{"id":"https://openalex.org/W4210455276","doi":"https://doi.org/10.1007/s11696-021-02005-y","title":"New trinuclear nickel(II) complexes as potential topoisomerase I/II\u03b1 inhibitors: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines","display_name":"New trinuclear nickel(II) complexes as potential topoisomerase I/II\u03b1 inhibitors: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines","publication_year":2022,"publication_date":"2022-01-28","ids":{"openalex":"https://openalex.org/W4210455276","doi":"https://doi.org/10.1007/s11696-021-02005-y"},"language":"en","primary_location":{"id":"doi:10.1007/s11696-021-02005-y","doi":"https://doi.org/10.1007/s11696-021-02005-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11696-021-02005-y","pdf_url":null,"source":{"id":"https://openalex.org/S201842594","display_name":"Chemical Papers","issn_l":"0366-6352","issn":["0366-6352","1336-9075","2585-7290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Papers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029622938","display_name":"Tolga G\u00f6kt\u00fcrk","orcid":"https://orcid.org/0000-0002-7234-8079","observed_orcids":["https://orcid.org/0000-0002-7234-8079"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tolga G\u00f6kt\u00fcrk","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-7234-8079","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021381759","display_name":"Cansu G\u00f6k\u00e7e Topkaya","orcid":"https://orcid.org/0000-0002-6834-4841","observed_orcids":["https://orcid.org/0000-0002-6834-4841"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cansu Topkaya","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-6834-4841","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087083814","display_name":"Esin Sakall\u0131 \u00c7etin","orcid":"https://orcid.org/0000-0002-9715-1424","observed_orcids":["https://orcid.org/0000-0002-9715-1424"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esin Sakall\u0131 \u00c7etin","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9715-1424","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018865054","display_name":"Ramazan G\u00fcp","orcid":"https://orcid.org/0000-0001-5731-6733","observed_orcids":["https://orcid.org/0000-0001-5731-6733"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ramazan G\u00fcp","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-5731-6733","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000, Mu\u011fla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018865054"],"corresponding_institution_ids":["https://openalex.org/I79946792"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":null,"fwci":2.5947,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.92199285,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"76","issue":"4","first_page":"2093","last_page":"2109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nickel-ii-complexes","display_name":"nickel(II) complexes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/trinuclear-complexes","display_name":"trinuclear complexes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibition","display_name":"topoisomerase I inhibition","score":0.796999990940094},{"id":"https://openalex.org/keywords/topoisomerase-iialpha-inhibition","display_name":"topoisomerase II\u03b1 inhibition","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.6230000257492065},{"id":"https://openalex.org/keywords/groove-binding","display_name":"groove binding","score":0.777999997138977},{"id":"https://openalex.org/keywords/dna-cleavage","display_name":"DNA cleavage","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.6729999780654907},{"id":"https://openalex.org/keywords/anticancer-metal-complexes","display_name":"anticancer metal complexes","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6745767593383789},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.6377674341201782},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.596877932548523},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5194946527481079},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4963579773902893},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.47390806674957275},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.46312910318374634},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.39617425203323364},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3604090213775635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2587239742279053},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24690112471580505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18446099758148193},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s11696-021-02005-y","doi":"https://doi.org/10.1007/s11696-021-02005-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11696-021-02005-y","pdf_url":null,"source":{"id":"https://openalex.org/S201842594","display_name":"Chemical