{"id":"https://openalex.org/W4210544591","doi":"https://doi.org/10.18502/ssu.v29i11.8503","title":"Comparison of Pro-inflammatory Gene Expression Profile in Spleen and Peripheral Blood Neutrophils of BALB/C Mice Infected with Leishmania Major","display_name":"Comparison of Pro-inflammatory Gene Expression Profile in Spleen and Peripheral Blood Neutrophils of BALB/C Mice Infected with Leishmania Major","publication_year":2022,"publication_date":"2022-01-26","ids":{"openalex":"https://openalex.org/W4210544591","doi":"https://doi.org/10.18502/ssu.v29i11.8503"},"language":"en","primary_location":{"id":"doi:10.18502/ssu.v29i11.8503","doi":"https://doi.org/10.18502/ssu.v29i11.8503","is_oa":true,"landing_page_url":"https://doi.org/10.18502/ssu.v29i11.8503","pdf_url":null,"source":{"id":"https://openalex.org/S4306537396","display_name":"\u0645\u0627\u0647\u0646\u0627\u0645\u0647 \u0639\u0644\u0645\u06cc \u067e\u200d\u0698\u0648\u0647\u0634\u06cc \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0635\u062f\u0648\u0642\u06cc \u06cc\u0632\u062f","issn_l":"2228-5733","issn":["2228-5733","2228-5741"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Shahid Sadoughi University of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18502/ssu.v29i11.8503","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006073997","display_name":"Hossein Rezvan","orcid":"https://orcid.org/0000-0002-9328-0245","observed_orcids":["https://orcid.org/0000-0002-9328-0245"]},"institutions":[{"id":"https://openalex.org/I167694869","display_name":"Bu-Ali Sina University","ror":"https://ror.org/04ka8rx28","country_code":"IR","type":"education","lineage":["https://openalex.org/I167694869"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Rezvan","raw_affiliation_strings":["\n             Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.    \n\t","institution_ids":["https://openalex.org/I167694869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011936366","display_name":"Sahar Hamoon Navard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I167694869","display_name":"Bu-Ali Sina University","ror":"https://ror.org/04ka8rx28","country_code":"IR","type":"education","lineage":["https://openalex.org/I167694869"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sahar Hamoon Navard","raw_affiliation_strings":["\n             Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.    \n\t","institution_ids":["https://openalex.org/I167694869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077199956","display_name":"Soheyla Akhzari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I167694869","display_name":"Bu-Ali Sina University","ror":"https://ror.org/04ka8rx28","country_code":"IR","type":"education","lineage":["https://openalex.org/I167694869"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Soheyla Akhzari","raw_affiliation_strings":["\n             Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.    \n\t","institution_ids":["https://openalex.org/I167694869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I167694869"],"apc_list":null,"apc_paid":null,"fwci":0.202,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45584917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-leishmaniasis","display_name":"cutaneous leishmaniasis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.996999979019165},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8759999871253967},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7229999899864197},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8259999752044678},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.9890000224113464},{"id":"https://openalex.org/keywords/meglumine-antimoniate","display_name":"meglumine antimoniate","score":0.8640000224113464},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8090000152587891},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.9679999947547913},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.515999972820282},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6634843349456787},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6389412879943848},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5842818021774292},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.5792483687400818},{"id":"https://openalex.org/C110015553","wikidata":"https://www.wikidata.org/wiki/Q5009623","display_name":"CCL3","level":5,"score":0.5363131165504456},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5225593447685242},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.4876669645309448},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.48493102192878723},{"id":"https://openalex.org/C2780599195","wikidata":"https://www.wikidata.org/wiki/Q1950715","display_name":"Leishmania major","level":4,"score":0.4567687213420868},{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.44788405299186707},{"id":"https://openalex.org/C2778702967","wikidata":"https://www.wikidata.org/wiki/Q2590966","display_name":"Cutaneous