{"id":"https://openalex.org/W4210497145","doi":"https://doi.org/10.20944/preprints202202.0017.v1","title":"Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left-Heart Syndrome, Ciliopathies and Neurodevelopmental Delays","display_name":"Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left-Heart Syndrome, Ciliopathies and Neurodevelopmental Delays","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4210497145","doi":"https://doi.org/10.20944/preprints202202.0017.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202202.0017.v1","doi":"https://doi.org/10.20944/preprints202202.0017.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202202.0017.v1","pdf_url":"https://www.preprints.org/manuscript/202202.0017/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/manuscript/202202.0017/v1/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066367676","display_name":"Kalyani Bindu Karunakaran","orcid":"https://orcid.org/0000-0003-1279-7750","observed_orcids":["https://orcid.org/0000-0003-1279-7750"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kalyani B Karunakaran","raw_affiliation_strings":["Supercomputer Education and Research Centre , Indian Institute of Science , Bangalore 560012 , India","Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supercomputer Education and Research Centre , Indian Institute of Science , Bangalore 560012 , India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065678444","display_name":"George C. Gabriel","orcid":"https://orcid.org/0000-0003-3250-2518","observed_orcids":["https://orcid.org/0000-0003-3250-2518"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George C Gabriel","raw_affiliation_strings":["Department of Developmental Biology , School of Medicine , University of Pittsburgh , Pittsburgh , PA , USA","Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology , School of Medicine , University of Pittsburgh , Pittsburgh , PA , USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079308710","display_name":"N Balakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N Balakrishnan","raw_affiliation_strings":["Supercomputer Education and Research Centre , Indian Institute of Science , Bangalore 560012 , India","Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supercomputer Education and Research Centre , Indian Institute of Science , Bangalore 560012 , India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022595874","display_name":"Cecilia W. Y. Lo","orcid":"https://orcid.org/0000-0003-4314-3434","observed_orcids":["https://orcid.org/0000-0003-4314-3434"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia W Lo","raw_affiliation_strings":["Department of Developmental Biology , School of Medicine , University of Pittsburgh , Pittsburgh , PA , USA","Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology , School of Medicine , University of Pittsburgh , Pittsburgh , PA , USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000049528","display_name":"Madhavi K. Ganapathiraju","orcid":"https://orcid.org/0000-0002-3825-0924","observed_orcids":["https://orcid.org/0000-0002-3825-0924"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Madhavi K Ganapathiraju","raw_affiliation_strings":["Department of Biomedical Informatics , School of Medicine , University of Pittsburgh , Pittsburgh , PA , USA","Intelligent Systems Program , School of Computing and Information , University of Pittsburgh , Pittsburgh , PA , USA","Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","Intelligent Systems Program, School of Computing and Information, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3825-0924","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics , School of Medicine , University of Pittsburgh , Pittsburgh , PA , USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Intelligent Systems Program , School of Computing and Information , University of Pittsburgh , Pittsburgh , PA , USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Intelligent Systems Program, School of Computing and Information, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000049528"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoplastic-left-heart-syndrome","display_name":"hypoplastic left heart syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ciliopathy","display_name":"ciliopathies","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neurodevelopmental-delay","display_name":"neurodevelopmental delay","score":0.9760000109672546},{"id":"https://openalex.org/keywords/microcephaly","display_name":"microcephaly","score":0.7799999713897705},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.753000020980835},{"id":"https://openalex.org/keywords/tor-signaling","display_name":"TOR signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.8289999961853027},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.949999988079071},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.7210000157356262},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.4339999854564667},{"id":"https://openalex.org/keywords/extracardiac-anomalies","display_name":"extracardiac anomalies","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.8548189401626587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6032310724258423},{"id":"https://openalex.org/C2776395126","wikidata":"https://www.wikidata.org/wiki/Q431643","display_name":"Microcephaly","level":2,"score":0.5609482526779175},{"id":"https://openalex.org/C2780561973","wikidata":"https://www.wikidata.org/wiki/Q203031","display_name":"Ciliopathy","level":4,"score":0.5448387861251831},{"id":"https://openalex.org/C2779545397","wikidata":"https://www.wikidata.org/wiki/Q1641399","display_name":"Hypoplastic left heart syndrome","level":3,"score":0.45837002992630005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42075392603874207},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.415330708026886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4067651033401489},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3920647203922272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.320796400308609},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.2850778102874756},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21545115113258362},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.1554475724697113},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.20944/preprints202202.0017.v1","doi":"https://doi.org/10.20944/preprints202202.0017.