{"id":"https://openalex.org/W4210484136","doi":"https://doi.org/10.24125/sanamed.v16i3.528","title":"The importance of determining the uromodulin serum concentration in diabetes mellitus type 2 patients","display_name":"The importance of determining the uromodulin serum concentration in diabetes mellitus type 2 patients","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W4210484136","doi":"https://doi.org/10.24125/sanamed.v16i3.528"},"language":"en","primary_location":{"id":"doi:10.24125/sanamed.v16i3.528","doi":"https://doi.org/10.24125/sanamed.v16i3.528","is_oa":true,"landing_page_url":"https://doi.org/10.24125/sanamed.v16i3.528","pdf_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-662X/2021/1452-662X2103201J.pdf","source":{"id":"https://openalex.org/S4210169594","display_name":"SANAMED","issn_l":"1452-662X","issn":["1452-662X","2217-8171"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310321692","host_organization_name":"Association of medical doctors Sanamed Novi Pazar","host_organization_lineage":["https://openalex.org/P4310321692"],"host_organization_lineage_names":["Association of medical doctors Sanamed Novi Pazar"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sanamed","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-662X/2021/1452-662X2103201J.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082297301","display_name":"Elena Jordanova","orcid":"https://orcid.org/0000-0003-2698-6843","observed_orcids":["https://orcid.org/0000-0003-2698-6843"]},"institutions":[{"id":"https://openalex.org/I4210139372","display_name":"Zemun Hospital","ror":"https://ror.org/03efvsk51","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210139372"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Elena Jordanova","raw_affiliation_strings":["Clinical Hospital Center Zemun Vukova 9 , 11080 Zemun , Belgrade , Serbia","Department of Nephrology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia"],"raw_orcid":"https://orcid.org/0000-0003-2698-6843","affiliations":[{"raw_affiliation_string":"Clinical Hospital Center Zemun Vukova 9 , 11080 Zemun , Belgrade , Serbia","institution_ids":[]},{"raw_affiliation_string":"Department of Nephrology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210139372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059868971","display_name":"Vladimir S. Samardzic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139372","display_name":"Zemun Hospital","ror":"https://ror.org/03efvsk51","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210139372"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Vladimir Samard\u017ei\u0107","raw_affiliation_strings":["Department of Endocrinology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210139372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068099946","display_name":"Gordana Pekovi\u0107-Peruni\u010di\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139372","display_name":"Zemun Hospital","ror":"https://ror.org/03efvsk51","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210139372"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Gordana Pekovi\u0107-Peruni\u010di\u0107","raw_affiliation_strings":["Department of Nephrology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210139372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017299309","display_name":"Jelena Tica-Jevti\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139372","display_name":"Zemun Hospital","ror":"https://ror.org/03efvsk51","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210139372"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Jelena Tica-Jevti\u0107","raw_affiliation_strings":["Department of Endocrinology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Clinic for Internal Medicine, Clinical Hospital Center Zemun, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210139372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016810918","display_name":"Sanja Simi\u0107\u2010Ogrizovi\u0107","orcid":"https://orcid.org/0000-0003-2989-2922","observed_orcids":["https://orcid.org/0000-0003-2989-2922"]},"institutions":[{"id":"https://openalex.org/I173887773","display_name":"University of Banja Luka","ror":"https://ror.org/0282m7c06","country_code":"BA","type":"education","lineage":["https://openalex.org/I173887773"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Sanja