{"id":"https://openalex.org/W4210697799","doi":"https://doi.org/10.1002/trc2.12241","title":"Diet\u2010induced Alzheimer's\u2010like syndrome in the rabbit","display_name":"Diet\u2010induced Alzheimer's\u2010like syndrome in the rabbit","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4210697799","doi":"https://doi.org/10.1002/trc2.12241","pmid":"https://pubmed.ncbi.nlm.nih.gov/35128030","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8804622"},"language":"en","primary_location":{"id":"doi:10.1002/trc2.12241","doi":"https://doi.org/10.1002/trc2.12241","is_oa":true,"landing_page_url":"https://doi.org/10.1002/trc2.12241","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/trc2.12241","source":{"id":"https://openalex.org/S2898321583","display_name":"Alzheimer s & Dementia Translational Research & Clinical Interventions","issn_l":"2352-8737","issn":["2352-8737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia: Translational Research & Clinical Interventions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/trc2.12241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013348982","display_name":"Craig Weiss","orcid":"https://orcid.org/0000-0002-9861-8727","observed_orcids":["https://orcid.org/0000-0002-9861-8727"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig Weiss","raw_affiliation_strings":["Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047278015","display_name":"Nicola Bertolino","orcid":"https://orcid.org/0000-0002-5924-0995","observed_orcids":["https://orcid.org/0000-0002-5924-0995"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicola Bertolino","raw_affiliation_strings":["Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036111609","display_name":"Daniele Procissi","orcid":"https://orcid.org/0000-0001-5350-0170","observed_orcids":["https://orcid.org/0000-0001-5350-0170"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniele Procissi","raw_affiliation_strings":["Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066449312","display_name":"Grazia Aleppo","orcid":"https://orcid.org/0000-0003-1644-5947","observed_orcids":["https://orcid.org/0000-0003-1644-5947"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grazia Aleppo","raw_affiliation_strings":["Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057678403","display_name":"Quinn C. Smith","orcid":"https://orcid.org/0000-0003-3632-6945","observed_orcids":["https://orcid.org/0000-0003-3632-6945"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quinn C. Smith","raw_affiliation_strings":["Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033839136","display_name":"Kirsten L. Viola","orcid":"https://orcid.org/0000-0002-9862-6436","observed_orcids":["https://orcid.org/0000-0002-9862-6436"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten L. Viola","raw_affiliation_strings":["Department of Neurobiology, Northwestern University, Evanston, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Northwestern University, Evanston, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019040676","display_name":"Samuel C. Bartley","orcid":"https://orcid.org/0009-0007-1551-3318","observed_orcids":["https://orcid.org/0009-0007-1551-3318"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel C. Bartley","raw_affiliation_strings":["Department of Neurobiology, Northwestern University, Evanston, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Northwestern University, Evanston, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054687151","display_name":"William L. Klein","orcid":"https://orcid.org/0000-0002-3047-9978","observed_orcids":["https://orcid.org/0000-0002-3047-9978"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Klein","raw_affiliation_strings":["Department of Neurobiology, Northwestern University, Evanston, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Northwestern University, Evanston, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033108105","display_name":"John F. Disterhoft","orcid":"https://orcid.org/0000-0002-8817-7913","observed_orcids":["https://orcid.org/0000-0002-8817-7913"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Disterhoft","raw_affiliation_strings":["Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013348982"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":1.5482,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.80793708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"e12241","last_page":"e12241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8840000033378601},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.8880000114440918},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/fructose-diet","display_name":"fructose diet","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.824999988079071},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7250000238418579},{"id":"https://openalex.org/keywords/object-location-memory","display_name":"object location memory","score":0.9509999752044678},{"id":"https://openalex.org/keywords/novel-object-recognition","display_name":"novel object recognition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/eyeblink-conditioning","display_name":"eyeblink conditioning","score":0.9390000104904175},{"id":"https://openalex.org/keywords/resting-state-functional-connectivity","display_name":"resting-state functional connectivity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/r2-mri","display_name":"R2* MRI","score":0.9169999957084656},{"id":"https://openalex.org/keywords/amyloid","display_name":"amyloid","score":0.6119999885559082},{"id":"https://openalex.org/keywords/dietary-risk-factors","display_name":"dietary risk