{"id":"https://openalex.org/W4210629528","doi":"https://doi.org/10.1016/j.dnarep.2022.103289","title":"DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR","display_name":"DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4210629528","doi":"https://doi.org/10.1016/j.dnarep.2022.103289","pmid":"https://pubmed.ncbi.nlm.nih.gov/35124373"},"language":"en","primary_location":{"id":"doi:10.1016/j.dnarep.2022.103289","doi":"https://doi.org/10.1016/j.dnarep.2022.103289","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2022.103289","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1568786422000180/pdf","source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1568786422000180/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073784093","display_name":"Michelle L. Swift","orcid":"https://orcid.org/0000-0003-3645-1308","observed_orcids":["https://orcid.org/0000-0003-3645-1308"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L. Swift","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048106880","display_name":"Jane Azizkhan\u2010Clifford","orcid":"https://orcid.org/0000-0002-6441-5198","observed_orcids":["https://orcid.org/0000-0002-6441-5198"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jane Azizkhan-Clifford","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: jane.clifford@drexel.edu","Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: jane.clifford@drexel.edu","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048106880"],"corresponding_institution_ids":["https://openalex.org/I72816309"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":{"value":4140,"currency":"USD","value_usd":4140},"fwci":0.8987,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.69140478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"111","issue":null,"first_page":"103289","last_page":"103289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/rnf4","display_name":"RNF4","score":0.9539999961853027},{"id":"https://openalex.org/keywords/53bp1","display_name":"53BP1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8920000195503235},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.984000027179718},{"id":"https://openalex.org/keywords/atm-phosphorylation","display_name":"ATM phosphorylation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cyclin-a-cdk2","display_name":"CDK2/cyclin A","score":0.8579999804496765},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.6759999990463257},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/parp-inhibition","display_name":"PARP inhibition","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.9367800951004028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7194390296936035},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6921646595001221},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6253860592842102},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6065177917480469},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5619828104972839},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.5491573214530945},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4825226962566376},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.4602351188659668},{"id":"https://openalex.org/C138599941","wikidata":"https://www.wikidata.org/wiki/Q18031158","display_name":"RNF4","level":5,"score":0.43872788548469543},{"id":"https://openalex.org/C193104389","wikidata":"https://www.wikidata.org/wiki/Q18032397","display_name":"Ku80","level":5,"score":0.42899012565612793},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.41830259561538696},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.37753868103027344},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.22173047065734863},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.19041332602500916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.189272940158844},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.1813197135925293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07335153222084045}],"mesh":[{"descriptor_ui":"D000071857","descriptor_name":"Tumor Suppressor p53-Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071857","descriptor_name":"Tumor Suppressor p53-Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071857","descriptor_name":"Tumor Suppressor p53-Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.dnarep.2022.103289","doi":"https://doi.org/10.1016/j.dnarep.2022.103289","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2022.103289","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1568786422000180/pdf","source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},{"id":"pmid:35124373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35124373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA repair","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.dnarep.2022.103289","doi":"https://doi.org/10.1016/j.dnarep.2022.103289","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2022.103289","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1568786422000180/pdf","source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332642","display_name":"College of Medicine, Drexel University","ror":"https://ror.org/04bdffz58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210629528.pdf","grobid_xml":"https://content.openalex.org/works/W4210629528.