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202202.0017.v1","pdf_url":"https://www.preprints.org/manuscript/202202.0017/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai::71935","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12733/1581113","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNICAMP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:americanae.aecid.es:2818723","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unicamp.br/jspui/handle/REPOSIP/253845","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da Unicamp","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositorio.unicamp.br:REPOSIP/253845","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unicamp.br/jspui/handle/REPOSIP/253845","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da Unicamp","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.20944/preprints202202.0017.v1","doi":"https://doi.org/10.20944/preprints202202.0017.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202202.0017.v1","pdf_url":"https://www.preprints.org/manuscript/202202.0017/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210497145.pdf","grobid_xml":"https://content.openalex.org/works/W4210497145.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W161485841","https://openalex.org/W1527927437","https://openalex.org/W1533942137","https://openalex.org/W1666345410","https://openalex.org/W1863582575","https://openalex.org/W1951862796","https://openalex.org/W1964395129","https://openalex.org/W1965098533","https://openalex.org/W1978527132","https://openalex.org/W1989684700","https://openalex.org/W1992231023","https://openalex.org/W1996449188","https://openalex.org/W2004723483","https://openalex.org/W2010457001","https://openalex.org/W2012034410","https://openalex.org/W2017230497","https://openalex.org/W2032167669","https://openalex.org/W2039176012","https://openalex.org/W2046778872","https://openalex.org/W2050536025","https://openalex.org/W2054035764","https://openalex.org/W2062533676","https://openalex.org/W2104276565","https://openalex.org/W2122863289","https://openalex.org/W2126924893","https://openalex.org/W2145601137","https://openalex.org/W2159675211","https://openalex.org/W2162143298","https://openalex.org/W2163485494","https://openalex.org/W2167898988","https://openalex.org/W2181483150","https://openalex.org/W2238514531","https://openalex.org/W2258597767","https://openalex.org/W2344057082","https://openalex.org/W2478929223","https://openalex.org/W2482501744","https://openalex.org/W2537679995","https://openalex.org/W2545674646","https://openalex.org/W2597263729","https://openalex.org/W2615483894","https://openalex.org/W2734540391","https://openalex.org/W2769637435","https://openalex.org/W2897279578","https://openalex.org/W2945275601","https://openalex.org/W2947596336","https://openalex.org/W2989068523","https://openalex.org/W3004531765","https://openalex.org/W3037058363","https://openalex.org/W3088412737","https://openalex.org/W3090607968","https://openalex.org/W3111559404","https://openalex.org/W3112012115","https://openalex.org/W3142818195","https://openalex.org/W3162624364","https://openalex.org/W4210497145","https://openalex.org/W4237335579","https://openalex.org/W4244711466","https://openalex.org/W4244734753","https://openalex.org/W4245702457","https://openalex.org/W4248234957","https://openalex.org/W4248517597","https://openalex.org/W4249856617","https://openalex.org/W4250460366","https://openalex.org/W4255739241","https://openalex.org/W6827846073","https://openalex.org/W6846557823"],"related_works":["https://openalex.org/W4292634579","https://openalex.org/W2528419842","https://openalex.org/W2081566357","https://openalex.org/W2410611725","https://openalex.org/W2964314049","https://openalex.org/W4319262239","https://openalex.org/W2076876795","https://openalex.org/W2890749285","https://openalex.org/W2808983856","https://openalex.org/W2022326234"],"abstract_inverted_index":{"Hypoplastic":[0],"left":[1],"heart":[2,9],"syndrome":[3],"(HLHS)":[4],"is":[5,50],"a":[6,27,53,123],"severe":[7],"congenital":[8],"disease":[10],"(CHD)":[11],"affecting":[12],"1":[13],"in":[14,69,167],"5,000":[15],"newborns.":[16],"We":[17],"constructed":[18],"the":[19,78,90,151,159,179],"interactome":[20,49,91,146],"of":[21,72,80,89,93,111,137,153,182,187],"74":[22],"HLHS-associated":[23],"genes":[24,61,95,118,121,132,161,165],"identified":[25],"from":[26],"large-scale":[28],"mouse":[29],"mutagenesis":[30],"screen,":[31],"augmenting":[32],"it":[33],"with":[34,55,129,150,158,194],"408":[35],"novel":[36,64],"protein-protein":[37],"interactions":[38],"(PPIs)":[39],"using":[40],"our":[41],"High-precision":[42],"Protein-Protein":[43],"Interaction":[44],"Prediction":[45],"(HiPPIP)":[46],"model.":[47],"The":[48,144],"available":[51],"on":[52],"webserver":[54],"advanced":[56],"search":[57],"capabilities":[58],"(http://severus.dbmi.pitt.edu/wiki-HLHS).":[59],"364":[60],"including":[62],"73":[63],"interactors":[65],"were":[66],"differentially":[67],"regulated":[68],"tissues/iPSC-derived":[70],"cardiomyocytes":[71],"HLHS":[73,103,120,145,192],"patients.":[74],"Novel":[75],"PPIs":[76],"facilitated":[77],"identification":[79],"TOR":[81],"signaling":[82],"and":[83,101,115,142,155,173,185,197],"endoplasmic":[84],"reticulum":[85],"stress":[86],"modules.":[87],"60.5%":[88],"consisted":[92],"housekeeping":[94],"that":[96],"may":[97],"harbor":[98],"large-effect":[99],"mutations":[100],"drive":[102],"etiology":[104],"but":[105],"show":[106],"limited":[107],"transmission.":[108],"Network":[109],"proximity":[110],"diabetes,":[112],"Alzheimer\u2019s":[113],"disease,":[114],"liver":[116,141],"carcinoma-associated":[117],"to":[119],"suggested":[122],"mechanistic":[124],"basis":[125],"for":[126,135,164],"their":[127],"comorbidity":[128],"HLHS.":[130],"Interactome":[131],"showed":[133],"tissue-specificity":[134],"sites":[136],"extracardiac":[138],"anomalies":[139],"(placenta,":[140],"brain).":[143],"shared":[147,160],"significant":[148],"overlaps":[149],"interactomes":[152],"ciliopathy":[154,183],"microcephaly-associated":[156],"genes,":[157],"respectively":[162],"enriched":[163],"involved":[166],"intellectual":[168],"disability":[169],"and/or":[170],"developmental":[171,195],"delay,":[172],"neuronal":[174],"death":[175],"pathways.":[176],"This":[177],"supported":[178],"increased":[180],"burden":[181],"variants":[184],"prevalence":[186],"neurological":[188],"abnormalities":[189],"observed":[190],"among":[191],"patients":[193],"delay":[196],"microcephaly":[198],"respectively.":[199]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2025-10-10T00:00:00"}