Simi\u0107-Ogrizovi\u0107","raw_affiliation_strings":["Medigroup Hospital, New Belgrade, Belgrade, Serbia","University of Banja Luka, School of Medicine, Banja Luka, Bosnia and Herzegovina"],"raw_orcid":"https://orcid.org/0000-0003-2989-2922","affiliations":[{"raw_affiliation_string":"Medigroup Hospital, New Belgrade, Belgrade, Serbia","institution_ids":[]},{"raw_affiliation_string":"University of Banja Luka, School of Medicine, Banja Luka, Bosnia and Herzegovina","institution_ids":["https://openalex.org/I173887773"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082297301"],"corresponding_institution_ids":["https://openalex.org/I4210139372"],"apc_list":{"value":150,"currency":"EUR","value_usd":161},"apc_paid":{"value":150,"currency":"EUR","value_usd":161},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"3","first_page":"201","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uromodulin","display_name":"uromodulin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/early-renal-injury","display_name":"early renal damage","score":0.7889999747276306},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gfr-estimation","display_name":"glomerular filtration rate estimation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cockcroft-gault-equation","display_name":"Cockcroft-Gault formula","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ckd-epi-equation","display_name":"CKD-EPI equation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8199999928474426},{"id":"https://openalex.org/keywords/thick-ascending-limb-of-henle","display_name":"thick ascending limb of Henle's loop","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C74460091","wikidata":"https://www.wikidata.org/wiki/Q420024","display_name":"Tamm\u2013Horsfall protein","level":3,"score":0.9897766709327698},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.754961371421814},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6881731748580933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6389747858047485},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6376305818557739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6258136034011841},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5469253063201904},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5254158973693848},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5202940106391907},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4579881429672241},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.43030375242233276},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3561050295829773},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35520440340042114},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2965543866157532}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.24125/sanamed.v16i3.528","doi":"https://doi.org/10.24125/sanamed.v16i3.528","is_oa":true,"landing_page_url":"https://doi.org/10.24125/sanamed.v16i3.528","pdf_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-662X/2021/1452-662X2103201J.pdf","source":{"id":"https://openalex.org/S4210169594","display_name":"SANAMED","issn_l":"1452-662X","issn":["1452-662X","2217-8171"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310321692","host_organization_name":"Association of medical doctors Sanamed Novi Pazar","host_organization_lineage":["https://openalex.org/P4310321692"],"host_organization_lineage_names":["Association of medical doctors Sanamed Novi Pazar"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sanamed","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f64cb5bfd85f4ecdb0141dd2593b09ff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f64cb5bfd85f4ecdb0141dd2593b09ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sanamed, Vol 16, Iss 3, Pp 201-207 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.24125/sanamed.v16i3.528","doi":"https://doi.org/10.24125/sanamed.v16i3.528","is_oa":true,"landing_page_url":"https://doi.org/10.24125/sanamed.v16i3.528","pdf_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-662X/2021/1452-662X2103201J.pdf","source":{"id":"https://openalex.org/S4210169594","display_name":"SANAMED","issn_l":"1452-662X","issn":["1452-662X","2217-8171"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310321692","host_organization_name":"Association of medical doctors Sanamed Novi Pazar","host_organization_lineage":["https://openalex.org/P4310321692"],"host_organization_lineage_names":["Association of medical doctors Sanamed Novi Pazar"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sanamed","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210484136.pdf","grobid_xml":"https://content.openalex.org/works/W4210484136.