factors","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4927811920642853},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.48790356516838074},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4759494960308075},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4672546088695526},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.446618914604187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4464932978153229},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4210440218448639},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4166909456253052},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40671032667160034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39713260531425476},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3913750648498535},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3671504259109497},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3000138998031616},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27256274223327637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2135089635848999},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.1910085678100586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/trc2.12241","doi":"https://doi.org/10.1002/trc2.12241","is_oa":true,"landing_page_url":"https://doi.org/10.1002/trc2.12241","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/trc2.12241","source":{"id":"https://openalex.org/S2898321583","display_name":"Alzheimer s & Dementia Translational Research & Clinical Interventions","issn_l":"2352-8737","issn":["2352-8737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia: Translational Research & Clinical Interventions","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8804622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8804622","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement (N Y)","raw_type":"Text"},{"id":"pmid:35128030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35128030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia (New York, N. Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4cd0d89d401245cc9ddee8795292d543","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4cd0d89d401245cc9ddee8795292d543","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer\u2019s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/trc2.12241","doi":"https://doi.org/10.1002/trc2.12241","is_oa":true,"landing_page_url":"https://doi.org/10.1002/trc2.12241","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/trc2.12241","source":{"id":"https://openalex.org/S2898321583","display_name":"Alzheimer s & Dementia Translational Research & Clinical Interventions","issn_l":"2352-8737","issn":["2352-8737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia: Translational Research & Clinical Interventions","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1059255601","display_name":"Defining native proteoform landscape for amyloid-beta in Alzheimers disease","funder_award_id":"RF1AG063903","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1235087432","display_name":"Sporadic Alzheimer's Disease modeled with diabetes and high cholesterol in rabbit","funder_award_id":"1r56ag050492-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1286070804","display_name":"Cellular mechanisms of hippocampal network neuroplasticity generated by brain stimulation","funder_award_id":"R01NS113804","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1975909699","display_name":null,"funder_award_id":"R56 AG050492","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2136883219","display_name":"Physiological role of naturally-occuring amyloid beta oligomers","funder_award_id":"R21AG060203","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G243501062","display_name":"Synaptic substrates of age-dependent memory deficits","funder_award_id":"RF1AG017139","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2587344121","display_name":null,"funder_award_id":"RRID:SCR_017767","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G4621770907","display_name":"Synaptic Substrates of Age-Dependent Memory Deficits","funder_award_id":"R01AG017139","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4785076029","display_name":"Northwestern University Clinical and Translational Science Institute (NUCATS)","funder_award_id":"UL1TR001422","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4991500723","display_name":"Slow Outward Currents and Learning In Aging Hippocampus","funder_award_id":"R37AG008796","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5494874922","display_name":"Abeta oligomers (ADDLs) in Alzheimer's Disease pathology","funder_award_id":"R01AG022547","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7707125228","display_name":null,"funder_award_id":"UL1 TR001422","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G781831529","display_name":"Northwestern University Postbaccalaureate Research Education Program","funder_award_id":"R25GM121231","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7840397398","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG013854","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8778916289","display_name":"NEUROLOGICAL DEFICITS DUE TO TOXIC A BETA OLIGOMERS","funder_award_id":"R01AG018877","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000227227","display_name":null,"funder_award_id":"AG013854","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210697799.pdf","grobid_xml":"https://content.openalex.org/works/W4210697799.