{"id":"https://openalex.org/W4211025944","doi":"https://doi.org/10.3791/62920","title":"Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays","display_name":"Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays","publication_year":2022,"publication_date":"2022-02-09","ids":{"openalex":"https://openalex.org/W4211025944","doi":"https://doi.org/10.3791/62920","pmid":"https://pubmed.ncbi.nlm.nih.gov/35225253"},"language":"en","primary_location":{"id":"doi:10.3791/62920","doi":"https://doi.org/10.3791/62920","is_oa":false,"landing_page_url":"https://doi.org/10.3791/62920","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018604633","display_name":"Jacqueline A. Iredale","orcid":"https://orcid.org/0000-0002-2733-3177","observed_orcids":["https://orcid.org/0000-0002-2733-3177"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Jacqueline A Iredale","raw_affiliation_strings":["School of Biomedical Sciences and Pharmacy, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and Pharmacy, University of Newcastle","institution_ids":["https://openalex.org/I78757542","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025180534","display_name":"Jeremy G. Stoddard","orcid":"https://orcid.org/0000-0001-8363-1489","observed_orcids":["https://orcid.org/0000-0001-8363-1489"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeremy G. Stoddard","raw_affiliation_strings":["School of Electrical Engineering, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical Engineering, University of Newcastle","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037931280","display_name":"Hannah R. Drury","orcid":"https://orcid.org/0000-0003-2208-8288","observed_orcids":["https://orcid.org/0000-0003-2208-8288"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Hannah R. Drury","raw_affiliation_strings":["School of Biomedical Sciences and Pharmacy, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and Pharmacy, University of Newcastle","institution_ids":["https://openalex.org/I78757542","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049801924","display_name":"Tyler J. Browne","orcid":"https://orcid.org/0000-0001-7621-0045","observed_orcids":["https://orcid.org/0000-0001-7621-0045"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Tyler J. Browne","raw_affiliation_strings":["School of Biomedical Sciences and Pharmacy, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and Pharmacy, University of Newcastle","institution_ids":["https://openalex.org/I78757542","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082940433","display_name":"Augustus Elton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Augustus Elton","raw_affiliation_strings":["School of Electrical Engineering, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical Engineering, University of Newcastle","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065842185","display_name":"Jessica F. Madden","orcid":"https://orcid.org/0009-0008-9280-7579","observed_orcids":["https://orcid.org/0009-0008-9280-7579"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Jessica F. Madden","raw_affiliation_strings":["School of Biomedical Sciences and Pharmacy, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and Pharmacy, University of Newcastle","institution_ids":["https://openalex.org/I78757542","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020517274","display_name":"Robert J. Callister","orcid":"https://orcid.org/0000-0003-2087-3274","observed_orcids":["https://orcid.org/0000-0003-2087-3274"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Robert J. Callister","raw_affiliation_strings":["School of Biomedical Sciences and Pharmacy, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and Pharmacy, University of Newcastle","institution_ids":["https://openalex.org/I78757542","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007334324","display_name":"James Stuart Welsh","orcid":"https://orcid.org/0000-0001-8313-1361","observed_orcids":["https://orcid.org/0000-0001-8313-1361"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James S. Welsh","raw_affiliation_strings":["School of Electrical Engineering, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical Engineering, University of Newcastle","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032142618","display_name":"Brett Anthony Graham","orcid":"https://orcid.org/0000-0002-8070-0503","observed_orcids":["https://orcid.org/0000-0002-8070-0503"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Brett A. Graham","raw_affiliation_strings":["School of Biomedical Sciences and Pharmacy, University of Newcastle; brett.graham@newcastle.edu.au","School of Biomedical Sciences and Pharmacy, University of Newcastle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and Pharmacy, University of Newcastle; brett.graham@newcastle.edu.au","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"School of Biomedical Sciences and Pharmacy, University of Newcastle","institution_ids":["https://openalex.org/I78757542","https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1484,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37512202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":"180","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8489999771118164},{"id":"https://openalex.org/keywords/microelectrode-arrays","display_name":"microelectrode arrays","score":0.8999999761581421},{"id":"https://openalex.org/keywords/network-activity","display_name":"network activity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/slice-orientation","display_name":"slice orientation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chronic-pain-model","display_name":"chronic pain