{"id":"https://openalex.org/W4210690818","doi":"https://doi.org/10.1016/j.yrtph.2022.105127","title":"A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 3: Inflammatory response following acute inhalation exposure correlates with lower tier data","display_name":"A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 3: Inflammatory response following acute inhalation exposure correlates with lower tier data","publication_year":2022,"publication_date":"2022-02-03","ids":{"openalex":"https://openalex.org/W4210690818","doi":"https://doi.org/10.1016/j.yrtph.2022.105127","pmid":"https://pubmed.ncbi.nlm.nih.gov/35124137"},"language":"en","primary_location":{"id":"doi:10.1016/j.yrtph.2022.105127","doi":"https://doi.org/10.1016/j.yrtph.2022.105127","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2022.105127","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0273230022000149/pdf","source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0273230022000149/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015306223","display_name":"Vanessa Viegas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105448","display_name":"Cobalt Institute","ror":"https://ror.org/00yq7f263","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210105448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vanessa Viegas","raw_affiliation_strings":["Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK. Electronic address: vviegas@cobaltinstitute.org","Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK. Electronic address: vviegas@cobaltinstitute.org","institution_ids":["https://openalex.org/I4210105448"]},{"raw_affiliation_string":"Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK","institution_ids":["https://openalex.org/I4210105448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024195782","display_name":"Arne Burzlaff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arne Burzlaff","raw_affiliation_strings":["EBRC Consulting GmbH, Raffaelstra\u00dfe 4, 30177, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EBRC Consulting GmbH, Raffaelstra\u00dfe 4, 30177, Hannover, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089417356","display_name":"Thomas O. Brock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas O. Brock","raw_affiliation_strings":["Duke Occupational & Environmental Medicine, DUMC 3834, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Occupational & Environmental Medicine, DUMC 3834, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048139538","display_name":"Ruth Danzeisen","orcid":"https://orcid.org/0000-0003-2967-7659","observed_orcids":["https://orcid.org/0000-0003-2967-7659"]},"institutions":[{"id":"https://openalex.org/I4210105448","display_name":"Cobalt Institute","ror":"https://ror.org/00yq7f263","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210105448"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ruth Danzeisen","raw_affiliation_strings":["Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK. Electronic address: rdanzeisen@cobaltinstitute.org","Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK"],"raw_orcid":"https://orcid.org/0000-0003-2967-7659","affiliations":[{"raw_affiliation_string":"Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK. Electronic address: rdanzeisen@cobaltinstitute.org","institution_ids":["https://openalex.org/I4210105448"]},{"raw_affiliation_string":"Cobalt Institute, 18 Jeffries Passage, Guildford, GU1 4AP, UK","institution_ids":["https://openalex.org/I4210105448"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048139538"],"corresponding_institution_ids":["https://openalex.org/I4210105448"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":1.1265,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.73096816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"130","issue":null,"first_page":"105127","last_page":"105127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhalation-toxicity","display_name":"inhalation toxicity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/acute-inhalation-exposure","display_name":"acute inhalation exposure","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lung-histopathology","display_name":"lung histopathology","score":0.8029999732971191},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tiered-approach","display_name":"tiered