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W108682491","https://openalex.org/W2001124618","https://openalex.org/W2007789292","https://openalex.org/W2091537474","https://openalex.org/W2091658812","https://openalex.org/W2115378896","https://openalex.org/W2139991445","https://openalex.org/W2149374583","https://openalex.org/W2149988067","https://openalex.org/W2168357775","https://openalex.org/W2341947654","https://openalex.org/W2511066808","https://openalex.org/W2575681376","https://openalex.org/W2586648535","https://openalex.org/W2750659915","https://openalex.org/W2778121448","https://openalex.org/W2911139160","https://openalex.org/W2945356552","https://openalex.org/W2969678144","https://openalex.org/W2970302173","https://openalex.org/W3080908768","https://openalex.org/W3201595862"],"related_works":["https://openalex.org/W2619581167","https://openalex.org/W2763749414","https://openalex.org/W2561343653","https://openalex.org/W2586648535","https://openalex.org/W2951449302","https://openalex.org/W3117859411","https://openalex.org/W2924869597","https://openalex.org/W3085327969","https://openalex.org/W2888178015","https://openalex.org/W2888522006"],"abstract_inverted_index":{"Introduction:":[0],"In":[1],"the":[2,6,11,14,24,27,39],"kidney,":[3],"cells":[4],"in":[5,31,38,174,266],"thick":[7],"ascending":[8],"limb":[9],"of":[10,13,26,42,56,74,82,243,253],"loop":[12],"Henle":[15],"synthesized":[16],"uromodulin":[17,28,86,163,180,245,259],"(UMOD).":[18],"This":[19],"study":[20,49,255],"aims":[21],"to":[22,154],"present":[23],"evaluation":[25],"serum":[29,80,132,162,230,244,260],"concentration":[30,81,133,164,231,246,261],"diabetes":[32],"mellitus":[33],"type":[34],"2":[35],"(T2DM)":[36],"patients":[37,53,100,109,128,145,158],"early":[40,263],"detection":[41],"kidney":[43,264],"damage.":[44],"Materials":[45],"and":[46,70,89,106,122,142,150,181,227],"methods:":[47],"The":[48,241,251],"included":[50],"50":[51],"T2DM":[52,127,144,157,267],"mean":[54],"age":[55,213],"60.75":[57],"\u00b1":[58,67,166,170],"11.23":[59],"years":[60],"estimated":[61],"glomerular":[62],"filtration":[63],"rate":[64],"(eGFR)":[65],"114.38":[66],"22.12":[68],"ml/min":[69],"a":[71],"control":[72,155],"group":[73],"20":[75],"healthy":[76],"persons.":[77],"We":[78,93],"measured":[79],"haemoglobin,":[83],"urea,":[84],"creatinine,":[85],"(ELISA":[87],"method),":[88],"cystatin":[90,151,201,228],"C":[91,152,202,229],"(nephelometry).":[92],"determined":[94],"formulas:":[95,140],"Cockcroft-Gault#":[96,141,182],"(combination":[97],"Cockcroft-Gault":[98],"for":[99,108],"with":[101,110,212],"BMI":[102,111,149,220],"<":[103],"30":[104,113],"kg/m2":[105],"Cockcroft-GaultLBW":[107],"\u2265":[112],"kg/m2),":[114],"CKD-EPI":[115,189],"(Chronic":[116],"Kidney":[117],"Disease":[118],"Epidemiology":[119],"Collaboration":[120],"equation),":[121],"simple":[123,200],"Cystatin":[124],"C.":[125],"Results:":[126],"had":[129,146,159],"lower":[130,161],"hemoglobin":[131],"as":[134,136,197,199],"well":[135,198],"eGFR":[137],"calculated":[138],"by":[139],"CKD-EPI.":[143],"significantly":[147,160],"higher":[148],"compared":[153],"group.":[156],"(136.51":[165],"84.34":[167],"vs":[168],"220.50":[169],"92.39":[171],"ng/ml)":[172],"than":[173],"controls.":[175],"Significant":[176],"positive":[177],"correlation":[178,211],"between":[179],"(r":[183,190,203,214,221,232],"=":[184,187,191,194,204,207,215,218,222,225,233,236],"0.432,":[185],"p":[186,193,206,217,224,235],"0.000),":[188,219],"0.439;":[192],"0.000)":[195],"formulas":[196],"0.250,":[205],"0.02),":[208],"but":[209],"negative":[210],"-0.476,":[216],"-0.313,":[223],"0.002)":[226],"-0.293,":[234],"0.015)":[237],"were":[238],"found.":[239],"Conclusion:":[240],"role":[242],"is":[247],"not":[248],"still":[249],"fortified.":[250],"results":[252],"this":[254],"showed":[256],"that":[257],"reduced":[258],"indicated":[262],"damage":[265],"patients.":[268]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-02-08T00:00:00"}