model","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.8372502326965332},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8047881126403809},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7305753231048584},{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.6611060500144958},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.5937802195549011},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5825569033622742},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.5813613533973694},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.511141836643219},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.4642159938812256},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.45860183238983154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39441120624542236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2863801121711731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.261881947517395},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1567046046257019},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08473137021064758},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.07270827889442444},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059225","descriptor_name":"Nociception","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066148","descriptor_name":"Spinal Cord Dorsal Horn","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3791/62920","doi":"https://doi.org/10.3791/62920","is_oa":false,"landing_page_url":"https://doi.org/10.3791/62920","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"doi:10.3791/62920-v","doi":"https://doi.org/10.3791/62920-v","is_oa":false,"landing_page_url":"https://doi.org/10.3791/62920-v","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"pmid:35225253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35225253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of visualized experiments : JoVE","raw_type":"Journal Article"},{"id":"pmh:uon:47016","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.13/1464495","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1526675921","https://openalex.org/W1592037135","https://openalex.org/W1617948373","https://openalex.org/W1723694197","https://openalex.org/W1969643787","https://openalex.org/W1969751124","https://openalex.org/W2000263316","https://openalex.org/W2015386261","https://openalex.org/W2021417436","https://openalex.org/W2026910668","https://openalex.org/W2047025508","https://openalex.org/W2048527341","https://openalex.org/W2051695641","https://openalex.org/W2059635921","https://openalex.org/W2066734670","https://openalex.org/W2081129882","https://openalex.org/W2084148692","https://openalex.org/W2084593773","https://openalex.org/W2091908009","https://openalex.org/W2092776809","https://openalex.org/W2129229909","https://openalex.org/W2140480932","https://openalex.org/W2161754062","https://openalex.org/W2165030136","https://openalex.org/W2170342175","https://openalex.org/W2185541914","https://openalex.org/W2502211973","https://openalex.org/W2547373552","https://openalex.org/W2601813741","https://openalex.org/W2609684457","https://openalex.org/W2781641643","https://openalex.org/W2796422959","https://openalex.org/W2809398650","https://openalex.org/W2942058459","https://openalex.org/W2961172235","https://openalex.org/W2988909879","https://openalex.org/W3013647964","https://openalex.org/W3091872105","https://openalex.org/W3100514562"],"related_works":["https://openalex.org/W4403927785","https://openalex.org/W2904623611","https://openalex.org/W2254974624","https://openalex.org/W1532977413","https://openalex.org/W7140183608","https://openalex.org/W57552791","https://openalex.org/W2113648694","https://openalex.org/W2300579784","https://openalex.org/W2343921058","https://openalex.org/W2008524049"],"abstract_inverted_index":{"The":[0,115],"roles":[1],"and":[2,63,84,131,160],"connectivity":[3],"of":[4,7,29,39,60,69,87,93,157,187],"specific":[5],"types":[6],"neurons":[8,62],"within":[9],"the":[10,30,37,47,58,67,91,122,185,195],"spinal":[11,33,97,172,196],"cord":[12,98,173,197],"dorsal":[13],"horn":[14],"(DH)":[15],"are":[16],"being":[17],"delineated":[18],"at":[19],"a":[20,143,179],"rapid":[21,180],"rate":[22],"to":[23,100,121,145,183,191],"provide":[24],"an":[25],"increasingly":[26],"detailed":[27],"view":[28],"circuits":[31,109],"underpinning":[32],"pain":[34],"processing.":[35],"However,":[36],"effects":[38],"these":[40],"connections":[41],"for":[42],"broader":[43],"network":[44],"activity":[45,59,77,103,118,149,193],"in":[46,135,150,170,194],"DH":[48,102,108,147],"remain":[49],"less":[50],"well":[51],"understood":[52],"because":[53],"most":[54],"studies":[55],"focus":[56],"on":[57],"single":[61],"small":[64],"microcircuits.":[65],"Alternatively,":[66],"use":[68,92],"microelectrode":[70],"arrays":[71],"(MEAs),":[72],"which":[73],"can":[74,132,175],"monitor":[75],"electrical":[76],"across":[78],"many":[79],"cells,":[80],"provides":[81,142],"high":[82],"spatial":[83],"temporal":[85],"resolution":[86],"neural":[88],"activity.":[89],"Here,":[90],"MEAs":[94],"with":[95,110,162],"mouse":[96],"slices":[99,174],"study":[101],"induced":[104],"by":[105,129],"chemically":[106],"stimulating":[107],"4-aminopyridine":[111],"(4-AP)":[112],"is":[113,119],"described.":[114],"resulting":[116],"rhythmic":[117],"restricted":[120],"superficial":[123],"DH,":[124],"stable":[125],"over":[126],"time,":[127],"blocked":[128],"tetrodotoxin,":[130],"be":[133,176],"investigated":[134],"different":[136],"slice":[137],"orientations.":[138],"Together,":[139],"this":[140],"preparation":[141],"platform":[144],"investigate":[146],"circuit":[148],"tissue":[151],"from":[152],"na\u00efve":[153],"animals,":[154],"animal":[155],"models":[156],"chronic":[158],"pain,":[159],"mice":[161],"genetically":[163],"altered":[164],"nociceptive":[165],"function.":[166],"Furthermore,":[167],"MEA":[168],"recordings":[169],"4-AP-stimulated":[171],"used":[177],"as":[178],"screening":[181],"tool":[182],"assess":[184],"capacity":[186],"novel":[188],"antinociceptive":[189],"compounds":[190],"disrupt":[192],"DH.":[198]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-02-13T00:00:00"}
