{"id":"https://openalex.org/W4210453031","doi":"https://doi.org/10.1186/s12882-021-02593-7","title":"Chronic kidney disease mediates cardiac dysfunction associated with increased resident cardiac macrophages","display_name":"Chronic kidney disease mediates cardiac dysfunction associated with increased resident cardiac macrophages","publication_year":2022,"publication_date":"2022-01-28","ids":{"openalex":"https://openalex.org/W4210453031","doi":"https://doi.org/10.1186/s12882-021-02593-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/35090403","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8796634"},"language":"en","primary_location":{"id":"doi:10.1186/s12882-021-02593-7","doi":"https://doi.org/10.1186/s12882-021-02593-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12882-021-02593-7","pdf_url":"https://bmcnephrol.biomedcentral.com/counter/pdf/10.1186/s12882-021-02593-7","source":{"id":"https://openalex.org/S172421378","display_name":"BMC Nephrology","issn_l":"1471-2369","issn":["1471-2369"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcnephrol.biomedcentral.com/counter/pdf/10.1186/s12882-021-02593-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091147485","display_name":"Marie\u2010Anne Mawhin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M. A. Mawhin","raw_affiliation_strings":["Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK. m.mawhin@imperial.ac.uk","Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK. m.mawhin@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020838732","display_name":"R. G. Bright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. G. Bright","raw_affiliation_strings":["Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083151540","display_name":"Jerome Fourre","orcid":"https://orcid.org/0000-0002-0101-3466","observed_orcids":["https://orcid.org/0000-0002-0101-3466"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. D. Fourre","raw_affiliation_strings":["Faculty of Medicine, National Heart & Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, National Heart & Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073445324","display_name":"Eleni Vloumidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. I. Vloumidi","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025844625","display_name":"James A. P. Tomlinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Tomlinson","raw_affiliation_strings":["Renal Directorate, Imperial College Healthcare NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Directorate, Imperial College Healthcare NHS Trust, London, UK","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022423823","display_name":"Alex Sardini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Sardini","raw_affiliation_strings":["MRC London Institute of Medical Sciences, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC London Institute of Medical Sciences, Imperial College London, London, UK","institution_ids":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083936882","display_name":"Charles Dickson Pusey","orcid":"https://orcid.org/0000-0002-1424-3906","observed_orcids":["https://orcid.org/0000-0002-1424-3906"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. D. Pusey","raw_affiliation_strings":["Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084089745","display_name":"Kevin J. Woollard","orcid":"https://orcid.org/0000-0002-9839-5463","observed_orcids":["https://orcid.org/0000-0002-9839-5463"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"K. J. Woollard","raw_affiliation_strings":["Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK. k.woollard@imperial.ac.uk","Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK. k.woollard@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084089745","https://openalex.org/A5091147485"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":1.2241,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.78534156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"23","issue":"1","first_page":"47","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-macrophages","display_name":"cardiac macrophages","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cardiorenal-syndrome","display_name":"cardiorenal syndrome","score":0.875},{"id":"https://openalex.org/keywords/uremic-cardiomyopathy","display_name":"uremic cardiomyopathy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.9599999785423279},{"id":"https://openalex.org/keywords/monocyte-recruitment","display_name":"monocyte recruitment","score":0.6290000081062317},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.578000009059906},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.734000027179718},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.9459999799728394},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8232409954071045},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.734281599521637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.578163743019104},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5571345686912537},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.5548052191734314},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.48811110854148865},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4748544692993164},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46983879804611206},{"id":"https://openalex.org/C2781309322","wikidata":"https://www.wikidata.org/wiki/Q5038718","display_name":"Cardiorenal syndrome","level":3,"score":0.4692435562610626},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.4398396909236908},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4397915303707123},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.42637407779693604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36966389417648315},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34631848335266113},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3252456784248352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12014502286911011},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12882-021-02593-7","doi":"https://doi.org/10.1186/s12882-021-02593-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12882-021-02593-7","pdf_url":"https://bmcnephrol.biomedcentral.com/counter/pdf/10.1186/s12882-021-02593-7","source":{"id":"https://openalex.org/S172421378","display_name":"BMC Nephrology","issn_l":"1471-2369","issn":["1471-2369"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Nephrology","raw_type":"journal-article"},{"id":"pmid:35090403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35090403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC