{"id":"https://openalex.org/W4210694600","doi":"https://doi.org/10.3389/fpsyt.2021.755171","title":"The Gut-Brain-Immune Axis in Autism Spectrum Disorders: A State-of-Art Report","display_name":"The Gut-Brain-Immune Axis in Autism Spectrum Disorders: A State-of-Art Report","publication_year":2022,"publication_date":"2022-02-03","ids":{"openalex":"https://openalex.org/W4210694600","doi":"https://doi.org/10.3389/fpsyt.2021.755171","pmid":"https://pubmed.ncbi.nlm.nih.gov/35185631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8850385"},"language":"en","primary_location":{"id":"doi:10.3389/fpsyt.2021.755171","doi":"https://doi.org/10.3389/fpsyt.2021.755171","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2021.755171","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2021.755171/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2021.755171/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048021304","display_name":"Chiara Puricelli","orcid":"https://orcid.org/0000-0002-0416-6687","observed_orcids":["https://orcid.org/0000-0002-0416-6687"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I4210119436","display_name":"Azienda Ospedaliero Universitaria Maggiore della Carita","ror":"https://ror.org/02gp92p70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119436"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Puricelli","raw_affiliation_strings":["Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy","Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy","institution_ids":["https://openalex.org/I4210119436"]},{"raw_affiliation_string":"Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067778460","display_name":"Roberta Rolla","orcid":"https://orcid.org/0000-0003-0805-8285","observed_orcids":["https://orcid.org/0000-0003-0805-8285"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I4210119436","display_name":"Azienda Ospedaliero Universitaria Maggiore della Carita","ror":"https://ror.org/02gp92p70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119436"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Roberta Rolla","raw_affiliation_strings":["Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy","Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy","institution_ids":["https://openalex.org/I4210119436"]},{"raw_affiliation_string":"Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063681638","display_name":"Casimiro Luca Gigliotti","orcid":"https://orcid.org/0000-0002-3127-5686","observed_orcids":["https://orcid.org/0000-0002-3127-5686"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Gigliotti","raw_affiliation_strings":["Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067397711","display_name":"Elena Maria Boggio","orcid":"https://orcid.org/0000-0003-2700-3597","observed_orcids":["https://orcid.org/0000-0003-2700-3597"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Boggio","raw_affiliation_strings":["Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044541283","display_name":"Eleonora Beltrami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119436","display_name":"Azienda Ospedaliero Universitaria Maggiore della Carita","ror":"https://ror.org/02gp92p70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119436"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Beltrami","raw_affiliation_strings":["Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy","institution_ids":["https://openalex.org/I4210119436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030390675","display_name":"Umberto Dianzani","orcid":"https://orcid.org/0000-0001-6723-3931","observed_orcids":["https://orcid.org/0000-0001-6723-3931"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I4210119436","display_name":"Azienda Ospedaliero Universitaria Maggiore della Carita","ror":"https://ror.org/02gp92p70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119436"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Dianzani","raw_affiliation_strings":["Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy","Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Laboratory, Ospedale Maggiore della Carit\u00e0, Novara, Italy","institution_ids":["https://openalex.org/I4210119436"]},{"raw_affiliation_string":"Department of Health Sciences, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089378070","display_name":"Roberto Keller","orcid":"https://orcid.org/0000-0002-6873-9827","observed_orcids":["https://orcid.org/0000-0002-6873-9827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Keller","raw_affiliation_strings":["Mental Health Department, Adult Autism Center, ASL Citt\u00e0 di Torino, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Department, Adult Autism Center, ASL Citt\u00e0 di