{"id":"https://openalex.org/W4210337474","doi":"https://doi.org/10.1055/s-0040-1719875","title":"Strategies for ortho-tert-Butylation of Phenols and their Analogues","display_name":"Strategies for ortho-tert-Butylation of Phenols and their Analogues","publication_year":2022,"publication_date":"2022-01-28","ids":{"openalex":"https://openalex.org/W4210337474","doi":"https://doi.org/10.1055/s-0040-1719875"},"language":"en","primary_location":{"id":"doi:10.1055/s-0040-1719875","doi":"https://doi.org/10.1055/s-0040-1719875","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0040-1719875","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1719875.pdf","source":{"id":"https://openalex.org/S80698544","display_name":"Synlett","issn_l":"0936-5214","issn":["0936-5214","1437-2096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synlett","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1719875.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022051408","display_name":"Thomas R. R. Pettus","orcid":"https://orcid.org/0000-0001-5462-3973","observed_orcids":["https://orcid.org/0000-0001-5462-3973"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210110804","display_name":"Thieme Medical Publishers (Germany)","ror":"https://ror.org/01zg9j813","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210110804"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Thomas R. R. Pettus","raw_affiliation_strings":["Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe 14 , 70469 Stuttgart","Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe","Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California, 93106, USA","Germany","University of California Santa","University of California Santa Barbara in 1998"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe 14 , 70469 Stuttgart","institution_ids":["https://openalex.org/I4210110804"]},{"raw_affiliation_string":"Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe","institution_ids":["https://openalex.org/I4210110804"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California, 93106, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"University of California Santa","institution_ids":[]},{"raw_affiliation_string":"University of California Santa Barbara in 1998","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089200492","display_name":"Kazaf KC Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210110804","display_name":"Thieme Medical Publishers (Germany)","ror":"https://ror.org/01zg9j813","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210110804"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Kazaf KC Chan","raw_affiliation_strings":["Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe 14 , 70469 Stuttgart","Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe","Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California, 93106, USA","Germany","University of California Santa","University of California Santa Barbara in 1998"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe 14 , 70469 Stuttgart","institution_ids":["https://openalex.org/I4210110804"]},{"raw_affiliation_string":"Georg Thieme Verlag KG R\u00fcdigerstra\u00dfe","institution_ids":["https://openalex.org/I4210110804"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California, 93106, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"University of California Santa","institution_ids":[]},{"raw_affiliation_string":"University of California Santa Barbara in 1998","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00463494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"06","first_page":"575","last_page":"580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.18199999630451202,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.18199999630451202,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.14270000159740448,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ortho-quinone-methides","display_name":"ortho-quinone methides","score":0.7749999761581421},{"id":"https://openalex.org/keywords/friedel-crafts-alkylation","display_name":"Friedel-Crafts alkylation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/regioselectivity","display_name":"regioselectivity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/functional-group-tolerance","display_name":"functional group tolerance","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9303004741668701},{"id":"https://openalex.org/C59759590","wikidata":"https://www.wikidata.org/wiki/Q2275927","display_name":"Regioselectivity","level":3,"score":0.8053888082504272},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.7794882655143738},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.6765998601913452},{"id":"https://openalex.org/C9061509","wikidata":"https://www.wikidata.org/wiki/Q901713","display_name":"Nucleophilic aromatic substitution","level":3,"score":0.666175127029419},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.5757468938827515},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5181752443313599},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.47152385115623474},{"id":"https://openalex.org/C202224193","wikidata":"https://www.wikidata.org/wiki/Q649999","display_name":"Friedel\u2013Crafts