{"id":"https://openalex.org/W4210697757","doi":"https://doi.org/10.3389/fcell.2021.803645","title":"CD26 Inhibition Potentiates the Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence","display_name":"CD26 Inhibition Potentiates the Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4210697757","doi":"https://doi.org/10.3389/fcell.2021.803645","pmid":"https://pubmed.ncbi.nlm.nih.gov/35178399"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2021.803645","doi":"https://doi.org/10.3389/fcell.2021.803645","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.803645","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2021.803645","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101840593","display_name":"Miyeon Kim","orcid":"https://orcid.org/0000-0003-0497-8148","observed_orcids":["https://orcid.org/0000-0003-0497-8148"]},"institutions":[{"id":"https://openalex.org/I4210144002","display_name":"Medipost (South Korea)","ror":"https://ror.org/03vnxht79","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210144002"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Miyeon Kim","raw_affiliation_strings":["Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea","institution_ids":["https://openalex.org/I4210144002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020802600","display_name":"Jinyoung Go","orcid":"https://orcid.org/0000-0002-3296-191X","observed_orcids":["https://orcid.org/0000-0002-3296-191X"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinyoung Go","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029953668","display_name":"Ji Hye Kwon","orcid":"https://orcid.org/0000-0002-5129-7903","observed_orcids":["https://orcid.org/0000-0002-5129-7903"]},"institutions":[{"id":"https://openalex.org/I4210144002","display_name":"Medipost (South Korea)","ror":"https://ror.org/03vnxht79","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210144002"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Hye Kwon","raw_affiliation_strings":["Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea","institution_ids":["https://openalex.org/I4210144002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101910582","display_name":"Hye Jin Jin","orcid":"https://orcid.org/0000-0002-1209-2083","observed_orcids":["https://orcid.org/0000-0002-1209-2083"]},"institutions":[{"id":"https://openalex.org/I4210144002","display_name":"Medipost (South Korea)","ror":"https://ror.org/03vnxht79","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210144002"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Jin Jin","raw_affiliation_strings":["Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea","institution_ids":["https://openalex.org/I4210144002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017668676","display_name":"Yun Kyung Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144002","display_name":"Medipost (South Korea)","ror":"https://ror.org/03vnxht79","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210144002"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun Kyung Bae","raw_affiliation_strings":["Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea","institution_ids":["https://openalex.org/I4210144002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370227","display_name":"Eun\u2010Young Kim","orcid":"https://orcid.org/0000-0002-2368-6426","observed_orcids":["https://orcid.org/0000-0002-2368-6426"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Young Kim","raw_affiliation_strings":["Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058368777","display_name":"Eun\u2010Ju Chang","orcid":"https://orcid.org/0000-0001-8324-5406","observed_orcids":["https://orcid.org/0000-0001-8324-5406"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Ju Chang","raw_affiliation_strings":["Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101798620","display_name":"Soo Jin Choi","orcid":"https://orcid.org/0000-0002-2914-6797","observed_orcids":["https://orcid.org/0000-0002-2914-6797"]},"institutions":[{"id":"https://openalex.org/I4210144002","display_name":"Medipost (South Korea)","ror":"https://ror.org/03vnxht79","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210144002"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Soo Jin Choi","raw_affiliation_strings":["Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam, South Korea","institution_ids":["https://openalex.org/I4210144002"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037618161","display_name":"Seong Who Kim","orcid":"https://orcid.org/0000-0002-3731-9109","observed_orcids":["https://orcid.org/0000-0002-3731-9109"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seong Who Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037618161","https://openalex.org/A5101798620"],"corresponding_institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I4210144002"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.894,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70626375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"803645","last_page":"803645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd26","display_name":"CD26","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-4","display_name":"dipeptidyl peptidase IV","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":1.0},{"id":"https://openalex.org/keywords/in-vitro-expansion","display_name":"in vitro expansion","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.3720000088214874},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cell-sorting","display_name":"cell