{"id":"https://openalex.org/W4210888990","doi":"https://doi.org/10.1186/s12885-022-09200-4","title":"Angiotensin blockade therapy and survival in pancreatic cancer: a population study","display_name":"Angiotensin blockade therapy and survival in pancreatic cancer: a population study","publication_year":2022,"publication_date":"2022-02-07","ids":{"openalex":"https://openalex.org/W4210888990","doi":"https://doi.org/10.1186/s12885-022-09200-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/35130875"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-022-09200-4","doi":"https://doi.org/10.1186/s12885-022-09200-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-022-09200-4","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-022-09200-4","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-022-09200-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010670331","display_name":"Scott W. Keith","orcid":"https://orcid.org/0000-0002-9428-1151","observed_orcids":["https://orcid.org/0000-0002-9428-1151"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott W. Keith","raw_affiliation_strings":["Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, 130 S 9th St., 17th Floor, 19107, Philadelphia, PA, USA. scott.keith@jefferson.edu","Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, 130 S 9th St., 17th Floor, 19107, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9428-1151","affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, 130 S 9th St., 17th Floor, 19107, Philadelphia, PA, USA. scott.keith@jefferson.edu","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, 130 S 9th St., 17th Floor, 19107, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045278377","display_name":"Vittorio Maio","orcid":"https://orcid.org/0000-0001-9971-6989","observed_orcids":["https://orcid.org/0000-0001-9971-6989"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vittorio Maio","raw_affiliation_strings":["Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Suite 319, 19107, Philadelphia, PA, USA","Jefferson College of Population Health, Thomas Jefferson University, 901 Walnut Street, 10th Floor, 19107, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9971-6989","affiliations":[{"raw_affiliation_string":"Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Suite 319, 19107, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Jefferson College of Population Health, Thomas Jefferson University, 901 Walnut Street, 10th Floor, 19107, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088939674","display_name":"Hwyda A. Arafat","orcid":"https://orcid.org/0000-0003-3400-7705","observed_orcids":["https://orcid.org/0000-0003-3400-7705"]},"institutions":[{"id":"https://openalex.org/I275799156","display_name":"University of New England","ror":"https://ror.org/02n2ava60","country_code":"US","type":"education","lineage":["https://openalex.org/I275799156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hwyda A. Arafat","raw_affiliation_strings":["Department of Biomedical Sciences, University of New England, 11 Hills Beach Road, 04005, Biddeford, Maine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of New England, 11 Hills Beach Road, 04005, Biddeford, Maine, USA","institution_ids":["https://openalex.org/I275799156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051248335","display_name":"Matthew James Alcusky","orcid":"https://orcid.org/0000-0001-5604-721X","observed_orcids":["https://orcid.org/0000-0001-5604-721X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Alcusky","raw_affiliation_strings":["Division of Epidemiology, Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-5604-721X","affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084182369","display_name":"Thomas Karagiannis","orcid":"https://orcid.org/0000-0001-5242-0574","observed_orcids":["https://orcid.org/0000-0001-5242-0574"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Karagiannis","raw_affiliation_strings":["Jefferson College of Population Health, Thomas Jefferson University, 901 Walnut Street, 10th Floor, 19107, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jefferson College of Population Health, Thomas Jefferson University, 901 Walnut Street, 10th Floor, 19107, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113516775","display_name":"Carol Rabinowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Rabinowitz","raw_affiliation_strings":["Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Suite 319, 19107, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Suite 319, 19107, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057922763","display_name":"Harish Lavu","orcid":"https://orcid.org/0000-0001-8907-9242","observed_orcids":["https://orcid.org/0000-0001-8907-9242"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harish Lavu","raw_affiliation_strings":["Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St., College Bldg., 6th Floor, 19107, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St., College Bldg., 6th Floor, 19107, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108349144","display_name":"Daniel Z. Louis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Z. Louis","raw_affiliation_strings":["Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Suite 319, 19107, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Suite 319, 19107, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010670331"],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":2.6188,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.92191492,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"150","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.996999979019165},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.824999988079071},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6520000100135803},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.4970000088214874},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6650000214576721},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.6380000114440918},{"id":"https://openalex.org/keywords/emilia-romagna","display_name":"Emilia-Romagna","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.946891188621521},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.615172266960144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6087691783905029},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5476081967353821},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5273398160934448},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5192732810974121},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.51019287109375},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.4789370000362396},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.43770310282707214},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.07723096013069153},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12885-022-09200-4","doi":"https://doi.org/10.1186/s12885-022-09200-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-022-09200-4","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-022-09200-4","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmid:35130875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35130875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8819908","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8819908","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:jdc.jefferson.edu:healthpolicyfaculty-1149","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/healthpolicyfaculty/143","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"College