approach","score":0.550000011920929},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.8463214635848999},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.740341067314148},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5888849496841431},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5217224359512329},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5000503063201904},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.48128002882003784},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4509630799293518},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.41489285230636597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39895331859588623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38425329327583313},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.37045514583587646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2930060625076294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21163058280944824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16869452595710754},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.11029517650604248},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08543476462364197},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019570","descriptor_name":"Inhalation Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.yrtph.2022.105127","doi":"https://doi.org/10.1016/j.yrtph.2022.105127","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2022.105127","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0273230022000149/pdf","source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:35124137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35124137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory toxicology and pharmacology : RTP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.yrtph.2022.105127","doi":"https://doi.org/10.1016/j.yrtph.2022.105127","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2022.105127","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0273230022000149/pdf","source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210690818.pdf","grobid_xml":"https://content.openalex.org/works/W4210690818.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W88511457","https://openalex.org/W1507326555","https://openalex.org/W1965037168","https://openalex.org/W2021947467","https://openalex.org/W2028612478","https://openalex.org/W2046783953","https://openalex.org/W2080274549","https://openalex.org/W2094156327","https://openalex.org/W2103154710","https://openalex.org/W2132019805","https://openalex.org/W2557019237","https://openalex.org/W2605466593","https://openalex.org/W2741885356","https://openalex.org/W2891659819","https://openalex.org/W3006639556","https://openalex.org/W3029098010","https://openalex.org/W4205359305","https://openalex.org/W4206510207","https://openalex.org/W4206950830","https://openalex.org/W4210586378","https://openalex.org/W4210615633","https://openalex.org/W4211055562"],"related_works":["https://openalex.org/W4210615633","https://openalex.org/W4211055562","https://openalex.org/W4206950830","https://openalex.org/W4206510207","https://openalex.org/W1989040608","https://openalex.org/W2010787626","https://openalex.org/W2118547942","https://openalex.org/W2049921946","https://openalex.org/W2891659819","https://openalex.org/W2055500773"],"abstract_inverted_index":{"In":[0],"vitro":[1,85],"studies":[2,168],"have":[3],"shown":[4],"that":[5],"cobalt":[6,109],"substances":[7,17,110,146],"predominantly":[8],"induce":[9],"pre-inflammatory":[10],"biomarkers,":[11],"resulting":[12],"in":[13,84,90,113,115,151],"a":[14,28,35,116,148],"grouping":[15],"of":[16,37,45,56,69,96,155,161,178],"either":[18],"predicted":[19],"to":[20,50,58,63,92,104,125,172],"cause":[21],"inflammation":[22],"following":[23,43],"inhalation,":[24],"or":[25,153],"those":[26],"with":[27,121,143,164],"different":[29],"reactivity":[30],"profile":[31],"(poorly-reactive).":[32],"There":[33],"is":[34,55],"lack":[36],"data":[38],"on":[39,134],"whole-organ":[40],"lung":[41],"responses":[42],"inhalation":[44],"these":[46,162],"substances,":[47],"especially":[48],"relating":[49],"the":[51,66,70,94,100,144,156,174,179],"poorly-reactive":[52,101,165,180],"group.":[53],"It":[54],"interest":[57],"generate":[59],"tissue-specific":[60],"histopathological":[61],"correlation":[62],"better":[64],"ascertain":[65],"predictive":[67],"nature":[68],"lower":[71],"tier":[72,75],"tests":[73],"(i.e.":[74],"1":[76],"-":[77,83],"bioelution,":[78],"tiers":[79],"2a":[80],"and":[81,87,103,136,159],"b":[82],"markers":[86,163],"ToxTracker":[88],"testing),":[89],"order":[91],"understand":[93],"type":[95],"effects":[97,177],"caused":[98],"by":[99],"group":[102],"gauge":[105],"long-term":[106],"effects.":[107],"Eight":[108],"were":[111,131],"tested":[112],"vivo":[114],"customized":[117],"4-h":[118],"toxicity":[119],"test;":[120],"animals":[122],"sacrificed":[123],"up":[124],"14-days":[126],"post-exposure.":[127],"Histopathological":[128],"severity":[129],"scores":[130],"assigned":[132],"based":[133],"inflammatory":[135],"pre-carcinogenic":[137],"markers.":[138],"A":[139],"clear":[140],"pattern":[141],"emerged,":[142],"reactive":[145],"causing":[147],"persistent":[149],"increase":[150],"one":[152],"more":[154],"selected":[157],"markers,":[158],"absence":[160],"substances.":[166,181],"Longer-term":[167],"should":[169],"be":[170],"conducted":[171],"investigate":[173],"repeated":[175],"dose":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-02-08T00:00:00"}