leishmaniasis","level":3,"score":0.4296717047691345},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.40300047397613525},{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.3256887197494507},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.1460774838924408},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.07869327068328857},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18502/ssu.v29i11.8503","doi":"https://doi.org/10.18502/ssu.v29i11.8503","is_oa":true,"landing_page_url":"https://doi.org/10.18502/ssu.v29i11.8503","pdf_url":null,"source":{"id":"https://openalex.org/S4306537396","display_name":"\u0645\u0627\u0647\u0646\u0627\u0645\u0647 \u0639\u0644\u0645\u06cc \u067e\u200d\u0698\u0648\u0647\u0634\u06cc \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0635\u062f\u0648\u0642\u06cc \u06cc\u0632\u062f","issn_l":"2228-5733","issn":["2228-5733","2228-5741"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Shahid Sadoughi University of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:681fa020ab704796927a91b0ef416962","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/681fa020ab704796927a91b0ef416962","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i D\u0101nishg\u0101h-i \u2019Ul\u016bm-i Pizishk\u012b-i Shah\u012bd \u1e62ad\u016bq\u012b Yazd, Vol 29, Iss 11, Pp 4268-4280 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18502/ssu.v29i11.8503","doi":"https://doi.org/10.18502/ssu.v29i11.8503","is_oa":true,"landing_page_url":"https://doi.org/10.18502/ssu.v29i11.8503","pdf_url":null,"source":{"id":"https://openalex.org/S4306537396","display_name":"\u0645\u0627\u0647\u0646\u0627\u0645\u0647 \u0639\u0644\u0645\u06cc \u067e\u200d\u0698\u0648\u0647\u0634\u06cc \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0635\u062f\u0648\u0642\u06cc \u06cc\u0632\u062f","issn_l":"2228-5733","issn":["2228-5733","2228-5741"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Shahid Sadoughi University of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2566683755","https://openalex.org/W1946880381","https://openalex.org/W7168238919","https://openalex.org/W2981341017","https://openalex.org/W2810882662","https://openalex.org/W2566967227","https://openalex.org/W2894460911","https://openalex.org/W2923404982","https://openalex.org/W2082748314","https://openalex.org/W4414072630"],"abstract_inverted_index":{"Introduction:":[0],"Leishmaniasis":[1],"is":[2],"one":[3],"of":[4,21,27,40,43,59,65,96,102,184,211],"the":[5,18,44,63,66,71,81,94,97,173,181,185,204,209,215],"common":[6],"diseases":[7],"between":[8],"humans":[9],"and":[10,80,99,116,125,143,170],"animals.":[11],"The":[12,132,195],"present":[13],"study":[14],"was":[15,118,178],"to":[16,33],"investigate":[17],"expression":[19,105,182,210],"pattern":[20,183],"pro-inflammatory":[22],"genes":[23,186,213],"in":[24,31,56,62,120,166,172,187,218],"different":[25,179],"stages":[26,42],"cutaneous":[28],"leishmaniasis":[29],"progression":[30,217],"order":[32],"provide":[34],"a":[35],"standard":[36],"framework":[37],"for":[38,87],"diagnosis":[39],"various":[41],"disease.":[45],"Methods:":[46],"In":[47,152],"this":[48],"experimental":[49],"study,":[50],"2\u00d7106":[51],"Leishmania":[52,153,188],"major":[53],"were":[54,73,134,146,175],"injected":[55],"two":[57],"groups":[58],"BALB/c":[60],"mice":[61,190],"base":[64],"tail.":[67],"After":[68],"skin":[69],"lesion,":[70],"animals":[72],"divided":[74],"into":[75],"control":[76],"group,":[77],"without":[78],"treatment":[79,157],"test":[82,145],"group":[83],"treated":[84,191],"with":[85,158,192],"glucantime":[86],"30":[88],"days":[89],"by":[90],"intralesion":[91],"injection.":[92],"At":[93],"end":[95],"second":[98],"fourth":[100],"weeks":[101],"treatment,":[103],"gene":[104],"cytokines":[106,196],"IL-12p35,":[107],"CCL3,":[108],"CCL4,":[109],"IL-12p40,":[110,164],"TNF-\u03b1,":[111],"CCL5,":[112],"IL-1\u03b1,":[113],"IL-1\u03b2,":[114,161],"IFN-\u03b3":[115,171],"CCR5":[117],"performed":[119],"peripheral":[121,167],"blood":[122,168],"neutrophil":[123],"cells":[124,127],"spleen":[126],"using":[128],"conventional":[129],"PCR":[130],"technique.":[131],"data":[133],"analyzed":[135],"through":[136],"SPSS":[137],"software":[138],"version":[139],"16;":[140],"t-tests,":[141],"ANOVA":[142],"Tukey's":[144],"also":[147],"run":[148],"(P":[149],"\u02c20.05).":[150],"Results:":[151],"infected":[154,189],"mice,":[155],"before":[156],"glucantime,":[159],"IFN-\u03b3,":[160],"CCR5,":[162],"CCL-5,":[163],"IL-12p35":[165],"neutrophils":[169],"spleens":[174],"expressed,":[176],"which":[177],"from":[180],"Glucantim.":[193],"Conclusion:":[194],"(IFN-\u03b3,":[197],"IL-12,":[198],"TNF-\u03b1)":[199],"are":[200],"important":[201],"factors":[202],"affecting":[203],"immune":[205],"response":[206],"as":[207],"reducing":[208],"these":[212],"causes":[214],"lesion":[216],"leishmaniasis.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-02-08T00:00:00"}