of Population Health Faculty Papers","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4164b3ec62fb45018c70b0ad9522e8ba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4164b3ec62fb45018c70b0ad9522e8ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-022-09200-4","doi":"https://doi.org/10.1186/s12885-022-09200-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-022-09200-4","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-022-09200-4","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8899999856948853}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6556341070","display_name":null,"funder_award_id":"IRG 08-060-04","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210888990.pdf","grobid_xml":"https://content.openalex.org/works/W4210888990.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1603491949","https://openalex.org/W1968397367","https://openalex.org/W1968432383","https://openalex.org/W1976776113","https://openalex.org/W1976954810","https://openalex.org/W1978861616","https://openalex.org/W1983143756","https://openalex.org/W1992146834","https://openalex.org/W1997386973","https://openalex.org/W2005007397","https://openalex.org/W2005081343","https://openalex.org/W2029442595","https://openalex.org/W2053713685","https://openalex.org/W2057780602","https://openalex.org/W2060287969","https://openalex.org/W2082943727","https://openalex.org/W2085686527","https://openalex.org/W2087759558","https://openalex.org/W2091446228","https://openalex.org/W2098054841","https://openalex.org/W2102509488","https://openalex.org/W2111714917","https://openalex.org/W2119562899","https://openalex.org/W2142080475","https://openalex.org/W2161354300","https://openalex.org/W2169471480","https://openalex.org/W2530522266","https://openalex.org/W2605321974","https://openalex.org/W2607127971","https://openalex.org/W2623209858","https://openalex.org/W2914396258","https://openalex.org/W2947955936"],"related_works":["https://openalex.org/W4238067486","https://openalex.org/W4295540420","https://openalex.org/W4309413642","https://openalex.org/W2779530153","https://openalex.org/W4323306248","https://openalex.org/W4246054013","https://openalex.org/W3126136375","https://openalex.org/W4224861992","https://openalex.org/W2994686985","https://openalex.org/W4281722959"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pancreatic":[1],"cancer":[2,12,23],"(PC)":[3],"is":[4,269],"one":[5],"of":[6,22,173,202,263,292],"the":[7,19,26,65,71,169,239,290],"most":[8,243],"aggressive":[9],"and":[10,61,89,103,119,134,212,225,242,258,287,294],"challenging":[11],"types":[13],"to":[14,33,142,148,165,210,256,266,285],"effectively":[15],"treat,":[16],"ranking":[17],"as":[18],"fourth-leading":[20],"cause":[21],"death":[24],"in":[25,70,299],"United":[27],"States.":[28],"We":[29],"investigated":[30],"if":[31],"exposures":[32,106,209],"angiotensin":[34,40],"II":[35],"receptor":[36],"blockers":[37],"(ARBs)":[38],"or":[39,281],"I":[41],"converting":[42],"enzyme":[43],"(ACE)":[44],"inhibitors":[45,167,214,227,296],"after":[46,107,150,175,190,215],"PC":[47,54,108,113,151,176,216,234,300],"diagnosis":[48,60,152,177,217],"are":[49,218,254],"associated":[50,220],"with":[51,131,221,238],"survival.":[52,223],"METHODS:":[53],"patients":[55,114],"were":[56,115,129],"identified":[57,116],"by":[58,138],"ICD-9":[59],"procedure":[62],"codes":[63],"among":[64,121],"3.7":[66],"million":[67],"adults":[68],"living":[69],"Emilia-Romagna":[72],"Region":[73],"from":[74],"their":[75],"administrative":[76],"health":[77],"care":[78],"database":[79],"containing":[80],"patient":[81],"data":[82],"on":[83,297],"demographics,":[84],"hospital":[85],"discharges,":[86],"all-cause":[87],"mortality,":[88],"outpatient":[90],"pharmacy":[91],"prescriptions.":[92],"Cox":[93],"modeling":[94],"estimated":[95],"covariate-adjusted":[96],"mortality":[97,156,181],"hazard":[98],"ratios":[99],"for":[100,232,273],"time-dependent":[101],"ARB":[102],"ACE":[104,166,213,226,295],"inhibitor":[105],"diagnosis.":[109],"RESULTS:":[110],"8,158":[111],"incident":[112],"between":[117],"2003":[118],"2011,":[120],"whom":[122],"20%":[123,154],"had":[124],"pancreas":[125],"resection":[126],"surgery,":[127],"36%":[128],"diagnosed":[130],"metastatic":[132],"disease,":[133],"7,027":[135],"(86%)":[136],"died":[137],"December":[139],"2012.":[140],"Compared":[141],"otherwise":[143],"similar":[144],"patients,":[145,235,267],"those":[146,237],"exposed":[147,164],"ARBs":[149,211,224,293],"experienced":[153,178],"lower":[155,180],"risk":[157,182,262],"(HR=0.80;":[158],"95%":[159,184,195],"CI:":[160,185,196],"0.72,":[161],"0.89).":[162],"Those":[163],"during":[168],"first":[170],"three":[171,192],"years":[172,193],"survival":[174,298],"13%":[179],"(HR=0.87;":[183],"0.80,":[186],"0.94)":[187],"which":[188],"attenuated":[189],"surviving":[191],"(HR=1.14;":[194],"0.90,":[197],"1.45).":[198],"CONCLUSIONS:":[199],"The":[200],"results":[201],"this":[203],"large":[204,277],"population":[205],"study":[206],"suggest":[207],"that":[208,248],"significantly":[219],"improved":[222],"could":[228],"be":[229],"important":[230],"considerations":[231],"treating":[233],"particularly":[236],"worst":[240],"prognosis":[241],"limited":[244],"treatment":[245],"options.":[246],"Considering":[247],"these":[249],"common":[250],"FDA":[251],"approved":[252],"drugs":[253],"inexpensive":[255],"payers":[257],"present":[259],"minimal":[260],"increased":[261],"adverse":[264],"events":[265],"there":[268],"an":[270],"urgent":[271],"need":[272],"randomized":[274,279],"clinical":[275,283],"trials,":[276,280],"simple":[278],"pragmatic":[282],"trials":[284],"formally":[286],"broadly":[288],"evaluate":[289],"effects":[291],"patients.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