Torino, Turin, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067778460"],"corresponding_institution_ids":["https://openalex.org/I123338534","https://openalex.org/I4210119436"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.2301,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.79474308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":null,"first_page":"755171","last_page":"755171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-brain-immune-axis","display_name":"gut-brain-immune axis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.7599999904632568},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8339999914169312},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":1.0},{"id":"https://openalex.org/keywords/microbiome-based-therapy","display_name":"microbiota-based therapy","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.6819400787353516},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6612342596054077},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6459853649139404},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5378038287162781},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5192701816558838},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5089547634124756},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5039219260215759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4859517812728882},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4493813216686249},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33033472299575806},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2576853632926941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24800485372543335},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12236756086349487},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11838001012802124},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fpsyt.2021.755171","doi":"https://doi.org/10.3389/fpsyt.2021.755171","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2021.755171","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2021.755171/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},{"id":"pmid:35185631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35185631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8850385","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8850385/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Psychiatry","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d500649dcc414683ba12719e36a7c8a2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d500649dcc414683ba12719e36a7c8a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Psychiatry, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fpsyt.2021.755171","doi":"https://doi.org/10.3389/fpsyt.2021.755171","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2021.755171","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2021.755171/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1026955993","display_name":null,"funder_award_id":"20714","funder_id":"https://openalex.org/F4320321499","funder_display_name":"Fondazione Cariplo"},{"id":"https://openalex.org/G2384877610","display_name":null,"funder_award_id":"2017-0535","funder_id":"https://openalex.org/F4320321499","funder_display_name":"Fondazione Cariplo"},{"id":"https://openalex.org/G5729993698","display_name":null,"funder_award_id":"IG20714","funder_id":"https://openalex.org/F4320321499","funder_display_name":"Fondazione Cariplo"},{"id":"https://openalex.org/G5875942590","display_name":null,"funder_award_id":"IG20714","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320321499","display_name":"Fondazione Cariplo","ror":"https://ror.org/01gb56c55"},{"id":"https://openalex.org/F4320322823","display_name":"Fondazione Umberto Veronesi","ror":"https://ror.org/041g7jm83"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210694600.pdf","grobid_xml":"https://content.openalex.org/works/W4210694600.grobid-xml"},"referenced_works_count":184,"referenced_works":["https://openalex.org/W180227797","https://openalex.org/W1490861410","https://openalex.org/W1515023627","https://openalex.org/W1588685142","https://openalex.org/W1594747697","https://openalex.org/W1663623302","https://openalex.org/W1711618188","https://openalex.org/W1758745343","https://openalex.org/W1776463731","https://openalex.org/W1908994104","https://openalex.org/W1918697652","https://openalex.org/W1920510593","https://openalex.org/W1941562583","https://openalex.org/W1951069276","https://openalex.org/W1959664751","https://openalex.org/W1964227923","https://openalex.org/W1965769215","https://openalex.org/W1967340481","https://openalex.org/W1968106422","https://openalex.org/W1969144895","https://openalex.org/W1974864175","