":"https://www.wikidata.org/wiki/Q5255430","display_name":"Demise","level":2,"score":0.5084973573684692},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.46796566247940063},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.4563491940498352},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.44065871834754944},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.438432514667511},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43008938431739807},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40684449672698975},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38365235924720764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19960692524909973},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18680015206336975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10772705078125},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07307520508766174},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410380604","doi":"https://doi.org/10.1002/ana.410380604","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410380604","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:8526456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8526456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5496588077","display_name":"Mechanism of inhibition of neurodegeneration and aging","funder_award_id":"R01AG012282","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W36530132","https://openalex.org/W193161715","https://openalex.org/W1042014336","https://openalex.org/W1470758466","https://openalex.org/W1479786696","https://openalex.org/W1484205189","https://openalex.org/W1514575046","https://openalex.org/W1529927626","https://openalex.org/W1530629109","https://openalex.org/W1554380543","https://openalex.org/W1577393853","https://openalex.org/W1613986623","https://openalex.org/W1648720631","https://openalex.org/W1692410213","https://openalex.org/W1916777863","https://openalex.org/W1929145610","https://openalex.org/W1940692702","https://openalex.org/W1941848008","https://openalex.org/W1950367760","https://openalex.org/W1961142230","https://openalex.org/W1964230438","https://openalex.org/W1965069029","https://openalex.org/W1966475047","https://openalex.org/W1966879144","https://openalex.org/W1968210150","https://openalex.org/W1968328677","https://openalex.org/W1970458627","https://openalex.org/W1970770376","https://openalex.org/W1972409470","https://openalex.org/W1973363947","https://openalex.org/W1975449325","https://openalex.org/W1975896299","https://openalex.org/W1976312800","https://openalex.org/W1976692354","https://openalex.org/W1977410382","https://openalex.org/W1982748405","https://openalex.org/W1983668432","https://openalex.org/W1984332162","https://openalex.org/W1984338631","https://openalex.org/W1984925149","https://openalex.org/W1985822867","https://openalex.org/W1986308149","https://openalex.org/W1986841583","https://openalex.org/W1986974533","https://openalex.org/W1988244142","https://openalex.org/W1990073151","https://openalex.org/W1993336052","https://openalex.org/W1996180957","https://openalex.org/W1996708582","https://openalex.org/W1997208169","https://openalex.org/W1997577743","https://openalex.org/W1998025452","https://openalex.org/W2000646975","https://openalex.org/W2002507218","https://openalex.org/W2005167009","https://openalex.org/W2007861801","https://openalex.org/W2009603041","https://openalex.org/W2010298858","https://openalex.org/W2011272696","https://openalex.org/W2013052118","https://openalex.org/W2014447449","https://openalex.org/W2017729786","https://openalex.org/W2019126647","https://openalex.org/W2025955916","https://openalex.org/W2030829559","https://openalex.org/W2033727409","https://openalex.org/W2033828028","https://openalex.org/W2035807473","https://openalex.org/W2036528355","https://openalex.org/W2037473273","https://openalex.org/W2038768123","https://openalex.org/W2045086385","https://openalex.org/W2049108649","https://openalex.org/W2051658957","https://openalex.org/W2053640261","https://openalex.org/W2056326326","https://openalex.org/W2057123987","https://openalex.org/W2057257609","https://openalex.org/W2063176993","https://openalex.org/W2063960864","https://openalex.org/W2067244066","https://openalex.org/W2068807148","https://openalex.org/W2069333165","https://openalex.org/W2070090561","https://openalex.org/W2070693959","https://openalex.org/W2072894284","https://openalex.org/W2074114480","https://openalex.org/W2074846656","https://openalex.org/W2078001244","https://openalex.org/W2078457332","https://openalex.org/W2078581194","https://openalex.org/W2080889643","https://openalex.org/W2082814018","https://openalex.org/W2083560313","https://openalex.org/W2084609653","https://openalex.org/W2089298737","https://openalex.org/W2089624538","https://openalex.org/W2089843401","https://openalex.org/W2090233462","https://openalex.org/W2091085026","https://openalex.org/W2093423926","https://openalex.org/W2094544625","https://openalex.org/W2095159309","https://openalex.org/W2096386031","https://openalex.org/W2100067355","https://openalex.org/W2105928417","https://openalex.org/W2107768418","https://openalex.org/W2117477385","https://openalex.org/W2118385360","https://openalex.org/W2119361990","https://openalex.org/W2125956665","https://openalex.org/W2128696674","https://openalex.org/W2133287830","https://openalex.org/W2134979684","https://openalex.org/W2143772496","https://openalex.org/W2144695914","https://openalex.org/W2145963372","https://openalex.org/W2148354219","https://openalex.org/W2150462979","https://openalex.org/W2150912846","https://openalex.org/W2152381245","https://openalex.org/W2152445095","https://openalex.org/W2152719751","https://openalex.org/W2153385508","https://openalex.org/W2164658118","https://openalex.org/W2166155593","https://openalex.org/W2167264857","https://openalex.org/W2265226651","https://openalex.org/W2416848600","https://openalex.org/W2896439758","https://openalex.org/W2913868291"],"related_works":["https://openalex.org/W2410904064","https://openalex.org/W2415983252","https://openalex.org/W1993283995","https://openalex.org/W2152554775","https://openalex.org/W1997265216","https://openalex.org/W2068350737","https://openalex.org/W2121802881","https://openalex.org/W1791120176","https://openalex.org/W2482584938","https://openalex.org/W134659854"],"abstract_inverted_index":{"Apoptosis":[0],"is":[1,53],"a":[2],"mode":[3],"of":[4,21,26,33,120],"cell":[5,10,82,129],"death":[6,95],"in":[7,15,61,65,96,134],"which":[8,37,104],"the":[9,24,31,34,48,100,118,125,128],"plays":[11,130],"an":[12,131],"active":[13,132],"role":[14,133],"its":[16,135],"own":[17,136],"demise.":[18],"The":[19],"study":[20],"neural":[22,56,94],"apoptosis,":[23,29],"identification":[25],"genes":[27,39,78,106],"controlling":[28],"and":[30,73,89,116,123,138],"examination":[32],"mechanisms":[35,102],"by":[36,103],"these":[38,105],"achieve":[40],"their":[41],"effects":[42],"have":[43],"assumed":[44],"increasing":[45],"importance":[46],"over":[47],"past":[49],"few":[50],"years.":[51],"This":[52],"because":[54],"(1)":[55],"apoptosis":[57,108],"occurs":[58],"not":[59],"only":[60],"development,":[62],"but":[63],"also":[64,91],"pathophysiological":[66],"states":[67],"such":[68,84],"as":[69,85],"stroke,":[70],"glutamate":[71],"toxicity,":[72],"beta-amyloid":[74],"peptide":[75],"toxicity;":[76],"(2)":[77],"that":[79,127,139,146],"control":[80,107],"apoptotic":[81],"death,":[83],"bcl-2,":[86],"p35,":[87],"p53,":[88],"p75NTR,":[90],"modulate":[92],"necrotic":[93],"some":[97],"cases;":[98],"(3)":[99],"emerging":[101],"may":[109,149],"be":[110,150],"relevant":[111],"for":[112,117],"understanding":[113],"neurodegenerative":[114],"processes,":[115],"design":[119],"therapeutic":[121,147],"agents;":[122],"(4)":[124],"findings":[126],"demise,":[137],"specific":[140],"gene":[141],"products":[142],"are":[143],"involved,":[144],"suggest":[145],"intervention":[148],"feasible.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-02-13T00:00:00"}