sorting","score":0.4000000059604645},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.9220482110977173},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7625182271003723},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.548892617225647},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5367988348007202},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5133208632469177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5052593350410461},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.4967053532600403},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49168306589126587},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43452924489974976},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4205484688282013},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32888320088386536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27956661581993103},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.17996814846992493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2021.803645","doi":"https://doi.org/10.3389/fcell.2021.803645","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.803645","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:35178399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35178399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8846329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8846329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:321205a1ae0c4a33a37a78823dfe7544","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/321205a1ae0c4a33a37a78823dfe7544","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2021.803645","doi":"https://doi.org/10.3389/fcell.2021.803645","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.803645","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2365052410","display_name":null,"funder_award_id":"2018R1A5A2020732","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2721572020","display_name":null,"funder_award_id":"2018R1A5A2020732","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G4184948842","display_name":null,"funder_award_id":"2018R1A5A2020732","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4306502684","display_name":null,"funder_award_id":"2018R1A5A2020732","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G461513927","display_name":null,"funder_award_id":"2020R1A2C1011879","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320323011","display_name":"Asan Institute for Life Sciences, Asan Medical Center","ror":"https://ror.org/03s5q0090"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W178300840","https://openalex.org/W1530824105","https://openalex.org/W1978511802","https://openalex.org/W1985429617","https://openalex.org/W1986345877","https://openalex.org/W2010417927","https://openalex.org/W2010874271","https://openalex.org/W2019276374","https://openalex.org/W2020573317","https://openalex.org/W2031338932","https://openalex.org/W2045264627","https://openalex.org/W2047003893","https://openalex.org/W2073365731","https://openalex.org/W2092810335","https://openalex.org/W2095666785","https://openalex.org/W2100764718","https://openalex.org/W2101024920","https://openalex.org/W2106072740","https://openalex.org/W2108273756","https://openalex.org/W2114651025","https://openalex.org/W2115852450","https://openalex.org/W2131078803","https://openalex.org/W2138946470","https://openalex.org/W2146512944","https://openalex.org/W2154677662","https://openalex.org/W2155659380","https://openalex.org/W2181115262","https://openalex.org/W2220139942","https://openalex.org/W2429117898","https://openalex.org/W2592059614","https://openalex.org/W2606373359","https://openalex.org/W2752614382","https://openalex.org/W2758799065","https://openalex.org/W2765951134","https://openalex.org/W2766202858","https://openalex.org/W2793486642","https://openalex.org/W2801147897","https://openalex.org/W2804434142","https://openalex.org/W2915975767","https://openalex.org/W2920148369","https://openalex.org/W3023538751","https://openalex.org/W3153016638","https://openalex.org/W4292330637"],"related_works":["https://openalex.org/W4312304759","https://openalex.org/W3114022144","https://openalex.org/W3032240238","https://openalex.org/W3113349758","https://openalex.org/W2783355185","https://openalex.org/W1998612406","https://openalex.org/W3213450778","https://openalex.org/W4210697757","https://openalex.org/W2275907327","https://openalex.org/W2003070656"],"abstract_inverted_index":{"Mesenchymal":[0],"stem":[1],"cells":[2],"(MSCs)":[3],"are":[4,29,37,84],"recognized":[5],"as":[6,15,122],"potential":[7,197],"treatments":[8],"for":[9,88,200,206],"multiple":[10,151],"degenerative":[11],"and":[12,20,116,158,172],"inflammatory":[13],"disorders":[14],"a":[16,196],"number":[17],"of":[18,51,58,73,93,109,136,147,160,203],"animal":[19],"human":[21],"studies":[22],"have":[23],"indicated":[24],"their":[25,150,207],"therapeutic":[26,71,182],"effects.":[27],"There":[28],"also":[30,120,179],"several":[31],"clinically":[32],"approved":[33],"medicinal":[34],"products":[35],"that":[36,118,133],"manufactured":[38],"using":[39],"these":[40,94],"cells.":[41,75,95],"For":[42],"such":[43],"large-scale":[44],"manufacturing":[45,210],"requirements,":[46],"the":[47,70,74,134,144,156,201],"in":[48,153,168,184,209],"vitro":[49,169],"expansion":[50],"harvested":[52],"MSCs":[53,83,110,148,162,178,205],"is":[54,66,124,195],"essential.":[55],"Multiple":[56],"subculturing":[57],"MSCs,":[59],"however,":[60],"provokes":[61],"cellular":[62,107,128,145],"senescence":[63,108],"processes":[64],"which":[65],"known":[67,121],"to":[68,77,106],"deteriorate":[69],"efficacy":[72,183],"Strategies":[76],"rejuvenate":[78],"or":[79,140],"selectively":[80],"remove":[81],"senescent":[82,204],"therefore":[85],"highly":[86],"desirable":[87],"fostering":[89],"future":[90],"clinical":[91],"applications":[92],"In":[96],"this":[97],"present":[98,190],"study,":[99],"we":[100],"investigated":[101],"gene":[102],"expression":[103],"changes":[104],"related":[105],"derived":[111],"from":[112,163],"umbilical":[113],"cord":[114],"blood":[115],"found":[117],"CD26,":[119],"DPP4,":[123],"significantly":[125],"upregulated":[126],"upon":[127],"aging.":[129],"We":[130],"further":[131],"observed":[132],"inhibition":[135],"CD26":[137,194],"by":[138],"genetic":[139],"pharmacologic":[141],"means":[142],"delayed":[143],"aging":[146],"with":[149],"passaging":[152],"culture.":[154],"Moreover,":[155],"sorting":[157],"exclusion":[159],"CD26-positive":[161],"heterogenous":[164],"cell":[165,170],"population":[166],"enhanced":[167],"attachment":[171],"reduced":[173],"senescence-associated":[174],"cytokine":[175],"secretion.":[176],"CD26-negative":[177],"showed":[180],"superior":[181],"mouse":[185],"lung":[186],"emphysema":[187],"model.":[188],"Our":[189],"results":[191],"collectively":[192],"suggest":[193],"novel":[198],"target":[199],"rejuvenation":[202],"use":[208],"MSC-based":[211],"applications.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}