https://openalex.org/W1978316667","https://openalex.org/W1979285653","https://openalex.org/W1980050771","https://openalex.org/W1980865555","https://openalex.org/W1981867040","https://openalex.org/W1986624226","https://openalex.org/W1989095500","https://openalex.org/W1992526987","https://openalex.org/W1996441448","https://openalex.org/W2003788503","https://openalex.org/W2004279679","https://openalex.org/W2011447176","https://openalex.org/W2014254878","https://openalex.org/W2019018422","https://openalex.org/W2020523926","https://openalex.org/W2022596880","https://openalex.org/W2023046869","https://openalex.org/W2025450822","https://openalex.org/W2025589766","https://openalex.org/W2028318503","https://openalex.org/W2028686080","https://openalex.org/W2029071453","https://openalex.org/W2030047475","https://openalex.org/W2030500910","https://openalex.org/W2032236023","https://openalex.org/W2033386838","https://openalex.org/W2034082915","https://openalex.org/W2039769789","https://openalex.org/W2044216294","https://openalex.org/W2044459025","https://openalex.org/W2053695875","https://openalex.org/W2054241879","https://openalex.org/W2054586661","https://openalex.org/W2056270090","https://openalex.org/W2057411492","https://openalex.org/W2057871265","https://openalex.org/W2058716454","https://openalex.org/W2062011235","https://openalex.org/W2062201650","https://openalex.org/W2067549157","https://openalex.org/W2068375039","https://openalex.org/W2070157770","https://openalex.org/W2076087096","https://openalex.org/W2081313422","https://openalex.org/W2082473379","https://openalex.org/W2086216523","https://openalex.org/W2087370309","https://openalex.org/W2093207028","https://openalex.org/W2093455511","https://openalex.org/W2095602099","https://openalex.org/W2097875133","https://openalex.org/W2098038342","https://openalex.org/W2099594801","https://openalex.org/W2099856240","https://openalex.org/W2107369528","https://openalex.org/W2109113634","https://openalex.org/W2110235509","https://openalex.org/W2111271085","https://openalex.org/W2111453841","https://openalex.org/W2111574450","https://openalex.org/W2111583447","https://openalex.org/W2112024369","https://openalex.org/W2112948254","https://openalex.org/W2113822705","https://openalex.org/W2116846792","https://openalex.org/W2117029190","https://openalex.org/W2118649010","https://openalex.org/W2125826054","https://openalex.org/W2127716652","https://openalex.org/W2132438753","https://openalex.org/W2133766725","https://openalex.org/W2134254908","https://openalex.org/W2141048530","https://openalex.org/W2143196592","https://openalex.org/W2144961872","https://openalex.org/W2145159460","https://openalex.org/W2147725723","https://openalex.org/W2149756110","https://openalex.org/W2150968312","https://openalex.org/W2152612457","https://openalex.org/W2155465918","https://openalex.org/W2157920869","https://openalex.org/W2158871837","https://openalex.org/W2160130122","https://openalex.org/W2163759450","https://openalex.org/W2164342861","https://openalex.org/W2165067288","https://openalex.org/W2165456770","https://openalex.org/W2168959836","https://openalex.org/W2180997009","https://openalex.org/W2183550287","https://openalex.org/W2264701027","https://openalex.org/W2283572643","https://openalex.org/W2283710302","https://openalex.org/W2291518653","https://openalex.org/W2313364663","https://openalex.org/W2328023807","https://openalex.org/W2329924046","https://openalex.org/W2332044667","https://openalex.org/W2337392459","https://openalex.org/W2345604850","https://openalex.org/W2438121633","https://openalex.org/W2470154003","https://openalex.org/W2472167991","https://openalex.org/W2522829059","https://openalex.org/W2524997198","https://openalex.org/W2535108642","https://openalex.org/W2548933161","https://openalex.org/W2550965594","https://openalex.org/W2553893874","https://openalex.org/W2567500573","https://openalex.org/W2568451172","https://openalex.org/W2572551054","https://openalex.org/W2581406049","https://openalex.org/W2589854016","https://openalex.org/W2591891851","https://openalex.org/W2600505436","https://openalex.org/W2602396184","https://openalex.org/W2604323123","https://openalex.org/W2608258222","https://openalex.org/W2609646274","https://openalex.org/W2611324209","https://openalex.org/W2626990662","https://openalex.org/W2729863430","https://openalex.org/W2739906482","https://openalex.org/W2740399096","https://openalex.org/W2758382607","https://openalex.org/W2766026683","https://openalex.org/W2767316205","https://openalex.org/W2773437815","https://openalex.org/W2782333299","https://openalex.org/W2789274700","https://openalex.org/W2790240175","https://openalex.org/W2792168441","https://openalex.org/W2792