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1758502057","https://openalex.org/W1945773609","https://openalex.org/W1963961667","https://openalex.org/W1970488978","https://openalex.org/W1983218764","https://openalex.org/W1985165882","https://openalex.org/W1988995986","https://openalex.org/W1989643386","https://openalex.org/W1994242043","https://openalex.org/W1994427703","https://openalex.org/W2003144810","https://openalex.org/W2005182677","https://openalex.org/W2005711961","https://openalex.org/W2005833414","https://openalex.org/W2008185037","https://openalex.org/W2013108773","https://openalex.org/W2020856591","https://openalex.org/W2021044341","https://openalex.org/W2022912676","https://openalex.org/W2028154024","https://openalex.org/W2039143648","https://openalex.org/W2039501969","https://openalex.org/W2042499074","https://openalex.org/W2043369995","https://openalex.org/W2044432481","https://openalex.org/W2054782539","https://openalex.org/W2061462200","https://openalex.org/W2068668324","https://openalex.org/W2073229191","https://openalex.org/W2074469807","https://openalex.org/W2074615071","https://openalex.org/W2074636979","https://openalex.org/W2078046348","https://openalex.org/W2078519341","https://openalex.org/W2082478286","https://openalex.org/W2086438431","https://openalex.org/W2089130084","https://openalex.org/W2090221766","https://openalex.org/W2094105923","https://openalex.org/W2096626023","https://openalex.org/W2097130665","https://openalex.org/W2112651502","https://openalex.org/W2113354406","https://openalex.org/W2114860131","https://openalex.org/W2130953564","https://openalex.org/W2132396299","https://openalex.org/W2134071049","https://openalex.org/W2139538368","https://openalex.org/W2140537269","https://openalex.org/W2140740835","https://openalex.org/W2140898599","https://openalex.org/W2145200068","https://openalex.org/W2147917253","https://openalex.org/W2148789090","https://openalex.org/W2152440925","https://openalex.org/W2152900205","https://openalex.org/W2156238710","https://openalex.org/W2157899948","https://openalex.org/W2158546639","https://openalex.org/W2167048638","https://openalex.org/W2304280967","https://openalex.org/W2332271182","https://openalex.org/W2419391715","https://openalex.org/W2596851526","https://openalex.org/W2618777797","https://openalex.org/W2771132013","https://openalex.org/W2781323229","https://openalex.org/W2788085902","https://openalex.org/W2898273645","https://openalex.org/W3046596788","https://openalex.org/W3138720169","https://openalex.org/W3179346786"],"related_works":["https://openalex.org/W34474889","https://openalex.org/W2770420481","https://openalex.org/W2100200896","https://openalex.org/W2021044341","https://openalex.org/W2151854650","https://openalex.org/W2941810629","https://openalex.org/W2140537269","https://openalex.org/W2156238710","https://openalex.org/W3170378354","https://openalex.org/W2046682827"],"abstract_inverted_index":{"The":[0,18],"factors":[1,31,215],"involved":[2],"in":[3,151,155,186,207],"DNA":[4,28,56,78,213],"damage":[5,29],"recognition":[6],"and":[7,65,71,103,123,147,159,182,204,210],"repair":[8,15,30,44,214],"are":[9,171],"tightly":[10],"regulated":[11],"to":[12,98,173,177,179],"ensure":[13],"proper":[14],"pathway":[16,45],"choice.":[17],"mechanism(s)":[19],"that":[20,37,189],"determines":[21],"the":[22,66,91,126,199,208],"cell":[23],"cycle-dependent":[24],"turnover":[25],"of":[26,49,68,77,94,106,137,144,194,202,212],"these":[27],"remains":[32],"unclear.":[33],"Here,":[34],"we":[35],"show":[36],"Sp1,":[38],"which":[39,87],"regulates":[40],"double-strand":[41],"break":[42],"(DSB)":[43],"choice":[46],"through":[47],"localization":[48],"53BP1,":[50],"is":[51,60,88,118,190],"sumoylated":[52],"at":[53,83,108,139,216],"Lys16":[54,140],"following":[55],"damage;":[57],"Sp1":[58,70,81,107,133,138,146,181,203],"sumoylation":[59,93,134],"required":[61],"for":[62,90,120],"its":[63,205],"degradation":[64,124],"removal":[67,143],"both":[69,145],"53BP1":[72,148],"from":[73,149],"DSB":[74],"sites.":[75],"Induction":[76],"DSBs":[79,84,150],"induces":[80],"phosphorylation":[82,102,105],"by":[85,110,125,135,192],"ATM,":[86],"necessary":[89,119],"subsequent":[92],"Sp1.":[95],"In":[96],"addition":[97],"this":[99],"damage-induced":[100],"ATM-dependent":[101],"sumoylation,":[104],"Ser59":[109],"Cyclin":[111],"A/cdk2":[112],"upon":[113],"entry":[114],"into":[115],"S":[116,152],"phase":[117],"recognition,":[121],"ubiquitination":[122],"SUMO-targeted":[127],"E3":[128],"ubiquitin":[129],"ligase,":[130],"RNF4.":[131],"Eliminating":[132],"mutation":[136],"(K16R)":[141],"precluded":[142],"phase,":[153],"resulting":[154,185],"decreased":[156],"BRCA1":[157,165,184],"recruitment":[158],"defective":[160,187],"homologous":[161],"recombination":[162],"(HR).":[163],"Like":[164],"deficient":[166],"cells,":[167],"cells":[168],"expressing":[169],"Sp1K16R":[170],"sensitive":[172],"PARP":[174],"inhibition":[175],"due":[176],"failure":[178],"degrade":[180],"recruit":[183],"HR":[188],"rescued":[191],"knockdown":[193],"53BP1.":[195],"These":[196],"results":[197],"reveal":[198],"dynamic":[200],"regulation":[201],"role":[206],"assembly":[209],"disassembly":[211],"DSBs.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-10T00:00:00"}