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1498003589","https://openalex.org/W1686589535","https://openalex.org/W1754828011","https://openalex.org/W1881006356","https://openalex.org/W1968015356","https://openalex.org/W1981891948","https://openalex.org/W1986154975","https://openalex.org/W1986590619","https://openalex.org/W1989082922","https://openalex.org/W1993703850","https://openalex.org/W1995077831","https://openalex.org/W1998487518","https://openalex.org/W1999808638","https://openalex.org/W1999836898","https://openalex.org/W2004858913","https://openalex.org/W2013896520","https://openalex.org/W2018761259","https://openalex.org/W2028931209","https://openalex.org/W2039905869","https://openalex.org/W2046948105","https://openalex.org/W2046993793","https://openalex.org/W2069246823","https://openalex.org/W2078212921","https://openalex.org/W2120937046","https://openalex.org/W2139236929","https://openalex.org/W2144531560","https://openalex.org/W2146249493","https://openalex.org/W2155904810","https://openalex.org/W2156409633","https://openalex.org/W2169017969","https://openalex.org/W2185289999","https://openalex.org/W2232848818","https://openalex.org/W2236795097","https://openalex.org/W2284289392","https://openalex.org/W2395819942","https://openalex.org/W2620184464","https://openalex.org/W2775635068","https://openalex.org/W2798054687","https://openalex.org/W2810529327","https://openalex.org/W2828501242","https://openalex.org/W2897406334","https://openalex.org/W2960505072","https://openalex.org/W3040737124","https://openalex.org/W3083100064","https://openalex.org/W3088515853","https://openalex.org/W3092479751","https://openalex.org/W3166282030","https://openalex.org/W3176983361","https://openalex.org/W4210697799","https://openalex.org/W4211139529","https://openalex.org/W4240980427"],"related_works":["https://openalex.org/W2981019781","https://openalex.org/W2049954377","https://openalex.org/W2133025814","https://openalex.org/W1498245711","https://openalex.org/W7117129108","https://openalex.org/W2800412559","https://openalex.org/W2146738703","https://openalex.org/W2412863273","https://openalex.org/W2128344266","https://openalex.org/W2804100403"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Although":[2],"mouse":[3,41],"models":[4,23],"of":[5,13,17,21,32,46,69,112,132,145,165,191,227,303,321],"Alzheimer's":[6,26],"disease":[7],"(AD)":[8],"have":[9,50],"increased":[10],"our":[11,74],"understanding":[12,65],"the":[14,18,40,43,56,66,267,299,318],"molecular":[15,67],"basis":[16,68],"disease,":[19],"none":[20],"those":[22],"represent":[24],"late\u2010onset":[25],"Disease":[27],"which":[28],"accounts":[29],"for":[30,87,284],">90%":[31],"AD":[33,286],"cases,":[34],"and":[35,48,102,120,141,170,205,232,249,287,301],"no":[36],"therapeutics":[37,305],"developed":[38],"in":[39,52,64,90,258,298,312],"(with":[42,80],"possible":[44],"exceptions":[45],"aduhelm/aducanumab":[47],"gantenerumab)":[49],"succeeded":[51],"preventing":[53],"or":[54,159,217],"reversing":[55],"disease.":[57],"This":[58],"technology":[59],"has":[60],"allowed":[61],"much":[62],"progress":[63],"AD.":[70,327],"To":[71],"further":[72,316],"enhance":[73],"understanding,":[75],"we":[76],"used":[77,199,293],"wild\u2010type":[78],"rabbit":[79,124],"a":[81,116,126,152,188],"nearly":[82],"identical":[83],"amino":[84],"acid":[85],"sequence":[86],"amyloid":[88],"as":[89,125,187],"humans)":[91],"to":[92,129,177,200,264,294,325],"model":[93,128,324],"LOAD":[94,276],"by":[95,241,245,280],"stressing":[96,281],"risk":[97,134,282],"factors":[98,135,283],"including":[99],"age,":[100],"hypercholesterolemia,":[101],"elevated":[103,218,257],"blood":[104],"glucose":[105],"levels":[106],"(BGLs),":[107],"upon":[108],"an":[109],"\u03b53\u2010like":[110],"isoform":[111],"apolipoprotein.":[113],"We":[114,271],"report":[115],"combined":[117],"behavioral,":[118],"imaging,":[119],"metabolic":[121],"study":[122,326],"using":[123],"non\u2010transgenic":[127,323],"examine":[130],"effects":[131],"AD\u2010related":[133],"on":[136,266],"cognition,":[137],"intrinsic":[138,234],"functional":[139,235],"connectivity,":[140],"magnetic":[142],"resonance\u2010based":[143],"biomarkers":[144],"neuropathology.":[146],"Methods":[147],"Aging":[148],"rabbits":[149,265,315],"were":[150,175,256],"fed":[151],"diet":[153,243,261],"enriched":[154],"with":[155],"either":[156],"2%":[157],"cholesterol":[158],"10%":[160],"fat/30%":[161],"fructose.":[162],"Monthly":[163],"tests":[164],"novel":[166],"object":[167,171],"recognition":[168],"(NOR)":[169],"location":[172],"memory":[173],"(OLM)":[174],"administered":[176,186],"track":[178],"cognitive":[179,192],"impairment.":[180,193],"Trace":[181],"eyeblink":[182],"conditioning":[183],"(EBC)":[184],"was":[185,198,238],"final":[189],"test":[190],"Magnetic":[194],"resonance":[195],"imaging":[196],"(MRI)":[197],"obtain":[201],"resting":[202],"state":[203],"connectivity":[204],"quantitative":[206],"parametric":[207],"data":[208],"(R":[209],"2":[210,252],"*).":[211],"Results":[212],"Experimental":[213],"diets":[214,222],"induced":[215,223],"hypercholesterolemia":[216],"BGL.":[219],"Both":[220],"experimental":[221,260],"statistically":[224],"significant":[225],"impairment":[226],"OLM":[228],"(but":[229],"not":[230],"NOR)":[231],"altered":[233],"connectivity.":[236],"EBC":[237],"more":[239],"impaired":[240],"fat/fructose":[242],"than":[244],"cholesterol.":[246],"Whole":[247],"brain":[248],"regional":[250],"R":[251],"*":[253],"MRI":[254,311],"values":[255],"both":[259],"groups":[262],"relative":[263],"control":[268],"diet.":[269],"Discussion":[270],"propose":[272],"that":[273,288],"mechanisms":[274],"underlying":[275],"can":[277,291],"be":[278,292],"assessed":[279],"inducing":[285],"dietary":[289],"manipulations":[290],"assess":[295],"etiological":[296],"differences":[297],"pathologies":[300],"effectiveness":[302],"potential":[304],"against":[306],"LOAD.":[307],"In":[308],"addition,":[309],"non\u2010invasive":[310],"awake,":[313],"non\u2010anesthetized":[314],"increases":[317],"translational":[319],"value":[320],"this":[322]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-02-08T00:00:00"}