{"id":"https://openalex.org/W4210692745","doi":"https://doi.org/10.1177/09603271211073708","title":"Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection","display_name":"Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4210692745","doi":"https://doi.org/10.1177/09603271211073708","pmid":"https://pubmed.ncbi.nlm.nih.gov/35112887"},"language":"en","primary_location":{"id":"doi:10.1177/09603271211073708","doi":"https://doi.org/10.1177/09603271211073708","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09603271211073708","pdf_url":null,"source":{"id":"https://openalex.org/S147701277","display_name":"Human & Experimental Toxicology","issn_l":"0960-3271","issn":["0960-3271","1477-0903"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & Experimental Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/09603271211073708","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020445618","display_name":"Anna Ram\u00edrez","orcid":"https://orcid.org/0000-0001-6984-4058","observed_orcids":["https://orcid.org/0000-0001-6984-4058"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Anna C Ram\u00edrez-Su\u00e1rez","raw_affiliation_strings":["Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":"https://orcid.org/0000-0001-6984-4058","affiliations":[{"raw_affiliation_string":"Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091548941","display_name":"Taim\u00ed Paneque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Taimi Paneque-Guerrero","raw_affiliation_strings":["Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087656278","display_name":"Dionne Casillas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Dionne Casillas-Casanova","raw_affiliation_strings":["Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027834397","display_name":"Karelia Cosme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Karelia Cosme","raw_affiliation_strings":["Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058295204","display_name":"Dania Bacard\u00ed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Dania Bacard\u00ed","raw_affiliation_strings":["Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033324803","display_name":"Carlos A. Duarte","orcid":"https://orcid.org/0000-0001-5308-9676","observed_orcids":["https://orcid.org/0000-0001-5308-9676"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Carlos A Duarte","raw_affiliation_strings":["Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017006976","display_name":"Julio Anc\u00edzar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Julio Anc\u00edzar","raw_affiliation_strings":["Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emma Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Emma Brown","raw_affiliation_strings":["Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jorge Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Jorge Castro","raw_affiliation_strings":["Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018441249","display_name":"Jos\u00e9 Su\u00e1rez-Alba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Su\u00e1rez-Alba","raw_affiliation_strings":["Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074444464","display_name":"Hilda Garay","orcid":"https://orcid.org/0000-0003-3101-255X","observed_orcids":["https://orcid.org/0000-0003-3101-255X"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Hilda Garay","raw_affiliation_strings":["Chemical and Physical Department, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Physical Department, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013408784","display_name":"Karla Pereira","orcid":"https://orcid.org/0000-0002-4405-9640","observed_orcids":["https://orcid.org/0000-0002-4405-9640"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Karla Pereira","raw_affiliation_strings":["Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030426253","display_name":"Celia Fern\u00e1ndez\u2010Ortega","orcid":"https://orcid.org/0000-0001-8973-3240","observed_orcids":["https://orcid.org/0000-0001-8973-3240"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":true,"raw_author_name":"Celia Fern\u00e1ndez-Ortega","raw_affiliation_strings":["Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba"],"raw_orcid":"https://orcid.org/0000-0001-8973-3240","affiliations":[{"raw_affiliation_string":"Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030426253"],"corresponding_institution_ids":["https://openalex.org/I4210130720"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00363031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"9603271211073708","last_page":"9603271211073708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.4246000051498413,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.4246000051498413,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.364300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.13809999823570251,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-hiv-peptides","display_name":"anti-HIV peptides","score":0.878000020980835},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7850000262260437},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6320000290870667},{"id":"https://openalex.org/keywords/repeated-dose-toxicity","display_name":"repeated-dose toxicity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.8939999938011169},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.9229999780654907},{"id":"https://openalex.org/keywords/splenocyte-proliferation","display_name":"splenocyte