nephrology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8796634","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8796634/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Nephrol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:971ce48e3e854b1691bc8977e69e3d97","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/971ce48e3e854b1691bc8977e69e3d97","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Nephrology, Vol 23, Iss 1, Pp 1-15 (2022)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/92823","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/92823","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"15","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12882-021-02593-7","doi":"https://doi.org/10.1186/s12882-021-02593-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12882-021-02593-7","pdf_url":"https://bmcnephrol.biomedcentral.com/counter/pdf/10.1186/s12882-021-02593-7","source":{"id":"https://openalex.org/S172421378","display_name":"BMC Nephrology","issn_l":"1471-2369","issn":["1471-2369"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Nephrology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4265994242","display_name":null,"funder_award_id":"SG_JFS_RP_002_20170914","funder_id":"https://openalex.org/F4320320008","funder_display_name":"Kidney Research UK"},{"id":"https://openalex.org/G6609238873","display_name":null,"funder_award_id":"RP_019_20160303","funder_id":"https://openalex.org/F4320320008","funder_display_name":"Kidney Research UK"},{"id":"https://openalex.org/G7665220714","display_name":null,"funder_award_id":"RP_002_20170914","funder_id":"https://openalex.org/F4320320008","funder_display_name":"Kidney Research UK"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320008","display_name":"Kidney Research UK","ror":"https://ror.org/02kx7se86"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320284","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210453031.pdf","grobid_xml":"https://content.openalex.org/works/W4210453031.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W197772224","https://openalex.org/W240049905","https://openalex.org/W1538116717","https://openalex.org/W1584726811","https://openalex.org/W1929509592","https://openalex.org/W1963606632","https://openalex.org/W1965859404","https://openalex.org/W1972436508","https://openalex.org/W1978081390","https://openalex.org/W1978095098","https://openalex.org/W1980371716","https://openalex.org/W1984378291","https://openalex.org/W1994455716","https://openalex.org/W1997882924","https://openalex.org/W2005759195","https://openalex.org/W2010484682","https://openalex.org/W2015668150","https://openalex.org/W2024626836","https://openalex.org/W2024641784","https://openalex.org/W2026027152","https://openalex.org/W2032576629","https://openalex.org/W2040372855","https://openalex.org/W2054540776","https://openalex.org/W2059762308","https://openalex.org/W2098954540","https://openalex.org/W2099339447","https://openalex.org/W2104003768","https://openalex.org/W2106079757","https://openalex.org/W2107915827","https://openalex.org/W2111443452","https://openalex.org/W2112526496","https://openalex.org/W2121254199","https://openalex.org/W2129480322","https://openalex.org/W2133904980","https://openalex.org/W2135703618","https://openalex.org/W2149030597","https://openalex.org/W2152533590","https://openalex.org/W2157068697","https://openalex.org/W2393059332","https://openalex.org/W2405183840","https://openalex.org/W2467628122","https://openalex.org/W2475261460","https://openalex.org/W2487377689","https://openalex.org/W2513245700","https://openalex.org/W2597102949","https://openalex.org/W2604206413","https://openalex.org/W2605975631","https://openalex.org/W2607031541","https://openalex.org/W2607351488","https://openalex.org/W2608146344","https://openalex.org/W2783025516","https://openalex.org/W2791059232","https://openalex.org/W2800905301","https://openalex.org/W2800978027","https://openalex.org/W2805322110","https://openalex.org/W2806102216","https://openalex.org/W2889326414","https://openalex.org/W2893944541","https://openalex.org/W2902050841","https://openalex.org/W2902652978","https://openalex.org/W2904624968","https://openalex.org/W2912227678","https://openalex.org/W2914169043","https://openalex.org/W2915920279","https://openalex.org/W2949746255","https://openalex.org/W2982367920","https://openalex.org/W2982611189","https://openalex.org/W4242141803"],"related_works":["https://openalex.org/W6958266684","https://openalex.org/W2738339575","https://openalex.org/W6920797903","https://openalex.org/W3182676955","https://openalex.org/W2414573100","https://openalex.org/W4288052789","https://openalex.org/W2920733286","https://openalex.org/W4408814465","https://openalex.org/W2973127623","https://openalex.org/W4388966649"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"leading":[2],"cause":[3],"of":[4,36,49,71,95,103,107,143,159],"death":[5],"in":[6,21,33,51,63,92,98,125,136,145,164],"end-stage":[7],"kidney":[8,24,89],"disease":[9,25],"is":[10,39],"related":[11],"to":[12,18,45,79,111],"cardiovascular":[13],"disease.":[14,54,127],"Macrophages":[15],"are":[16],"known":[17],"be":[19],"involved":[20],"both":[22],"chronic":[23],"(CKD)":[26],"and":[27,56,67,75,139,147],"heart":[28],"failure,":[29],"however":[30],"their":[31],"role":[32,48,158],"the":[34,47,69,93,141,157,160],"development":[35],"cardiorenal":[37],"syndrome":[38],"less":[40],"clear.":[41],"We":[42,60,85,114],"thus":[43],"sought":[44],"investigate":[46],"macrophages":[50],"uremic":[52,126,165],"cardiac":[53,77,96,122,148],"METHODS:":[55],"anti-CXCL10":[57],"treated":[58],"mice.":[59],"quantified":[61],"CXCL10":[62,116,134,144],"human":[64,72],"CKD":[65,82],"plasma":[66,133],"tested":[68],"response":[70],"iPSC-derived":[73],"cardiomyocytes":[74,146],"primary":[76],"fibroblasts":[78],"serum":[80],"from":[81],"donors.":[83],"RESULTS:":[84],"found":[86,131],"that":[87],"reduced":[88],"function":[90],"resulted":[91],"expansion":[94,124],"macrophages,":[97],"particular":[99],"through":[100],"local":[101],"proliferation":[102],"resident":[104],"populations.":[105],"Influx":[106],"circulating":[108],"monocytes":[109],"contributed":[110],"this":[112],"increase.":[113],"identified":[115,140],"as":[117],"a":[118],"crucial":[119],"factor":[120],"for":[121],"macrophage":[123],"In":[128],"humans,":[129],"we":[130],"increased":[132],"concentrations":[135],"advanced":[137],"CKD,":[138],"production":[142],"fibroblasts.":[149],"CONCLUSIONS:":[150],"This":[151],"study":[152],"provides":[153],"new":[154],"insight":[155],"into":[156],"innate":[161],"immune":[162],"system":[163],"cardiomyopathy.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-02-08T00:00:00"}