reaction","level":3,"score":0.4288950562477112},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.417233943939209},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.39031243324279785},{"id":"https://openalex.org/C135731615","wikidata":"https://www.wikidata.org/wiki/Q658656","display_name":"Nucleophilic substitution","level":2,"score":0.14760541915893555},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.13225126266479492},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0040-1719875","doi":"https://doi.org/10.1055/s-0040-1719875","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0040-1719875","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1719875.pdf","source":{"id":"https://openalex.org/S80698544","display_name":"Synlett","issn_l":"0936-5214","issn":["0936-5214","1437-2096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synlett","raw_type":"journal-article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6qj5d7p4","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6qj5d7p4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Synlett, vol 33, iss 06","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1055/s-0040-1719875","doi":"https://doi.org/10.1055/s-0040-1719875","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0040-1719875","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1719875.pdf","source":{"id":"https://openalex.org/S80698544","display_name":"Synlett","issn_l":"0936-5214","issn":["0936-5214","1437-2096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synlett","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332500","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210337474.pdf","grobid_xml":"https://content.openalex.org/works/W4210337474.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1965399826","https://openalex.org/W1967188973","https://openalex.org/W1975911187","https://openalex.org/W1978883015","https://openalex.org/W1993684663","https://openalex.org/W1997216283","https://openalex.org/W2004072584","https://openalex.org/W2012406770","https://openalex.org/W2013450477","https://openalex.org/W2043423092","https://openalex.org/W2043958277","https://openalex.org/W2047382466","https://openalex.org/W2047738597","https://openalex.org/W2054031347","https://openalex.org/W2060863510","https://openalex.org/W2062910798","https://openalex.org/W2065393427","https://openalex.org/W2072945029","https://openalex.org/W2077449367","https://openalex.org/W2078742784","https://openalex.org/W2081347725","https://openalex.org/W2085493094","https://openalex.org/W2089385547","https://openalex.org/W2121029205","https://openalex.org/W2128711500","https://openalex.org/W2131542850","https://openalex.org/W2158756493","https://openalex.org/W2159843352","https://openalex.org/W2161832818","https://openalex.org/W2317894234","https://openalex.org/W2319536091","https://openalex.org/W2320031123","https://openalex.org/W2321224584","https://openalex.org/W2418366832","https://openalex.org/W2767007305","https://openalex.org/W2783182590","https://openalex.org/W2788444601","https://openalex.org/W2807202131","https://openalex.org/W2899339174","https://openalex.org/W2949062535","https://openalex.org/W2952050809","https://openalex.org/W2952121801","https://openalex.org/W2952276871","https://openalex.org/W2995178155"],"related_works":["https://openalex.org/W7028829000","https://openalex.org/W1989452747","https://openalex.org/W1979585233","https://openalex.org/W2952516982","https://openalex.org/W2952050809","https://openalex.org/W2085688366","https://openalex.org/W1975334368","https://openalex.org/W1995311950","https://openalex.org/W2952121801","https://openalex.org/W2107138464"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"new":[2],"general":[3],"process":[4,50],"for":[5,62],"constructing":[6],"ortho-tert-butyl":[7],"phenols":[8,65],"is":[9,46],"presented":[10],"within":[11],"the":[12,48],"context":[13],"of":[14,37,76,86,95,100],"other":[15,59],"known":[16,60],"methods.":[17],"All":[18],"are":[19],"briefly":[20],"evaluated":[21],"with":[22],"regards":[23],"to":[24,80],"regioselectivity,":[25],"efficiency,":[26],"and":[27,55,66,89],"functional":[28],"group":[29],"tolerance.":[30],"In":[31],"addition,":[32],"we":[33],"present":[34],"an":[35],"assortment":[36],"tert-butyl":[38],"substrates":[39],"accessed":[40],"through":[41],"o-QM":[42,49],"chemistry.":[43],"Our":[44],"conclusion":[45],"that":[47],"provides":[51],"greater":[52],"yields,":[53],"flexibility,":[54],"generality":[56],"than":[57],"most":[58],"methods":[61],"delivering":[63],"ortho-tert-buytlated":[64],"their":[67],"derivatives.":[68],"1":[69],"Introduction":[70],"2":[71],"Friedel\u2013Crafts":[72],"Alkylation":[73],"3":[74],"Addition":[75],"t-Bu\u2013":[77],"or":[78],"t-Bu\u2022":[79],"Carbonyl":[81],"Compounds":[82],"4":[83],"ipso-SNAr":[84],"Reactions":[85],"Aryl":[87,96],"Methoxy":[88],"tert-Butylsulfoxide":[90],"Moieties":[91],"5":[92],"Metal-Mediated":[93],"Coupling":[94],"Bromides":[97],"6":[98],"Applications":[99],"o-Quinone":[101],"Methides":[102],"(o-QMs)":[103],"7":[104],"Conclusion":[105]},"counts_by_year":[],"updated_date":"2026-09-08T07:41:39.490200","created_date":"2022-02-08T00:00:00"}