proliferation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.48899999260902405},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6135432124137878},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6069083213806152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.598867654800415},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5396392941474915},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5313107967376709},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.513766884803772},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48063984513282776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43521010875701904},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3223118185997009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.256523072719574},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21247461438179016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/09603271211073708","doi":"https://doi.org/10.1177/09603271211073708","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09603271211073708","pdf_url":null,"source":{"id":"https://openalex.org/S147701277","display_name":"Human & Experimental Toxicology","issn_l":"0960-3271","issn":["0960-3271","1477-0903"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & Experimental Toxicology","raw_type":"journal-article"},{"id":"pmid:35112887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35112887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & experimental toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/09603271211073708","doi":"https://doi.org/10.1177/09603271211073708","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09603271211073708","pdf_url":null,"source":{"id":"https://openalex.org/S147701277","display_name":"Human & Experimental Toxicology","issn_l":"0960-3271","issn":["0960-3271","1477-0903"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & Experimental Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1904411247","https://openalex.org/W1971350188","https://openalex.org/W1974096769","https://openalex.org/W2057524089","https://openalex.org/W2059793819","https://openalex.org/W2096176556","https://openalex.org/W2099115964","https://openalex.org/W2108318095","https://openalex.org/W2114918609","https://openalex.org/W2126048177","https://openalex.org/W2136197663","https://openalex.org/W2137091788","https://openalex.org/W2139556375","https://openalex.org/W2144576828","https://openalex.org/W2145341929","https://openalex.org/W2167907545","https://openalex.org/W2416290131","https://openalex.org/W2443329401","https://openalex.org/W2803001373","https://openalex.org/W2807596407","https://openalex.org/W2911752236","https://openalex.org/W2993610649","https://openalex.org/W3028275166","https://openalex.org/W3034382140","https://openalex.org/W3114693725","https://openalex.org/W4247050267","https://openalex.org/W7099781825"],"related_works":["https://openalex.org/W2907038866","https://openalex.org/W2149265956","https://openalex.org/W2019498905","https://openalex.org/W4247333677","https://openalex.org/W2160205846","https://openalex.org/W2041669109","https://openalex.org/W2321011144","https://openalex.org/W2115679902","https://openalex.org/W2065543232","https://openalex.org/W1987337455"],"abstract_inverted_index":{"Current":[0],"human":[1],"immunodeficiency":[2],"virus":[3],"treatments":[4],"need":[5],"to":[6,34,124],"be":[7],"periodically":[8],"administered":[9],"lifelong.":[10],"In":[11],"this":[12],"study":[13,151],"we":[14],"assess":[15],"the":[16,50,59,77,82,92,98,132,146,150,169],"effect":[17],"of":[18,21,32,39,58,91,97,119,135,145],"repeated":[19,133],"doses":[20],"an":[22],"anti-HIV":[23],"peptide":[24,60],"drug":[25],"candidate":[26],"in":[27,89,105,165,168],"C57BL6":[28,166],"strain.":[29],"Two":[30],"schemes":[31],"up":[33],"15":[35],"administrations":[36],"and":[37,109,121,154,174],"one":[38],"30,":[40],"daily":[41],"dosing":[42],"for":[43,143],"5":[44],"days":[45],"per":[46],"week,":[47],"all":[48],"by":[49,131],"subcutaneous":[51],"route":[52],"were":[53,61,128,138],"evaluated.":[54],"Different":[55],"dose":[56,170],"concentrations":[57],"assayed.":[62],"CIGB-210":[63,161],"treated":[64,153],"animals":[65,78],"showed":[66,86],"no":[67,87],"symptoms":[68],"or":[69,114],"abnormal":[70],"behavior":[71],"as":[72],"compared":[73],"with":[74],"placebo.":[75],"All":[76],"gained":[79],"weight":[80],"during":[81,149],"study.":[83],"Macroscopic":[84],"evaluation":[85],"alterations":[88],"any":[90,144],"organs":[93],"studied.":[94],"Microscopic":[95],"analysis":[96],"tissues":[99],"did":[100],"not":[101,129,139],"show":[102],"morphological":[103],"changes":[104],"thymus,":[106],"stomach,":[107],"small":[108],"large":[110],"intestines,":[111],"kidney,":[112],"brain,":[113],"cerebellum.":[115],"The":[116],"proliferative":[117],"response":[118],"splenocytes":[120],"their":[122],"capacity":[123],"secrete":[125],"gamma":[126],"interferon":[127],"compromised":[130],"administration":[134],"CIGB-210.":[136],"There":[137],"statistically":[140],"significant":[141],"differences":[142],"parameters":[147],"evaluated":[148],"among":[152],"non-treated":[155],"groups.":[156],"We":[157],"can":[158],"conclude":[159],"that":[160],"is":[162],"well":[163],"tolerated":[164],"mice":[167],"concentration":[171],"range":[172],"explored":[173],"merits":[175],"subsequent":[176],"toxicological":[177],"studies.":[178]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-02-08T00:00:00"}