Papers","issn_l":"0366-6352","issn":["0366-6352","1336-9075","2585-7290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Papers","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5248652478","display_name":"Bis(oksim) ve Bis(dioksim) Temelli Topoizomeraz I ve II Inhibit\u00f6ru\u0308 Ge\u00e7i\u015f Metal Komplekslerinin Sentezi ve Karakterizasyonu: In vitro DNA Ba\u011flanma, Nu\u0308kleaz Aktivite ve \u00c7e\u015fitli \u0130nsan Kanser Hu\u0308crelerine Kar\u015f\u0131 Sitotoksisiteleri","funder_award_id":"215Z236","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W74691089","https://openalex.org/W170902164","https://openalex.org/W602212531","https://openalex.org/W1067357380","https://openalex.org/W1590106897","https://openalex.org/W1592286099","https://openalex.org/W1958849729","https://openalex.org/W1967693432","https://openalex.org/W1970241274","https://openalex.org/W1971915629","https://openalex.org/W1977774549","https://openalex.org/W1981073585","https://openalex.org/W1984883623","https://openalex.org/W1987604182","https://openalex.org/W1993620369","https://openalex.org/W1995723298","https://openalex.org/W1999318478","https://openalex.org/W2000966510","https://openalex.org/W2001976945","https://openalex.org/W2011357687","https://openalex.org/W2011458878","https://openalex.org/W2013046242","https://openalex.org/W2014014132","https://openalex.org/W2017753309","https://openalex.org/W2024425990","https://openalex.org/W2028621883","https://openalex.org/W2028714831","https://openalex.org/W2033591223","https://openalex.org/W2036400146","https://openalex.org/W2038124483","https://openalex.org/W2041756320","https://openalex.org/W2042062103","https://openalex.org/W2044851985","https://openalex.org/W2045980057","https://openalex.org/W2048447619","https://openalex.org/W2050829041","https://openalex.org/W2053011422","https://openalex.org/W2055326754","https://openalex.org/W2057627334","https://openalex.org/W2060069937","https://openalex.org/W2063567576","https://openalex.org/W2065970047","https://openalex.org/W2066681346","https://openalex.org/W2068026117","https://openalex.org/W2070543278","https://openalex.org/W2074257185","https://openalex.org/W2074959313","https://openalex.org/W2078160716","https://openalex.org/W2080215881","https://openalex.org/W2080869878","https://openalex.org/W2089459455","https://openalex.org/W2091796741","https://openalex.org/W2101539565","https://openalex.org/W2103638131","https://openalex.org/W2105462450","https://openalex.org/W2114918609","https://openalex.org/W2115530210","https://openalex.org/W2119031705","https://openalex.org/W2119727971","https://openalex.org/W2121454394","https://openalex.org/W2129559031","https://openalex.org/W2137600468","https://openalex.org/W2142716713","https://openalex.org/W2145538324","https://openalex.org/W2150165172","https://openalex.org/W2153383148","https://openalex.org/W2272503715","https://openalex.org/W2296740576","https://openalex.org/W2320099782","https://openalex.org/W2402506318","https://openalex.org/W2517231312","https://openalex.org/W2522570141","https://openalex.org/W2553030472","https://openalex.org/W2592902934","https://openalex.org/W2742480748","https://openalex.org/W2767428700","https://openalex.org/W2767486330","https://openalex.org/W2769661028","https://openalex.org/W2775778565","https://openalex.org/W2791951146","https://openalex.org/W2808781586","https://openalex.org/W2899066446","https://openalex.org/W2900168165","https://openalex.org/W2916006490","https://openalex.org/W2917203895","https://openalex.org/W2919501738","https://openalex.org/W2940838628","https://openalex.org/W2950245450","https://openalex.org/W2970881843","https://openalex.org/W2990861760","https://openalex.org/W3013083999","https://openalex.org/W3022022437","https://openalex.org/W3022052101","https://openalex.org/W3035404049","https://openalex.org/W3042561800","https://openalex.org/W3088002071","https://openalex.org/W3098757512","https://openalex.org/W4211057122","https://openalex.org/W4211246351"],"related_works":["https://openalex.org/W2916006490","https://openalex.org/W3142974544","https://openalex.org/W2006146762","https://openalex.org/W2272503715","https://openalex.org/W6939296367","https://openalex.org/W4282022908","https://openalex.org/W2566209798","https://openalex.org/W6976903869","https://openalex.org/W3035404049","https://openalex.org/W2767486330"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-02-08T00:00:00"}