845386","https://openalex.org/W2793162366","https://openalex.org/W2802053593","https://openalex.org/W2807772034","https://openalex.org/W2889311756","https://openalex.org/W2892188201","https://openalex.org/W2899188916","https://openalex.org/W2901608395","https://openalex.org/W2916032641","https://openalex.org/W2921779752","https://openalex.org/W2922159940","https://openalex.org/W2926398038","https://openalex.org/W2936474142","https://openalex.org/W2939665291","https://openalex.org/W2944658106","https://openalex.org/W2948845813","https://openalex.org/W2953625730","https://openalex.org/W2978324930","https://openalex.org/W2981914118","https://openalex.org/W2994042930","https://openalex.org/W3003581441","https://openalex.org/W3038573574","https://openalex.org/W3040225286","https://openalex.org/W3084019892","https://openalex.org/W3125416908","https://openalex.org/W3128095651","https://openalex.org/W3169942103","https://openalex.org/W3216151710","https://openalex.org/W4240479841"],"related_works":["https://openalex.org/W2900692287","https://openalex.org/W2295923470","https://openalex.org/W4416234109","https://openalex.org/W2951557576","https://openalex.org/W7108934753","https://openalex.org/W4286587455","https://openalex.org/W7165617903","https://openalex.org/W4210693705","https://openalex.org/W2778780507","https://openalex.org/W7124837441"],"abstract_inverted_index":{"The":[0,142],"interest":[1],"elicited":[2],"by":[3,64,68],"the":[4,9,29,33,48,86,100,103,113,116,121,130,135,150,156,159,167,180,192,196,240,244,253,266],"large":[5],"microbial":[6,118,277],"population":[7],"colonizing":[8],"human":[10,245],"gut":[11,52,197,246],"has":[12,16,38,54,145,189],"ancient":[13],"origins":[14],"and":[15,45,57,71,81,89,102,120,126,165,177,182,204,248,257,268,284],"gone":[17],"through":[18],"a":[19,109,200,262,274],"long":[20],"evolution":[21],"during":[22,179],"history.":[23],"However,":[24],"it":[25],"is":[26,73,112],"only":[27],"in":[28,55,78,252],"last":[30],"decades":[31],"that":[32,51,84,231],"introduction":[34],"of":[35,123,138,158,169,210,255],"high-throughput":[36],"technologies":[37],"allowed":[39],"to":[40,46,75,148,194,202,206,224],"broaden":[41],"this":[42,107,170,213],"research":[43],"field":[44],"disentangle":[47],"numerous":[49],"implications":[50],"microbiota":[53,198,226],"health":[56],"disease.":[58],"This":[59,186,235],"comprehensive":[60],"ecosystem,":[61],"constituted":[62],"mainly":[63],"bacteria":[65],"but":[66],"also":[67,190],"fungi,":[69],"parasites,":[70],"viruses,":[72],"proven":[74],"be":[76],"involved":[77],"several":[79],"physiological":[80],"pathological":[82],"processes":[83],"transcend":[85],"intestinal":[87,117,276],"homeostasis":[88],"are":[90],"deeply":[91],"intertwined":[92],"with":[93,228,261],"apparently":[94],"unrelated":[95],"body":[96],"systems,":[97],"such":[98],"as":[99,161,199,279,281],"immune":[101],"nervous":[104],"ones.":[105],"In":[106,212],"regard,":[108],"novel":[110],"speculation":[111],"relationship":[114],"between":[115],"flora":[119],"pathogenesis":[122,254],"some":[124,215],"neurological":[125],"neurodevelopmental":[127,184],"disorders,":[128,260],"including":[129],"clinical":[131],"entities":[132],"defined":[133],"under":[134],"umbrella":[136],"term":[137,151],"autism":[139,256],"spectrum":[140],"disorders.":[141],"bidirectional":[143],"interplay":[144],"led":[146],"researchers":[147],"coin":[149],"gut-brain-immune":[152],"system":[153],"axis,":[154],"subverting":[155],"theory":[157,188],"brain":[160],"an":[162],"immune-privileged":[163],"site":[164],"underscoring":[166],"importance":[168],"reciprocal":[171],"influence":[172],"already":[173],"from":[174,221],"fetal":[175],"life":[176],"especially":[178],"pre-":[181],"post-natal":[183],"process.":[185],"revolutionary":[187],"unveiled":[191],"possibility":[193],"modify":[195],"way":[201],"treat":[203],"even":[205],"prevent":[207],"different":[208],"kinds":[209],"pathologies.":[211],"sense,":[214],"attempts":[216],"have":[217],"been":[218],"made,":[219],"ranging":[220],"probiotic":[222],"administration":[223],"fecal":[225],"transplantation,":[227],"promising":[229],"results":[230],"need":[232],"further":[233],"elaboration.":[234],"state-of-art":[236],"report":[237],"will":[238],"describe":[239],"main":[241],"aspects":[242],"regarding":[243],"microbiome":[247],"its":[249,258],"specific":[250],"role":[251],"related":[259],"final":[263],"discussion":[264],"on":[265],"therapeutic":[267],"preventive":[269],"strategies":[270],"aiming":[271],"at":[272],"creating":[273],"healthy":[275],"environment,":[278],"well":[280],"their":[282],"safety":[283],"ethical":[285],"implications.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-02-08T00:00:00"}
