{"id":"https://openalex.org/W4210831778","doi":"https://doi.org/10.1007/s00223-022-00952-6","title":"Bilateral Atypical Femur Fractures After Denosumab in a Bisphosphonate Naive Patient: A Case Report","display_name":"Bilateral Atypical Femur Fractures After Denosumab in a Bisphosphonate Naive Patient: A Case Report","publication_year":2022,"publication_date":"2022-02-08","ids":{"openalex":"https://openalex.org/W4210831778","doi":"https://doi.org/10.1007/s00223-022-00952-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/35132455"},"language":"en","primary_location":{"id":"doi:10.1007/s00223-022-00952-6","doi":"https://doi.org/10.1007/s00223-022-00952-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00223-022-00952-6","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue International","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4210831778"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067993676","display_name":"Jeremy Keng Meng Goh","orcid":"https://orcid.org/0000-0002-8864-7006","observed_orcids":["https://orcid.org/0000-0002-8864-7006"]},"institutions":[{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Jeremy Keng Meng Goh","raw_affiliation_strings":["Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore. jeremy.goh2@mohh.com.sg","Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-8864-7006","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore. jeremy.goh2@mohh.com.sg","institution_ids":["https://openalex.org/I2251586001"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I2251586001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067988660","display_name":"Joyce Suang Bee Koh","orcid":"https://orcid.org/0000-0003-4135-0288","observed_orcids":["https://orcid.org/0000-0003-4135-0288"]},"institutions":[{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Joyce Suang Bee Koh","raw_affiliation_strings":["Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I2251586001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110495903","display_name":"Alvin Choong Meng Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800542734","display_name":"Mount Elizabeth Hospital","ror":"https://ror.org/019z9dk17","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2800542734"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Alvin Choong Meng Ng","raw_affiliation_strings":["Mount Elizabeth Medical Centre, The Endocrine Clinic, 3 Mount Elizabeth #15-04, Singapore, 228510, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Elizabeth Medical Centre, The Endocrine Clinic, 3 Mount Elizabeth #15-04, Singapore, 228510, Singapore","institution_ids":["https://openalex.org/I2800542734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082095284","display_name":"Meng Ai Png","orcid":"https://orcid.org/0000-0002-6060-3140","observed_orcids":["https://orcid.org/0000-0002-6060-3140"]},"institutions":[{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Meng Ai Png","raw_affiliation_strings":["Department of Diagnostic Radiology, Singapore General Hospital, Block 2, Level 1, Outram Road, Singapore, 169608, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology, Singapore General Hospital, Block 2, Level 1, Outram Road, Singapore, 169608, Singapore","institution_ids":["https://openalex.org/I2251586001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048647924","display_name":"Tet Sen Howe","orcid":"https://orcid.org/0000-0002-2933-6830","observed_orcids":["https://orcid.org/0000-0002-2933-6830"]},"institutions":[{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Tet Sen Howe","raw_affiliation_strings":["Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I2251586001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067993676"],"corresponding_institution_ids":["https://openalex.org/I2251586001"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":2.2905,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86138412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"111","issue":"1","first_page":"96","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.1395999938249588,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-femoral-fractures","display_name":"atypical femoral fractures","score":0.9049999713897705},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hip-pain","display_name":"hip pain","score":0.6100000143051147},{"id":"https://openalex.org/keywords/conservative-treatment","display_name":"conservative treatment","score":0.9300000071525574},{"id":"https://openalex.org/keywords/protected-weight-bearing","display_name":"protected weight bearing","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9329258799552917},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.9048817157745361},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.8694717884063721},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6903454661369324},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.653052568435669},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.6341139078140259},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5868095755577087},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.5262400507926941},{"id":"https://openalex.org/C2778227786","wikidata":"https://www.wikidata.org/wiki/Q22350468","display_name":"Hip pain","level":2,"score":0.43145668506622314},{"id":"https://openalex.org/C2911223091","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone Density Conservation Agents","level":4,"score":0.43094539642333984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1877751648426056},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.11815693974494934}],"mesh":[{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00223-022-00952-6","doi":"https://doi.org/10.1007/s00223-022-00952-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00223-022-00952-6","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue International","raw_type":"journal-article"},{"id":"pmid:35132455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35132455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified tissue international","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1882645054","https://openalex.org/W1906609770","https://openalex.org/W1911703092","https://openalex.org/W2006957166","https://openalex.org/W2030974692","https://openalex.org/W2054104359","https://openalex.org/W2062180609","https://openalex.org/W2072109115","https://openalex.org/W2076257942","https://openalex.org/W2084457170","https://openalex.org/W2099385877","https://openalex.org/W2122467899","https://openalex.org/W2158208410","https://openalex.org/W2169251377","https://openalex.org/W2408474885","https://openalex.org/W2520995084","https://openalex.org/W2523056901","https://openalex.org/W2924972170","https://openalex.org/W2946894129","https://openalex.org/W2964027860","https://openalex.org/W2981726330","https://openalex.org/W2996449431","https://openalex.org/W2997700279","https://openalex.org/W3036234746","https://openalex.org/W3075871984"],"related_works":["https://openalex.org/W4396778463","https://openalex.org/W2062180609","https://openalex.org/W4411248369","https://openalex.org/W4298119337","https://openalex.org/W2158208410","https://openalex.org/W4200274190","https://openalex.org/W4411641001","https://openalex.org/W7223466070","https://openalex.org/W2418607468","https://openalex.org/W4385442591"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-02-09T00:00:00"}